PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ECM29 UBE2Q1 20682791 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EXOSC7 UBE2Q1 19549727 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 RNF7 19549727 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 RNF26 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 IRF2BPL 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TP53 UBE2Q1 25987028 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FHL3 UBE2Q1 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G TCEAL1 UBE2Q1 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SNW1 UBE2Q1 20467437 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LYPD3 UBE2Q1 26186194 biogrid exp G G G G G G G G G G G UBE2Q1 C1QTNF2 26186194 biogrid exp G G G G G G USP11 UBE2Q1 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 STUB1 16275660, 25402006 hprd,biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G B4GALT1 UBE2Q1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 SNIP1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 FBXL15 21836163 pred G G G G G G G G G G G G G G G G G G G G G G GOLGA7 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 AUP1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 FAF1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 EIF3L 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 AKTIP 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 ZDHHC7 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MATR3 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 ACTR10 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 IARS2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 UBE2T 23023127 pred G G G G G G G G G G G G G UBE2Q1 FAM96B 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2R2 UBE2Q1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DNAJB1 UBE2Q1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 MRPL18 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 PSMD13 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 PFDN2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 KLHDC2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 VPS28 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBAP2L UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PRKRIR UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SMAD4 UBE2Q1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBC UBE2Q1 23023127 pred UBE2Q1 MAP3K3 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 LMBRD1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSMD14 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2G1 UBE2Q1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RUNX2 UBE2Q1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 UBE2E2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CAMLG UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2G2 UBE2Q1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PARK2 UBE2Q1 25402006, 23023127 pred G G G G G G G G G G G G G G G G G UBE2Q1 NAGK 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2K UBE2Q1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 UBE2E3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DAP3 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 ATCAY 25402006 pred G G G G G G PSMD10 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PITPNB UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SRP9 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 YTHDF1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RPSA UBE2Q1 21836163 pred G G G G G G G G UBE2M UBE2Q1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 NIPA2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 SMARCD2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 CHCHD2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HMGN3 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 AMZ2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BAG6 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSMA1 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LONP1 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 ZDHHC6 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 ZNF706 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 RBM23 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 UBE2J2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2S UBE2Q1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D3 UBE2Q1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2E1 UBE2Q1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HSPD1 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NDUFA3 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 MMADHC 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2V1 UBE2Q1 23023127 pred UBE2C UBE2Q1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SELT UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EIF3D UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LRRC8D UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 TRIM44 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 PSMG2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ADRM1 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 FAM21C 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2V2 UBE2Q1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 GHITM 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ATP5B UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSMD8 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NDUFC2 UBE2Q1 21836163 pred UBE2Q1 NSUN5 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D1 UBE2Q1 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G WDR82 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SF3B1 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2U UBE2Q1 23023127 pred G UBE2L3 UBE2Q1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2N UBE2Q1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 UBE2D4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 NDUFB11 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2NL UBE2Q1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PPA1 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RPS15 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D2 UBE2Q1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DNTTIP2 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 MAP3K14 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CDC34 UBE2Q1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 NOP10 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 USP15 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2I UBE2Q1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSMD6 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 MAPKAPK5 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSMC6 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 B3GNT4 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2L6 UBE2Q1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GUCY1A2 UBE2Q1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G EDF1 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 C1orf43 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DCTN3 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DHX15 UBE2Q1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 UFC1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q1 OAZ3 21836163 pred G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q7Z7E8 Q9UNE7 two hybrid 16275660 direct interaction X 2 Q7Z7E8 Q9UNE7 pull down 16275660 direct interaction X 2 Q7Z7E8 Q9UNE7 unspecified method 16275660 direct interaction X 2 Q7Z7E8 Q9BY78 two hybrid 19690564 direct interaction X 2 Q9H1B7 Q7Z7E8 two hybrid 19690564 direct interaction X 2 J3KN16 Q7Z7E8 two hybrid 20682791 direct interaction X 2 Q7Z7E8 Q13643 two hybrid 25416956 direct interaction X 2 Q7Z7E8 Q9UBF6-2 two hybrid 19549727 direct interaction X 2 P0CG48 Q7Z7E8 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q7Z7E8 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q7Z7E8 affinity chromatography technology 21890473 physical association X 2 Q7Z7E8 Q9UNE7 in vivo 16275660 - X 2 Q7Z7E8 Q9UNE7 two hybrid 16275660 - X 2 Q7Z7E8 Q9UNE7 in vitro 16275660 - X 2 Q7Z7E8 Q9UNE7 in vivo 16275660 - X 2 Q7Z7E8 Q9UNE7 two hybrid 16275660 - X 2 Q7Z7E8 Q9UNE7 in vitro 16275660 - X 2 Q7Z7E8 Q9UNE7 filter binding 16275660 physical association X 2 Q7Z7E8 Q9UNE7 pull down 16275660 physical association X 2 Q7Z7E8 Q9UNE7 two hybrid 16275660 physical association X 2 Q7Z7E8 A0A024R2P7 two hybrid 19549727 physical association X 2 Q7Z7E8 Q9BY78 two hybrid array 19690564 physical association X 2 Q9H1B7 Q7Z7E8 two hybrid array 19690564 physical association X 2 Q9UBF6 Q7Z7E8 two hybrid array 19549727 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBE2Q1 IRF2BPL MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102622|BIOGRID_123633 bait|bait prey|prey UBC UBE2Q1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_269044|BIOGRID_170347|BIOGRID_174732 bait|bait|bait prey|prey|prey UBE2Q1 RNF7 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101181|BIOGRID_124213 bait|bait prey|prey UBE2Q1 STUB1 MI:0049(filter binding)|MI:0493(in vivo)|MI:0049(filter binding)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0049(filter binding) 16275660 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0468(hprd)|(intact)|(biogrid)|(biogrid)|(intact) UniProt_82124|HPRD_32158|UniProt_82109|BIOGRID_193658|BIOGRID_193653|UniProt_82132 prey|-|prey|prey|prey|prey bait|-|bait|bait|bait|bait ECM29 UBE2Q1 MI:0018(two hybrid) 20682791 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_199715 prey bait UBE2Q1 RNF26 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102623|BIOGRID_123634 bait|bait prey|prey EXOSC7 UBE2Q1 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100924 prey bait

PPI - HINT Gene A Gene B PMID Method Quality LYPD3 UBE2Q1 26186194 0004 HT USP11 UBE2Q1 26496610,26496610 0007,0004 HT TCEAL1 UBE2Q1 26186194 0004 HT UBE2Q1 C1QTNF2 26186194 0004 HT LYPD3 UBE2Q1 26186194 0004 HT USP11 UBE2Q1 26496610,26496610 0007,0004 HT TCEAL1 UBE2Q1 26186194 0004 HT UBE2Q1 C1QTNF2 26186194 0004 HT FHL3 UBE2Q1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT EXOSC7 UBE2Q1 19549727 0018 HT ECM29 UBE2Q1 20682791 0018 LC UBE2Q1 UBE2Q1 22496338 0114 LC UBE2Q1 RNF26 19690564,19690564 0397,0018 HT UBE2Q1 IRF2BPL 19690564,19690564 0397,0018 HT UBE2Q1 RNF7 19549727,19549727 0397,0018 HT UBE2Q1 STUB1 16275660,16275660,16275660,16275660 0018,0004,0049,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q7Z7E8 P04637 UBE2Q1 TP53 0.569 25987028 Q7Z7E8 Q13643 UBE2Q1 FHL3 0.454 25416956 Q7Z7E8 Q15024 UBE2Q1 EXOSC7 0.183 19549727 Q7Z7E8 Q5VYK3 UBE2Q1 ECM29 0.183 20682791 Q7Z7E8 O95274 UBE2Q1 LYPD3 0.126 26186194 Q7Z7E8 Q13573 UBE2Q1 SNW1 0.236 20467437 Q7Z7E8 P51784 UBE2Q1 USP11 0.236 26496610 Q9H1B7 Q7Z7E8 IRF2BPL UBE2Q1 0.286 19690564 Q9UNE7 Q7Z7E8 STUB1 UBE2Q1 0.659 16275660 Q9BXJ5 Q7Z7E8 C1QTNF2 UBE2Q1 0.126 26186194 Q9BY78 Q7Z7E8 RNF26 UBE2Q1 0.286 19690564 Q9UBF6 Q7Z7E8 RNF7 UBE2Q1 0.376 19549727 Q7Z7E8 Q15170 UBE2Q1 TCEAL1 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 LYPD3 UBE2Q1 MI:0045 experimental interaction detection MI:0461 interaction database TP53 UBE2Q1 MI:0045 experimental interaction detection MI:0461 interaction database UBC UBE2Q1 MI:0045 experimental interaction detection MI:0461 interaction database B4GALT1 UBE2Q1 MI:0362 inference MI:0461 interaction database USP11 UBE2Q1 MI:0045 experimental interaction detection MI:0461 interaction database SNW1 UBE2Q1 MI:0045 experimental interaction detection MI:0461 interaction database FHL3 UBE2Q1 MI:0045 experimental interaction detection MI:0461 interaction database EXOSC7 UBE2Q1 MI:0045 experimental interaction detection MI:0461 interaction database TCEAL1 UBE2Q1 MI:0045 experimental interaction detection MI:0461 interaction database ECM29 UBE2Q1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2Q1 C1QTNF2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2Q1 RNF26 MI:0045 experimental interaction detection MI:0461 interaction database UBE2Q1 UBA5 MI:0362 inference MI:0461 interaction database UBE2Q1 IRF2BPL MI:0045 experimental interaction detection MI:0461 interaction database UBE2Q1 RNF7 MI:0045 experimental interaction detection MI:0461 interaction database UBE2Q1 STUB1 MI:0045 experimental interaction detection MI:0461 interaction database