PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TDGF1 RMND5A 26186194 biogrid exp PRG2 RMND5A 26186194 biogrid exp G GP G G GP G G SOX2 RMND5A 23667531 biogrid exp P G P GP G P GP G P P GP P GP GP P G P GP P GP P GP GP G RANBP10 RMND5A 26186194 biogrid exp G GP G G G G G G GP G G G G G G GP G G GP G G G G G GP G GP G G GLIPR1L2 RMND5A 26186194 biogrid exp P P P P P P P P P P P P P P P P P P P AGMAT RMND5A 26186194 biogrid exp G G G G G G G GP G GP G G G GP G G G G G G G GP G GP G G WDR26 RMND5A 26186194 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G HTRA2 RMND5A 26186194 biogrid exp G GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G HLA-DPB1 RMND5A 26186194 biogrid exp G GP G G GP GP G G GP G GP G GP GP G GP GP G GP G G GP GP G GP GP GP GP G PDHB RMND5A 26186194 biogrid exp G GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G TGFB1 RMND5A 26186194 biogrid exp G G G G GP G G G G G G G G G G GP G G G G GP G G GP GP GP G G MMP7 RMND5A 26186194 biogrid exp G GP G G G GP G GP G G GP G GP G G GP GP G GP G G G G G GP G G G SFRP2 RMND5A 26186194 biogrid exp G G G G G GP G G G G G G G G G GP G G G P GP G G G G G G RMND5A MKLN1 26186194,17467196 biogrid exp G GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G RANBP9 RMND5A 26186194,17467196 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G GID4 RMND5A 26186194 biogrid exp P P P P P P P P P P P P P P P P P GP GDNF RMND5A 26186194 biogrid exp G GP G G G GP GP GP G GP P P P G G GP G GP G P GP G G GP GP GP G ARMC8 RMND5A 26186194 biogrid exp G GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP GP GP GP G PAPD7 RMND5A 26186194 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G RMND5A WARS2 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G APP RMND5A 21832049 biogrid exp G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP G ZMYND19 RMND5A 26186194 biogrid exp G GP G G GP GP G P GP G GP GP GP GP G GP GP G P G GP GP GP G GP GP GP GP G MRPL4 RMND5A 26186194 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G YPEL5 RMND5A 26186194 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G RMND5A WBP5 26186194 biogrid exp G GP G G GP GP G GP GP G G G GP G G GP GP G GP G GP G G G GP G GP GP G VKORC1 RMND5A 21103663 biogrid exp G GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G HBP1 RMND5A 26186194 biogrid exp G GP G G G GP G GP GP G GP G G G G G GP G G G GP GP G G G G GP GP G ZCCHC14 RMND5A 26186194 biogrid exp G GP G G GP GP G GP GP G GP G G G G GP GP G GP G GP G GP G GP GP GP G G GPS2 RMND5A 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SMAD9 RMND5A 15231748 hprd,biogrid,i2d,mint,intact exp G GP G P GP G GP GP G GP GP GP G GP GP G P G GP GP GP G GP GP GP GP G MEOX2 RMND5A 25416956 biogrid,intact exp G G G G P GP GP G GP G G G P RMND5A GID8 26186194,17467196 biogrid exp, ortho G GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G MAEA RMND5A 26186194,17467196 biogrid exp, ortho G G G G G GP G G G G G G G G G G GP G G G G G GP G G G G GP G RMND5A IPP ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NUP107 RMND5A ortho G GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G LMO4 RMND5A ortho G GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G ATP1A3 RMND5A ortho G G G GP G GP G G GP G G G G RMND5A RMND5A ortho G GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G RMND5A MARCH7 25402006 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9H871 A0A024RDR3 - 15231748 - X 2 Q9H871 Q9NWU2 affinity chromatography technology 17467196 physical association X 2 Q9H871 Q9NWU2 pull down 17467196 direct interaction X 2 Q9H871 B4DVN3 affinity chromatography technology 17467196 physical association X 2 Q9H871 B4DVN3 affinity chromatography technology 17467196 physical association X 2 Q9H871 P48431 affinity chromatography technology 23667531 physical association X 2 Q9H871 P0CG48 affinity chromatography technology 21139048 physical association X 2 Q9H871 P0CG48 affinity chromatography technology 21890473 physical association X 2 Q9H871 P0CG48 affinity chromatography technology 21906983 physical association X 2 Q9H871 A0A024QZW3 affinity chromatography technology 17467196 physical association X 2 Q9H871 A0A024QZW3 affinity chromatography technology 17467196 physical association X 2 Q9H871 affinity chromatography technology 17467196 physical association X 2 Q9H871 P05067-7 pull down 21832049 direct interaction X 2 Q9H871 Q9BQB6-3 two hybrid 21103663 direct interaction X 2 Q9H871 two hybrid 15231748 direct interaction X 2 Q9H871 P50222 two hybrid 25416956 direct interaction X 2 Q9H871 coimmunoprecipitation 17467196 association C 5 Q9H871 A0A024RDR3 two hybrid 15231748 - X 2 Q9H871 A0A024RDR3 two hybrid 15231748 - X 2 Q9H871 O15198 two hybrid 15231748 physical association X 2 Q9H871 Q5NI24 two hybrid pooling approach 20711500 physical association X 2 Q9H871 Q5NGW2 two hybrid pooling approach 20711500 physical association X 2 Q9H871 A4D127 two hybrid prey pooling approach 25416956 physical association X 2 Q9H871 A4D127 two hybrid array 25416956 physical association X 2 Q9H871 A4D127 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SMAD9 RMND5A MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0468(hprd)|(biogrid)|MI:0471(mint)|MI:0471(mint) UniProt_79140|HPRD_2429|BIOGRID_258791|MINT_32624|MINT_61472 bait|-|bait|bait|bait prey|-|prey|prey|prey SOX2 RMND5A MI:0004(affinity chromatography technology) 23667531 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_275099 bait prey ARMC8 RMND5A MI:0004(affinity chromatography technology) 17467196 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_218690 bait prey MAEA RMND5A MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17467196 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_218714|BIOGRID_218713 bait|prey prey|bait RANBP9 RMND5A MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17467196 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_218679|BIOGRID_218684 bait|bait prey|prey APP RMND5A MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229673 prey bait RMND5A GID8 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17467196 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_218702|BIOGRID_218708 prey|prey bait|bait UBC RMND5A MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_180135|BIOGRID_170914|BIOGRID_175536 bait|bait|bait prey|prey|prey VKORC1 RMND5A MI:0018(two hybrid) 21103663 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_250090 bait prey RMND5A MKLN1 MI:0004(affinity chromatography technology) 17467196 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_218696 prey bait

PPI - HINT Gene A Gene B PMID Method Quality HTRA2 RMND5A 26186194 0004 HT HBP1 RMND5A 26186194 0004 HT TGFB1 RMND5A 26186194 0004 HT HLA-DPB1 RMND5A 26186194 0004 HT MMP7 RMND5A 26186194 0004 HT PDHB RMND5A 26186194 0004 HT TDGF1 RMND5A 26186194 0004 HT PRG2 RMND5A 26186194 0004 HT DDX5 RMND5A 27173435 0676 HT GDNF RMND5A 26186194 0004 HT YPEL5 RMND5A 26186194 0004 HT GPS2 RMND5A 26186194 0004 HT GLIPR1L2 RMND5A 26186194 0004 HT EFHC2 RMND5A 27173435 0676 HT PAPD7 RMND5A 26186194 0004 HT RANBP10 RMND5A 26186194,27173435 0004,0676 HT MAEA RMND5A 17467196,26186194 0004,0004 LC,HT ARMC8 RMND5A 26186194,27173435 0004,0676 HT GID4 RMND5A 26186194,27173435 0004,0676 HT ZCCHC14 RMND5A 26186194 0004 HT MAML1 RMND5A 27173435 0676 HT SECISBP2L RMND5A 27173435 0676 HT ZMYND19 RMND5A 26186194 0004 HT SFRP2 RMND5A 26186194 0004 HT RANBP9 RMND5A 17467196,26186194,27173435 0004,0004,0676 LC,HT AGMAT RMND5A 26186194 0004 HT MRPL4 RMND5A 26186194 0004 HT WDR26 RMND5A 26186194,27173435 0004,0676 HT RMND5A GID8 17467196,17467196,26186194,27173435 0004,0096,0004,0676 LC,HT RMND5A WARS2 26186194 0004 HT RMND5A WBP5 26186194 0004 HT RMND5A MKLN1 17467196,26186194,27173435 0004,0004,0676 LC,HT HTRA2 RMND5A 26186194 0004 HT HBP1 RMND5A 26186194 0004 HT TGFB1 RMND5A 26186194 0004 HT HLA-DPB1 RMND5A 26186194 0004 HT MMP7 RMND5A 26186194 0004 HT PDHB RMND5A 26186194 0004 HT TDGF1 RMND5A 26186194 0004 HT PRG2 RMND5A 26186194 0004 HT DDX5 RMND5A 27173435 0676 HT GDNF RMND5A 26186194 0004 HT YPEL5 RMND5A 26186194 0004 HT GPS2 RMND5A 26186194 0004 HT GLIPR1L2 RMND5A 26186194 0004 HT EFHC2 RMND5A 27173435 0676 HT PAPD7 RMND5A 26186194 0004 HT RANBP10 RMND5A 26186194,27173435 0004,0676 HT MAEA RMND5A 26186194 0004 HT ARMC8 RMND5A 26186194,27173435 0004,0676 HT GID4 RMND5A 26186194,27173435 0004,0676 HT ZCCHC14 RMND5A 26186194 0004 HT MAML1 RMND5A 27173435 0676 HT SECISBP2L RMND5A 27173435 0676 HT ZMYND19 RMND5A 26186194 0004 HT SFRP2 RMND5A 26186194 0004 HT RANBP9 RMND5A 26186194,27173435 0004,0676 HT AGMAT RMND5A 26186194 0004 HT MRPL4 RMND5A 26186194 0004 HT WDR26 RMND5A 26186194,27173435 0004,0676 HT RMND5A GID8 26186194,27173435 0004,0676 HT RMND5A WARS2 26186194 0004 HT RMND5A WBP5 26186194 0004 HT RMND5A MKLN1 26186194,27173435 0004,0676 HT MAEA RMND5A 17467196 0004 LC RANBP9 RMND5A 17467196 0004 LC RMND5A GID8 17467196,17467196 0004,0096 LC RMND5A MKLN1 17467196 0004 LC SMAD9 RMND5A 15231748 0018 HT MEOX2 RMND5A 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT VKORC1 RMND5A 21103663 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9H871 Q5NGW2 RMND5A Q5NGW2 0.126 20711500 Q9H871 P61006 RMND5A RAB8A 0.126 unassigned1312 Q9H871 A4D127 RMND5A MEOX2 {ECO:0000313|EMBL:EAL24289.1} 0.332 25416956 Q9H871 O43464 RMND5A HTRA2 0.126 26186194 Q9H871 O60381 RMND5A HBP1 0.126 26186194 Q9H871 P05067 RMND5A APP 0.183 21832049 Q9H871 Q5NI24 RMND5A Q5NI24 0.126 20711500 Q9H871 Q5XG87 RMND5A PAPD7 0.126 26186194 Q9H871 Q8WYQ9 RMND5A ZCCHC14 0.126 26186194 Q9H871 Q96E35 RMND5A ZMYND19 0.126 26186194 Q9UGM6 Q9H871 WARS2 RMND5A 0.126 26186194 Q9UHQ7 Q9H871 WBP5 RMND5A 0.126 26186194 Q9H871 P01137 RMND5A TGFB1 0.126 26186194 Q9H871 P11177 RMND5A PDHB 0.126 26186194 Q9H871 P09237 RMND5A MMP7 0.126 26186194 Q9H871 P13385 RMND5A TDGF1 0.126 26186194 Q9H871 P13727 RMND5A PRG2 0.126 26186194 Q9H871 P04440 RMND5A HLA-DPB1 0.126 26186194 Q9H871 Q7L5Y9 RMND5A MAEA 0.523 unassigned1312,26186194,17467196 Q9H871 Q6VN20 RMND5A RANBP10 0.416 unassigned1312,26186194,27173435 Q9UL63 Q9H871 MKLN1 RMND5A 0.539 26186194,27173435,17467196,unassigned1312 Q9H871 Q93073 RMND5A SECISBP2L 0.236 27173435,unassigned1312 Q9H871 Q8IUR7 RMND5A ARMC8 0.416 unassigned1312,26186194,27173435 Q9H871 Q96S59 RMND5A RANBP9 0.539 26186194,27173435,17467196,unassigned1312 Q9H871 Q9H7D7 RMND5A WDR26 0.416 unassigned1312,26186194,27173435 Q9H871 O15198 RMND5A SMAD9 0.332 15231748 Q9H871 Q5JST6 RMND5A EFHC2 0.236 27173435,unassigned1312 Q9H871 P62700 RMND5A YPEL5 0.236 26496610 Q9H871 Q8IVV7 RMND5A GID4 0.332 unassigned1312,26186194,27173435 Q9NWU2 Q9H871 GID8 RMND5A 0.681 26186194,27173435,17467196,unassigned1312 Q9H871 Q92585 RMND5A MAML1 0.236 27173435,unassigned1312 Q9H871 Q96G75 RMND5A RMND5B 0.126 unassigned1312 Q9H871 Q96HF1 RMND5A SFRP2 0.126 26186194 Q9H871 Q9BQB6 RMND5A VKORC1 0.183 21103663 Q9H871 Q9BSE5 RMND5A AGMAT 0.126 26186194 Q9H871 Q9BYD3 RMND5A MRPL4 0.126 26186194 Q9H871 P39905 RMND5A GDNF 0.126 26186194 Q9H871 P62699 RMND5A YPEL5 0.236 unassigned1312,26186194 Q9H871 P17844 RMND5A DDX5 0.236 27173435,unassigned1312 Q9H871 P48431 RMND5A SOX2 0.126 23667531 Q9H871 P50222 RMND5A MEOX2 0.183 25416956 Q9H871 Q13227 RMND5A GPS2 0.126 26186194 Q9H871 Q4G1C9 RMND5A GLIPR1L2 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SMAD9 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database HTRA2 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database HBP1 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database TGFB1 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database HLA-DPB1 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database APP RMND5A MI:0045 experimental interaction detection MI:0461 interaction database MMP7 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database UBC RMND5A MI:0045 experimental interaction detection MI:0461 interaction database PDHB RMND5A MI:0045 experimental interaction detection MI:0461 interaction database TDGF1 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database ATP1A3 RMND5A MI:0362 inference MI:0461 interaction database PRG2 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database DDX5 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database GDNF RMND5A MI:0045 experimental interaction detection MI:0461 interaction database SOX2 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database MEOX2 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database NUP107 RMND5A MI:0362 inference MI:0461 interaction database LMO4 RMND5A MI:0362 inference MI:0461 interaction database YPEL5 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database GPS2 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database GLIPR1L2 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database EFHC2 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database PAPD7 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database RANBP10 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database MAEA RMND5A MI:0045 experimental interaction detection MI:0461 interaction database ARMC8 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database GID4 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database ZCCHC14 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database MAML1 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database SECISBP2L RMND5A MI:0045 experimental interaction detection MI:0461 interaction database ZMYND19 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database SFRP2 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database RANBP9 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database VKORC1 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database AGMAT RMND5A MI:0045 experimental interaction detection MI:0461 interaction database MRPL4 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database WDR26 RMND5A MI:0045 experimental interaction detection MI:0461 interaction database RMND5A GID8 MI:0045 experimental interaction detection MI:0461 interaction database RMND5A WARS2 MI:0045 experimental interaction detection MI:0461 interaction database RMND5A TCEAL9 MI:0045 experimental interaction detection MI:0461 interaction database RMND5A MKLN1 MI:0045 experimental interaction detection MI:0461 interaction database RMND5A IPP MI:0362 inference MI:0461 interaction database