PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus APP FBXL2 22399757 biogrid exp G G G G G G G G G G G G G G G G G G G G G FBXO3 FBXL2 24123678 innatedb exp G G G G G G G G G G G G G G G G G G G G G PPP1CC FBXL2 21382349 intact exp G G G G G G G G G G G G G G G G G G G G G UBE2D3 FBXL2 23604317 biogrid exp G G G G G G G G G G G G G G G G G G G G G PTPN13 FBXL2 23604317 biogrid exp G G G G G G G G G G G G G G G G G G G G UBE2D1 FBXL2 26037928 biogrid exp G G G G G G G G G G G G G G G G G G G G G AURKB FBXL2 23370391 biogrid exp G G G G G HSP90AA1 FBXL2 22939624 biogrid exp G G G G G G G G G G G G G G G G G G G G G AARSD1 FBXL2 25036637 intact exp PIK3R2 FBXL2 23604317 biogrid exp G G G G G G G G G G G G G G G G G G G G G PTPLAD1 FBXL2 18160438 intact exp G G G G G G G G G G G G G G G G G G G G G FBXL2 SUGT1 25036637 intact exp G G G G G G G G G G G G G G G G G G G G G CCND2 FBXL2 22323446 biogrid exp G G G G G G G G G G G G G G G G G G G G G COL7A1 FBXL2 16169070 hprd,mint,intact exp G G G G G G G G G G G G G G G G G G G G G RABGGTB FBXL2 24035498 biogrid exp G G G G G G G G G G G G G G G G G G G G G CDC34 FBXL2 23604317 biogrid exp G G G G G G G G G G G G G G G G G G G G G NLRP3 FBXL2 26037928 biogrid exp PIK3R1 FBXL2 23604317 biogrid exp G G G G G G G G G G G G G G G G G G G G G HSP90AB1 FBXL2 25036637,22939624 intact exp G G G G G G G G G G G G G G G G G G G G G UBE2G1 FBXL2 26037928, 16082366 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G CUL2 FBXL2 23604317, 23023127, 16082366 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G SKP1 FBXL2 19159283,22399757,10531037,10508920,23604317, 25402006, 23023127, 16082366 hprd,biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G CUL1 FBXL2 22399757, 25402006, 16082366 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G TCP1 FBXL2 ortho CCND3 FBXL2 ortho G G G G G G G G G G G G G G G G G G G G G FBXO6 FBXL2 25402006 pred G G G G G G G G G G G G G G G G G G G G ATP6V0C FBXL2 23023127 pred G G G G G G G G G G G G G G G G G G G G G FBXL2 FBXO7 25402006 pred G G G G G G G G G G G G G G G G G G G G G FBXL2 BTBD3 23023127 pred G G G G G G G G G G G G G G G G G G G G G ATP6V1H FBXL2 23023127 pred G G G G G G G G G G G G G G G G G G G G G FBXO18 FBXL2 25402006 pred G G G G G G G G G G G G G G G G G G G G G PPEF1 FBXL2 23023127 pred G G G G G G G G G BTBD6 FBXL2 23023127 pred G G G G G G G G G G G G G G G G G G G G G FBXW9 FBXL2 25402006 pred G G G G G G G G G G G G G G G G G G G G G CACYBP FBXL2 25402006 pred G G G G G G G G G G G G G G G G G G G G G FBXO34 FBXL2 25402006 pred G G G G G G G G G G G G G G G G G G G G G FBXL2 FBXW2 25402006 pred G G G G G G G G G G G G G G G G G G G G G FBXO17 FBXL2 25402006 pred G G G G G G G G G G RBX1 FBXL2 25402006 pred G G G G G G G G G G G G G G G G G G G G G FBXL2 FBXO5 25402006 pred G G G G SKP2 FBXL2 25402006 pred G G G G G G G G G G G G G G G G G G G G G EIF4A2 FBXL2 23023127 pred G FBXO45 FBXL2 23023127 pred G G G G G G G G G G G G G G G G G G G G G NFKBIA FBXL2 25402006 pred G G G G G G G G G G G G G G G G G G G G G FBXO2 FBXL2 25402006 pred G G G G G G G G G G G G G G G G G G G G UBQLN2 FBXL2 23023127 pred G G G G G G G G G G G G G G G G G G G G G EZR FBXL2 21836163 pred G G G G G G G G G G G G G G G G G G G G G MAPK3 FBXL2 23023127 pred G G G G G G G G G G G G G G G G G G G G G FBXL2 FBXO4 25402006 pred G G G G G G G G G G G G G G G G G G G AXL FBXL2 21836163 pred G G G G G G G G G G G G G G G G G G G G G FBXL2 BTRC 25402006 pred G G G G G G G G G G G G G G G G G G G G G FBXL8 FBXL2 25402006 pred FBXO31 FBXL2 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G CDCA3 FBXL2 25402006 pred G G G G G G G G G G G G G G G G FBXW5 FBXL2 25402006 pred G G G G G G G G G G G G G G G G G G G G G FBXW11 FBXL2 25402006 pred G G G G G G G G G G G G G G G G G G G G G KLHL3 FBXL2 23023127 pred G G G G G G G G G G G G G G G G G G G G G BIN1 FBXL2 23023127 pred G G G G G G G G G G G G G G G G G G G G G FBXL2 FBXL3 25402006 pred G G G G G G G G G G G G G G G G G G G G G ZC3HC1 FBXL2 25402006 pred G G G G G G G G G G G G G G G G G G G G G MPP5 FBXL2 23023127 pred G G G G G G G G G G G G G G G G G G G G G SATB1 FBXL2 23023127 pred G G G G G G G G G G G G G G G G G G G G G FBXW8 FBXL2 25402006 pred CUL7 FBXL2 25402006 pred G G G G G G G G G G G G G G G G G G G G G KLHL26 FBXL2 23023127 pred G G G G G G G G G G G G G G G G BANF1 FBXL2 23023127 pred G G G G G G G G G G G G G G G G G G G G G TCEB1 FBXL2 23023127 pred G G G G G G G G G G G G G G G G G G G G G FBXO44 FBXL2 25402006 pred G G G G G G G G G G G G G G G G G G G G G FBXO46 FBXL2 25402006 pred G G G G G G G G G G G G G G G G G G G G G NR3C2 FBXL2 23023127 pred G G G G G G G G G G G G G G G G G G G G G PVRL1 FBXL2 23023127 pred G G G G G G G G G G G G G G G G G G G G G FBXW7 FBXL2 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9UKC9 Q02388 two hybrid pooling approach 16169070 physical association X 2 Q9WMX2 Q9UKC9 anti tag coimmunoprecipitation 15893726 physical association X 2 Q9WMX2 Q9UKC9 anti tag coimmunoprecipitation 15893726 physical association X 2 Q9UKC9 anti tag coimmunoprecipitation 25036637 association C 3 Q9UKC9 Q9P035 anti tag coimmunoprecipitation 18160438 physical association X 2 Q9UKC9 P36873-2 two hybrid 21382349 physical association X 2 Q9UKC9 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2 P63208 Q9UKC9 mammalian protein protein interaction trap 19159283 physical association X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9UKC9 P07900 FBXL2 HSP90AA1 0.126 22939624 Q9UKC9 P30279 FBXL2 CCND2 0.454 22323446 Q9UKC9 P05067 FBXL2 APP 0.454 22399757 Q9UKC9 Q08050 FBXL2 FOXM1 0.376 26790640 Q9UKC9 P63208 FBXL2 SKP1 0.902 19159283,27705803,22399757,10508920,26790640,23604317,unassigned1304,10531037 Q9UKC9 Q13616 FBXL2 CUL1 0.507 26790640,22399757 Q9UKC9 P36873 FBXL2 PPP1CC 0.183 21382349 Q9UKC9 Q96GD4 FBXL2 AURKB 0.569 23370391 Q9UKC9 Q96P20 FBXL2 NLRP3 0.569 26037928 Q9UKC9 P08238 FBXL2 HSP90AB1 0.236 22939624,25036637 Q9UKC9 P27986 FBXL2 PIK3R1 0.21 23604317 Q9UKC9 P49427 FBXL2 CDC34 0.309 23604317 Q9UKC9 P51668 FBXL2 UBE2D1 0.309 26037928 Q9UKC9 P53611 FBXL2 RABGGTB 0.376 24035498 Q9UKC9 P61077 FBXL2 UBE2D3 0.309 23604317 Q9UKC9 P62253 FBXL2 UBE2G1 0.309 26037928 Q9UKC9 Q02388 FBXL2 COL7A1 0.126 16169070 Q9UKC9 Q12923 FBXL2 PTPN13 0.21 23604317 Q9UKC9 Q13617 FBXL2 CUL2 0.21 23604317 Q9Y2Z0 Q9UKC9 SUGT1 FBXL2 0.126 25036637 Q9UKC9 O00459 FBXL2 PIK3R2 0.569 23604317

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PIK3R2 FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database APP FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database UBB FBXL2 MI:0362 inference MI:0461 interaction database UBC FBXL2 MI:0362 inference MI:0461 interaction database TCP1 FBXL2 MI:0362 inference MI:0461 interaction database CALML3 FBXL2 MI:0362 inference MI:0461 interaction database PIK3R1 FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database CCND2 FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database CCND3 FBXL2 MI:0362 inference MI:0461 interaction database PPP1CC FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database CDC34 FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database RABGGTB FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database RAD23A FBXL2 MI:0362 inference MI:0461 interaction database RAD23B FBXL2 MI:0362 inference MI:0461 interaction database UBE2D3 FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database CALM1 FBXL2 MI:0362 inference MI:0461 interaction database UBE2G1 FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database SKP1 FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database XPC FBXL2 MI:0362 inference MI:0461 interaction database COL7A1 FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database FOXM1 FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database PTPN13 FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database CUL1 FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database CUL2 FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database RIMS1 FBXL2 MI:0362 inference MI:0461 interaction database AURKB FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database NLRP3 FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database HACD3 FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database FBXL2 SUGT1 MI:0045 experimental interaction detection MI:0461 interaction database