PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBE2U TRIM74 19549727 biogrid,intact exp LRSAM1 TRIM74 22493164 biogrid,intact exp HSP90AB1 TRIM74 22939624 intact exp MGRN1 TRIM74 22493164 biogrid,intact exp TRIM74 USP32 23105109 biogrid exp RBX1 TRIM74 22493164 biogrid,intact exp HSP90AA1 TRIM74 22939624 biogrid exp USP2 TRIM74 23105109 biogrid exp TRIM74 USP15 23105109 biogrid exp FECH TRIM74 26186194 biogrid exp CNOT1 TRIM74 26186194 biogrid exp TRIM74 DTNBP1 26186194 biogrid exp BRCA1 TRIM74 22493164 biogrid,intact exp REL TRIM74 25416956 biogrid,intact exp TRIM74 TSG101 19549727 biogrid,intact exp TRIM74 RNF32 22493164 biogrid,intact exp TRIM74 TRIM36 23023127 pred TRIM28 TRIM74 23023127 pred TRIM74 TRIM10 23023127 pred TRIM74 TRIM54 23023127 pred MEFV TRIM74 23023127 pred TRIM75P TRIM74 23023127 pred TRIM74 TRIM52 23023127 pred TRIM74 TRIM31 23023127 pred TRIM74 TRIM31 23023127 pred BSPRY TRIM74 23023127 pred TRIM37 TRIM74 23023127 pred TRIM74 TRIM63 23023127 pred TRIM21 TRIM74 23023127 pred TRIM74 TRIM22 23023127 pred TRIM71 TRIM74 23023127 pred TRIM26 TRIM74 23023127 pred TRIM38 TRIM74 23023127 pred TRIM74 TRIM9 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q86UV6 Q9Y4E8-2 two hybrid 23105109 direct interaction X 2 Q86UV6 P07900-2 affinity chromatography technology 22939624 physical association X 2 Q86UV6 P62877 two hybrid 22493164 direct interaction X 2 Q86UV6 A0A024R870 two hybrid 22493164 direct interaction X 2 Q86UV6 Q04864 two hybrid 25416956 direct interaction X 2 Q8NFA0 Q86UV6 two hybrid 23105109 direct interaction X 2 Q86UV6 O75604-2 two hybrid 23105109 direct interaction X 2 Q86UV6 two hybrid 22493164 direct interaction X 2 Q86UV6 two hybrid 22493164 direct interaction X 2 Q86UV6 two hybrid 19549727 direct interaction X 2 Q86UV6 Q99816 two hybrid 19549727 direct interaction X 2 A0A024RD87 Q86UV6 two hybrid 22493164 direct interaction X 2 Q86UV6 Q5VVX9 two hybrid array 19549727 physical association X 2 Q86UV6 P62877 two hybrid array 22493164 physical association X 2 Q86UV6 A0A024R870 two hybrid array 22493164 physical association X 2 Q86UV6 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2 O60291 Q86UV6 two hybrid array 22493164 physical association X 2 P38398 Q86UV6 two hybrid array 22493164 physical association X 2 Q86UV6 Q99816 two hybrid array 19549727 physical association X 2 A0A024RD87 Q86UV6 two hybrid array 22493164 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B HSP90AA1 TRIM74 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255463 bait prey UBE2U TRIM74 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101187|BIOGRID_124216 bait|bait prey|prey MGRN1 TRIM74 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_283963|UniProt_122541 bait|prey prey|bait TRIM74 USP32 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248225 prey bait TRIM74 USP15 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248209 prey bait TRIM74 RNF32 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122616|BIOGRID_284111 prey|bait bait|prey LRSAM1 TRIM74 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122601|BIOGRID_284092 bait|bait prey|prey HSP90AB1 TRIM74 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125117 prey bait TRIM74 TSG101 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_100993|BIOGRID_124217 prey|prey bait|bait RBX1 TRIM74 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284048|UniProt_122523 bait|bait prey|prey BRCA1 TRIM74 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122615|BIOGRID_284067 prey|prey bait|bait USP2 TRIM74 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248182 bait prey

PPI - HINT Gene A Gene B PMID Method Quality CNOT1 TRIM74 26186194 0004 HT DKFZP686P18130 TRIM74 26186194 0004 HT TRIM74 DTNBP1 26186194 0004 HT CNOT1 TRIM74 26186194 0004 HT DKFZP686P18130 TRIM74 26186194 0004 HT TRIM74 DTNBP1 26186194 0004 HT MGRN1 TRIM74 22493164,22493164 0018,0397 HT USP2 TRIM74 23105109 0018 LC HSP90AB1 TRIM74 22939624 0729 HT BRCA1 TRIM74 22493164,22493164 0018,0397 HT RBX1 TRIM74 22493164,22493164 0018,0397 HT REL TRIM74 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT UBE2U TRIM74 19549727,19549727 0397,0018 HT LRSAM1 TRIM74 22493164,22493164 0018,0397 HT TRIM74 USP32 23105109 0018 LC TRIM74 TSG101 19549727,19549727 0397,0018 HT TRIM74 RNF32 22493164,22493164 0018,0397 HT TRIM74 USP15 23105109 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q86UV6 Q5VVX9 TRIM74 UBE2U 0.286 19549727 Q8NFA0 Q86UV6 USP32 TRIM74 0.183 23105109 Q86UV6 P07900 TRIM74 HSP90AA1 0.126 22939624 Q9Y4E8 Q86UV6 USP15 TRIM74 0.183 23105109 Q86UV6 O75604 TRIM74 USP2 0.183 23105109 Q86UV6 A5YKK6 TRIM74 CNOT1 0.126 26186194 Q86UV6 P08238 TRIM74 HSP90AB1 0.126 22939624 Q86UV6 P22830 TRIM74 FECH 0.126 26186194 Q86UV6 Q04864 TRIM74 REL 0.454 25416956 Q96EV8 Q86UV6 DTNBP1 TRIM74 0.126 26186194 Q99816 Q86UV6 TSG101 TRIM74 0.286 19549727 Q86UV6 Q6UWE0 TRIM74 LRSAM1 0.286 22493164 Q9H0A6 Q86UV6 RNF32 TRIM74 0.286 22493164 Q86UV6 O60291 TRIM74 MGRN1 0.286 22493164 Q86UV6 P62877 TRIM74 RBX1 0.286 22493164 Q86UV6 P38398 TRIM74 BRCA1 0.286 22493164

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 CNOT1 TRIM74 MI:0045 experimental interaction detection MI:0461 interaction database MGRN1 TRIM74 MI:0045 experimental interaction detection MI:0461 interaction database USP2 TRIM74 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 TRIM74 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 TRIM74 MI:0045 experimental interaction detection MI:0461 interaction database FECH TRIM74 MI:0045 experimental interaction detection MI:0461 interaction database BRCA1 TRIM74 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 TRIM74 MI:0045 experimental interaction detection MI:0461 interaction database REL TRIM74 MI:0045 experimental interaction detection MI:0461 interaction database UBE2U TRIM74 MI:0045 experimental interaction detection MI:0461 interaction database LRSAM1 TRIM74 MI:0045 experimental interaction detection MI:0461 interaction database TRIM74 USP32 MI:0045 experimental interaction detection MI:0461 interaction database TRIM74 DTNBP1 MI:0045 experimental interaction detection MI:0461 interaction database TRIM74 TSG101 MI:0045 experimental interaction detection MI:0461 interaction database TRIM74 RNF32 MI:0045 experimental interaction detection MI:0461 interaction database TRIM74 USP15 MI:0045 experimental interaction detection MI:0461 interaction database