PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CSNK2A1 RNF111 25416956,21516116 biogrid,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G LRSAM1 RNF111 22493164 biogrid,intact exp P GP G P GP G P GP G GP GP P GP P GP GP GP G P GP P P P GP P P G KRTAP5-9 RNF111 25416956,21516116 biogrid,mint,intact exp HSP90AB1 RNF111 22939624 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 UBE2E3 19549727,19690564 biogrid,intact exp GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G GP GP G GP GP G TRIM21 RNF111 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 RB1CC1 21795712 biogrid exp G GP G G G GP G G GP G GP G GP G G GP GP GP GP G GP GP GP G GP G GP GP G UBE2M RNF111 19549727 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G TRAF5 RNF111 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G RNF111 UBE2W 19549727,19690564 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ACTN3 RNF111 25416956 innatedb,biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G CREB1 RNF111 20936779 biogrid,i2d,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 UBE2E2 19549727 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 PHF7 22493164 biogrid,intact exp P GP G G GP P G GP P G GP GP GP GP G P GP GP GP G P GP GP GP P P GP G UBE2E1 RNF111 19549727,19690564 biogrid,intact exp GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G GP GP G GP GP G RNF111 TRIM8 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G XPC RNF111 23751493 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 UBE2Q2 19549727 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D3 RNF111 25416956,19549727,23530056,19690564 biogrid,intact exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G UBA1 RNF111 25260751 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2N RNF111 23751493,25260751 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G UBE2D2 RNF111 19549727,23530056,19690564 biogrid,intact exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G RNF111 EDARADD 25416956 biogrid,intact exp P P G GP P GP P P P P GP P P GP G GP P P P P GP P FHL2 RNF111 23212909 biogrid exp GP GP G G GP GP G GP GP GP GP GP G G GP GP GP G G GP GP G GP GP G GP GP G RNF111 UBE2D4 19549727,19690564 biogrid,intact exp GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G RNF111 MARCH7 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G UBE2V1 RNF111 19549727,25260751 biogrid,intact exp MVP RNF111 24722188 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP G GP G GP GP GP GP G CSNK2A2 RNF111 26186194,23455922 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2G2 RNF111 19690564 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G RNF111 ANAPC11 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SUMO1 RNF111 23530056,23086935 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 TSG101 19549727 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2K RNF111 19549727 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CTBP1 RNF111 24722188 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 RNF111 23212909,25416956,22493164,23751493 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HSP90AA1 RNF111 22939624 biogrid exp GP GP G G G GP G G GP G G G G G G G GP G G G GP G G G G G G GP G PML RNF111 22493164,23530056 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G LCE4A RNF111 25416956 biogrid,intact exp SMAD7 RNF111 14657019,23530056, 25402006, 21836163 hprd,biogrid exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G SMAD2 RNF111 17591695,23530056,18451154, 25402006, 21836163 biogrid exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G AXIN1 RNF111 16601693, 25402006 hprd,mint,intact exp, ortho, pred GP GP G GP GP G P GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SKIL RNF111 17591695,23530056,17510063, 25402006 biogrid exp, ortho, pred GP GP G G GP GP G G GP G GP GP GP G G GP GP G G G GP GP GP GP GP G GP GP G SMAD3 RNF111 17591695,14657019,23530056,18950738,18451154, 25402006, 21836163 hprd,biogrid exp, pred GP GP G G G GP G G G G G G GP GP G G GP G GP G GP G G G G G G G G UBE2D1 RNF111 25416956,19549727,19690564, 21836163 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G SMAD6 RNF111 14657019, 25402006 hprd,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G RNF111 DTX3L 22493164, 25402006 biogrid,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP G G GP G GP GP GP GP GP GP G SUMO3 RNF111 23530056, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SKI RNF111 23530056,17510063,18451154, 25402006, 21836163 biogrid exp, pred GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2I RNF111 25416956,19549727,20936779, 25402006 biogrid,i2d,intact exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RNF111 SMURF2 15231748, 25402006, 21836163 hprd,biogrid,i2d,mint,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SUMO2 RNF111 23530056,23086935,23751493, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 AXIN2 25402006 ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TNFRSF1A RNF111 25402006, 21836163 ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE3A RNF111 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 BTRC 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G CDKN1B RNF111 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 AMFR 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ETS1 RNF111 25402006 pred G G G G GP G G G G G G G G GP G G G G G G G G G G G GP G G G APC RNF111 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G P GP GP GP GP GP GP GP PSMD9 RNF111 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 SIAH1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PSMC6 RNF111 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 FBXO2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G RPN1 RNF111 21836163 pred G GP G G GP GP G GP GP G G GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G DVL1 RNF111 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 TRAF6 25402006 pred GP GP G G GP G G GP GP G GP GP GP G G GP G GP G G GP GP GP G GP GP GP GP G SMAD1 RNF111 25402006 pred G G G G G G G G GP G G G G G G G G G G G G G G G G G G GP G PSMC2 RNF111 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K1 RNF111 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CTNNB1 RNF111 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G RNF111 RNF126 25402006 pred GP G G G GP GP G G GP G GP G GP GP G GP GP GP P G GP GP G G GP GP GP GP G ATF2 RNF111 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RNF111 RNF26 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G NFKBIA RNF111 25402006 pred G GP G G GP GP G GP GP G G G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PSMA6 RNF111 21836163 pred P P P P P P P P P P P P P P P P P P P P PJA2 RNF111 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RFWD3 RNF111 25402006 pred G G G G G G G G G G G G G G G G G G MAP3K7 RNF111 25402006 pred GP GP G G G GP G G GP G G GP GP G G G GP G GP G GP GP G G G G GP GP G USP1 RNF111 21836163 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP G G G GP G GP GP GP GP GP GP G RNF111 UCHL5 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ANP32A RNF111 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TGFBR1 RNF111 25402006 pred GP G G G GP GP G GP GP G GP GP GP G G GP GP G G G G G G G GP G GP G G NCK2 RNF111 25402006 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 SNIP1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G UBOX5 RNF111 25402006 pred GP GP G G G GP G GP P G G G GP GP G P GP G G G G G GP P GP GP GP G G RNF111 STUB1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 SMURF1 25402006 pred G GP G G GP GP G G GP G GP G GP G G G GP GP G G GP G G G G GP G GP G BRCA1 RNF111 25402006 pred P P G GP P P P P P P P GP P P P P P P P P P P GP CSNK1A1 RNF111 25402006 pred G G G G G G G G G G G G G G G G G G GP G G G G G G G G G G ADRBK1 RNF111 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 KAT2B 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF111 POMP 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G EP300 RNF111 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G BIRC3 RNF111 25402006 pred GP G GP G G GP P GP G GP G GP G GP P G GP GP GP GP GP RNF4 RNF111 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP GP G G GP GP GP GP G G GP GP G FKBP1A RNF111 25402006 pred G GP G G G GP G G GP G GP GP G G G GP GP GP GP G GP GP GP G GP G GP GP G RNF111 TRIM39 25402006 pred P P P P P P P P P P P P P PSMD14 RNF111 21836163 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G G GP GP G GP GP G SIAH2 RNF111 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G SREBF2 RNF111 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP G G GP G GP GP GP GP GP GP G PIAS2 RNF111 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF111 RNF25 25402006 pred P G P P P P P P P P P P P P P GP P P RNF111 UBA2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G G GP GP GP GP GP GP GP G RNF111 ARIH1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 RNF5 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G PSMD10 RNF111 21836163 pred GP G G G G GP G G GP G G G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G GPR37 RNF111 21836163 pred G G G G PSMD11 RNF111 21836163 pred G GP G G GP GP G GP GP G GP G GP G G G GP G G G GP G G G G G G GP G RNF111 WWP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 PAAF1 21836163 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G JUN RNF111 25402006 pred GP GP G G G GP G G GP G GP G GP G G GP GP G G G GP G GP G GP G GP G G WWP2 RNF111 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G RNF111 UBR1 21836163 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP GP G RNF111 RNF125 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G RNF111 DZIP3 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G P GP GP GP GP G GP GP G PSMB4 RNF111 21836163 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP G G GP GP GP GP G CNOT4 RNF111 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 ITCH 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 RNF2 25402006 pred P P P P GP P P P P P P P P P P P SMAD4 RNF111 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP GP GP GP G PIAS1 RNF111 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 BARD1 25402006 pred P G GP P P GP P P P GP G GP P G P P GP P GP P GP GP GP G RNF43 RNF111 25402006 pred P GP P P P GP GP G P P G GP P GP GP G GP GP GP P GP P GP GP G AR RNF111 25402006 pred GP G G G G G G G G G G G G G G G G G G G G G G G GP G RNF111 RNF11 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 STRAP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 DTX2 25402006 pred GP P P P GP GP P GP G GP GP P G GP G G G GP GP P G GP GP G PSMA3 RNF111 21836163 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G RNF111 ZNRF1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 RNF14 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 PIAS4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G NEDD4 RNF111 25402006 pred GP GP G GP P G GP GP GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G XIAP RNF111 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G G GP GP G GP G GP GP G PSMD7 RNF111 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ATXN1 RNF111 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q969T4 Q6ZNA4 two hybrid array 19549727 physical association X 2 Q969T4 Q6ZNA4 two hybrid array 19690564 physical association X 2 P68400 Q6ZNA4 two hybrid 21516116 physical association X 2 P68400 Q6ZNA4 two hybrid prey pooling approach 25416956 physical association X 2 P68400 Q6ZNA4 two hybrid array 25416956 physical association X 2 P68400 Q6ZNA4 validated two hybrid 25416956 physical association X 2 Q6ZNA4 A0A024RDH2 two hybrid array 19549727 physical association X 2 Q6ZNA4 B3KSH4 two hybrid array 19549727 physical association X 2 Q6ZNA4 Q99816 two hybrid array 19549727 physical association X 2 Q6ZNA4 A0A024RDH2 two hybrid array 19690564 physical association X 2 Q6ZNA4 Q8CZW3 two hybrid pooling approach 20711500 physical association X 2 Q6ZNA4 P16220 two hybrid pooling approach 20936779 physical association X 2 Q6ZNA4 P26371 two hybrid 21516116 physical association X 2 Q6ZNA4 P29590 two hybrid array 22493164 physical association X 2 Q6ZNA4 Q6ZNA4 two hybrid array 22493164 physical association X 2 Q6ZNA4 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2 Q6ZNA4 Q6ZNA4 two hybrid array 25416956 physical association X 2 Q6ZNA4 A0A024RDH2 two hybrid prey pooling approach 25416956 physical association X 2 Q6ZNA4 Q5TA78 two hybrid prey pooling approach 25416956 physical association X 2 Q6ZNA4 P26371 two hybrid prey pooling approach 25416956 physical association X 2 Q6ZNA4 Q8WWZ3 two hybrid prey pooling approach 25416956 physical association X 2 Q6ZNA4 A0A024RDH2 two hybrid array 25416956 physical association X 2 Q6ZNA4 Q5TA78 two hybrid array 25416956 physical association X 2 Q6ZNA4 P26371 two hybrid array 25416956 physical association X 2 Q6ZNA4 Q8WWZ3 two hybrid array 25416956 physical association X 2 Q6ZNA4 P26371 validated two hybrid 25416956 physical association X 2 Q6ZNA4 Q5TA78 validated two hybrid 25416956 physical association X 2 Q6ZNA4 A0A024RDH2 validated two hybrid 25416956 physical association X 2 Q6ZNA4 Q8WWZ3 validated two hybrid 25416956 physical association X 2 Q6ZNA4 tandem affinity purification 23455922 association C 63 Q6ZNA4 ubiquitinase assay 25260751 ubiquitination reaction C 4 Q8WVN8 Q6ZNA4 two hybrid array 19549727 physical association X 2 P19474 Q6ZNA4 two hybrid array 22493164 physical association X 2 A0A024QZJ2 Q6ZNA4 two hybrid array 19549727 physical association X 2 A0A024QZJ2 Q6ZNA4 two hybrid array 19690564 physical association X 2 A0A024QZJ2 Q6ZNA4 two hybrid prey pooling approach 25416956 physical association X 2 A0A024QZJ2 Q6ZNA4 two hybrid array 25416956 physical association X 2 A0A024QZJ2 Q6ZNA4 validated two hybrid 25416956 physical association X 2 Q6ZNA4 Q9HAU4 two hybrid 15231748 physical association X 2 Q6ZNA4 O15169 anti bait coimmunoprecipitation 16601693 physical association X 2 Q6ZNA4 O15169 anti bait coimmunoprecipitation 16601693 physical association X 2 Q6ZNA4 Q96B02 two hybrid array 19549727 physical association X 2 Q6ZNA4 P62837 two hybrid array 19549727 physical association X 2 Q6ZNA4 P63279 two hybrid array 19549727 physical association X 2 Q6ZNA4 A0A024RA90 two hybrid array 19549727 physical association X 2 Q6ZNA4 A0A024R2K3 two hybrid array 19549727 physical association X 2 Q6ZNA4 A0A024R2Q2 two hybrid array 19549727 physical association X 2 Q6ZNA4 Q13404 two hybrid array 19549727 physical association X 2 Q6ZNA4 A0A024R4T4 two hybrid array 19549727 physical association X 2 Q6ZNA4 A0A024RA90 two hybrid array 19690564 physical association X 2 Q6ZNA4 A0A024R2K3 two hybrid array 19690564 physical association X 2 Q6ZNA4 P60604 two hybrid array 19690564 physical association X 2 Q6ZNA4 Q96B02 two hybrid array 19690564 physical association X 2 Q6ZNA4 P62837 two hybrid array 19690564 physical association X 2 Q6ZNA4 Q81M33 two hybrid pooling approach 20711500 physical association X 2 Q6ZNA4 P63279 two hybrid pooling approach 20936779 physical association X 2 Q6ZNA4 O00463 two hybrid array 22493164 physical association X 2 Q6ZNA4 A0A024R870 two hybrid array 22493164 physical association X 2 Q6ZNA4 Q8TDB6 two hybrid array 22493164 physical association X 2 Q6ZNA4 Q9NYG5 two hybrid array 22493164 physical association X 2 Q6ZNA4 A0A024R336 two hybrid array 22493164 physical association X 2 Q6ZNA4 Q9H992 two hybrid array 22493164 physical association X 2 Q6ZNA4 Q9BZR9 two hybrid array 22493164 physical association X 2 Q6ZNA4 B2R8Y4 two hybrid prey pooling approach 25416956 physical association X 2 Q6ZNA4 P63279 two hybrid prey pooling approach 25416956 physical association X 2 Q6ZNA4 B2R8Y4 two hybrid array 25416956 physical association X 2 Q6ZNA4 P63279 two hybrid array 25416956 physical association X 2 Q6ZNA4 B2R8Y4 validated two hybrid 25416956 physical association X 2 Q6ZNA4 P63279 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CSNK2A2 RNF111 MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification) 23455922 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_276352|UniProt_127595 bait|bait prey|prey PML RNF111 MI:0415(enzymatic study)|MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 22493164,23530056 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(biogrid) BIOGRID_284025|UniProt_122438|BIOGRID_272826 prey|bait|prey bait|prey|bait RNF111 SMURF2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|- MI:0471(mint)|MI:0471(mint)|(intact)|(biogrid)|MI:0468(hprd) MINT_32291|MINT_61139|UniProt_78815|BIOGRID_259396|HPRD_85 prey|prey|prey|prey|- bait|bait|bait|bait|- RNF111 MARCH7 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284071|UniProt_122562 bait|bait prey|prey KRTAP5-9 RNF111 MI:0018(two hybrid) 21516116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_114546 prey bait RNF111 UBE2E3 MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19549727,19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(intact) UniProt_102552|BIOGRID_124477|BIOGRID_123563|UniProt_101428 prey|prey|prey|prey bait|bait|bait|bait CSNK2A1 RNF111 MI:0018(two hybrid) 21516116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_114362 bait prey TRAF5 RNF111 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284120|UniProt_122439 prey|bait bait|prey RNF111 UBE2E2 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124482|UniProt_101324 prey|prey bait|bait RNF111 HIP2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_101205 prey bait RNF111 UBE2W MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid) 19549727,19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid)|(intact)|(biogrid) UniProt_101485|BIOGRID_124481|UniProt_102689|BIOGRID_123701 prey|prey|prey|prey bait|bait|bait|bait SUMO2 RNF111 MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21252943,21693764,23086935,23530056,23751493 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_247378|BIOGRID_183910|BIOGRID_282466|BIOGRID_282465|BIOGRID_247370|BIOGRID_272814|BIOGRID_272812|BIOGRID_272820|BIOGRID_165597 prey|bait|prey|prey|prey|bait|prey|prey|bait bait|prey|bait|bait|bait|prey|bait|bait|prey SUMO3 RNF111 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23530056 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_272813|BIOGRID_272811 prey|bait bait|prey RNF111 RB1CC1 MI:0004(affinity chromatography technology) 21795712 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_200040 prey bait HSP90AA1 RNF111 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255480 bait prey UBE2D1 RNF111 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid) 19549727,19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact)|(intact) BIOGRID_124176|BIOGRID_123425|UniProt_102414|UniProt_101008 bait|bait|bait|bait prey|prey|prey|prey RNF111 DTX3L MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_283978|UniProt_122451 prey|prey bait|bait UBE2M RNF111 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101416|BIOGRID_124478 bait|bait prey|prey XPC RNF111 MI:0004(affinity chromatography technology) 23751493 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_282472 prey bait FHL2 RNF111 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23212909 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_248653|BIOGRID_248652 bait|prey prey|bait SKIL RNF111 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17510063,17591695,23530056 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_272816|BIOGRID_118782|BIOGRID_197209|BIOGRID_118785 prey|prey|bait|prey bait|bait|prey|bait RNF111 ANAPC11 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122553|BIOGRID_284065 bait|prey prey|bait SMAD2 RNF111 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17591695,23530056 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_272817|BIOGRID_118783 prey|prey bait|bait UBE2G2 RNF111 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102566|BIOGRID_123577 bait|bait prey|prey SMAD3 RNF111 MI:0493(in vivo)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0492(in vitro)|MI:0004(affinity chromatography technology) 14657019,16601693,17591695,18950738,23530056 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) MI:0468(hprd)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid) HPRD_39705|HPRD_39703|BIOGRID_116360|BIOGRID_272818|BIOGRID_116361|BIOGRID_87322|HPRD_12009|BIOGRID_118784 -|-|prey|prey|bait|prey|-|prey -|-|bait|bait|prey|bait|-|bait UBC RNF111 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21963094,23212909,23751493 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_248655|BIOGRID_248656|BIOGRID_266468|BIOGRID_282468|BIOGRID_171969 prey|prey|bait|prey|bait bait|bait|prey|bait|prey SMAD7 RNF111 MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0492(in vitro)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0493(in vivo) 14657019,16601693,23530056 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|-|- MI:0468(hprd)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|MI:0468(hprd)|MI:0468(hprd) HPRD_39705|BIOGRID_272819|BIOGRID_87324|HPRD_11776|BIOGRID_87325|HPRD_39703|HPRD_39701 -|prey|prey|-|bait|-|- -|bait|bait|-|prey|-|- AXIN1 RNF111 MI:0493(in vivo)|MI:0006(anti bait coimmunoprecipitation)|MI:0493(in vivo)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0493(in vivo)|MI:0493(in vivo) 16601693 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|- MI:0468(hprd)|MI:0471(mint)|MI:0468(hprd)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|MI:0468(hprd)|MI:0468(hprd) HPRD_39705|MINT_49479|HPRD_31498|MINT_48884|MINT_80630|UniProt_84780|MINT_81672|UniProt_84781|HPRD_39703|HPRD_39701 -|prey|-|bait|bait|bait|prey|prey|-|- -|bait|-|prey|prey|prey|bait|bait|-|- UBE2D3 RNF111 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0018(two hybrid) 19549727,19690564,23530056 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|(intact)|(biogrid)|(biogrid) UniProt_101057|BIOGRID_272825|UniProt_102478|BIOGRID_123488|BIOGRID_124178 bait|prey|bait|bait|bait prey|bait|prey|prey|prey RNF111 TRIM8 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122422|BIOGRID_284085 prey|prey bait|bait RNF111 PHF7 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122556|BIOGRID_284076 bait|prey prey|bait LRSAM1 RNF111 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284066|UniProt_122447 bait|bait prey|prey UBE2D2 RNF111 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 19549727,19690564,23530056 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|(intact)|(biogrid)|(biogrid) UniProt_101033|BIOGRID_124177|UniProt_102442|BIOGRID_272824|BIOGRID_123454 bait|bait|bait|prey|bait prey|prey|prey|bait|prey UBE2K RNF111 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_124480 bait prey RNF111 TSG101 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124484|UniProt_101216 prey|prey bait|bait RNF111 UBE2Q2 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124483|UniProt_101509 prey|prey bait|bait UBE2N RNF111 MI:0004(affinity chromatography technology) 23751493 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_282467 bait prey UBE2I RNF111 MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19549727,20936779 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid)|(intact)|(biogrid) UniProt_110791|BIOGRID_124180|UniProt_101098|BIOGRID_127119 bait|bait|bait|bait prey|prey|prey|prey UBE2E1 RNF111 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid) 19549727,19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid)|(intact)|(biogrid) UniProt_101306|BIOGRID_124476|UniProt_102532|BIOGRID_123544 bait|bait|bait|bait prey|prey|prey|prey HSP90AB1 RNF111 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125083 prey bait UBE2V1 RNF111 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101402|BIOGRID_124479 bait|bait prey|prey CREB1 RNF111 MI:0018(two hybrid)|MI:0096(pull down) 20936779 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_127118|UniProt_110417 bait|bait prey|prey SMAD6 RNF111 MI:0492(in vitro)|MI:0004(affinity chromatography technology) 14657019 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_11765|BIOGRID_87323 -|prey -|bait RNF111 UBE2D4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid) 19549727,19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(intact)|(intact)|(biogrid) BIOGRID_123521|UniProt_101152|UniProt_102511|BIOGRID_124179 prey|prey|prey|prey bait|bait|bait|bait SUMO1 RNF111 MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 23086935,23530056 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_247379|BIOGRID_272810|BIOGRID_247375 prey|bait|prey bait|prey|bait SKI RNF111 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17510063,18451154,23530056 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_272815|BIOGRID_198975|BIOGRID_197210 prey|prey|prey bait|bait|bait TRIM21 RNF111 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284024|UniProt_122435 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality SMAD7 RNF111 14657019,23530056 0004,0004 LC SKI RNF111 18451154,17510063,23530056 0004,0004,0004 LC SKIL RNF111 17591695,17591695,17510063,23530056 0004,0415,0004,0004 LC CSNK2A2 RNF111 23455922,26186194,23455922 0004,0004,0676 HT SUMO2 RNF111 23086935,21252943,23751493,23086935,23751493 0096,0004,0096,0004,0004 LC UBE2D2 RNF111 26656854,23530056 0096,0096 LC SUMO1 RNF111 23086935,23530056,23086935 0096,0096,0004 LC SMAD3 RNF111 14657019,17591695,18950738 0004,0004,0004 LC SMAD2 RNF111 18451154,17591695,23530056 0004,0004,0004 LC RNF111 Q9P0T0 23530056,18451154,17591695,14657019,18950738 0004,0004,0004,0004,0004 LC RNF111 HEL-S-71 26656854,23751493 0096,0004 LC CSNK2A2 RNF111 23455922,26186194,23455922 0004,0004,0676 HT SMAD7 RNF111 14657019,23530056 0004,0004 LC SKI RNF111 18451154,17510063,23530056 0004,0004,0004 LC SKIL RNF111 17591695,17591695,17510063,23530056 0004,0415,0004,0004 LC SUMO2 RNF111 23086935,21252943,23751493,23086935,23751493 0096,0004,0096,0004,0004 LC UBE2D2 RNF111 26656854,23530056 0096,0096 LC SUMO1 RNF111 23086935,23530056,23086935 0096,0096,0004 LC SMAD3 RNF111 14657019,17591695,18950738 0004,0004,0004 LC SMAD2 RNF111 18451154,17591695,23530056 0004,0004,0004 LC RNF111 Q9P0T0 23530056,18451154,17591695,14657019,18950738 0004,0004,0004,0004,0004 LC RNF111 HEL-S-71 26656854,23751493 0096,0004 LC B2R8Y4 RNF111 25416956,25416956,25416956 1112,0397,1356 HT HIP2 RNF111 19549727 0397 HT TRAF5 RNF111 22493164,22493164 0018,0397 HT HSP90AB1 RNF111 22939624 0729 HT UBC RNF111 26656854 0415 LC SKIL RNF111 17591695,17591695 0004,0415 LC CREB1 RNF111 20936779,20936779 0398,0018 HT TRIM21 RNF111 22493164,22493164 0018,0397 HT UBA1 RNF111 25260751 0997 LC KRTAP5-9 RNF111 25416956,25416956,25416956,21516116,25416956 1112,0397,0018,0018,1356 HT PML RNF111 22493164,22493164 0018,0397 HT UBE2D1 RNF111 19549727,19690564,25416956,25416956,25416956,19690564,19549727,25416956 0397,0397,1112,0397,0018,0018,0018,1356 HT UBE2E1 RNF111 19690564,19549727,19549727,19690564 0397,0397,0018,0018 HT UBE2G2 RNF111 19690564,19690564 0397,0018 HT UBE2D3 RNF111 19549727,19690564,25416956,25416956,25416956,19690564,19549727,25416956 0397,0397,1112,0397,0018,0018,0018,1356 HT UBE2M RNF111 19549727,19549727 0397,0018 HT UBE2K RNF111 19549727 0018 HT UBE2N RNF111 25260751 0997 LC SUMO2 RNF111 23530056 0415 LC UBE2D2 RNF111 19549727,19690564,19690564,19549727 0397,0397,0018,0018 HT UBE2I RNF111 20936779,19549727,25416956,25416956,25416956,20936779,25416956,19549727 0398,0397,1112,0397,0018,0018,1356,0018 HT CSNK2A1 RNF111 25416956,25416956,25416956,21516116,25416956 1112,0397,0018,0018,1356 HT ACTN3 RNF111 25416956 0018 HT CTBP1 RNF111 24722188 0018 HT UBE2V1 RNF111 19549727,19549727,25260751 0397,0018,0997 HT,LC MVP RNF111 24722188 0018 HT LCE4A RNF111 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT LRSAM1 RNF111 22493164,22493164 0018,0397 HT RNF111 RNF111 22493164,25416956,25416956,23751493,23212909,22493164 0018,0397,0018,0415,0415,0397 HT,LC RNF111 DTX3L 22493164,22493164 0018,0397 HT RNF111 UBE2Q2 19549727,19549727 0397,0018 HT RNF111 EDARADD 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT RNF111 UBE2E3 19690564,19549727,19549727,19690564 0397,0397,0018,0018 HT RNF111 UBE2W 19690564,19549727,19549727,19690564 0397,0397,0018,0018 HT RNF111 UBE2E2 19549727,19549727 0397,0018 HT RNF111 TSG101 19549727,19549727 0397,0018 HT RNF111 PHF7 22493164 0397 HT RNF111 TRIM8 22493164,22493164 0018,0397 HT RNF111 MARCH7 22493164,22493164 0018,0397 HT RNF111 SMURF2 15231748 0018 HT RNF111 Q9NS08 22493164 0018 HT RNF111 ANAPC11 22493164,22493164 0018,0397 HT RNF111 UBE2D4 19690564,19549727,19549727,19690564 0397,0397,0018,0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q6ZNA4 B3KSH4 RNF111 HIP2 0.126 19549727 Q6ZNA4 P22736 RNF111 NR4A1 0.21 24584437 Q6ZNA4 P60604 RNF111 UBE2G2 0.286 19690564 Q6ZNA4 P61081 RNF111 UBE2M 0.286 19549727 Q6ZNA4 P61086 RNF111 UBE2K 0.183 19549727 Q6ZNA4 P61088 RNF111 UBE2N 0.472 25260751,23751493,26656854 Q6ZNA4 O15105 RNF111 SMAD7 0.507 23530056,14657019 Q6ZNA4 O15169 RNF111 AXIN1 0.21 16601693 Q8CZW3 Q6ZNA4 CRED RNF111 0.126 20711500 Q9H992 Q6ZNA4 MARCH7 RNF111 0.286 22493164 Q9HAU4 Q6ZNA4 SMURF2 RNF111 0.332 15231748 Q6ZNA4 P16220 RNF111 CREB1 0.286 20936779 Q9NYG5 Q6ZNA4 ANAPC11 RNF111 0.286 22493164 Q6ZNA4 P07900 RNF111 HSP90AA1 0.126 22939624 Q9Y2T1 Q6ZNA4 AXIN2 RNF111 0.21 24584437 Q6ZNA4 Q6UWE0 RNF111 LRSAM1 0.286 22493164 Q6ZNA4 O43541 RNF111 SMAD6 0.21 14657019 Q6ZNA4 P08238 RNF111 HSP90AB1 0.126 22939624 Q6ZNA4 P0CG48 RNF111 UBC 0.309 26656854 Q6ZNA4 P22314 RNF111 UBA1 0.033 25260751 Q6ZNA4 P51965 RNF111 UBE2E1 0.554 19690564,19549727 Q6ZNA4 P52490 RNF111 UBC13 0.309 23751493 Q6ZNA4 P53152 RNF111 MMS2 0.309 23751493 Q6ZNA4 Q01831 RNF111 XPC 0.21 23751493 Q6ZNA4 Q6NXG1 RNF111 ESRP1 0.21 26522722 Q969T4 Q6ZNA4 UBE2E3 RNF111 0.554 19690564,19549727 Q96B02 Q6ZNA4 UBE2W RNF111 0.554 19690564,19549727 Q96LR5 Q6ZNA4 UBE2E2 RNF111 0.376 19549727 Q99816 Q6ZNA4 TSG101 RNF111 0.376 19549727 Q9H6T0 Q6ZNA4 ESRP2 RNF111 0.21 26522722 Q81M33 Q6ZNA4 PEPQ1 RNF111 0.126 20711500 Q6ZNA4 P12757 RNF111 SKIL 0.659 17591695,23530056,17510063 Q8TDB6 Q6ZNA4 DTX3L RNF111 0.286 22493164 Q9BZR9 Q6ZNA4 TRIM8 RNF111 0.286 22493164 Q6ZNA4 Q13404 RNF111 UBE2V1 0.396 19549727,25260751 Q9Y2X8 Q6ZNA4 UBE2D4 RNF111 0.61 19690564,19549727 Q6ZNA4 P68400 RNF111 CSNK2A1 0.636 21516116,25416956 Q6ZNA4 P63279 RNF111 UBE2I 0.757 19549727,25416956,20936779 Q6ZNA4 P63165 RNF111 SUMO1 0.454 23086935 Q6ZNA4 Q15796 RNF111 SMAD2 0.507 17591695,23530056,18451154 Q6ZNA4 P12755 RNF111 SKI 0.507 23530056,17510063,18451154 Q6ZNA4 P26371 RNF111 KRTAP5-9 0.636 21516116,25416956 Q6ZNA4 B2R8Y4 RNF111 B2R8Y4 0.332 25416956 Q6ZNA4 P19784 RNF111 CSNK2A2 0.332 23455922,26186194 Q6ZNA4 Q5TA78 RNF111 LCE4A 0.454 25416956 Q6ZNA4 P51668 RNF111 UBE2D1 0.757 19690564,19549727,25416956 Q6ZNA4 P61077 RNF111 UBE2D3 0.832 19690564,25416956,23530056,19549727 Q6ZNA4 P62837 RNF111 UBE2D2 0.814 19690564,19549727,23530056,26656854 Q6ZNA4 P61956 RNF111 SUMO2 0.794 23530056,23086935,23751493 Q6ZNA4 Q6ZNA4 RNF111 RNF111 0.801 25416956,23212909,22493164,23751493 Q6ZNA4 P29590 RNF111 PML 0.436 23530056,22493164 Q8WVN8 Q6ZNA4 UBE2Q2 RNF111 0.286 19549727 Q8WWZ3 Q6ZNA4 EDARADD RNF111 0.454 25416956 Q9BWX1 Q6ZNA4 PHF7 RNF111 0.286 22493164 Q6ZNA4 P84022 RNF111 SMAD3 0.757 17591695,23530056,18950738,14657019,18451154 Q6ZNA4 Q14192 RNF111 FHL2 0.376 23212909 Q6ZNA4 Q14764 RNF111 MVP 0.183 24722188 Q6ZNA4 Q13363 RNF111 CTBP1 0.183 24722188 Q6ZNA4 P19474 RNF111 TRIM21 0.286 22493164 Q6ZNA4 O00463 RNF111 TRAF5 0.286 22493164 Q6ZNA4 Q08043 RNF111 ACTN3 0.183 25416956

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 CBX4 RNF111 MI:0362 inference MI:0461 interaction database TRAF5 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database SMAD7 RNF111 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database AXIN1 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database SMAD6 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database AP2A2 RNF111 MI:0362 inference MI:0461 interaction database HSP90AA1 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database PARP1 RNF111 MI:0362 inference MI:1106 pathways database UBB RNF111 MI:0362 inference MI:1106 pathways database UBC RNF111 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SKI RNF111 MI:0045 experimental interaction detection MI:0461 interaction database SKIL RNF111 MI:0045 experimental interaction detection MI:0461 interaction database CREB1 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database ERCC2 RNF111 MI:0362 inference MI:1106 pathways database TNFRSF1A RNF111 MI:0362 inference MI:0461 interaction database ERCC3 RNF111 MI:0362 inference MI:1106 pathways database TRIM21 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database CSNK2A2 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database UBA1 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database NR4A1 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database XPA RNF111 MI:0362 inference MI:1106 pathways database KRTAP5-9 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database PML RNF111 MI:0045 experimental interaction detection MI:0461 interaction database GTF2H1 RNF111 MI:0362 inference MI:1106 pathways database CETN2 RNF111 MI:0362 inference MI:1106 pathways database UBE2D1 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database RAD23B RNF111 MI:0362 inference MI:1106 pathways database SUMO3 RNF111 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UBE2G2 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database UBE2M RNF111 MI:0045 experimental interaction detection MI:0461 interaction database UBE2K RNF111 MI:0045 experimental interaction detection MI:0461 interaction database UBE2N RNF111 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SUMO2 RNF111 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UBE2D2 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 RNF111 MI:0362 inference MI:1106 pathways database RPS27A RNF111 MI:0362 inference MI:1106 pathways database UBA52 RNF111 MI:0362 inference MI:1106 pathways database AP2B1 RNF111 MI:0362 inference MI:0461 interaction database SUMO1 RNF111 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UBE2I RNF111 MI:0045 experimental interaction detection MI:0461 interaction database CSNK2A1 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database SMAD3 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database XPC RNF111 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ACTN3 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database CTBP1 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database UBE2V1 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database CUL4A RNF111 MI:0362 inference MI:1106 pathways database CUL4B RNF111 MI:0362 inference MI:1106 pathways database GTF2H2 RNF111 MI:0362 inference MI:1106 pathways database GTF2H3 RNF111 MI:0362 inference MI:1106 pathways database FHL2 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database MVP RNF111 MI:0045 experimental interaction detection MI:0461 interaction database SMAD2 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database UBE2V2 RNF111 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database DDB1 RNF111 MI:0362 inference MI:1106 pathways database UBE2NL RNF111 MI:0362 inference MI:0461 interaction database LCE4A RNF111 MI:0045 experimental interaction detection MI:0461 interaction database ESRP1 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database LRSAM1 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database RNF111 GTF2H5 MI:0362 inference MI:1106 pathways database RNF111 CHD1L MI:0362 inference MI:1106 pathways database RNF111 DTX3L MI:0045 experimental interaction detection MI:0461 interaction database RNF111 RB1CC1 MI:0045 experimental interaction detection MI:0461 interaction database RNF111 UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database RNF111 EDARADD MI:0045 experimental interaction detection MI:0461 interaction database RNF111 DDB2 MI:0362 inference MI:1106 pathways database RNF111 GTF2H4 MI:0362 inference MI:1106 pathways database RNF111 UBE2E3 MI:0045 experimental interaction detection MI:0461 interaction database RNF111 UBE2W MI:0045 experimental interaction detection MI:0461 interaction database RNF111 AP2M1 MI:0362 inference MI:0461 interaction database RNF111 UBE2E2 MI:0045 experimental interaction detection MI:0461 interaction database RNF111 TSG101 MI:0045 experimental interaction detection MI:0461 interaction database RNF111 PHF7 MI:0045 experimental interaction detection MI:0461 interaction database RNF111 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database RNF111 UBE2O MI:0362 inference MI:0461 interaction database RNF111 ESRP2 MI:0045 experimental interaction detection MI:0461 interaction database RNF111 MARCH7 MI:0045 experimental interaction detection MI:0461 interaction database RNF111 SMURF2 MI:0045 experimental interaction detection MI:0461 interaction database RNF111 ANAPC11 MI:0045 experimental interaction detection MI:0461 interaction database RNF111 AXIN2 MI:0045 experimental interaction detection MI:0461 interaction database RNF111 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database