PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBA1 DCUN1D2 25260751 intact exp GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP G GP G GP G GP GP G CUL4B DCUN1D2 23201271,19617556 biogrid,dip exp GP GP G G GP GP G GP GP G GP G G G G GP GP G GP G GP G GP G GP G GP GP G DCUN1D2 UBE2F 23201271 biogrid exp GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP G GP G GP G GP GP G UBE2N DCUN1D2 25260751 intact exp GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP G GP G GP G GP GP G DCUN1D2 CUL5 23201271,19617556 biogrid,dip exp GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP G GP G GP G GP GP G MAP3K1 DCUN1D2 25260751 biogrid exp GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP G GP G GP G GP GP G APP DCUN1D2 21832049 biogrid exp G GP G G GP GP G G GP G G G G G G GP GP G GP G GP G G G GP G G GP G CUL1 DCUN1D2 23201271,19617556 biogrid,dip exp GP G G G G GP G GP GP G GP G GP G G GP GP G GP G GP G GP G GP G GP GP G DCUN1D2 DCUN1D1 21145461 biogrid exp P G G G GP G P P G P P P GP G GP G GP G P G GP P GP G UBE2V1 DCUN1D2 25260751 intact exp CUL3 DCUN1D2 23201271,19617556 biogrid,dip exp, ortho GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP G GP G GP G GP GP G CUL2 DCUN1D2 23201271,19617556 biogrid,dip exp, ortho GP GP G G G GP G G GP G GP G GP G G G GP G GP G GP G GP G G G GP GP G UBE2M DCUN1D2 23201271,19617556 biogrid,dip exp, ortho GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP G GP G GP G GP GP G CUL4A DCUN1D2 23201271,19617556 biogrid,dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBA52 DCUN1D2 ortho GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP G GP G GP G GP GP G DCUN1D2 DCUN1D2 ortho GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP G GP G GP G GP GP G UBC DCUN1D2 ortho GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP G GP G GP G GP GP G RPS27A DCUN1D2 ortho GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP G GP G GP G GP GP G NEDD8 DCUN1D2 ortho GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP G GP G GP G GP GP G DCUN1D2 LSM2 ortho GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP G GP G GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6PH85 A0A024R475 pull down 23201271 direct interaction X 2 Q6PH85 Q13620-3 pull down 23201271 direct interaction X 2 Q6PH85 Q93034 pull down 23201271 direct interaction X 2 Q6PH85 A0A024R475 affinity chromatography technology 19617556 physical association X 2 Q6PH85 Q13620-3 affinity chromatography technology 19617556 physical association X 2 Q6PH85 Q93034 affinity chromatography technology 19617556 physical association X 2 Q6PH85 A0A024R475 enzymatic study 23201271 direct interaction X 2 Q6PH85 Q13620-3 enzymatic study 23201271 direct interaction X 2 Q6PH85 Q93034 enzymatic study 23201271 direct interaction X 2 Q6PH85 Q96GG9 affinity chromatography technology 21145461 physical association X 2 Q6PH85 P05067-7 pull down 21832049 direct interaction X 2 Q6PH85 A0A090N7U0 pull down 23201271 direct interaction X 2 Q6PH85 Q13617 pull down 23201271 direct interaction X 2 Q6PH85 B2RBV7 pull down 23201271 direct interaction X 2 Q6PH85 Q969M7 pull down 23201271 direct interaction X 2 Q6PH85 A0A024R4T4 pull down 23201271 direct interaction X 2 Q6PH85 A0A024R4T4 x-ray crystallography 23201271 association X 2 Q6PH85 A0A090N7U0 affinity chromatography technology 19617556 physical association X 2 Q6PH85 Q13617 affinity chromatography technology 19617556 physical association X 2 Q6PH85 B2RBV7 affinity chromatography technology 19617556 physical association X 2 Q6PH85 A0A024R4T4 affinity chromatography technology 19617556 physical association X 2 Q6PH85 A0A090N7U0 enzymatic study 23201271 direct interaction X 2 Q6PH85 Q13617 enzymatic study 23201271 direct interaction X 2 Q6PH85 B2RBV7 enzymatic study 23201271 direct interaction X 2 Q6PH85 anti tag coimmunoprecipitation 19617556 - C 7 Q6PH85 A0A024R475 anti tag coimmunoprecipitation 19617556 physical association X 2 Q6PH85 Q13620 anti tag coimmunoprecipitation 19617556 physical association X 2 Q6PH85 Q93034 anti tag coimmunoprecipitation 19617556 physical association X 2 Q6PH85 A0A024R4T4 anti tag coimmunoprecipitation 19617556 physical association X 2 Q6PH85 A0A090N7U0 anti tag coimmunoprecipitation 19617556 physical association X 2 Q6PH85 Q13617 anti tag coimmunoprecipitation 19617556 physical association X 2 Q6PH85 Q13619 anti tag coimmunoprecipitation 19617556 physical association X 2 Q6PH85 ubiquitinase assay 25260751 ubiquitination reaction C 5

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBE2M DCUN1D2 MI:0096(pull down)|MI:0096(pull down) 23201271 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0914(association) (biogrid)|(biogrid) BIOGRID_251323|BIOGRID_251332 bait|bait prey|prey DCUN1D2 UBE2F MI:0096(pull down) 23201271 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248872 prey bait CUL4A DCUN1D2 MI:0096(pull down) 23201271 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248854 prey bait CUL4B DCUN1D2 MI:0096(pull down) 23201271 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248859 prey bait CUL1 DCUN1D2 MI:0096(pull down) 23201271 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248839 prey bait CUL3 DCUN1D2 MI:0096(pull down) 23201271 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248849 prey bait DCUN1D2 DCUN1D1 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205935 prey bait CUL2 DCUN1D2 MI:0096(pull down) 23201271 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248844 prey bait NRF1 DCUN1D2 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_296064 bait prey APP DCUN1D2 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229153 prey bait DCUN1D2 CUL5 MI:0096(pull down) 23201271 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248864 bait prey

PPI - HINT Gene A Gene B PMID Method Quality UBE2M DCUN1D2 23201271,19617556,19617556,26906416,23201271 0114,0007,0004,0096,0096 LC CUL1 DCUN1D2 19617556,19617556,23201271,23201271,26906416 0007,0004,0415,0096,0004 LC CUL2 DCUN1D2 19617556,19617556,23201271,23201271,26906416 0007,0004,0415,0096,0004 LC CUL3 DCUN1D2 23201271,19617556,26906416,26906416,19617556,23201271,26906416 0096,0007,0096,0415,0004,0415,0004 LC CUL4A DCUN1D2 19617556,19617556,23201271,23201271,26906416 0007,0004,0415,0096,0004 LC CUL4B DCUN1D2 19617556,19617556,23201271,23201271,26906416 0007,0004,0415,0096,0004 LC DCUN1D2 CUL5 19617556,19617556,23201271,23201271,26906416 0007,0004,0415,0096,0004 LC DCUN1D2 DCUN1D1 21145461 0004 HT DCUN1D2 DCUN1D1 21145461 0004 HT UBE2M DCUN1D2 23201271,19617556,19617556,26906416,23201271 0114,0007,0004,0096,0096 LC CUL1 DCUN1D2 19617556,19617556,23201271,23201271,26906416 0007,0004,0415,0096,0004 LC CUL2 DCUN1D2 19617556,19617556,23201271,23201271,26906416 0007,0004,0415,0096,0004 LC CUL3 DCUN1D2 23201271,19617556,26906416,26906416,19617556,23201271,26906416 0096,0007,0096,0415,0004,0415,0004 LC CUL4A DCUN1D2 19617556,19617556,23201271,23201271,26906416 0007,0004,0415,0096,0004 LC CUL4B DCUN1D2 19617556,19617556,23201271,23201271,26906416 0007,0004,0415,0096,0004 LC DCUN1D2 CUL5 19617556,19617556,23201271,23201271,26906416 0007,0004,0415,0096,0004 LC UBA1 DCUN1D2 25260751 0997 LC UBE2M DCUN1D2 23201271,23201271 0114,0096 LC UBE2N DCUN1D2 25260751 0997 LC MAP3K1 DCUN1D2 25260751 0415 LC UBE2V1 DCUN1D2 25260751 0997 LC CUL1 DCUN1D2 23201271,23201271 0415,0096 LC CUL2 DCUN1D2 23201271,23201271 0415,0096 LC CUL3 DCUN1D2 23201271,26906416,26906416,23201271,26906416 0096,0096,0415,0415,0004 LC CUL4A DCUN1D2 23201271,23201271 0415,0096 LC CUL4B DCUN1D2 23201271,23201271 0415,0096 LC DCUN1D2 CUL5 23201271,23201271 0415,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q6PH85 P05067 DCUN1D2 APP 0.183 21832049 Q6PH85 P22314 DCUN1D2 UBA1 0.033 25260751 Q6PH85 P61081 DCUN1D2 UBE2M 0.454 23201271,26906416 Q6PH85 P61088 DCUN1D2 UBE2N 0.033 25260751 Q6PH85 P62877 DCUN1D2 RBX1 0.126 26906416 Q6PH85 Q13404 DCUN1D2 UBE2V1 0.033 25260751 Q6PH85 Q15370 DCUN1D2 TCEB2 0.126 26906416 Q6PH85 Q62925 DCUN1D2 MAP3K1 0.033 25260751 Q9UBF6 Q6PH85 RNF7 DCUN1D2 0.126 26906416 Q86VP6 Q6PH85 CAND1 DCUN1D2 0.286 26906416 Q6PH85 Q13617 DCUN1D2 CUL2 0.416 26906416,23201271 Q6PH85 Q13616 DCUN1D2 CUL1 0.416 26906416,23201271 Q6PH85 Q13619 DCUN1D2 CUL4A 0.416 26906416,23201271 Q6PH85 Q13620 DCUN1D2 CUL4B 0.416 26906416,23201271 Q93034 Q6PH85 CUL5 DCUN1D2 0.416 26906416,23201271 Q6PH85 Q13618 DCUN1D2 CUL3 0.61 26906416,23201271 Q969M7 Q6PH85 UBE2F DCUN1D2 0.183 23201271 Q96GG9 Q6PH85 DCUN1D1 DCUN1D2 0.126 21145461 Q6PH85 Q13233 DCUN1D2 MAP3K1 0.183 25260751

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 CDC14B DCUN1D2 MI:0362 inference MI:0461 interaction database APP DCUN1D2 MI:0045 experimental interaction detection MI:0461 interaction database UBC DCUN1D2 MI:0362 inference MI:0461 interaction database UBA1 DCUN1D2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2M DCUN1D2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2N DCUN1D2 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 DCUN1D2 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K1 DCUN1D2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2V1 DCUN1D2 MI:0045 experimental interaction detection MI:0461 interaction database CUL1 DCUN1D2 MI:0045 experimental interaction detection MI:0461 interaction database CUL2 DCUN1D2 MI:0045 experimental interaction detection MI:0461 interaction database CUL3 DCUN1D2 MI:0045 experimental interaction detection MI:0461 interaction database CUL4A DCUN1D2 MI:0045 experimental interaction detection MI:0461 interaction database CUL4B DCUN1D2 MI:0045 experimental interaction detection MI:0461 interaction database TCEB2 DCUN1D2 MI:0045 experimental interaction detection MI:0461 interaction database NEDD8 DCUN1D2 MI:0045 experimental interaction detection MI:0461 interaction database DCUN1D2 CAND1 MI:0045 experimental interaction detection MI:0461 interaction database DCUN1D2 CUL5 MI:0045 experimental interaction detection MI:0461 interaction database DCUN1D2 UBE2F MI:0045 experimental interaction detection MI:0461 interaction database DCUN1D2 DCUN1D1 MI:0045 experimental interaction detection MI:0461 interaction database DCUN1D2 RNF7 MI:0045 experimental interaction detection MI:0461 interaction database DCUN1D2 CDC14A MI:0362 inference MI:0461 interaction database DCUN1D2 LSM2 MI:0362 inference MI:0461 interaction database