PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus KRT85 ATG10 20562859 biogrid exp G G G G G G G G G G G G G G G G G G G G MAP1B ATG10 20562859 biogrid,intact exp G GP G G G GP G G GP G GP G G G GP G GP G GP GP G G G P G ADSS ATG10 20562859 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP P GP GP GP G GP GP G GP GP P P P G ATG10 ATG4B 20562859 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G USP11 ATG10 20562859 biogrid,intact exp G GP G G G GP G G GP G GP G G G GP G G G G G G G G P G USP7 ATG10 20562859 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G GABARAP ATG10 20562859 intact exp G G G G G G G G G G G G G G G G G G G G G G G G HAT1 ATG10 20562859 biogrid,intact exp GP GP G G GP G G G GP G GP G G GP P G GP GP G GP GP GP GP GP P P G GABARAPL1 ATG10 20562859 intact exp GP GP G G GP GP G GP GP G GP GP GP G P GP G G G GP G GP GP GP P P G MAP1LC3B2 ATG10 20562859 intact exp P P P P P P P P P P P P GABARAPL2 ATG10 20562859 intact exp G GP G G GP GP G GP GP G GP G G G P GP G GP G G GP GP G GP P P G ATG10 ATG10 20562859 intact exp GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G RBBP7 ATG10 20562859 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G MAP1LC3B ATG10 20562859 intact exp, ortho G GP G G GP GP G GP GP G GP G G G P GP G G G G G G GP GP P P G ATG10 ATG5 12482611,16963840, 25402006, 21836163 innatedb,hprd exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G ATG12 ATG10 12482611,16963840,26186194,17353931, 25402006, 21836163 innatedb,hprd,biogrid,intact exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G ATG7 ATG10 20562859,12482611,26186194, 25402006 hprd,biogrid,intact exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G ATG10 ATG3 20562859, 25402006 biogrid,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP G P GP G GP G GP GP GP G GP P P P G MAP1LC3C ATG10 20562859, 25402006, 21836163 intact exp, pred G G G HPRT1 ATG10 25402006 pred GP GP G G G GP G G GP G GP GP GP GP P GP G GP G GP GP GP G GP P P P G RPS16 ATG10 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP P GP GP GP G GP GP GP G GP P P P G ATG10 IKBKG 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G ATG10 SPNS1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP G P G GP GP G G GP P P P G EP300 ATG10 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G ATG10 LARS 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G ATG4C ATG10 21836163 pred GP GP G P GP G GP GP G GP GP GP GP P GP GP GP GP GP GP P P P P P GOT2 ATG10 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G TRAF5 ATG10 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP G GP G GP GP GP GP GP P P P G ATG10 ZNF106 21836163 pred GP GP G G GP GP G GP GP G GP G G GP P GP G GP G GP G GP GP GP P P P G CHUK ATG10 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G ATG10 UVRAG 21836163 pred G G G G G GP G GP G G GP G GP G GP G G G GP G G G G P P G DDX58 ATG10 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP P GP GP P G GP GP GP GP GP P P P G ATG10 CARD9 21836163 pred G GP P P P P P P P P TECPR1 ATG10 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G P GP G GP G GP GP GP GP GP P P G IMPDH2 ATG10 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G ERC1 ATG10 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G PIK3C3 ATG10 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G IKBKE ATG10 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G ATG10 EIF2AK4 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP GP GP GP G GP GP GP GP G P P P G ATG16L2 ATG10 25402006 pred GP G G G G GP G GP GP G GP G G G GP G P G GP G G G G P P G BECN1 ATG10 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G IFIH1 ATG10 25402006 pred GP GP P P G GP GP GP GP GP P P G P G GP GP GP P GP P P P ATG10 MAP1LC3A 25402006, 21836163 pred G GP G G G GP G G GP G G GP G G P GP G GP G G G G G GP P G ATG10 EIF2AK3 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G TP53 ATG10 23023127 pred G G G G G G G G G G G G G G P G G G G GP G G G GP P G BNIP3L ATG10 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G NFKBIE ATG10 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP GP GP GP GP GP P P P G ATG16L1 ATG10 25402006, 21836163 pred GP G GP GP G G GP GP G GP G G G G G P G TRAF3IP2 ATG10 21836163 pred GP GP P P G P GP GP GP GP GP P P GP GP G GP GP GP P GP P P P G ATG10 BAZ2A 21836163 pred G GP G G G GP G G GP G GP G GP G GP G GP G GP G G GP G P P G NLRP4 ATG10 21836163 pred P P P P P P P P P P P P P P P P P P P MAVS ATG10 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G NFKBIB ATG10 21836163 pred GP P G GP GP G GP P G GP GP GP GP P GP P GP G GP GP GP GP GP P P P G WDFY3 ATG10 25402006, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G EEF1D ATG10 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G TTF1 ATG10 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G MAP4K4 ATG10 21836163 pred G G G G G GP G GP G G GP GP GP G P GP G G G G G G G GP P P G HNRNPUL1 ATG10 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G ATG9A ATG10 21836163 pred G GP G G G GP G GP GP G GP G G G P GP G GP G G G GP G GP P P G TRAPPC9 ATG10 21836163 pred G GP G G G GP G GP GP G GP G GP G P GP G GP G G G G GP GP P P G RAB33A ATG10 21836163 pred P G G GP GP G G P G P GP GP P GP G GP G G G P P P P G RGS19 ATG10 21836163 pred GP GP G G GP GP G G GP G GP GP GP GP GP G GP G GP GP GP GP G P P P G ELP2 ATG10 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G VMP1 ATG10 21836163 pred GP GP G GP P G GP GP GP GP GP GP P GP GP GP G GP GP GP P GP P P P G TAGLN2 ATG10 25402006 pred G G G G GP GP G G G G GP G GP G GP G GP G G G G G G P G HSPE1 ATG10 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP GP G GP GP GP GP GP P P P G OTUD7B ATG10 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9H0Y0 P78386 affinity chromatography technology 20562859 physical association X 2 Q9H0Y0 P46821 affinity chromatography technology 20562859 physical association X 2 Q9H0Y0 Q9Y4P1 affinity chromatography technology 20562859 physical association X 2 Q9H0Y0 O14929 affinity chromatography technology 20562859 physical association X 2 Q9H0Y0 A0A024R5Q7 affinity chromatography technology 20562859 physical association X 2 Q9H0Y0 O94817 affinity chromatography technology 17353931 physical association X 2 Q9H0Y0 O95352 affinity chromatography technology 20562859 physical association X 2 Q9H0Y0 P51784 affinity chromatography technology 20562859 physical association X 2 Q9H0Y0 Q9NT62 affinity chromatography technology 20562859 physical association X 2 Q9H0Y0 Q93009 affinity chromatography technology 20562859 physical association X 2 Q9H0Y0 Q16576 affinity chromatography technology 20562859 physical association X 2 Q9H0Y0 O95352-3 two hybrid 12482611 - X 2 Q9H0Y0 O95352-3 two hybrid 12482611 - X 2 Q9H0Y0 O94817 in vitro 12482611 - X 2 Q9H0Y0 O94817 in vivo 12482611 - X 2 Q9H0Y0 A9UGY9 two hybrid 12482611 - X 2 Q9H0Y0 O94817 in vitro 12482611 - X 2 Q9H0Y0 O94817 in vivo 12482611 - X 2 Q9H0Y0 A9UGY9 two hybrid 12482611 - X 2 Q9H0Y0 anti tag coimmunoprecipitation 20562859 physical association C 11 Q9H0Y0 anti tag coimmunoprecipitation 20562859 physical association C 11 Q9H0Y0 O95166 pull down 20562859 direct interaction X 2 Q9H0Y0 P60520 pull down 20562859 direct interaction X 2 Q9H0Y0 Q658J6 pull down 20562859 direct interaction X 2 Q9H0Y0 A0A024RAP5 pull down 20562859 direct interaction X 2 Q9H0Y0 O94817 anti bait coimmunoprecipitation 17353931 physical association X 2 Q9H0Y0 Q9BXW4 pull down 20562859 direct interaction X 2 Q9H0Y0 Q81SN0 two hybrid pooling approach 20711500 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B GABARAPL1 ATG10 MI:0007(anti tag coimmunoprecipitation) 20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (intact) UniProt_106599 bait prey GABARAPL2 ATG10 MI:0007(anti tag coimmunoprecipitation) 20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (intact) UniProt_106660 bait prey ATG12 ATG10 MI:0493(in vivo)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 12482611,17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|(intact)|(biogrid) HPRD_14832|UniProt_146595|BIOGRID_82579 -|bait|bait -|prey|prey MAP1LC3C ATG10 MI:0007(anti tag coimmunoprecipitation) 20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (intact) UniProt_106706 bait prey KRT85 ATG10 MI:0004(affinity chromatography technology) 20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_124982 prey bait NRF1 ATG10 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295984 bait prey ATG10 ATG5 MI:0493(in vivo) 12482611 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_16223 - - ATG10 MAP1LC3B MI:0007(anti tag coimmunoprecipitation) 20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (intact) UniProt_106668 prey bait USP7 ATG10 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_106954|BIOGRID_124987 prey|prey prey|bait RBBP7 ATG10 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124989|UniProt_106954 prey|prey bait|bait ATG10 ATG4B MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_106954|BIOGRID_124985 bait|bait prey|prey HAT1 ATG10 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_106954|BIOGRID_124988 prey|prey prey|bait ATG10 ATG3 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_106954|BIOGRID_124986 prey|bait prey|prey MAP1B ATG10 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_106954|BIOGRID_124983 prey|prey bait|bait GABARAP ATG10 MI:0007(anti tag coimmunoprecipitation) 20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (intact) UniProt_106558 bait prey ATG7 ATG10 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 12482611,20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|- (intact)|(biogrid)|MI:0468(hprd) UniProt_106954|BIOGRID_124981|HPRD_15987 prey|prey|- bait|bait|- ADSS ATG10 MI:0004(affinity chromatography technology) 20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_124990 prey bait USP11 ATG10 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_106954|BIOGRID_124984 prey|prey bait|bait

PPI - HINT Gene A Gene B PMID Method Quality MAP1LC3B2 ATG10 20562859 0007 HT HAT1 ATG10 20562859,20562859 0007,0004 HT ATG12 ATG10 17353931,26186194,17353931 0006,0004,0004 HT ATG7 ATG10 20562859,20562859,26186194 0004,0007,0004 HT ADSS ATG10 20562859 0004 HT MAP1B ATG10 20562859,20562859 0007,0004 HT USP11 ATG10 20562859,20562859 0007,0004 HT GABARAPL2 ATG10 20562859 0096 HT KRT85 ATG10 20562859 0004 HT RBBP7 ATG10 20562859,20562859 0007,0004 HT PCID2 ATG10 20562859 0096 HT DKFZP762B153 ATG10 20562859 0096 HT USP7 ATG10 20562859,20562859 0007,0004 HT MAP1LC3C ATG10 20562859 0096 HT MAP1LC3B ATG10 20562859 0096 HT GABARAPL1 ATG10 20562859 0096 HT ATG10 ATG10 20562859 0007 HT ATG10 ATG3 20562859,20562859 0007,0004 HT ATG10 ATG4B 20562859,20562859 0007,0004 HT MAP1LC3B2 ATG10 20562859 0007 HT HAT1 ATG10 20562859,20562859 0007,0004 HT ATG12 ATG10 17353931,26186194,17353931 0006,0004,0004 HT ATG7 ATG10 20562859,20562859,26186194 0004,0007,0004 HT ADSS ATG10 20562859 0004 HT MAP1B ATG10 20562859,20562859 0007,0004 HT USP11 ATG10 20562859,20562859 0007,0004 HT GABARAPL2 ATG10 20562859 0096 HT KRT85 ATG10 20562859 0004 HT RBBP7 ATG10 20562859,20562859 0007,0004 HT PCID2 ATG10 20562859 0096 HT DKFZP762B153 ATG10 20562859 0096 HT USP7 ATG10 20562859,20562859 0007,0004 HT MAP1LC3C ATG10 20562859 0096 HT MAP1LC3B ATG10 20562859 0096 HT GABARAPL1 ATG10 20562859 0096 HT ATG10 ATG10 20562859 0007 HT ATG10 ATG3 20562859,20562859 0007,0004 HT ATG10 ATG4B 20562859,20562859 0007,0004 HT ATG7 ATG10 12482611 0018 LC ATG10 ATG5 12482611 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9H0Y0 Q9GZQ8 ATG10 MAP1LC3B 0.183 20562859 Q9H0Y0 O95166 ATG10 GABARAP 0.183 20562859 Q9H0Y0 P78386 ATG10 KRT85 0.126 20562859 Q9H0Y0 A6NCE7 ATG10 MAP1LC3B2 0.126 20562859 Q9H0Y0 P30520 ATG10 ADSS 0.126 20562859 Q9H0Y0 P60520 ATG10 GABARAPL2 0.183 20562859 Q9H0Y0 Q9H0Y0 ATG10 ATG10 0.155 20562859 Q9H0Y0 Q81SN0 ATG10 Q81SN0 0.126 20711500 Q9H0Y0 Q9BXW4 ATG10 MAP1LC3C 0.183 20562859 Q9H0Y0 Q9H0R8 ATG10 GABARAPL1 0.183 20562859 Q9H0Y0 O14929 ATG10 HAT1 0.236 20562859 Q9H0Y0 O94817 ATG10 ATG12 0.416 17353931,26186194 Q9H0Y0 P46821 ATG10 MAP1B 0.236 20562859 Q9H0Y0 P51784 ATG10 USP11 0.236 20562859 Q9H0Y0 Q16576 ATG10 RBBP7 0.236 20562859 Q9H0Y0 Q93009 ATG10 USP7 0.236 20562859 Q9H1Y0 Q9H0Y0 ATG5 ATG10 0.236 unassigned1304 Q9NT62 Q9H0Y0 ATG3 ATG10 0.236 20562859 Q9Y4P1 Q9H0Y0 ATG4B ATG10 0.236 20562859 Q9H0Y0 O95352 ATG10 ATG7 0.332 20562859,26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MAP1LC3B2 ATG10 MI:0045 experimental interaction detection MI:0461 interaction database HAT1 ATG10 MI:0045 experimental interaction detection MI:0461 interaction database ATG12 ATG10 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database GABARAP ATG10 MI:0045 experimental interaction detection MI:0461 interaction database ATG7 ATG10 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ADSS ATG10 MI:0045 experimental interaction detection MI:0461 interaction database MAP1B ATG10 MI:0045 experimental interaction detection MI:0461 interaction database USP11 ATG10 MI:0045 experimental interaction detection MI:0461 interaction database GABARAPL2 ATG10 MI:0045 experimental interaction detection MI:0461 interaction database KRT85 ATG10 MI:0045 experimental interaction detection MI:0461 interaction database RBBP7 ATG10 MI:0045 experimental interaction detection MI:0461 interaction database USP7 ATG10 MI:0045 experimental interaction detection MI:0461 interaction database MAP1LC3C ATG10 MI:0045 experimental interaction detection MI:0461 interaction database MAP1LC3B ATG10 MI:0045 experimental interaction detection MI:0461 interaction database GABARAPL1 ATG10 MI:0045 experimental interaction detection MI:0461 interaction database ATG10 ATG5 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database ATG10 MAP1LC3A MI:0362 inference MI:0461 interaction database ATG10 ATG3 MI:0045 experimental interaction detection MI:0461 interaction database ATG10 CHMP5 MI:0362 inference MI:0461 interaction database ATG10 ATG4B MI:0045 experimental interaction detection MI:0461 interaction database