PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus WWP2 UBE2J2 22496338 biogrid exp G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G XIAP UBE2J2 19549727 biogrid exp G G G G G G G GP GP G G G GP G G GP G G G G G G G G GP G G G G UBC UBE2J2 22496338 biogrid exp G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G HERC4 UBE2J2 22496338 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2J2 RNF10 19549727 biogrid exp G G G G G G G GP GP G G G GP G G GP G G G G GP G G G GP G G G G MGRN1 UBE2J2 19549727 biogrid exp G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G UBE2J2 ITCH 22496338 biogrid exp G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G PDE4DIP UBE2J2 19549727 intact exp G G G G G GP GP G GP P G G G GP GP GP G UBE2J2 ATP13A2 22645275 biogrid,intact exp G G G G G G P GP G G GP G G GP G G G GP G G P GP G G TMEM129 UBE2J2 24807418 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2J2 FAM193B 19549727 intact exp G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G UBE2J2 UBE2J2 20061386 biogrid exp, ortho G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G UBE2J2 NEDD4L 22496338 biogrid exp, ortho G G G G G GP GP G G G GP G GP G G G G GP G G G GP G G G UBE2G2 UBE2J2 8393731, 25402006, 23023127, 21836163 hprd exp, ortho, pred G G G G G G G G GP G G G GP G G GP G G G G GP G G G GP G G G G UBA1 UBE2J2 19549727, 16082366 intact exp, ortho, pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G TRIM25 UBE2J2 19549727, 23023127 biogrid exp, pred G G G G G G G G GP G G G GP G G GP G G G G GP G G G GP G G G G PARK2 UBE2J2 16720581, 23023127 biogrid exp, pred G G G G GP GP G G P G P G G G P G GP GP G G UBE2J2 RUVBL1 ortho G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP G G G G TUBB4B UBE2J2 ortho G G G G G G G G GP G G G G G G GP G G G G GP G G G GP G G G G UBE2J2 IPO4 ortho G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G MOCS3 UBE2J2 ortho G G G G G G GP G G G G GP G GP G G G G GP G G GP GP G G G UBE2J2 ELOVL4 ortho G G G G G G G G UBE2J2 RUVBL2 ortho G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G ATP5A1 UBE2J2 ortho G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G ACTR1B UBE2J2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2J2 TUBA1C ortho G G G G G G G GP GP G G G GP G G GP G G G G GP G G G GP G G G G UBE2J2 ARFGEF1 ortho G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G CAD UBE2J2 ortho G G G G G G G GP GP G G G GP G G GP G G G G GP G G P GP G G G G TPT1 UBE2J2 ortho G G G G G G G G GP G G G GP G G GP G G G G GP G G GP GP G G G G RAB1A UBE2J2 ortho G G G G G G G GP GP G G G GP G G GP G G G G GP G G G GP G G G G ICMT UBE2J2 ortho G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G UTP20 UBE2J2 16082366 ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G XPOT UBE2J2 16082366 ortho, pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G UBE2J2 GCN1L1 16082366 ortho, pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G UBE2S UBE2J2 23023127 pred G G G G G G G G GP G G G G G G G G G G G G G G G G G SUMO1 UBE2J2 23023127 pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G UBE2J2 AKTIP 23023127 pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G UBC UBE2J2 23023127 pred UBE2L6 UBE2J2 23023127 pred G G G G G G G G GP G G G GP G G GP G G G G GP G G G GP G G G G UBE2J2 HERPUD2 23023127 pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G UBE2N UBE2J2 23023127 pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G UBE2I UBE2J2 23023127 pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G G GP G G G G UBE2J2 UBE2E3 23023127 pred G G G G G G G G GP G G G G G G GP G G G G GP G G GP GP G G G G UBE2J2 UBE2D4 23023127 pred G G G G G G G G GP G G G GP G G G G G G G GP G G GP G G G G G UBE2NL UBE2J2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2K UBE2J2 23023127 pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G UBE2J2 UBE2F 23023127 pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G UBE2J2 UBE2E2 23023127 pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G UBE2J2 UBE2T 23023127 pred G G G G G GP P GP G GP G GP G G UBE2J2 STUB1 23023127 pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G SUMO2 UBE2J2 23023127 pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G UBE2V1 UBE2J2 23023127 pred UBE2L3 UBE2J2 23023127 pred G G G G G G G GP GP G G G G G G GP G G G G G G G GP GP G G G G UBE2B UBE2J2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D2 UBE2J2 23023127 pred G G G G G G G G GP G G G GP G G G G G G G GP G G GP G G G G G CNOT4 UBE2J2 23023127 pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G UBE2V2 UBE2J2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 UBE2J2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2J2 RNF5 23023127 pred G G G G G G G G GP G G G GP G G GP G G G G GP G G GP GP G G G G UBE2J2 NSFL1C 23023127 pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G G GP G G G G UBE2U UBE2J2 23023127 pred P P P P P P P G CDC34 UBE2J2 23023127 pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G ATP5F1 UBE2J2 16082366 pred G G G G G G G GP GP G G G G G G GP G G G G GP G G GP GP G G G G UBE2R2 UBE2J2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D1 UBE2J2 23023127 pred G G G G G G G G GP G G G GP G G G G G G G GP G G GP G G G G G UBE2D3 UBE2J2 23023127 pred G G G G G G G G GP G G G GP G G G G G G G GP G G GP G G G G G UBE2J2 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2H UBE2J2 23023127 pred G G G G G G G GP G G G G GP G G GP G G G G GP G G GP GP G G G G UBE2G1 UBE2J2 23023127 pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G UBE2C UBE2J2 23023127 pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G HERPUD1 UBE2J2 23023127 pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G SLC25A3 UBE2J2 21836163 pred G G G G G G G GP GP G G G G G G GP G G G G GP G G GP GP G G G G UBE2M UBE2J2 23023127 pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G UBE2A UBE2J2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2E1 UBE2J2 23023127 pred G G G G G G G G GP G G G G G G GP G G G G GP G G GP GP G G G G UBE2J2 EIF2AK4 23023127 pred G G G G G G G GP GP G G G GP G G G G G G G GP G G GP G G G G G UBE2J2 UBXN4 23023127 pred G G G G G G G GP GP G G G GP G G GP G G G G GP G G GP GP G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBE2J2 ITCH MI:0415(enzymatic study) 22496338 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226069 prey bait UBE2J2 NEDD4L MI:0415(enzymatic study) 22496338 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226057 prey bait UBE2J2 ATP13A2 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 22645275 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_124463|BIOGRID_220377 prey|prey bait|bait UBC UBE2J2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 16720581,21139048,21890473,21906983,21963094,22496338 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_266064|BIOGRID_168862|BIOGRID_208076|BIOGRID_178200|BIOGRID_211530|BIOGRID_174277 bait|bait|prey|bait|prey|bait prey|prey|bait|prey|bait|prey UBE2J2 RNF10 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_124472 bait prey UBE1 UBE2J2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100953 prey bait UBE2G2 UBE2J2 MI:0492(in vitro) 8393731 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_12032 - - PDE4DIP UBE2J2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100954 prey bait PARK2 UBE2J2 MI:0096(pull down) 16720581 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_208078 bait prey WWP2 UBE2J2 MI:0415(enzymatic study) 22496338 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226064 bait prey MGRN1 UBE2J2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_124414 prey bait HERC4 UBE2J2 MI:0415(enzymatic study) 22496338 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226053 bait prey TRIM25 UBE2J2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_124538 prey bait XIAP UBE2J2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_124236 prey bait FLJ10404 UBE2J2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100955 prey bait

PPI - HINT Gene A Gene B PMID Method Quality MGRN1 UBE2J2 19549727 0018 HT UBC UBE2J2 22496338 0415 LC XIAP UBE2J2 19549727 0018 HT TRIM25 UBE2J2 19549727 0018 HT PDE4DIP UBE2J2 19549727 0018 HT FLJ10404 UBE2J2 19549727 0018 HT UBE1 UBE2J2 19549727 0018 HT UBE2J2 UBE2J2 20061386,22496338 0415,0114 LC UBE2J2 RNF10 19549727 0018 HT UBE2J2 ATP13A2 22645275,22645275 0112,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8N2K1 Q5VU43 UBE2J2 PDE4DIP 0.332 19549727 Q8N2K1 O60291 UBE2J2 MGRN1 0.183 19549727 Q8N2K1 P0CG48 UBE2J2 UBC 0.309 22496338 Q8N2K1 P98170 UBE2J2 XIAP 0.183 19549727 Q8N2K1 Q14258 UBE2J2 TRIM25 0.183 19549727 Q8N2K1 Q6IPW0 UBE2J2 FLJ10404 0.332 19549727 Q8N2K1 Q712V1 UBE2J2 UBE1 0.332 19549727 Q8N5U6 Q8N2K1 RNF10 UBE2J2 0.183 19549727 Q8N2K1 O60260 UBE2J2 PARK2 0.21 16720581 Q8N2K1 Q76N89 UBE2J2 HECW1 0.309 26949039 Q9NQ11 Q8N2K1 ATP13A2 UBE2J2 0.286 22645275 Q8N2K1 Q8IWR1 UBE2J2 TRIM59 0.236 unassigned1304 Q8N2K1 A0A0A0MQT0 UBE2J2 A0A0A0MQT0 0.236 unassigned1304 Q96GF1 Q8N2K1 RNF185 UBE2J2 0.21 24019521 Q96J02 Q8N2K1 ITCH UBE2J2 0.309 22496338 Q8N2K1 O00308 UBE2J2 WWP2 0.309 22496338 Q8N2K1 A0AVI4 UBE2J2 TMEM129 0.21 24807418

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TMEM129 UBE2J2 MI:0045 experimental interaction detection MI:0461 interaction database TUBAL3 UBE2J2 MI:0362 inference MI:0461 interaction database WWP2 UBE2J2 MI:0045 experimental interaction detection MI:0461 interaction database NR5A2 UBE2J2 MI:0362 inference MI:0461 interaction database STK25 UBE2J2 MI:0362 inference MI:0461 interaction database SLC30A4 UBE2J2 MI:0362 inference MI:0461 interaction database TM9SF1 UBE2J2 MI:0362 inference MI:0461 interaction database SLC31A1 UBE2J2 MI:0362 inference MI:0461 interaction database RNF13 UBE2J2 MI:0362 inference MI:0461 interaction database XPOT UBE2J2 MI:0362 inference MI:0461 interaction database PARK2 UBE2J2 MI:0045 experimental interaction detection MI:0461 interaction database MGRN1 UBE2J2 MI:0045 experimental interaction detection MI:0461 interaction database MARCH6 UBE2J2 MI:0362 inference MI:0461 interaction database ICMT UBE2J2 MI:0362 inference MI:0461 interaction database SEC22B UBE2J2 MI:0362 inference MI:0461 interaction database UTP20 UBE2J2 MI:0362 inference MI:0461 interaction database GOSR1 UBE2J2 MI:0362 inference MI:0461 interaction database MOCS3 UBE2J2 MI:0362 inference MI:0461 interaction database SFT2D2 UBE2J2 MI:0362 inference MI:0461 interaction database TUBB4A UBE2J2 MI:0362 inference MI:0461 interaction database SLC25A5 UBE2J2 MI:0362 inference MI:0461 interaction database TUBB UBE2J2 MI:0362 inference MI:0461 interaction database HSP90AB1 UBE2J2 MI:0362 inference MI:0461 interaction database UBC UBE2J2 MI:0045 experimental interaction detection MI:0461 interaction database TXN UBE2J2 MI:0362 inference MI:0461 interaction database SLC25A4 UBE2J2 MI:0362 inference MI:0461 interaction database SLC25A6 UBE2J2 MI:0362 inference MI:0461 interaction database TPT1 UBE2J2 MI:0362 inference MI:0461 interaction database HK1 UBE2J2 MI:0362 inference MI:0461 interaction database UBA1 UBE2J2 MI:0362 inference MI:0461 interaction database KDELR1 UBE2J2 MI:0362 inference MI:0461 interaction database ATP5A1 UBE2J2 MI:0362 inference MI:0461 interaction database CAD UBE2J2 MI:0362 inference MI:0461 interaction database KDELR2 UBE2J2 MI:0362 inference MI:0461 interaction database GCK UBE2J2 MI:0362 inference MI:0461 interaction database ACTR1B UBE2J2 MI:0362 inference MI:0461 interaction database NEDD4 UBE2J2 MI:0362 inference MI:0461 interaction database CLCN7 UBE2J2 MI:0362 inference MI:0461 interaction database UBE2G2 UBE2J2 MI:0362 inference MI:0461 interaction database ACTR1A UBE2J2 MI:0362 inference MI:0461 interaction database SEC61A1 UBE2J2 MI:0362 inference MI:0461 interaction database DAD1 UBE2J2 MI:0362 inference MI:0461 interaction database RAB1A UBE2J2 MI:0362 inference MI:0461 interaction database SEC11A UBE2J2 MI:0362 inference MI:0461 interaction database TUBA1B UBE2J2 MI:0362 inference MI:0461 interaction database TUBA4A UBE2J2 MI:0362 inference MI:0461 interaction database TUBB4B UBE2J2 MI:0362 inference MI:0461 interaction database XIAP UBE2J2 MI:0045 experimental interaction detection MI:0461 interaction database SLC25A3 UBE2J2 MI:0362 inference MI:0461 interaction database STK3 UBE2J2 MI:0362 inference MI:0461 interaction database NR5A1 UBE2J2 MI:0362 inference MI:0461 interaction database TUBB3 UBE2J2 MI:0362 inference MI:0461 interaction database TUBA3C UBE2J2 MI:0362 inference MI:0461 interaction database TUBB2A UBE2J2 MI:0362 inference MI:0461 interaction database TRIM25 UBE2J2 MI:0045 experimental interaction detection MI:0461 interaction database DDR2 UBE2J2 MI:0362 inference MI:0461 interaction database TUBB8 UBE2J2 MI:0362 inference MI:0461 interaction database HERC4 UBE2J2 MI:0045 experimental interaction detection MI:0461 interaction database PDE4DIP UBE2J2 MI:0045 experimental interaction detection MI:0461 interaction database TUBA3E UBE2J2 MI:0362 inference MI:0461 interaction database TUBA1A UBE2J2 MI:0362 inference MI:0461 interaction database HECW1 UBE2J2 MI:0045 experimental interaction detection MI:0461 interaction database SLC35E3 UBE2J2 MI:0362 inference MI:0461 interaction database SCD5 UBE2J2 MI:0362 inference MI:0461 interaction database UBE2J2 RNF10 MI:0045 experimental interaction detection MI:0461 interaction database UBE2J2 IPO4 MI:0362 inference MI:0461 interaction database UBE2J2 TM9SF4 MI:0362 inference MI:0461 interaction database UBE2J2 GCN1 MI:0362 inference MI:0461 interaction database UBE2J2 CDS1 MI:0362 inference MI:0461 interaction database UBE2J2 MUL1 MI:0362 inference MI:0461 interaction database UBE2J2 PGAP3 MI:0362 inference MI:0461 interaction database UBE2J2 RNF185 MI:0045 experimental interaction detection MI:0461 interaction database UBE2J2 ITCH MI:0045 experimental interaction detection MI:0461 interaction database UBE2J2 SLC35E1 MI:0362 inference MI:0461 interaction database UBE2J2 NEDD4L MI:0045 experimental interaction detection MI:0461 interaction database UBE2J2 DERL3 MI:0362 inference MI:0461 interaction database UBE2J2 SLC2A13 MI:0362 inference MI:0461 interaction database UBE2J2 SLC30A2 MI:0362 inference MI:0461 interaction database UBE2J2 TUBB6 MI:0362 inference MI:0461 interaction database UBE2J2 C20orf24 MI:0362 inference MI:0461 interaction database UBE2J2 TUBB2B MI:0362 inference MI:0461 interaction database UBE2J2 SEC11C MI:0362 inference MI:0461 interaction database UBE2J2 DERL2 MI:0362 inference MI:0461 interaction database UBE2J2 SLC25A31 MI:0362 inference MI:0461 interaction database UBE2J2 TMEM222 MI:0362 inference MI:0461 interaction database UBE2J2 RAB1B MI:0362 inference MI:0461 interaction database UBE2J2 SLC35B3 MI:0362 inference MI:0461 interaction database UBE2J2 TUBB1 MI:0362 inference MI:0461 interaction database UBE2J2 SEC61A2 MI:0362 inference MI:0461 interaction database UBE2J2 TMBIM4 MI:0362 inference MI:0461 interaction database UBE2J2 ATP13A2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2J2 TUBA8 MI:0362 inference MI:0461 interaction database UBE2J2 STK26 MI:0362 inference MI:0461 interaction database UBE2J2 RUVBL2 MI:0362 inference MI:0461 interaction database UBE2J2 RUVBL1 MI:0362 inference MI:0461 interaction database UBE2J2 ARFGEF2 MI:0362 inference MI:0461 interaction database UBE2J2 ARFGEF1 MI:0362 inference MI:0461 interaction database UBE2J2 STK24 MI:0362 inference MI:0461 interaction database