PTM - CPLM Gene Name UniProt ID Type Position Code PSMD4; MCB1 P55036 Ubiquitination 40 K PSMD4; MCB1 P55036 Ubiquitination 122 K PSMD4; MCB1 P55036 Ubiquitination 262 K PSMD4; MCB1 P55036 Ubiquitination 74 K PSMD4; MCB1 P55036 Ubiquitination 81 K PSMD4; MCB1 P55036 Ubiquitination 83 K PSMD4; MCB1 P55036 Ubiquitination 126 K PSMD4; MCB1 P55036 Ubiquitination 135 K PSMD4; MCB1 P55036 Ubiquitination 152 K PSMD4; MCB1 P55036 Ubiquitination 129 K PSMD4; MCB1 P55036 Ubiquitination 369 K PSMD4; MCB1 P55036 Ubiquitination 365 K PSMD4; MCB1 P55036 Ubiquitination 98 K

PTM - dbPAF Gene Name UniProt ID Position Type Species PSMD4; MCB1 P55036 115 S Homo sapiens(Human) PSMD4; MCB1 P55036 250 T Homo sapiens(Human) PSMD4; MCB1 P55036 253 T Homo sapiens(Human) PSMD4; MCB1 P55036 256 S Homo sapiens(Human) PSMD4; MCB1 P55036 264 T Homo sapiens(Human) PSMD4; MCB1 P55036 266 S Homo sapiens(Human) PSMD4; MCB1 P55036 358 S Homo sapiens(Human) PSMD4; MCB1 P55036 361 S Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type PSMD4; MCB1 rs3197034 CAA->CAT Q->H 266 S ALLKMTISQQEFGRT 266 Phosphorylation TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P55036 K122-ac Acetylation sPVEDNEkDLVkLAk P55036 K126-ac Acetylation DNEkDLVkLAkRLKk P55036 K365-ac Acetylation sLAsQATkDGkkDKK P55036 K368-ac Acetylation sQATkDGkkDKKEED P55036 S115-p Phosphorylation RIIAFVGsPVEDNEk P55036 S242-p Phosphorylation ARRAAAAsAAEAGIA P55036 T250-p Phosphorylation AAEAGIAtTGtEDsD P55036 T253-p Phosphorylation AGIAtTGtEDsDDAL P55036 S256-p Phosphorylation AtTGtEDsDDALLkM P55036 S266-p Phosphorylation ALLkMTIsQQEFGRT P55036 Y326-p Phosphorylation PAKEEDDyDVMQDPE P55036 S358-p Phosphorylation AIRNAMGsLAsQATk P55036 S361-p Phosphorylation NAMGsLAsQATkDGk P55036 K40-ub Ubiquitination VNIVCHSkTRSNPEN P55036 K74-ub Ubiquitination DTGRILSkLHTVQPk P55036 K81-ub Ubiquitination kLHTVQPkGkITFCT P55036 K83-ub Ubiquitination HTVQPkGkITFCTGI P55036 K98-ub Ubiquitination RVAHLALkHRQGKNH P55036 K122-ub Ubiquitination sPVEDNEkDLVkLAk P55036 K126-ub Ubiquitination DNEkDLVkLAkRLKk P55036 K129-ub Ubiquitination kDLVkLAkRLKkEkV P55036 K133-ub Ubiquitination kLAkRLKkEkVNVDI P55036 K135-ub Ubiquitination AkRLKkEkVNVDIIN P55036 K152-ub Ubiquitination EEEVNTEkLTAFVNT P55036 K262-ub Ubiquitination DsDDALLkMTIsQQE P55036 K365-ub Ubiquitination sLAsQATkDGkkDKK P55036 K369-ub Ubiquitination QATkDGkkDKKEEDK

PTM - dbPTM UniProt ID Position Code Type Resources References P55036 266 S Phosphorylation Swiss-Prot 1010711 17323924;17525332;18669648;19690332 P55036 358 S Phosphorylation Swiss-Prot 1010711 17323924 P55036 361 S Phosphorylation Swiss-Prot 1010711 17323924 P55036 266 S Phosphorylation PhosphoELM.10011 18669648;17525332 P55036 122 K Ubiquitylation Phosphositeplus.1010730 20639865;20972266;21890473;21906983 P55036 126 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P55036 135 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P55036 152 K Ubiquitylation Phosphositeplus.1010730 21906983 P55036 262 K Ubiquitylation Phosphositeplus.1010730 21906983 P55036 365 K Ubiquitylation Phosphositeplus.1010730 21906983 P55036 40 K Ubiquitylation Phosphositeplus.1010730 20639865;21890473;21906983 P55036 74 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P55036 81 K Ubiquitylation Phosphositeplus.1010730 21906983 P55036 83 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P55036 98 K Ubiquitylation Phosphositeplus.1010730 21906983 P55036 115 S Phosphorylation Phosphositeplus.1010730 20068231 P55036 256 S Phosphorylation Phosphositeplus.1010730 21044959 P55036 266 S Phosphorylation Phosphositeplus.1010730 17323924;17525332;18077418;18669648;19690332;20058876;20068231;20166139;21044959;21406692;22115753 P55036 358 S Phosphorylation Phosphositeplus.1010730 17323924;20068231;21044959 P55036 361 S Phosphorylation Phosphositeplus.1010730 17323924 P55036 115 S Phosphorylation HPRD 9.0 20068231 P55036 256 S Phosphorylation HPRD 9.0 20068231 P55036 266 S Phosphorylation HPRD 9.0 17525332,18669648,18077418,18212344,20166139,20068231,20058876 P55036 358 S Phosphorylation HPRD 9.0 20068231 P55036 250 T Phosphorylation HPRD 9.0 15345747,20068231 P55036 250 T Phosphorylation HPRD 9.0 15345747 P55036 253 T Phosphorylation HPRD 9.0 20068231 P55036 264 T Phosphorylation HPRD 9.0 20068231 P55036 37 C S-nitrosylation dbSNO 1.0 19483679 P55036 87 C S-nitrosylation dbSNO 1.0 19483679 P55036 266 S Phosphorylation SysPTM 1.1 18212344;18669648

PTM - HPRD Symbol Position Code Type References PSMD4 115 S Phosphorylation 20068231 PSMD4 250 T Phosphorylation 15345747 PSMD4 250 T Phosphorylation 15345747,20068231 PSMD4 253 T Phosphorylation 20068231 PSMD4 256 S Phosphorylation 20068231 PSMD4 264 T Phosphorylation 20068231 PSMD4 266 S Phosphorylation 17525332,18669648,18077418,18212344,20166139,20068231,20058876 PSMD4 358 S Phosphorylation 20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P55036 266 S 18669648 HTP Phosphorylation P55036 266 S 17525332 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P55036 266 Phosphoserine 17525332;18669648;20068231;21406692;23186163 P55036 358 Phosphoserine 17323924;23186163 P55036 361 Phosphoserine 17323924;23186163

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 5710 111683 - K Ubiquitination 16196087 5710 111683 - K Ubiquitination 20639865 5710 111683 - K Ubiquitination 22118674 5710 111683 - K Ubiquitination 18781797 5710 111683 - K Ubiquitination 21987572 5710 111683 - K Ubiquitination 20972266 5710 111683 - K Sumoylation 21693764 5710 111683 - K Ubiquitination 21139048 5710 111683 - K Ubiquitination 21890473 5710 111683 - K Ubiquitination 21906983 5710 111683 - K Sumoylation 19471022 5710 111683 - K Ubiquitination 22053931 5710 111683 - K Ubiquitination 21853274 5710 111683 - K Ubiquitination 22505724 5710 111683 - K FAT10ylation 22797925 5710 111683 - K Ubiquitination 21963094 5710 111683 - K Ubiquitination 23000965 5710 111683 - K Ubiquitination 23831032 5710 111683 - K Ubiquitination 24654937 5710 111683 - K Ubiquitination 24816145 5710 111683 - K Ubiquitination 25015289 5710 111683 - K Ubiquitination 25147182 5710 111683 - K Ubiquitination 24743594 5710 111683 - K Ubiquitination 20542005

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID PSMD4 Homo sapiens (Human) 152; 81; 98; 368; 83; 126; 40; 265; 122; 74; 135 "152,EEVNTEKLTAFVN; 81,LHTVQPKGKITFC; 98,VAHLALKHRQGKN; 368,LASQATKDGKKDK; 83,TVQPKGKITFCTG; 126,NEKDLVKLAKRLK; 40,NIVCHSKTRSNPE; 265,SDDALLKMTISQQ; 122,PVEDNEKDLVKLA; 74,TGRILSKLHTVQP; 135,KRLKKEKVNVDII" "152:21906983; 81:21890473,21906983; 98:21906983; 368:21906983; 83:21890473,21906983; 126:21890473,21906983; 40:21890473,21906983; 265:21906983; 122:21890473,21906983; 74:21890473,21906983; 135:21890473,21906983" PSMD4 Homo sapiens (Human) 152; 81; 98; 262; 83; 126; 365; 40; 122; 74; 135 "152,EEVNTEKLTAFVN; 81,LHTVQPKGKITFC; 98,VAHLALKHRQGKN; 262,SDDALLKMTISQQ; 83,TVQPKGKITFCTG; 126,NEKDLVKLAKRLK; 365,LASQATKDGKKDK; 40,NIVCHSKTRSNPE; 122,PVEDNEKDLVKLA; 74,TGRILSKLHTVQP; 135,KRLKKEKVNVDII" "152:21906983; 81:21890473,21906983; 98:21906983; 262:21906983; 83:21890473,21906983; 126:21890473,21906983; 365:21906983; 40:21890473,21906983,22053931; 122:21890473,21906983; 74:21890473,21906983,22053931; 135:21890473,21906983" PSMD4 Homo sapiens (Human) 262; 40; 122; 74 "262,SDDALLKMTISQQ; 40,NIVCHSKTRSNPE; 122,PVEDNEKDLVKLA; 74,TGRILSKLHTVQP" "262:21139048; 40:22053931; 122:21139048,20972266; 74:22053931" PSMD4 Homo sapiens (Human) 68; 137; 66; 83; 25; 59; 111; 107; 120 "68,TVQPKGKITFCTG; 137,EEVNTEKLTAFVN; 66,LHTVQPKGKITFC; 83,VAHLALKHRQGKN; 25,NIVCHSKTRSNPE; 59,TGRILSKLHTVQP; 111,NEKDLVKLAKRLK; 107,PVEDNEKDLVKLA; 120,KRLKKEKVNVDII" "68:21906983,21890473; 137:21906983; 66:21906983,21890473; 83:21906983; 25:21906983,21890473; 59:21906983,21890473; 111:21906983,21890473; 107:21906983,21890473; 120:21906983,21890473" PSMD4 Homo sapiens (Human) 16; 20 "16,PVEDNEKDLVKLA; 20,NEKDLVKLAKRLK" 16:21890473; 20:21890473 PSMD4 Homo sapiens (Human) 81; 368; 83; 126; 40; 122; 135; 74 "81,LHTVQPKGKITFC; 368,LASQATKDGKKDK; 83,TVQPKGKITFCTG; 126,NEKDLVKLAKRLK; 40,NIVCHSKTRSNPE; 122,PVEDNEKDLVKLA; 135,KRLKKEKVNVDII; 74,TGRILSKLHTVQP" 81:21890473; 368:21906983; 83:21890473; 126:21890473; 40:21890473; 122:21890473; 135:21890473; 74:21890473 PSMD4 Homo sapiens (Human) 78; 14; 181 "78,SDDALLKMTISQQ; 14,NEKDLVKLAKRLK; 181,LASQATKDGKKDK" 78:21906983; 14:21906983; 181:21906983