PTM - CPLM Gene Name UniProt ID Type Position Code MYO1E; MYO1C Q12965 Ubiquitination 160 K MYO1E; MYO1C Q12965 Ubiquitination 444 K MYO1E; MYO1C Q12965 Ubiquitination 631 K MYO1E; MYO1C Q12965 Ubiquitination 1019 K

PTM - dbPAF Gene Name UniProt ID Position Type Species MYO1E; MYO1C Q12965 1002 S Homo sapiens(Human) MYO1E; MYO1C Q12965 1003 T Homo sapiens(Human) MYO1E; MYO1C Q12965 1004 S Homo sapiens(Human) MYO1E; MYO1C Q12965 1005 S Homo sapiens(Human) MYO1E; MYO1C Q12965 1009 S Homo sapiens(Human) MYO1E; MYO1C Q12965 1011 T Homo sapiens(Human) MYO1E; MYO1C Q12965 1014 S Homo sapiens(Human) MYO1E; MYO1C Q12965 1090 T Homo sapiens(Human) MYO1E; MYO1C Q12965 137 T Homo sapiens(Human) MYO1E; MYO1C Q12965 197 S Homo sapiens(Human) MYO1E; MYO1C Q12965 370 S Homo sapiens(Human) MYO1E; MYO1C Q12965 440 Y Homo sapiens(Human) MYO1E; MYO1C Q12965 47 Y Homo sapiens(Human) MYO1E; MYO1C Q12965 51 Y Homo sapiens(Human) MYO1E; MYO1C Q12965 560 T Homo sapiens(Human) MYO1E; MYO1C Q12965 575 T Homo sapiens(Human) MYO1E; MYO1C Q12965 609 Y Homo sapiens(Human) MYO1E; MYO1C Q12965 623 Y Homo sapiens(Human) MYO1E; MYO1C Q12965 625 Y Homo sapiens(Human) MYO1E; MYO1C Q12965 67 Y Homo sapiens(Human) MYO1E; MYO1C Q12965 7 Y Homo sapiens(Human) MYO1E; MYO1C Q12965 715 Y Homo sapiens(Human) MYO1E; MYO1C Q12965 736 S Homo sapiens(Human) MYO1E; MYO1C Q12965 745 Y Homo sapiens(Human) MYO1E; MYO1C Q12965 876 T Homo sapiens(Human) MYO1E; MYO1C Q12965 890 S Homo sapiens(Human) MYO1E; MYO1C Q12965 9 Y Homo sapiens(Human) MYO1E; MYO1C Q12965 919 S Homo sapiens(Human) MYO1E; MYO1C Q12965 928 S Homo sapiens(Human) MYO1E; MYO1C Q12965 935 T Homo sapiens(Human) MYO1E; MYO1C Q12965 936 T Homo sapiens(Human) MYO1E; MYO1C Q12965 939 T Homo sapiens(Human) MYO1E; MYO1C Q12965 941 Y Homo sapiens(Human) MYO1E; MYO1C Q12965 943 S Homo sapiens(Human) MYO1E; MYO1C Q12965 950 Y Homo sapiens(Human) MYO1E; MYO1C Q12965 961 Y Homo sapiens(Human) MYO1E; MYO1C Q12965 971 Y Homo sapiens(Human) MYO1E; MYO1C Q12965 974 Y Homo sapiens(Human) MYO1E; MYO1C Q12965 980 S Homo sapiens(Human) MYO1E; MYO1C Q12965 983 S Homo sapiens(Human) MYO1E; MYO1C Q12965 987 S Homo sapiens(Human) MYO1E; MYO1C Q12965 989 Y Homo sapiens(Human) MYO1E; MYO1C Q12965 990 T Homo sapiens(Human) MYO1E; MYO1C Q12965 991 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q12965 K613-ac Acetylation QVEyLGLkENIRVRR Q12965 K631-ac Acetylation AyRRIFQkFLQRYAI Q12965 R103-m2 Methylation YRNMIIDrENQCVII Q12965 Y7-p Phosphorylation _MGSKGVyQyHWQSH Q12965 Y9-p Phosphorylation GSKGVyQyHWQSHNV Q12965 Y47-p Phosphorylation KKRYMDDyIFTyIGS Q12965 Y51-p Phosphorylation MDDyIFTyIGSVLIS Q12965 Y67-p Phosphorylation NPFKQMPyFGEKEIE Q12965 T137-p Phosphorylation SRVSGGGtKVQHVKD Q12965 S197-p Phosphorylation SNFLLEksRVVMRNP Q12965 S370-p Phosphorylation VFDFLVDsINKAMEK Q12965 Y440-p Phosphorylation IRWTPIEyFNNKIVC Q12965 T560-p Phosphorylation DKKGRPTtAGSKIKK Q12965 Y609-p Phosphorylation RVKHQVEyLGLkENI Q12965 Y623-p Phosphorylation IRVRRAGyAyRRIFQ Q12965 Y625-p Phosphorylation VRRAGyAyRRIFQkF Q12965 Y715-p Phosphorylation KFVARKKyVQMREEA Q12965 S736-p Phosphorylation KKERRRNsINRNFIG Q12965 T876-p Phosphorylation LPLKFSNtLELKLKK Q12965 S890-p Phosphorylation KENWGPWsAGGSRQV Q12965 S919-p Phosphorylation SNkVLQVsIGPGLPK Q12965 S928-p Phosphorylation GPGLPKNsRPTRRNt Q12965 T935-p Phosphorylation sRPTRRNttQNtGyS Q12965 T936-p Phosphorylation RPTRRNttQNtGySs Q12965 T939-p Phosphorylation RRNttQNtGySsGTQ Q12965 Y941-p Phosphorylation NttQNtGySsGTQNA Q12965 S943-p Phosphorylation tQNtGySsGTQNANy Q12965 Y950-p Phosphorylation sGTQNANyPVRAAPP Q12965 Y961-p Phosphorylation AAPPPPGyHQNGVIR Q12965 Y971-p Phosphorylation NGVIRNQyVPyPHAP Q12965 Y974-p Phosphorylation IRNQyVPyPHAPGsQ Q12965 S980-p Phosphorylation PyPHAPGsQRsNQKs Q12965 S983-p Phosphorylation HAPGsQRsNQKsLyt Q12965 S987-p Phosphorylation sQRsNQKsLytsMAR Q12965 Y989-p Phosphorylation RsNQKsLytsMARPP Q12965 T990-p Phosphorylation sNQKsLytsMARPPL Q12965 S991-p Phosphorylation NQKsLytsMARPPLP Q12965 S1002-p Phosphorylation PPLPRQQstssDRVS Q12965 T1003-p Phosphorylation PLPRQQstssDRVSQ Q12965 S1004-p Phosphorylation LPRQQstssDRVSQt Q12965 S1005-p Phosphorylation PRQQstssDRVSQtP Q12965 T1011-p Phosphorylation ssDRVSQtPESLDFL Q12965 K160-ub Ubiquitination LEAFGNAkTVRNNNS Q12965 K196-ub Ubiquitination ISNFLLEksRVVMRN Q12965 K613-ub Ubiquitination QVEyLGLkENIRVRR Q12965 K914-ub Ubiquitination AVLKPSNkVLQVsIG Q12965 K1019-ub Ubiquitination PESLDFLkVPDQGAA

PTM - dbPTM UniProt ID Position Code Type Resources References Q12965 980 S Phosphorylation Swiss-Prot 1010711 18669648 Q12965 736 S Phosphorylation PhosphoELM.10011 17081983 Q12965 1002 S Phosphorylation Phosphositeplus.1010730 18669648;20736484 Q12965 1004 S Phosphorylation Phosphositeplus.1010730 20736484 Q12965 1005 S Phosphorylation Phosphositeplus.1010730 18669648;20736484 Q12965 736 S Phosphorylation Phosphositeplus.1010730 17081983;20068231;21406692 Q12965 919 S Phosphorylation Phosphositeplus.1010730 21406692 Q12965 928 S Phosphorylation Phosphositeplus.1010730 21406692 Q12965 980 S Phosphorylation Phosphositeplus.1010730 18491316;18669648;20068231 Q12965 1003 T Phosphorylation Phosphositeplus.1010730 20736484 Q12965 137 T Phosphorylation Phosphositeplus.1010730 20068230;20068231 Q12965 560 T Phosphorylation Phosphositeplus.1010730 16674116 Q12965 440 Y Phosphorylation Phosphositeplus.1010730 18180459 Q12965 7 Y Phosphorylation Phosphositeplus.1010730 18083107;18180459;20090780;20736484 Q12965 715 Y Phosphorylation Phosphositeplus.1010730 20736484 Q12965 941 Y Phosphorylation Phosphositeplus.1010730 18083107 Q12965 950 Y Phosphorylation Phosphositeplus.1010730 18083107 Q12965 971 Y Phosphorylation Phosphositeplus.1010730 18083107;18180459;20736484 Q12965 989 Y Phosphorylation Phosphositeplus.1010730 18083107;18180459;20090780;20736484 Q12965 197 S Phosphorylation HPRD 9.0 20058876 Q12965 736 S Phosphorylation HPRD 9.0 19651622,20068231 Q12965 980 S Phosphorylation HPRD 9.0 18669648,18491316,18212344,20068231 Q12965 1002 S Phosphorylation HPRD 9.0 18669648,20068231 Q12965 1004 S Phosphorylation HPRD 9.0 20068231 Q12965 1005 S Phosphorylation HPRD 9.0 18669648 Q12965 137 T Phosphorylation HPRD 9.0 20068230,20068231 Q12965 1003 T Phosphorylation HPRD 9.0 18669648,20068231 Q12965 980 S Phosphorylation SysPTM 1.1 18669648;18491316;18212344

PTM - HPRD Symbol Position Code Type References MYO1E 1002 S Phosphorylation 18669648,20068231 MYO1E 1003 T Phosphorylation 18669648,20068231 MYO1E 1004 S Phosphorylation 20068231 MYO1E 1005 S Phosphorylation 18669648 MYO1E 137 T Phosphorylation 20068230,20068231 MYO1E 197 S Phosphorylation 20058876 MYO1E 736 S Phosphorylation 19651622,20068231 MYO1E 980 S Phosphorylation 18669648,18491316,18212344,20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q12965 736 S 17081983 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q12965 980 Phosphoserine 18669648;20068231;23186163 Q12965 1002 Phosphoserine 18669648

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type MYO1E IPI00329672 S 981 YPHAPGpSQRSIQK phosphorylation MYO1E IPI00329672 T 1004 LPRQQSpTSSDRVS phosphorylation MYO1E IPI00329672 T 1091 DPSGWWpTGRLRGK phosphorylation MYO1E IPI00329672 T 575 ANDLVSpTLMKCTP phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 4643 110727 - K Ubiquitination 18781797 4643 110727 - K Ubiquitination 21987572 4643 110727 - K Ubiquitination 21139048 4643 110727 - K Ubiquitination 21906983 4643 110727 - K Ubiquitination 21890473 4643 110727 - K Ubiquitination 21963094 4643 110727 - K Sumoylation 25027693

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID MYO1C Homo sapiens (Human) 153; 686; 833; 369; 705 "153,EAFGNAKTLRNDN; 686,IFIRFPKTLFATE; 833,SISPEWKQQLQQK; 369,NRSLASKDVESPS; 705,RQSLATKIQAAWR" 153:21890473; 686:21890473; 833:21890473; 369:21890473; 705:21890473 MYO1C Homo sapiens (Human) 153; 686; 833; 369; 705 "153,EAFGNAKTLRNDN; 686,IFIRFPKTLFATE; 833,SISPEWKQQLQQK; 369,NRSLASKDVESPS; 705,RQSLATKIQAAWR" 153:21890473; 686:21890473; 833:21890473; 369:21890473; 705:21890473 MYO1C Homo sapiens (Human) 702; 169; 849; 721; 385 "702,IFIRFPKTLFATE; 169,EAFGNAKTLRNDN; 849,SISPEWKQQLQQK; 721,RQSLATKIQAAWR; 385,NRSLASKDVESPS" 702:21890473; 169:21890473; 849:21890473; 721:21890473; 385:21890473 MYO1E Homo sapiens (Human) 613; 160 "613,VEYLGLKENIRVR; 160,EAFGNAKTVRNNN" "613:21906983; 160:21890473,21906983" MYO1C Homo sapiens (Human) 868; 188; 721; 361; 404; 740 "868,SISPEWKQQLQQK; 188,EAFGNAKTLRNDN; 721,IFIRFPKTLFATE; 361,HRKIIAKGEELLS; 404,NRSLASKDVESPS; 740,RQSLATKIQAAWR" "868:21890473; 188:21890473,21906983; 721:21890473; 361:21906983; 404:21890473,21906983; 740:21890473" MYO1C Homo sapiens (Human) 326; 153; 686; 833; 369; 705 "326,HRKIIAKGEELLS; 153,EAFGNAKTLRNDN; 686,IFIRFPKTLFATE; 833,SISPEWKQQLQQK; 369,NRSLASKDVESPS; 705,RQSLATKIQAAWR" "326:21906983; 153:21890473,21906983; 686:21890473; 833:21890473; 369:21890473,21906983; 705:21890473" MYO1C Homo sapiens (Human) 702; 342; 169; 849; 721; 385 "702,IFIRFPKTLFATE; 342,HRKIIAKGEELLS; 169,EAFGNAKTLRNDN; 849,SISPEWKQQLQQK; 721,RQSLATKIQAAWR; 385,NRSLASKDVESPS" "702:21890473; 342:21906983; 169:21890473,21906983; 849:21890473; 721:21890473; 385:21890473,21906983"