PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus FASLG SH3RF2 19807924 biogrid,intact exp P P P G P P P P P P P P P P GP HSP90AB1 SH3RF2 22939624 intact exp P P P GP P P P P P P P P P P P GP SH3RF2 AMOTL2 25416956 biogrid,intact exp P GP P P P P G PAK4 SH3RF2 24130170 biogrid exp P P P GP P P P P P P P P P P P GP EIF4A1 SH3RF2 24130170 biogrid exp P P P P P P P P P DDX6 SH3RF2 24130170 biogrid exp P P P GP P P P P P P P P P P P GP CCDC50 SH3RF2 24130170 biogrid exp P P P G P P P P GP RAC1 SH3RF2 22128169 biogrid exp P P G P P P P P P GP SPERT SH3RF2 25416956 biogrid,intact exp GP MTUS2 SH3RF2 25416956 biogrid,intact exp P P P GP P P P P P P P P P P P P SH3RF2 RBPMS 25416956 biogrid,intact exp P P G P P P P P P P P GP G3BP1 SH3RF2 24130170 biogrid exp P P P G P P P P P P P P P P GP SH3RF2 DDX1 24130170 biogrid exp P P P GP P P P P P P P P P P P GP GOLGA2 SH3RF2 25416956 biogrid,intact exp P P P GP P P P P P P P P P P P GP HOMEZ SH3RF2 25416956 biogrid,intact exp P P P P P P P P P P P P NUFIP2 SH3RF2 24130170 biogrid exp P P P GP P P P P P P P P P P P GP BANP SH3RF2 25416956 biogrid,intact exp P P GP P P P P P P P P P P GP PCMT1 SH3RF2 24130170 biogrid exp P P P GP P P P P P P P P P P GP SH3RF2 NSMAF 24130170 biogrid exp P P P GP P P P P P P P P P P GP U2AF2 SH3RF2 24130170 biogrid exp P P P GP P P P P P P P P P P P GP PPP1CC SH3RF2 23080069,21382349 biogrid,intact exp P P P GP P P P P P P P P P P P GP APP SH3RF2 21832049 innatedb,biogrid exp P P G P P P P P P GP LSM12 SH3RF2 24130170 biogrid exp P P P GP P P P P P P P P P P P GP HSP90AA1 SH3RF2 22939624 biogrid exp P P P G P P GP PPP1CA SH3RF2 22321011,19945436,19389623 biogrid,intact exp P P P G P P P P P P P P P P GP KARS SH3RF2 24130170 biogrid exp P P P GP P P P P P P P P P P P GP SH3RF2 LZTS2 25416956 biogrid,intact exp P P P G P P P P P P P P P P GP SH3RF2 DNTTIP1 24130170 biogrid exp P P P GP P P P P P P P P P P P GP SH3RF1 SH3RF2 22128169, 23023127 biogrid exp, pred G G RAD23A SH3RF2 24130170, 23023127 biogrid exp, pred P P P GP P P P P P P P P P P P GP UBE2N SH3RF2 19690564, 23023127 biogrid,intact exp, pred P P P GP P P P P P P P P P P P GP CUL4A SH3RF2 21145461, 23023127 biogrid exp, pred G G LCK SH3RF2 23023127 pred G P NEDD9 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP CALM1, CALM2, CALM3 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP UBQLNL SH3RF2 23023127 pred P P P P P P P P GP PLCG2 SH3RF2 23023127 pred P P GP P P P P P P P GP UBXN8 SH3RF2 23023127 pred G G SH3RF2 SRMS 23023127 pred P P P P P P P P P P P P P P P P SH3RF2 EPS8L2 23023127 pred P P P P P P P P P P P P P P P GP BCAR1 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP PAK3 SH3RF2 23023127 pred P P P G CBX7 SH3RF2 23023127 pred P P P G P P P P P P P P P P P GP SH3RF2 SH2B3 23023127 pred P P GP P P P P P P P P P P P GP ARHGEF6 SH3RF2 23023127 pred P P G P P P P P P P P G FYB SH3RF2 23023127 pred P SH3RF2 NEDD4L 23023127 pred P P P GP P P P P P P P P G SH3RF2 ABI2 23023127 pred G G SH3RF2 UBQLN1 23023127 pred P P P GP P P P P P P P P P P P GP MAP3K11 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP RIMBP3C SH3RF2 23023127 pred P P P SH3RF2 OTOR 23023127 pred P P P P P P P P P P P P P P MYCBP2 SH3RF2 23023127 pred P P GP P P P P P P GP SH3RF2 PACSIN3 23023127 pred P P P GP P P P P P P P P P P P RIMBP3B SH3RF2 23023127 pred SH3RF2 DBNL 23023127 pred P P P G P P P P P P P P P P P GP GRB2 SH3RF2 23023127 pred P P P G P P P P P P P P P P P GP UBL4A SH3RF2 23023127 pred P P P G P P P P P P RAPH1 SH3RF2 23023127 pred P P P G P P P P P P P P P P P GP SORBS2 SH3RF2 23023127 pred P P P GP P P P P P P P P P P WHSC1 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP GRB7 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP GRB14 SH3RF2 23023127 pred P P P GP P P P P P P P P P GP SH3PXD2B SH3RF2 23023127 pred P P P G P P P P P P P GP SH3RF2 CIDEC 23023127 pred P P GP P P P P P P P P P P P GP DDI2 SH3RF2 23023127 pred P P P P P P P P P P P P NOSTRIN SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 SORBS1 23023127 pred P P P GP P P P P P P P P P P GP CEP350 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP CACNB4 SH3RF2 23023127 pred P P P P P P P P P P P P P P P P SH3RF2 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP CRKL SH3RF2 23023127 pred P P G P P P P P P P P G LASP1 SH3RF2 23023127 pred P G P P P P P P P P P P G ABL1 SH3RF2 25402006, 23023127 pred P P P GP P P P P P P P P P P P GP LIMS2 SH3RF2 23023127 pred P GP P P P P G NEBL SH3RF2 23023127 pred P P GP P P P P P P P P G SH3RF2 OSTF1 23023127 pred P P P GP P P P P P P P P P P GP SH3RF2 UBTD1 23023127 pred P P P GP P P P P P GP PTPN4 SH3RF2 23023127 pred P P P GP P P P P P P P P P GP SH3RF2 STAC 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 PEX13 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 MTF2 23023127 pred G G KDM4B SH3RF2 23023127 pred G G FXR2 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 PACSIN1 23023127 pred P G P P SH3RF2 ITCH 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 L3MBTL3 23023127 pred P P P GP P P P P P P P P GP HCLS1 SH3RF2 23023127 pred P G P P G SH3RF2 UBL7 23023127 pred P P P GP P P P P P P P P P P P GP APBB1 SH3RF2 23023127 pred P P P GP P P P P P P P P P GP PARK2 SH3RF2 23023127 pred P P P GP P P P P P P P P P GP SH3RF2 ASPSCR1 23023127 pred P P P GP P P P P P P P P P P GP RGS14 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP WBP4 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP YES1 SH3RF2 23023127 pred P P P GP P P P P P P P P P P GP SH3RF2 MIA2 23023127 pred P P P P P P P P P P P P P P MAP3K9 SH3RF2 23023127 pred P P P P P P P P P P P P P P GP MAGI3 SH3RF2 23023127 pred P P G P P P P P P P P P GP ABL2 SH3RF2 25402006, 23023127 pred P P P GP P P P P P P P P P P P GP TEC SH3RF2 23023127 pred P P P P P P P P P P P P P P ITK SH3RF2 23023127 pred G UBC SH3RF2 23023127 pred ENAH SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SH3D21 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP ARAF SH3RF2 23023127 pred G G RANBP2 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 CD2AP 23023127 pred P P P G P P P P P P P P P P P GP ARHGEF9 SH3RF2 23023127 pred P P P GP P P P P P P P P CTTN SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 PPP1R13B 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 VAV3 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 SH3GLB1 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 MYO15B 23023127 pred UBL4B SH3RF2 23023127 pred P P P P P P P P P P P P P P P NOXO1 SH3RF2 23023127 pred SH3RF2 BAIAP2 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 TDRKH 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 POMK 23023127 pred P P P GP P P P P P P P P P P P GP MYO1E SH3RF2 23023127 pred P P P GP P P P P P P P P P GP SH3RF2 STAM 23023127 pred P P P GP P P P P P P P P P P GP SH3RF2 PDLIM5 23023127 pred P P P GP P P P P P P P P P P P P TRIP10 SH3RF2 23023127 pred G G STAC2 SH3RF2 23023127 pred P P P G P P P P P P P P P P GP SH3RF2 SH3RF3 23023127 pred P P P GP P P P P P P P P P P P GP BZRAP1 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P P PRKCG SH3RF2 23023127 pred P G P G WWP2 SH3RF2 23023127 pred P P P GP P P P P P P P P P P GP SH3RF2 EPB41L3 23023127 pred P P G P P P P P P GP RUSC2 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP FYN SH3RF2 23023127 pred P P G P P P P P G SH3RF2 SLA2 23023127 pred G SORBS3 SH3RF2 23023127 pred P GP P P P P P P P P P P G SH3RF2 SH3GLB2 23023127 pred P P G P P P P P P GP WWC1 SH3RF2 23023127 pred P P P G P P P P P P P P P P GP SH3RF2 UBXN10 23023127 pred P P P GP P P P P P P P P P P GP SRGAP1 SH3RF2 23023127 pred P P G P P P P P P P GP RAD23B SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP ITSN1 SH3RF2 23023127 pred P P GP P P P P P P P P GP DCLK1 SH3RF2 23023127 pred P G P P P P P P P P SASH1 SH3RF2 23023127 pred P P P GP P P P P P P P P GP TMUB2 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 UBQLN2 23023127 pred P P P GP P P P P P P P P P P P GP SPTAN1 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP PHF20L1 SH3RF2 23023127 pred P P GP P P P P P P P GP SMN1, SMN2 SH3RF2 23023127 pred P P P P P P P P P P P P P P P PIK3R1 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 HERPUD2 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 STAC3 23023127 pred G G ARHGEF16 SH3RF2 23023127 pred P P P G P P P P P P P P P P P GP CBX6 SH3RF2 23023127 pred P P P GP P P P P P P P P P GP ARHGEF37 SH3RF2 23023127 pred P P P GP P P P P P P P P GP SH3RF2 SLC25A23 23023127 pred P GP P P P P P P P P P GP MAPK8IP2 SH3RF2 23023127 pred P P GP P P P P P P P P P P P GP STAM2 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 HECW2 23023127 pred P P P GP P P P P P P P P P GP SH2D1B SH3RF2 23023127 pred P P P P P P P P P P P P P P VAV1 SH3RF2 23023127 pred P P P P P P P P P P P P P P GP MIDN SH3RF2 23023127 pred P P P GP P P P P P P P P GP BTK SH3RF2 23023127 pred P SUMO2 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP CUL1 SH3RF2 23023127 pred P P GP P P P P P P P P P P P GP RIMBP2 SH3RF2 23023127 pred P P P P P P P P P P P P P P P P SH3RF2 EPB41L4B 23023127 pred P P P GP P P P P P P P P P P P GP SNRPN SH3RF2 23023127 pred P P SH3RF2 RUSC1 23023127 pred P P P GP P P P P P P P P P P GP TMPRSS6 SH3RF2 23023127 pred G G SH3RF2 ITSN2 23023127 pred P G P P P P P P P P P GP SH3RF2 PPP1R13L 23023127 pred P P GP P P P P P P P P P P GP SH3RF2 SNX18 23023127 pred P P P G P P P P P P P P GP CRK SH3RF2 23023127 pred P GP P P P P P P P P P G MIA3 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 CYLD 23023127 pred P P P GP P P P P P P P P P P P GP DFFA SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP OBSCN SH3RF2 23023127 pred P P P GP P P P P P P P P P P P P CIDEA SH3RF2 23023127 pred G EPB41L2 SH3RF2 23023127 pred P P G P P P P P GP UBE2K SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 ASAP1 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 UBASH3B 23023127 pred P P P P P P P P P P P P P P P P ARHGEF19 SH3RF2 23023127 pred MLK4 SH3RF2 23023127 pred P P P P P P P P P P P P P GP PLCG1 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SASH3 SH3RF2 23023127 pred P P G P P P P P P P GP EPS8L1 SH3RF2 23023127 pred P P GP P P P P P P G SH3RF2 ARHGAP39 23023127 pred P P P G P P P P P P P P P P GP NCF4 SH3RF2 23023127 pred P NCF4 SH3RF2 23023127 pred P PSTPIP1 SH3RF2 23023127 pred G P P SH3RF2 BAG1 23023127 pred P P P GP P P P P P P P P P P P GP SH2D7 SH3RF2 23023127 pred P P P P P P P P SH2D1A SH3RF2 23023127 pred SH3RF2 FAF1 23023127 pred P P P GP P P P P P P P P P P GP MYO1F SH3RF2 23023127 pred G P P G NGEF SH3RF2 23023127 pred P P P P P P P P P P P P P P P GP PIK3CA SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP DLG2 SH3RF2 23023127 pred P P P P P P P P HABP2 SH3RF2 23023127 pred P G P P P P P P P GP EFS SH3RF2 23023127 pred P P G P P P P P P P G SH3RF2 CASS4 23023127 pred P P P P P P P P P P P P P P P NOXA1 SH3RF2 23023127 pred P P P G P P P P P P P P P P GP DCTN1 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP LYN SH3RF2 23023127 pred P P G P P P P P P P P P G AMPH SH3RF2 23023127 pred P G P P P G NCF2 SH3RF2 23023127 pred G P SRGAP2 SH3RF2 23023127 pred G SH3RF2 RNF17 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 SAMSN1 23023127 pred P P P P P P P P P P P P P P SH3RF2 SH3BP4 23023127 pred P P P G P P P P P P P P P P GP UBFD1 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SOCS1 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP NPHP1 SH3RF2 23023127 pred P P P P P P P P P P P P P GP SUPT5H SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 SH3GL2 23023127 pred P P P G PRMT2 SH3RF2 23023127 pred P P GP P P P P P P P P P GP SH3RF2 UNC13A 23023127 pred P P P P P P P P P P P P WASL SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP F9 SH3RF2 23023127 pred MAP3K10 SH3RF2 23023127 pred P P P P P P P P P P P P P P P SH3RF2 NECAB3 23023127 pred G G CACNB3 SH3RF2 23023127 pred G G NFATC2IP SH3RF2 23023127 pred G G SH3RF2 SH3KBP1 23023127 pred P G P P G MIA SH3RF2 23023127 pred P P P P P P P P P P SH3RF2 NSFL1C 23023127 pred P P P GP P P P P P P P P P P P GP VAV2 SH3RF2 23023127 pred P P P G P P P P P P P P P P P GP AHI1 SH3RF2 23023127 pred P P P GP P P P P P P P P P P GP SUMO3 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SRGAP3 SH3RF2 23023127 pred P P GP P P P G FCHSD1 SH3RF2 23023127 pred P P P P P P P P P P P P P P P P SKAP1 SH3RF2 23023127 pred G P G UBASH3A SH3RF2 23023127 pred P P P KALRN SH3RF2 23023127 pred P P P P P P P P P P P P P P P P PRKCQ SH3RF2 23023127 pred G G TDRD5 SH3RF2 23023127 pred P P P P P P P P P P P P P P P GP SF3A1 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP HERPUD1 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP FRK SH3RF2 23023127 pred P P P P P P P P P P P P P P P SH3RF2 UBTD2 23023127 pred P P P GP P P P P P P P P P P GP FCHSD2 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P G SH3RF2 CABP5 23023127 pred P P P P P P P P P P P P P P P P NCK1 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP FRMD7 SH3RF2 23023127 pred P P P P P P P P P P P P P P P UBXN2B SH3RF2 23023127 pred P G P P P P P P GP SH3RF2 GABARAPL1 23023127 pred P P P GP P P P P P P P P GP SH3RF2 MAPK8IP1 23023127 pred P P P P P P P P P P P P P P P GP NEB SH3RF2 23023127 pred G P G PIK3R2 SH3RF2 23023127 pred G G SH2D5 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 SH3GL3 23023127 pred P G P P P GP SH3RF2 UBE2E2 23023127 pred P P P GP P P P P P P P P P P P GP UBE2L3 SH3RF2 23023127 pred P P GP P P P P P P P P GP RAB3A SH3RF2 23023127 pred P P G P P G TRIO SH3RF2 23023127 pred P P P G P P P P P P P P P P P GP SH3RF2 BAIAP2L1 23023127 pred P P P P P P P P P P P P P P P GP USP14 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 SH3YL1 23023127 pred P P G P P P P P P P P P P GP RASSF7 SH3RF2 23023127 pred G G SH3RF2 RIMBP3 23023127 pred ARHGAP4 SH3RF2 23023127 pred P TMPRSS15 SH3RF2 23023127 pred P P P GP P P P P GP BIN1 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 TDRD1 23023127 pred P P P P P P P P P P P P P P P GP LIMS1 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 SNX9 23023127 pred P P P GP P P P P P P P P P P P GP DNMBP SH3RF2 23023127 pred P P P GP P P P P G SH3RF2 ABI3 23023127 pred P GP P P P P P P SH3PXD2A SH3RF2 23023127 pred P P P GP P P P P P P P P P P GP MATK SH3RF2 23023127 pred P P P P P P P P P P P P P P P P HDGFL1 SH3RF2 23023127 pred G GP NCK2 SH3RF2 23023127 pred P P GP P P P P P P P P P P P GP SH3RF2 CLIP3 23023127 pred P P P GP P P P P P P P P P GP SH3RF2 DLG3 23023127 pred P G P P P GP SH3RF2 MYO15A 23023127 pred P P G P P P P P P P GP ABI1 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP TCERG1 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP RGL3 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P P RASA1 SH3RF2 23023127 pred P P G P P G BAIAP2L2 SH3RF2 23023127 pred P P P P P P P P P P P P P P P P EPS8L3 SH3RF2 23023127 pred P GP P P P P P P GP SUMO4 SH3RF2 23023127 pred P P P GP P P P P P P P P P GP SH3RF2 TMUB1 23023127 pred P P P GP P P P P P P P P P P GP UBXN2A SH3RF2 23023127 pred G G BAG6 SH3RF2 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 SGSM3 23023127 pred P P P GP P P P P P P P P P P P GP SH3RF2 RNF208 23023127 pred P P GP P P P P P P P P GP SH3RF2 ARHGAP26 23023127 pred P P P GP P P P P P P P P P GP ARHGEF7 SH3RF2 23023127 pred P P P GP P P P P P P P P P P GP GRAP2 SH3RF2 23023127 pred P P P P P P P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8TEC5 P36873-2 two hybrid 21382349 physical association X 2 Q8TEC5 Q8N9N5 two hybrid prey pooling approach 25416956 physical association X 2 Q8TEC5 Q8N9N5 two hybrid array 25416956 physical association X 2 Q8TEC5 Q8N9N5 validated two hybrid 25416956 physical association X 2 P62136 Q8TEC5 pull down 19389623 direct interaction X 2 P62136 Q8TEC5 far western blotting 19389623 physical association X 2 P62136 Q8TEC5 two hybrid 22321011 physical association X 2 P48023 Q8TEC5 phage display 19807924 direct interaction X 2 Q8TEC5 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2 A0A024RBP2 Q8TEC5 two hybrid 21382349 physical association X 2 P61088 Q8TEC5 two hybrid array 19690564 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B FASLG SH3RF2 MI:0084(phage display)|MI:0686(unspecified method) 19807924 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_103354|BIOGRID_210549 bait|bait prey|prey NSMAF SH3RF2 MI:0004(affinity chromatography technology) 24130170 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_293676 prey bait NUFIP2 SH3RF2 MI:0004(affinity chromatography technology) 24130170 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_293677 prey bait CUL4A SH3RF2 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_202975 bait prey SH3RF1 SH3RF2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22128169 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_190189|BIOGRID_190188 bait|prey prey|bait DDX1 SH3RF2 MI:0004(affinity chromatography technology) 24130170 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_293669 prey bait DDX6 SH3RF2 MI:0004(affinity chromatography technology) 24130170 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_293670 prey bait PCMT1 SH3RF2 MI:0004(affinity chromatography technology) 24130170 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_293679 prey bait LSM12 SH3RF2 MI:0004(affinity chromatography technology) 24130170 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_293675 prey bait HSP90AA1 SH3RF2 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255439 bait prey RAD23A SH3RF2 MI:0004(affinity chromatography technology) 24130170 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_293680 prey bait G3BP1 SH3RF2 MI:0004(affinity chromatography technology) 24130170 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_293673 prey bait HSP90AB1 SH3RF2 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125088 prey bait RAC1 SH3RF2 MI:0004(affinity chromatography technology) 22128169 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_190186 bait prey PPP1CA SH3RF2 MI:0047(far western blotting)|MI:0047(far western blotting)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0047(far western blotting) 19389623,19945436,22321011 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(intact) UniProt_98420|UniProt_98369|UniProt_121655|BIOGRID_182268|BIOGRID_212530|BIOGRID_212531|UniProt_167880 bait|bait|bait|bait|prey|prey|bait prey|prey|prey|prey|bait|bait|prey KARS SH3RF2 MI:0004(affinity chromatography technology) 24130170 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_293674 prey bait PPP1CC SH3RF2 MI:0018(two hybrid)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid) 21382349,23080069 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(intact)|(intact)|(biogrid) BIOGRID_251695|UniProt_112532|UniProt_112491|BIOGRID_246953 bait|null|null|bait prey|prey|prey|prey SH3RF2 DNTTIP1 MI:0004(affinity chromatography technology) 24130170 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_293671 bait prey PAK4 SH3RF2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24130170 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_293678|BIOGRID_293682|BIOGRID_293684|BIOGRID_293683 prey|prey|prey|bait bait|bait|bait|prey U2AF2 SH3RF2 MI:0004(affinity chromatography technology) 24130170 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_293681 prey bait APP SH3RF2 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_228048 prey bait EIF4A1 SH3RF2 MI:0004(affinity chromatography technology) 24130170 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_293672 prey bait CCDC50 SH3RF2 MI:0004(affinity chromatography technology) 24130170 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_293668 prey bait UBE2N SH3RF2 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123626|UniProt_102615 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality PPP1CA SH3RF2 19389623,19945436,19945436,19389623 0096,0004,0018,0047 LC CUL4A SH3RF2 21145461 0004 HT CUL4A SH3RF2 21145461 0004 HT PPP1CA SH3RF2 19389623,19945436,19945436,19389623 0096,0004,0018,0047 LC HSP90AB1 SH3RF2 22939624 0729 HT PPP1CC SH3RF2 23080069,21382349 0018,0018 LC FASLG SH3RF2 19807924 0084 LC UBE2N SH3RF2 19690564,19690564 0397,0018 HT PPP1CA SH3RF2 19389623,19945436,22321011,19945436,19389623 0096,0004,0018,0018,0047 LC GOLGA2 SH3RF2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT MTUS2 SH3RF2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT HOMEZ SH3RF2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT BANP SH3RF2 25416956,25416956,25416956 1112,0397,1356 HT SPERT SH3RF2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT SH3RF2 RBPMS 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT SH3RF2 LZTS2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT SH3RF2 DKFZP761H172 25416956 0018 HT SH3RF2 AMOTL2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT SH3RF2 HEL-S-71 19690564 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8TEC5 P62139 SH3RF2 PPP1CA 0.126 19389623 Q8TEC5 Q8IX15 SH3RF2 HOMEZ 0.183 25416956 Q8TEC5 Q8N9N5 SH3RF2 BANP 0.454 25416956 Q8TEC5 P05067 SH3RF2 APP 0.183 21832049 Q8TEC5 P08238 SH3RF2 HSP90AB1 0.126 22939624 Q8TEC5 P22061 SH3RF2 PCMT1 0.21 24130170 Q8TEC5 P26196 SH3RF2 DDX6 0.21 24130170 Q8TEC5 P26368 SH3RF2 U2AF2 0.21 24130170 Q8TEC5 P36873 SH3RF2 PPP1CC 0.554 21382349,23080069 Q8TEC5 P54725 SH3RF2 RAD23A 0.21 24130170 Q8TEC5 P60842 SH3RF2 EIF4A1 0.21 24130170 Q8TEC5 P61088 SH3RF2 UBE2N 0.376 19690564 Q8TEC5 Q13283 SH3RF2 G3BP1 0.21 24130170 Q8TEC5 Q15046 SH3RF2 KARS 0.21 24130170 Q8TEC5 Q3MHD2 SH3RF2 LSM12 0.21 24130170 Q8TEC5 Q7Z417 SH3RF2 NUFIP2 0.21 24130170 Q8TEC5 Q7Z6J0 SH3RF2 SH3RF1 0.376 22128169 Q8TEC5 Q8IVM0 SH3RF2 CCDC50 0.21 24130170 Q8TEC5 Q8NA61 SH3RF2 SPERT 0.183 25416956 Q92499 Q8TEC5 DDX1 SH3RF2 0.21 24130170 Q92636 Q8TEC5 NSMAF SH3RF2 0.21 24130170 Q9H147 Q8TEC5 DNTTIP1 SH3RF2 0.21 24130170 Q8TEC5 P07900 SH3RF2 HSP90AA1 0.126 22939624 Q9Y2J4 Q8TEC5 AMOTL2 SH3RF2 0.376 unassigned1304,25416956 Q8TEC5 O96013 SH3RF2 PAK4 0.569 24130170 Q9ULX6 Q8TEC5 AKAP8L SH3RF2 0.236 unassigned1304 Q8TEC5 A0A0C4DGS5 SH3RF2 A0A0C4DGS5 0.236 unassigned1304 Q9HC98 Q8TEC5 NEK6 SH3RF2 0.236 unassigned1304 Q8TEC5 O95429 SH3RF2 BAG4 0.236 unassigned1304 Q8TEC5 A5D8V6 SH3RF2 VPS37C 0.236 unassigned1304 Q8TEC5 B8A4K4 SH3RF2 CYSRT1 {ECO:0000313|ENSEMBL:ENSP00000386453} 0.236 unassigned1304 Q8TEC5 P62136 SH3RF2 PPP1CA 0.636 22321011,19945436 Q8TEC5 P48023 SH3RF2 FASLG 0.332 19807924 Q8TEC5 Q5JR59 SH3RF2 MTUS2 0.376 unassigned1304,25416956 Q93062 Q8TEC5 RBPMS SH3RF2 0.183 25416956 Q9BRK4 Q8TEC5 LZTS2 SH3RF2 0.183 25416956 Q8TEC5 Q13619 SH3RF2 CUL4A 0.126 21145461 Q8TEC5 P63000 SH3RF2 RAC1 0.21 22128169 Q8TEC5 Q08379 SH3RF2 GOLGA2 0.183 25416956

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PAK4 SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database APP SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database PCMT1 SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database DDX6 SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database U2AF2 SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database PPP1CC SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database FASLG SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database RAD23A SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database EIF4A1 SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2N SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database PPP1CA SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database RAC1 SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database GOLGA2 SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database G3BP1 SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database CUL4A SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database KARS SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database LSM12 SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database MTUS2 SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database NUFIP2 SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database SH3RF1 SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database CCDC50 SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database HOMEZ SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database BANP SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database SPERT SH3RF2 MI:0045 experimental interaction detection MI:0461 interaction database SH3RF2 DDX1 MI:0045 experimental interaction detection MI:0461 interaction database SH3RF2 NSMAF MI:0045 experimental interaction detection MI:0461 interaction database SH3RF2 RBPMS MI:0045 experimental interaction detection MI:0461 interaction database SH3RF2 LZTS2 MI:0045 experimental interaction detection MI:0461 interaction database SH3RF2 DNTTIP1 MI:0045 experimental interaction detection MI:0461 interaction database SH3RF2 AMOTL2 MI:0045 experimental interaction detection MI:0461 interaction database