PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus AHNAK KLHL40 24960163 biogrid exp GP G AXIN1 KLHL40 19888210 i2d exp GP G KLHL40 C7orf31 25416956 biogrid,intact exp G KLHL40 CC2D1B 24960163 biogrid exp GP G REL KLHL40 25416956 biogrid,intact exp G G KLHL40 FAM208B 25416956 biogrid,intact exp GP G FUS KLHL40 25192599 biogrid exp GP G ZBED1 KLHL40 25416956 biogrid,intact exp G G VDAC1 KLHL40 24960163 biogrid exp GP G CSNK1A1 KLHL40 19888210 i2d exp G G PTBP3 KLHL40 22575643 intact exp G G KLHL40 LRRC29 25416956 biogrid,intact exp GP KLHL40 AXIN2 19888210 i2d exp GP G CSNK1E KLHL40 19888210 i2d exp GP G LMOD3 KLHL40 24960163 biogrid exp, ortho GP G NEB KLHL40 24960163 biogrid exp, ortho GP G KLHL41 KLHL40 ortho GP G KLHL40 NRAP ortho GP G KLHL40 KANK2 ortho GP G ACTA1 KLHL40 ortho GP G KLHL40 TUBB1 ortho MYL12B KLHL40 ortho GP G TUBA1B KLHL40 ortho GP G IQGAP1 KLHL40 ortho G G KLHL40 ZBTB37 23023127 pred P BCL6 KLHL40 23023127 pred G G TCEB2 KLHL40 23023127 pred G G ZBTB16 KLHL40 23023127 pred G G KLHL40 KLHL25 23023127 pred GP G KLHL40 SOCS4 23023127 pred GP G KLHL40 NACC1 23023127 pred G G ZBTB48 KLHL40 23023127 pred P G KLHL40 KLHL36 23023127 pred GP G VHL KLHL40 23023127 pred G G KLHL40 KLHL34 23023127 pred GP G SOCS3 KLHL40 23023127 pred GP G KLHL40 KLHL13 23023127 pred GP G ZBTB43 KLHL40 23023127 pred G G MTA2 KLHL40 16082366 pred P SOCS2 KLHL40 23023127 pred GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A0A024R6W8 Q2TBA0 two hybrid 25416956 direct interaction X 2 Q2TBA0 two hybrid 25416956 direct interaction X 2 P21796 Q2TBA0 two hybrid 24960163 direct interaction X 2 Q2TBA0 Q5T0F9 two hybrid 24960163 direct interaction X 2 Q2TBA0 Q13344 affinity chromatography technology 25192599 physical association X 2 Q8N865 Q2TBA0 two hybrid 25416956 direct interaction X 2 Q2TBA0 affinity chromatography technology 24960163 physical association X 2 Q2TBA0 Q0VAK6 affinity chromatography technology 24960163 physical association X 2 Q2TBA0 two hybrid 24960163 direct interaction X 2 Q2TBA0 Q0VAK6 two hybrid 24960163 direct interaction X 2 Q2TBA0 Q09666 two hybrid 24960163 direct interaction X 2 Q2TBA0 Q04864 two hybrid 25416956 direct interaction X 2 Q2TBA0 A0A024RBU4 two hybrid 25416956 direct interaction X 2 Q2TBA0 anti bait coimmunoprecipitation 22575643 association C 122

PPI - HINT Gene A Gene B PMID Method Quality ZBED1 KLHL40 25416956 0018 HT VDAC1 KLHL40 24960163 0018 LC REL KLHL40 25416956 0018 HT AHNAK KLHL40 24960163 0018 LC LMOD3 KLHL40 24960163,24960163 0018,0004 LC KLHL40 CC2D1B 24960163 0018 LC KLHL40 FAM208B 25416956 0018 HT KLHL40 C7ORF31 25416956 0018 HT KLHL40 LRRC29 25416956 0018 HT KLHL40 Q96MF8 24960163,24960163 0018,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5VWN6 Q2TBA0 FAM208B KLHL40 0.376 unassigned1304,25416956 Q2TBA0 Q04864 KLHL40 REL 0.183 25416956 Q2TBA0 O95758 KLHL40 PTBP3 0.126 22575643 Q2TBA0 O96006 KLHL40 ZBED1 0.183 25416956 Q8IYX7 Q2TBA0 FAM154A KLHL40 0.236 unassigned1304 Q2TBA0 A1L4K1 KLHL40 FSD2 0.236 unassigned1304 Q8WV35 Q2TBA0 LRRC29 KLHL40 0.183 25416956 Q2TBA0 P35637 KLHL40 FUS 0.126 25192599 Q2TBA0 P20929 KLHL40 NEB 0.454 24960163 Q2TBA0 P21796 KLHL40 VDAC1 0.309 24960163 Q2TBA0 Q09666 KLHL40 AHNAK 0.309 24960163 Q2TBA0 Q0VAK6 KLHL40 LMOD3 0.454 24960163 Q5T0F9 Q2TBA0 CC2D1B KLHL40 0.309 24960163 Q8N865 Q2TBA0 C7ORF31 KLHL40 0.183 25416956

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MYL12B KLHL40 MI:0362 inference MI:0461 interaction database KLHL41 KLHL40 MI:0362 inference MI:0461 interaction database PTBP3 KLHL40 MI:0045 experimental interaction detection MI:0461 interaction database ZBED1 KLHL40 MI:0045 experimental interaction detection MI:0461 interaction database GAPDH KLHL40 MI:0362 inference MI:0461 interaction database NEB KLHL40 MI:0045 experimental interaction detection MI:0461 interaction database VDAC1 KLHL40 MI:0045 experimental interaction detection MI:0461 interaction database FUS KLHL40 MI:0045 experimental interaction detection MI:0461 interaction database IQGAP1 KLHL40 MI:0362 inference MI:0461 interaction database ACTA1 KLHL40 MI:0362 inference MI:0461 interaction database TUBA1B KLHL40 MI:0362 inference MI:0461 interaction database TUBA4A KLHL40 MI:0362 inference MI:0461 interaction database REL KLHL40 MI:0045 experimental interaction detection MI:0461 interaction database AHNAK KLHL40 MI:0045 experimental interaction detection MI:0461 interaction database LMOD3 KLHL40 MI:0045 experimental interaction detection MI:0461 interaction database TUBA3C KLHL40 MI:0362 inference MI:0461 interaction database KLHL40 CC2D1B MI:0045 experimental interaction detection MI:0461 interaction database KLHL40 FAM208B MI:0045 experimental interaction detection MI:0461 interaction database KLHL40 KANK2 MI:0362 inference MI:0461 interaction database KLHL40 TUBA3E MI:0362 inference MI:0461 interaction database KLHL40 TUBA1A MI:0362 inference MI:0461 interaction database KLHL40 NRAP MI:0362 inference MI:0461 interaction database KLHL40 C7orf31 MI:0045 experimental interaction detection MI:0461 interaction database KLHL40 LRRC29 MI:0045 experimental interaction detection MI:0461 interaction database KLHL40 SLC25A2 MI:0362 inference MI:0461 interaction database KLHL40 TUBB1 MI:0362 inference MI:0461 interaction database KLHL40 SLC25A15 MI:0362 inference MI:0461 interaction database