PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus DDB1 FBXW5 22910413,23314863,17079684,18381890 biogrid,dip exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G ODF3L2 FBXW5 26186194 biogrid exp GP GP G G GP GP GP G GP GP P GP GP G GP G P GP GP P GP GP XPO1 FBXW5 26673895 biogrid exp GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G FOXR1 FBXW5 25609649 intact exp TNFAIP8L1 FBXW5 24372178,24444419 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TSC1 FBXW5 18381890 innatedb,biogrid exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G REST FBXW5 18354482 biogrid exp GP GP G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G SASS6 FBXW5 21725316 biogrid exp GP G G GP P GP P P G G P G P G GP GP GP G P GP KRTAP10-8 FBXW5 25416956 biogrid,intact exp TSC2 FBXW5 24372178,18381890 hprd,biogrid exp G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G G G GP G GP GP G MAP3K7 FBXW5 19232515 innatedb,biogrid exp GP GP G G G GP G G GP G G GP GP G G G GP G GP G GP GP G G G G GP GP G FBXW5 HSPB9 26186194 biogrid exp G G CSNK1E FBXW5 19888210 i2d exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G SMAD1 FBXW5 15761153 i2d exp G G G G G G G G GP G G G G G G G G G G G G G G G G G G GP G ADAMTSL4 FBXW5 25416956 biogrid,intact exp G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G TRIM27 FBXW5 25416956 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G PLK4 FBXW5 21725316 biogrid exp P P G GP P P GP P P P P P P P P P P P GP GP MYB FBXW5 22910413,18765672 hprd,biogrid exp P P G GP P P GP P P GP G G GP P G P P GP GP P GP GP P G HSP90AA1 FBXW5 22939624 biogrid exp GP GP G G G GP G G GP G G G G G G G GP G G G GP G G G G G G GP G FBXW5 KRTAP4-12 16189514 hprd,biogrid,mint,intact exp BMPR1B FBXW5 15761153 i2d exp P GP G G GP GP G GP GP G GP P GP G GP GP G GP G P GP P GP GP G GP GP G NOTCH2NL FBXW5 25416956 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G GPS1 FBXW5 23314863 dip exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW5 DLC1 24082123 biogrid exp G G G G G GP G G GP G GP G G G G GP GP G G G G G G G GP G G GP G UBE2R2 FBXW5 21900206 biogrid,mint,intact exp G G G G GP G G G G G G G G G G G G G G G G G G G G G GP G G FBXW5 MDFI 16189514 hprd,biogrid,mint,intact exp G G G P G P G G P G GP P G G G GP P G FBXW5 COPS4 23314863 dip exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G CSNK1A1 FBXW5 19888210 i2d exp G G G G G G G G G G G G G G G G G G GP G G G G G G G G G G KRT40 FBXW5 25416956 biogrid,intact exp P P P P P P P P P P P P P P P P P P FBXW5 NLK 18765672 hprd,biogrid exp GP GP G G GP GP G G GP G G G G G G G GP G G G GP GP G G G G G GP G HSP90AB1 FBXW5 22939624 intact exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G WDR20 FBXW5 19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP G G GP GP G GP GP G SRFBP1 FBXW5 26186194 biogrid exp GP P GP G P P GP G P G P P GP P G GP G GP P EPS8 FBXW5 23314863 dip exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G RBX1 FBXW5 23314863 dip exp G G G G G GP G GP G G G G GP G G G GP G GP G GP GP G G G G G GP G FBXW5 FBXW5 25416956 intact exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G ZNRF1 FBXW5 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G FBXW5 KRTAP9-4 25416956 biogrid,intact exp P P P P P P GP P P P P KRTAP10-3 FBXW5 25416956 biogrid exp FAM168A FBXW5 21516116 biogrid,mint,intact exp G G G G G GP G GP G G G G G G G G GP G G G G G G GP G G G GP G CDC20 FBXW5 21725316 biogrid exp P G GP G GP P GP G G P GP GP GP CUL3 FBXW5 25011449 biogrid exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G S100B FBXW5 21516116 biogrid,mint,intact exp G G GP G P G G P GP G G G GP P G GP GP P G GP P UBA52 FBXW5 23314863 dip exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G KRT31 FBXW5 25416956 biogrid,intact exp G G G GP G P P P G P GP G P P GP G GP P G TGFBR1 FBXW5 15761153 i2d exp, ortho GP G G G GP GP G GP GP G GP GP GP G G GP GP G G G G G G G GP G GP G G SKP1 FBXW5 19159283,20596027,22632967,15070733,10531037,22388891,23319600, 25402006, 23023127, 21836163 hprd,biogrid,intact,dip exp, ortho, pred GP GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G CUL4A FBXW5 22910413,17079684,18381890, 21836163 innatedb,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL1 FBXW5 14603323,23314863,25515538,23319600,25143387,21145461, 25402006 biogrid,mint,intact,dip exp, pred GP G G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G FBXW5 NANOG ortho P P G P G P G P GP FBXW5 FBXO4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW5 FBXO44 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G P G GP GP GP GP GP G GP GP G CUL7 FBXW5 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G FBXW5 CACYBP 25402006 pred GP GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G FBXO31 FBXW5 25402006 pred GP GP G P GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G FBXW5 FBXO34 25402006 pred G GP G G G G G G GP G G G G G G G G G G G GP G G GP G G GP GP G FBXW5 FBXL8 25402006 pred P P P P P P P P P P P P P P P FBXW5 FBXW2 25402006 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G G G GP GP GP G GP GP G FBXW5 FBXL3 25402006 pred G G G G GP G G G G G G G G G G G G G G G G G G G G G G G G FBXW5 FBXL2 25402006 pred G G G G G G G G G G G G G G G G G G G G G FBXW5 BTBD6 23023127 pred G G G G GP G G G GP G G G G G G GP G G G G G G G GP GP G G G G FBXW8 FBXW5 25402006, 21836163 pred P P P P P P P P P P P P P P P P P P P FBXO18 FBXW5 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G ZC3HC1 FBXW5 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G FBXW9 FBXW5 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G G G G GP GP GP GP G GP GP G FBXW5 CDCA3 25402006 pred G GP G G GP P G GP GP P P GP G G GP P G G G GP GP GP GP G GP GP G FBXW5 FBXO17 25402006 pred G G G G G G G G G G G FBXW5 FBXO6 25402006 pred GP GP G G GP GP G G GP G GP GP GP G G GP GP G GP G P GP GP GP GP G GP GP G FBXW5 FBXO2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO46 FBXW5 25402006 pred GP G G G G GP G G GP G G G G G G GP GP G G G G G G GP GP G GP GP G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBE2R2 FBXW5 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact) BIOGRID_156589|UniProt_178360|UniProt_157762 bait|bait|bait prey|prey|prey TSC1 FBXW5 MI:0492(in vitro)|MI:0492(in vitro)|MI:0492(in vitro)|MI:0492(in vitro)|MI:0004(affinity chromatography technology) 18381890 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|-|-|MI:0915(physical association) MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd)|(biogrid) HPRD_40011|HPRD_40074|HPRD_40010|HPRD_40013|BIOGRID_117178 -|-|-|-|prey -|-|-|-|bait PLK4 FBXW5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21725316 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_142364|BIOGRID_142365 prey|bait bait|prey FAM168A FBXW5 MI:0018(two hybrid) 21516116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_114834 prey bait HSP90AA1 FBXW5 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255448 bait prey CUL1 FBXW5 MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation) 14603323,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|MI:0471(mint)|(biogrid)|(intact) MINT_55235|BIOGRID_256919|MINT_57906|BIOGRID_204519|UniProt_74167 prey|prey|prey|bait|prey bait|bait|bait|prey|bait REST FBXW5 MI:0004(affinity chromatography technology) 18354482 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_201067 prey bait FBXW5 KRTAP4-12 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|- MI:0471(mint)|MI:0471(mint)|(intact)|(biogrid)|MI:0468(hprd) MINT_36762|MINT_65916|UniProt_151567|BIOGRID_78710|HPRD_23582 bait|bait|unspecified role|bait|- prey|prey|unspecified role|prey|- NEDD8 FBXW5 MI:0004(affinity chromatography technology) 18247557 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_251583 bait prey HSP90AB1 FBXW5 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125005 prey bait MYB FBXW5 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 18765672,22910413 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_33199|BIOGRID_208387 -|bait -|prey DDB1 FBXW5 MI:0492(in vitro)|MI:0492(in vitro)|MI:0492(in vitro)|MI:0004(affinity chromatography technology)|MI:0401(biochemical)|MI:0004(affinity chromatography technology)|MI:0492(in vitro) 17079684,18381890,22910413 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) HPRD_40011|HPRD_40074|HPRD_40010|BIOGRID_208390|BIOGRID_200199|BIOGRID_117176|HPRD_40014 -|-|-|bait|bait|prey|- -|-|-|prey|prey|bait|- TSC2 FBXW5 MI:0492(in vitro)|MI:0492(in vitro)|MI:0492(in vitro)|MI:0492(in vitro)|MI:0004(affinity chromatography technology)|MI:0492(in vitro)|MI:0004(affinity chromatography technology) 18381890,24372178 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|-|-|MI:0915(physical association)|-|MI:0915(physical association) MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd)|(biogrid)|MI:0468(hprd)|(biogrid) HPRD_40011|HPRD_40074|HPRD_40010|HPRD_40013|BIOGRID_307752|HPRD_33176|BIOGRID_117179 -|-|-|-|prey|-|prey -|-|-|-|bait|-|bait UBC FBXW5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983,21963094,21987572,22053931,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_222158|BIOGRID_177301|BIOGRID_167871|BIOGRID_163509|BIOGRID_268290|BIOGRID_264583|BIOGRID_174808 bait|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey SKP1 FBXW5 MI:0004(affinity chromatography technology)|MI:0231(mammalian protein protein interaction trap)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 10531037,15070733,19159283,22388891,22632967 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(intact)|MI:0468(hprd)|(intact)|(intact)|(biogrid)|(biogrid) BIOGRID_219150|UniProt_98763|HPRD_31750|UniProt_122759|UniProt_77057|BIOGRID_197525|BIOGRID_197004 prey|bait|-|prey|prey|prey|bait bait|prey|-|bait|bait|bait|prey MAP3K7 FBXW5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19232515 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_219283|BIOGRID_219284 bait|bait prey|prey FBXW5 NLK MI:0004(affinity chromatography technology)|MI:0493(in vivo) 18765672 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_116462|HPRD_33202 prey|- bait|- FBXW5 TNFAIP8L1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24372178,24444419 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_307751|BIOGRID_307750|BIOGRID_307593|BIOGRID_307592 bait|prey|bait|prey prey|bait|prey|bait FBXW5 MDFI MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association) (intact)|(biogrid)|MI:0471(mint)|MI:0468(hprd)|MI:0471(mint) UniProt_152788|BIOGRID_79942|MINT_67357|HPRD_22961|MINT_38174 unspecified role|prey|prey|-|prey unspecified role|bait|bait|-|bait CDC20 FBXW5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21725316 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_142360|BIOGRID_142359 bait|prey prey|bait NRF1 FBXW5 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295209 bait prey WDR20 FBXW5 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120490|UniProt_100724 bait|bait prey|prey S100B FBXW5 MI:0018(two hybrid) 21516116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_114833 prey bait CUL4A FBXW5 MI:0492(in vitro)|MI:0492(in vitro)|MI:0492(in vitro)|MI:0492(in vitro)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0401(biochemical) 17079684,18381890,22910413 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|-|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid) HPRD_40011|HPRD_40074|HPRD_40010|HPRD_40014|BIOGRID_208392|BIOGRID_117177|BIOGRID_200197 -|-|-|-|bait|prey|bait -|-|-|-|prey|bait|prey SASS6 FBXW5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21725316 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_142361|BIOGRID_142362|BIOGRID_142363 bait|prey|prey prey|bait|bait FBXW5 DLC1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24082123 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_297054|BIOGRID_297053 bait|prey prey|bait

PPI - HINT Gene A Gene B PMID Method Quality TSC2 FBXW5 18381890,18381890,24372178 0018,0004,0004 LC SKP1 FBXW5 23319600,20596027,26087183,22388891,15070733,15070733,22632967,23314863,15070733 0004,0007,0004,0004,0007,0004,0007,0007,0019 LC CUL1 FBXW5 23319600,21145461,14603323,25143387,25515538,14603323,23314863 0004,0004,0004,0004,0004,0019,0007 LC,HT CUL4A FBXW5 22910413,18381890,17079684,18381890 0004,0007,0004,0004 LC DDB1 FBXW5 22910413,23314863,17079684,18381890 0004,0007,0004,0004 LC ODF3L2 FBXW5 26186194 0004 HT DKFZP686P0251 FBXW5 19615732 0004 HT FOXR1 FBXW5 25609649,25609649 0676,0004 HT ZNRF1 FBXW5 26186194 0004 HT SRFBP1 FBXW5 26186194 0004 HT WDR20 FBXW5 19615732,19615732 0004,0007 HT TNFAIP8L1 FBXW5 24372178,24444419 0004,0004 LC FBXW5 HSPB9 26186194 0004 HT CUL1 FBXW5 21145461 0004 HT ODF3L2 FBXW5 26186194 0004 HT DKFZP686P0251 FBXW5 19615732 0004 HT FOXR1 FBXW5 25609649,25609649 0676,0004 HT ZNRF1 FBXW5 26186194 0004 HT SRFBP1 FBXW5 26186194 0004 HT WDR20 FBXW5 19615732,19615732 0004,0007 HT FBXW5 HSPB9 26186194 0004 HT TSC2 FBXW5 18381890,18381890,24372178 0018,0004,0004 LC SKP1 FBXW5 23319600,20596027,26087183,22388891,15070733,15070733,22632967,23314863,15070733 0004,0007,0004,0004,0007,0004,0007,0007,0019 LC CUL1 FBXW5 23319600,14603323,25143387,25515538,14603323,23314863 0004,0004,0004,0004,0019,0007 LC CUL4A FBXW5 22910413,18381890,17079684,18381890 0004,0007,0004,0004 LC DDB1 FBXW5 22910413,23314863,17079684,18381890 0004,0007,0004,0004 LC TNFAIP8L1 FBXW5 24372178,24444419 0004,0004 LC BMPR1B FBXW5 15761153 0019 HT S100B FBXW5 21516116 0018 HT HSP90AB1 FBXW5 22939624 0729 HT TRIM27 FBXW5 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TGFBR1 FBXW5 15761153 0019 HT TSC2 FBXW5 18381890,18381890 0018,0004 LC KRTAP10-3 FBXW5 25416956 0018 HT KRTAP10-8 FBXW5 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT SKP1 FBXW5 15070733,19159283,19159283,15070733,15070733 0007,0018,0231,0004,0019 LC CUL1 FBXW5 14603323,14603323 0004,0019 LC KRT31 FBXW5 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT SMAD1 FBXW5 15761153 0019 HT KRT40 FBXW5 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT SASS6 FBXW5 21725316,21725316 0004,0415 LC ADAMTSL4 FBXW5 25416956,25416956,25416956 1112,0397,1356 HT UBE2R2 FBXW5 21900206 0018 HT NOTCH2NL FBXW5 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT FAM168A FBXW5 21516116 0018 HT FBXW5 MDFI 16189514,16189514 0398,0018 HT FBXW5 KRTAP4-12 16189514,16189514 0398,0018 HT FBXW5 KRTAP9-4 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT FBXW5 DKFZP434K1772 25416956 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q969U6 O14980 FBXW5 XPO1 0.126 26673895 Q969U6 O43318 FBXW5 MAP3K7 0.21 19232515 Q969U6 Q8ND25 FBXW5 ZNRF1 0.126 26186194 Q969U6 Q8NEF9 FBXW5 SRFBP1 0.126 26186194 Q969U6 P07900 FBXW5 HSP90AA1 0.126 22939624 Q969U6 P08238 FBXW5 HSP90AB1 0.126 22939624 Q969U6 Q6UVJ0 FBXW5 SASS6 0.569 21725316 Q969U6 Q6A162 FBXW5 KRT40 0.454 25416956 Q969U6 Q7Z3S9 FBXW5 NOTCH2NL 0.583 25416956,unassigned1304 Q969U6 Q6P5F9 FBXW5 XPO1 0.126 26673895 Q969U6 P10242 FBXW5 MYB 0.21 22910413 Q9WTX5 Q969U6 SKP1 FBXW5 0.236 26496610 Q969U6 Q8WVP5 FBXW5 TNFAIP8L1 0.61 24372178,24444419 Q969U6 Q8TBZ3 FBXW5 WDR20 0.236 19615732 Q9BYQ2 Q969U6 KRTAP9-4 FBXW5 0.454 25416956 Q969U6 P04271 FBXW5 S100B 0.332 21516116 Q969U6 O95967 FBXW5 EFEMP2 0.236 unassigned1304 Q969U6 A0A087WY89 FBXW5 KRTAP4-1 {ECO:0000313|ENSEMBL:ENSP00000481610} 0.236 unassigned1304 Q969U6 O76014 FBXW5 KRT37 0.236 unassigned1304 Q969U6 B8A4K4 FBXW5 CYSRT1 {ECO:0000313|ENSEMBL:ENSP00000386453} 0.236 unassigned1304 Q969U6 O76011 FBXW5 KRT34 0.236 unassigned1304 Q969U6 P49815 FBXW5 TSC2 0.376 24372178,18381890 Q969U6 P60411 FBXW5 KRTAP10-9 0.236 unassigned1304 Q969U6 P60328 FBXW5 KRTAP12-3 0.236 unassigned1304 Q969U6 P98095 FBXW5 FBLN2 0.236 unassigned1304 Q969U6 Q49A26 FBXW5 GLYR1 0.236 unassigned1304 Q9UJV3 Q969U6 MID2 FBXW5 0.236 unassigned1304 Q969U6 Q92567 FBXW5 FAM168A 0.332 21516116 Q9BYQ3 Q969U6 KRTAP9-3 FBXW5 0.236 unassigned1304 Q969U6 P14373 FBXW5 TRIM27 0.583 25416956,unassigned1304 Q969U6 A0A0G2JQ02 FBXW5 A0A0G2JQ02 0.236 unassigned1304 Q969U6 Q2TAL6 FBXW5 VWC2 0.236 unassigned1304 Q969U6 Q5JR59 FBXW5 MTUS2 0.236 unassigned1304 Q969U6 Q6PIV2 FBXW5 FOXR1 0.236 25609649 Q969U6 P60410 FBXW5 KRTAP10-8 0.583 25416956,unassigned1304 Q969U6 Q15323 FBXW5 KRT31 0.583 25416956,unassigned1304 Q969U6 P63208 FBXW5 SKP1 0.884 19159283,27705803,26087183,22388891,23319600,22632967,15070733 Q969U6 O00444 FBXW5 PLK4 0.376 21725316 Q969U6 P60369 FBXW5 KRTAP10-3 0.183 25416956 Q969U6 Q12834 FBXW5 CDC20 0.376 21725316 Q969U6 Q13127 FBXW5 REST 0.21 18354482 Q969U6 Q13619 FBXW5 CUL4A 0.507 22910413,17079684,18381890 Q969U6 Q16531 FBXW5 DDB1 0.507 22910413,17079684,18381890 Q969U6 Q6UY14 FBXW5 ADAMTSL4 0.583 25416956,unassigned1304 Q969U6 Q712K3 FBXW5 UBE2R2 0.332 21900206 Q969U6 Q92574 FBXW5 TSC1 0.21 18381890 Q96QB1 Q969U6 DLC1 FBXW5 0.376 24082123 Q99750 Q969U6 MDFI FBXW5 0.286 16189514 Q9BQ66 Q969U6 KRTAP4-12 FBXW5 0.286 16189514 Q9BQS6 Q969U6 HSPB9 FBXW5 0.126 26186194 Q9UBE8 Q969U6 NLK FBXW5 0.21 18765672 Q969U6 Q13616 FBXW5 CUL1 0.702 14603323,25515538,21145461,25143387,23319600 Q969U6 Q13618 FBXW5 CUL3 0.21 25011449 Q969U6 Q3SX64 FBXW5 ODF3L2 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 BMPR1B FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database PLK4 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database XPO1 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database SIAH2 FBXW5 MI:0362 inference MI:1106 pathways database MAP3K7 FBXW5 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FBXO21 FBXW5 MI:0362 inference MI:1106 pathways database S100B FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database UBB FBXW5 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBC FBXW5 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database MYB FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database TRIM27 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 FBXW5 MI:0362 inference MI:1106 pathways database TGFBR1 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database CCNF FBXW5 MI:0362 inference MI:1106 pathways database UBE2A FBXW5 MI:0362 inference MI:1106 pathways database TSC2 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database FBXW4 FBXW5 MI:0362 inference MI:1106 pathways database KRTAP10-3 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database KRTAP10-8 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 FBXW5 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database RPS27A FBXW5 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBA52 FBXW5 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database SKP1 FBXW5 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CDC20 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database EPS8 FBXW5 MI:0362 inference MI:0461 interaction database GPS1 FBXW5 MI:0362 inference MI:0461 interaction database REST FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database SKP2 FBXW5 MI:0362 inference MI:1106 pathways database CUL1 FBXW5 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CUL3 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database CUL4A FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database TRIP12 FBXW5 MI:0362 inference MI:1106 pathways database KRT31 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database SMAD1 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database NEDD8 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database DDB1 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database LONRF1 FBXW5 MI:0362 inference MI:1106 pathways database ODF3L2 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database HECTD2 FBXW5 MI:0362 inference MI:1106 pathways database FBXO31 FBXW5 MI:0362 inference MI:1106 pathways database FBXW9 FBXW5 MI:0362 inference MI:1106 pathways database FBXW10 FBXW5 MI:0362 inference MI:1106 pathways database RNF213 FBXW5 MI:0362 inference MI:1106 pathways database KRT40 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database FBXL22 FBXW5 MI:0362 inference MI:1106 pathways database FBXL19 FBXW5 MI:0362 inference MI:1106 pathways database FOXR1 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database SASS6 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database ADAMTSL4 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database FBXW12 FBXW5 MI:0362 inference MI:1106 pathways database RNF19B FBXW5 MI:0362 inference MI:1106 pathways database UBE2R2 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database NOTCH2NL FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database RNF144B FBXW5 MI:0362 inference MI:1106 pathways database RBBP6 FBXW5 MI:0362 inference MI:1106 pathways database HUWE1 FBXW5 MI:0362 inference MI:1106 pathways database TRIM69 FBXW5 MI:0362 inference MI:1106 pathways database SIAH1 FBXW5 MI:0362 inference MI:1106 pathways database HERC6 FBXW5 MI:0362 inference MI:1106 pathways database UBR2 FBXW5 MI:0362 inference MI:1106 pathways database FBXL14 FBXW5 MI:0362 inference MI:1106 pathways database FBXW8 FBXW5 MI:0362 inference MI:1106 pathways database FBXL16 FBXW5 MI:0362 inference MI:1106 pathways database FBXO15 FBXW5 MI:0362 inference MI:1106 pathways database ZNRF1 FBXW5 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FBXL13 FBXW5 MI:0362 inference MI:1106 pathways database SRFBP1 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database FBXO22 FBXW5 MI:0362 inference MI:1106 pathways database ZNRF2 FBXW5 MI:0362 inference MI:1106 pathways database FBXO27 FBXW5 MI:0362 inference MI:1106 pathways database FBXO30 FBXW5 MI:0362 inference MI:1106 pathways database WDR20 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database RNF217 FBXW5 MI:0362 inference MI:1106 pathways database DTX3L FBXW5 MI:0362 inference MI:1106 pathways database FBXO41 FBXW5 MI:0362 inference MI:1106 pathways database TNFAIP8L1 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database LMO7 FBXW5 MI:0362 inference MI:1106 pathways database MYLIP FBXW5 MI:0362 inference MI:1106 pathways database FAM168A FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database TSC1 FBXW5 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 FBXW5 MI:0362 inference MI:1106 pathways database FBXO32 FBXW5 MI:0362 inference MI:1106 pathways database FBXW5 MIB2 MI:0362 inference MI:1106 pathways database FBXW5 SPSB1 MI:0362 inference MI:1106 pathways database FBXW5 FBXL8 MI:0362 inference MI:1106 pathways database FBXW5 FBXO17 MI:0362 inference MI:1106 pathways database FBXW5 FBXL20 MI:0362 inference MI:1106 pathways database FBXW5 FBXL18 MI:0362 inference MI:1106 pathways database FBXW5 NEDD4L MI:0362 inference MI:1106 pathways database FBXW5 DLC1 MI:0045 experimental interaction detection MI:0461 interaction database FBXW5 MDFI MI:0045 experimental interaction detection MI:0461 interaction database FBXW5 KRTAP4-12 MI:0045 experimental interaction detection MI:0461 interaction database FBXW5 HSPB9 MI:0045 experimental interaction detection MI:0461 interaction database FBXW5 COPS4 MI:0362 inference MI:0461 interaction database FBXW5 RBCK1 MI:0362 inference MI:1106 pathways database FBXW5 KRTAP9-4 MI:0045 experimental interaction detection MI:0461 interaction database FBXW5 FBXL15 MI:0362 inference MI:1106 pathways database FBXW5 FBXO44 MI:0362 inference MI:1106 pathways database FBXW5 UNKL MI:0362 inference MI:1106 pathways database FBXW5 NANOG MI:0362 inference MI:0461 interaction database FBXW5 SMURF2 MI:0362 inference MI:1106 pathways database FBXW5 TRIM36 MI:0362 inference MI:1106 pathways database FBXW5 FBXO6 MI:0362 inference MI:1106 pathways database FBXW5 RNF19A MI:0362 inference MI:1106 pathways database FBXW5 RLIM MI:0362 inference MI:1106 pathways database FBXW5 FBXL12 MI:0362 inference MI:1106 pathways database FBXW5 NLK MI:0045 experimental interaction detection MI:0461 interaction database FBXW5 FBXO40 MI:0362 inference MI:1106 pathways database FBXW5 HERC5 MI:0362 inference MI:1106 pathways database FBXW5 FBXL7 MI:0362 inference MI:1106 pathways database FBXW5 FBXO2 MI:0362 inference MI:1106 pathways database FBXW5 FBXO10 MI:0362 inference MI:1106 pathways database FBXW5 FBXO9 MI:0362 inference MI:1106 pathways database FBXW5 FBXL5 MI:0362 inference MI:1106 pathways database FBXW5 FBXL4 MI:0362 inference MI:1106 pathways database FBXW5 FBXW11 MI:0362 inference MI:1106 pathways database FBXW5 FBXO4 MI:0362 inference MI:1106 pathways database FBXW5 FBXL21 MI:0362 inference MI:1106 pathways database FBXW5 FBXL3 MI:0362 inference MI:1106 pathways database FBXW5 FBXW2 MI:0362 inference MI:1106 pathways database FBXW5 BTRC MI:0362 inference MI:1106 pathways database FBXW5 FBXO7 MI:0362 inference MI:1106 pathways database FBXW5 RNF115 MI:0362 inference MI:1106 pathways database FBXW5 RNF114 MI:0362 inference MI:1106 pathways database FBXW5 WSB1 MI:0362 inference MI:1106 pathways database