Disease associated variation - GWASdb Chr Pos SNP ID(dbSNP 142) Ref Alt Ori SNP ID P-value Drug Name Drug Anno GWAS Trait HPO ID DO ID AA Type Trait or Drug 2 9416090 rs7605582 G A rs7605582 2.00E-04 TOPIRAMATE|FRUCTOSE ANTICONVULSANTS Cognitive impairment induced by topiramate HPOID:0100543 DOID:1561 G intron GWASdb_drug 2 9485625 rs116567340 G A rs116567340 9.39E-06 ARGININE DIMETHYLARGININE|TRANSAMINASES|ALANINE-GLYOXYLATE TRANSAMINASE|SLC25A45 PROTEIN, HUMAN|MITOCHONDRIAL PROTEINS|MEMBRANE PROTEINS Serum dimethylarginine levels (asymmetric/symetric ratio) HPOID:0001645|HPOID:0001658 DOID:10273|DOID:5844 G intron GWASdb_drug 2 9489788 rs116252892 G A rs116252892 9.65E-06 ARGININE DIMETHYLARGININE|TRANSAMINASES|ALANINE-GLYOXYLATE TRANSAMINASE|SLC25A45 PROTEIN, HUMAN|MITOCHONDRIAL PROTEINS|MEMBRANE PROTEINS Serum dimethylarginine levels (asymmetric/symetric ratio) HPOID:0001645|HPOID:0001658 DOID:10273|DOID:5844 G intron GWASdb_drug 2 9352517 rs16866958 G A rs16866958 2.64E-04 Alzheimer's disease (late onset) HPOID:0002511 DOID:10652 A intron GWASdb_trait 2 9353255 rs9287705 G T rs9287705 1.05E-05 Coronary heart disease HPOID:0001677 DOID:3393 G intron GWASdb_trait 2 9354669 rs12479189 G A rs12479189 8.89E-05 Waist-Hip Ratio HPOID:0001513 DOID:9970 G intron GWASdb_trait 2 9354669 rs12479189 G A rs12479189 1.38E-05 Waist-Hip Ratio HPOID:0001513 DOID:9970 G intron GWASdb_trait 2 9357533 rs11897394 T C rs11897394 3.34E-05 Coronary heart disease HPOID:0001677 DOID:3393 T intron GWASdb_trait 2 9403822 rs2666219 C T rs2666219 2.13E-04 Alzheimer's disease (late onset) HPOID:0002511 DOID:10652 C intron GWASdb_trait 2 9416090 rs7605582 G A rs7605582 2.00E-04 Cognitive impairment induced by topiramate HPOID:0100543 DOID:1561 G intron GWASdb_trait 2 9419106 rs10192751 G T rs10192751 4.08E-05 Waist-Hip Ratio HPOID:0001513 DOID:9970 T intron GWASdb_trait 2 9419583 rs10193254 G A rs10193254 6.79E-05 Waist-Hip Ratio HPOID:0001513 DOID:9970 A intron GWASdb_trait 2 9422788 rs4669381 A G rs4669381 1.77E-05 Waist Circumference HPOID:0001513 DOID:9970 A intron GWASdb_trait 2 9422788 rs4669381 A G rs4669381 9.91E-05 Waist-Hip Ratio HPOID:0001513 DOID:9970 A intron GWASdb_trait 2 9427591 rs12472609 A G rs12472609 5.18E-05 Waist-Hip Ratio HPOID:0001513 DOID:9970 A intron GWASdb_trait 2 9430778 rs7588636 G A rs7588636 9.82E-05 Body Mass Index HPOID:0001507 DOID:9970 A intron GWASdb_trait 2 9430778 rs7588636 G A rs7588636 7.98E-06 Waist Circumference HPOID:0001513 DOID:9970 A intron GWASdb_trait 2 9430778 rs7588636 G A rs7588636 8.08E-05 Weight HPOID:0004323 DOID:9970 A intron GWASdb_trait 2 9430778 rs7588636 G A rs7588636 7.83E-05 Waist-Hip Ratio HPOID:0001513 DOID:9970 A intron GWASdb_trait 2 9437413 rs3811600 C T rs3811600 4.89E-05 Waist-Hip Ratio HPOID:0001513 DOID:9970 G intron GWASdb_trait 2 9459986 rs10203328 T G rs10203328 9.19E-05 Waist-Hip Ratio HPOID:0001513 DOID:9970 T intron GWASdb_trait 2 9459986 rs10203328 T G rs10203328 1.48E-05 Waist Circumference HPOID:0001513 DOID:9970 T intron GWASdb_trait 2 9459986 rs10203328 T G rs10203328 6.42E-05 Waist-Hip Ratio HPOID:0001513 DOID:9970 T intron GWASdb_trait 2 9463454 rs12475160 C T rs12475160 5.87E-05 Body Mass Index HPOID:0001507 DOID:9970 C intron GWASdb_trait 2 9463454 rs12475160 C T rs12475160 5.29E-06 Waist Circumference HPOID:0001513 DOID:9970 C intron GWASdb_trait 2 9463454 rs12475160 C T rs12475160 2.87E-05 Weight HPOID:0004323 DOID:9970 C intron GWASdb_trait 2 9463454 rs12475160 C T rs12475160 7.05E-05 Waist-Hip Ratio HPOID:0001513 DOID:9970 C intron GWASdb_trait 2 9465687 rs10181704 G T rs10181704 3.24E-05 Waist Circumference HPOID:0001513 DOID:9970 T intron GWASdb_trait 2 9465687 rs10181704 G T rs10181704 9.97E-05 Waist-Hip Ratio HPOID:0001513 DOID:9970 T intron GWASdb_trait 2 9467815 rs7569295 C T rs7569295 9.98E-05 Waist-Hip Ratio HPOID:0001513 DOID:9970 C intron GWASdb_trait 2 9467815 rs7569295 C T rs7569295 1.68E-05 Waist Circumference HPOID:0001513 DOID:9970 C intron GWASdb_trait 2 9467815 rs7569295 C T rs7569295 6.93E-05 Waist-Hip Ratio HPOID:0001513 DOID:9970 C intron GWASdb_trait 2 9485625 rs116567340 G A rs116567340 9.39E-06 Serum dimethylarginine levels (asymmetric/symetric ratio) HPOID:0001645|HPOID:0001658 DOID:10273|DOID:5844 G intron GWASdb_trait 2 9489788 rs116252892 G A rs116252892 9.65E-06 Serum dimethylarginine levels (asymmetric/symetric ratio) HPOID:0001645|HPOID:0001658 DOID:10273|DOID:5844 G intron GWASdb_trait 2 9514573 rs2709580 T C rs2709580 4.48E-05 Waist-Hip Ratio HPOID:0001513 DOID:9970 C intron GWASdb_trait 2 9517647 rs2709586 A G rs2709586 5.82E-05 Waist-Hip Ratio HPOID:0001513 DOID:9970 C intron GWASdb_trait 2 9542286 rs10186062 G A rs10186062 6.94E-05 Waist-Hip Ratio HPOID:0001513 DOID:9970 A intron GWASdb_trait 2 9542286 rs10186062 G A rs10186062 2.53E-05 Waist-Hip Ratio HPOID:0001513 DOID:9970 A intron GWASdb_trait

Disease associated variation - GWAS Central Study Name Source Marker Accession Chromosome Marker Start Marker Stop Alleles Gene Section P-value -log(p-value) GWAS of prostate cancer rs7600853 2 9411732 9411732 intronic 0.840977 0.07521588162143951 GWAS of prostate cancer rs2709576 2 9499377 9499377 intronic 0.757066 0.120866257638171 GWAS of prostate cancer rs7588636 2 9430778 9430778 intronic 0.719399 0.143030170207783 GWAS of prostate cancer rs1510796 2 9397003 9397003 intronic 0.650365 0.18684283874835 GWAS of prostate cancer rs4669381 2 9422788 9422788 intronic 0.627282 0.20253717446303698

Disease associated variation - OMIM Ensembl_gene_ID Approved Gene Symbol MIM Number ENSG00000151693.9 ASAP2 603817