PTM - CPLM Gene Name UniProt ID Type Position Code NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 2067 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 2132 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 1828 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 2124 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 1716 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 855 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 1624 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 36 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 1883 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 939 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 2140 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 2153 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 1493 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 2321 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 2339 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 1058 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 1059 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 344 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 1841 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 2472 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 2437 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 554 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 833 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 1181 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 399 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 403 K NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 Ubiquitination 119 K

PTM - dbPAF Gene Name UniProt ID Position Type Species NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 1298 T Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 1301 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 1305 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 1306 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 1309 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 1322 T Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 1350 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 1381 T Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 1384 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 1388 T Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 1390 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 1410 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 1503 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 1647 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 1831 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 1855 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 1867 T Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 1869 T Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 1886 T Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2008 T Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2009 T Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2012 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2013 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2015 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2017 T Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2054 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2208 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 231 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 237 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2432 Y Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2434 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2436 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2440 T Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2734 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2735 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2739 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2742 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2743 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2746 T Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2748 Y Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 2751 T Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 389 T Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 39 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 393 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 395 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 41 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 720 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 729 Y Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 733 T Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 757 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 759 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 763 S Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 764 T Homo sapiens(Human) NBEAL2; KIAA0540; UNQ253/PRO290 Q6ZNJ1 863 S Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type NBEAL2; KIAA0540; UNQ253/PRO290 rs12893 GAA->AAA E->K 2748 Y VSSGETEYNPTEAR* 2754 Phosphorylation TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q6ZNJ1 S39-p Phosphorylation GAFKKSIsLsSLEPR Q6ZNJ1 S41-p Phosphorylation FKKSIsLsSLEPRRP Q6ZNJ1 S231-p Phosphorylation GSVKGLLsVVRGWsR Q6ZNJ1 S237-p Phosphorylation LsVVRGWsRGPAPDP Q6ZNJ1 S720-p Phosphorylation PSLSEPFsSCCIGSA Q6ZNJ1 Y729-p Phosphorylation CCIGSAGyRTTtTTT Q6ZNJ1 T733-p Phosphorylation SAGyRTTtTTTGLPT Q6ZNJ1 S757-p Phosphorylation THPALTRsQSVPASt Q6ZNJ1 T764-p Phosphorylation sQSVPAStGLGWGSG Q6ZNJ1 T1298-p Phosphorylation LYVLEAAtAGsPPPS Q6ZNJ1 S1301-p Phosphorylation LEAAtAGsPPPSSPE Q6ZNJ1 S1309-p Phosphorylation PPPSSPEsPTSPKPA Q6ZNJ1 T1322-p Phosphorylation PAPPKPPtESPAEPS Q6ZNJ1 T1381-p Phosphorylation GGSSGTLtPAsQPGt Q6ZNJ1 S1384-p Phosphorylation SGTLtPAsQPGtPsP Q6ZNJ1 T1388-p Phosphorylation tPAsQPGtPsPLDGP Q6ZNJ1 S1390-p Phosphorylation AsQPGtPsPLDGPRP Q6ZNJ1 S1410-p Phosphorylation GRHSSSLsNVLEDGS Q6ZNJ1 S1647-p Phosphorylation SATDEAGsPLAAAAA Q6ZNJ1 S1831-p Phosphorylation IPRWkLSsAETYSRM Q6ZNJ1 T1867-p Phosphorylation NLGEVPLtPtEEASL Q6ZNJ1 T1869-p Phosphorylation GEVPLtPtEEASLPL Q6ZNJ1 T1886-p Phosphorylation TKEAKVStPPELLQE Q6ZNJ1 T2008-p Phosphorylation NFPCKVGttPVssPS Q6ZNJ1 T2009-p Phosphorylation FPCKVGttPVssPSQ Q6ZNJ1 S2012-p Phosphorylation KVGttPVssPSQtPR Q6ZNJ1 S2013-p Phosphorylation VGttPVssPSQtPRP Q6ZNJ1 T2017-p Phosphorylation PVssPSQtPRPQPGP Q6ZNJ1 S2054-p Phosphorylation QGYLSSRsPQEMLRA Q6ZNJ1 S2208-p Phosphorylation AWQARLEsPADVKEL Q6ZNJ1 Y2432-p Phosphorylation YDRNISNyFsFsKDP Q6ZNJ1 S2434-p Phosphorylation RNISNyFsFsKDPtM Q6ZNJ1 S2436-p Phosphorylation ISNyFsFsKDPtMGS Q6ZNJ1 T2440-p Phosphorylation FsFsKDPtMGSHKTQ Q6ZNJ1 S2734-p Phosphorylation FARKLWRssRRIsQV Q6ZNJ1 S2735-p Phosphorylation ARKLWRssRRIsQVs Q6ZNJ1 S2739-p Phosphorylation WRssRRIsQVssGEt Q6ZNJ1 S2742-p Phosphorylation sRRIsQVssGEtEyN Q6ZNJ1 S2743-p Phosphorylation RRIsQVssGEtEyNP Q6ZNJ1 T2746-p Phosphorylation sQVssGEtEyNPtEA Q6ZNJ1 Y2748-p Phosphorylation VssGEtEyNPtEAR_ Q6ZNJ1 T2751-p Phosphorylation GEtEyNPtEAR____ Q6ZNJ1 K119-ub Ubiquitination TKLVAELkGCPPPQG Q6ZNJ1 K1624-ub Ubiquitination EACYVLSkLEAALGR Q6ZNJ1 K1828-ub Ubiquitination DTPIPRWkLSsAETY Q6ZNJ1 K1841-ub Ubiquitination TYSRMRLkLVPNHHF Q6ZNJ1 K2067-ub Ubiquitination RASGLTQkWVQREIS Q6ZNJ1 K2124-ub Ubiquitination AVFRDLSkPIGVVNP Q6ZNJ1 K2132-ub Ubiquitination PIGVVNPkHAQLVRE Q6ZNJ1 K2140-ub Ubiquitination HAQLVREkYESFEDP Q6ZNJ1 K2321-ub Ubiquitination VTDERERkALEGIIS Q6ZNJ1 K2339-ub Ubiquitination QTPCQLLkEPHPTRL

PTM - dbPTM UniProt ID Position Code Type Resources References Q6ZNJ1 39 S Phosphorylation Swiss-Prot 1010711 19690332 Q6ZNJ1 757 S Phosphorylation Swiss-Prot 1010711 19690332 Q6ZNJ1 1647 S Phosphorylation Swiss-Prot 1010711 18669648;18691976 Q6ZNJ1 1867 T Phosphorylation Swiss-Prot 1010711 18691976;19369195;19690332 Q6ZNJ1 2012 S Phosphorylation Swiss-Prot 1010711 18691976 Q6ZNJ1 2013 S Phosphorylation Swiss-Prot 1010711 18691976 Q6ZNJ1 2739 S Phosphorylation Swiss-Prot 1010711 18669648;19690332 Q6ZNJ1 2742 S Phosphorylation Swiss-Prot 1010711 19690332 Q6ZNJ1 2067 K Ubiquitylation Phosphositeplus.1010730 21906983 Q6ZNJ1 2140 K Ubiquitylation Phosphositeplus.1010730 21906983 Q6ZNJ1 1301 S Phosphorylation Phosphositeplus.1010730 20058876 Q6ZNJ1 1410 S Phosphorylation Phosphositeplus.1010730 20058876 Q6ZNJ1 1647 S Phosphorylation Phosphositeplus.1010730 18669648;18691976;20068231 Q6ZNJ1 2012 S Phosphorylation Phosphositeplus.1010730 18691976 Q6ZNJ1 2013 S Phosphorylation Phosphositeplus.1010730 18691976 Q6ZNJ1 2739 S Phosphorylation Phosphositeplus.1010730 18669648;19690332;20166139;22115753 Q6ZNJ1 2742 S Phosphorylation Phosphositeplus.1010730 19690332 Q6ZNJ1 2743 S Phosphorylation Phosphositeplus.1010730 19690332 Q6ZNJ1 39 S Phosphorylation Phosphositeplus.1010730 19690332 Q6ZNJ1 41 S Phosphorylation Phosphositeplus.1010730 19690332 Q6ZNJ1 757 S Phosphorylation Phosphositeplus.1010730 18669648;19690332 Q6ZNJ1 1298 T Phosphorylation Phosphositeplus.1010730 20058876 Q6ZNJ1 1322 T Phosphorylation Phosphositeplus.1010730 20058876 Q6ZNJ1 1867 T Phosphorylation Phosphositeplus.1010730 18669648;18691976;19369195;19690332;20058876 Q6ZNJ1 2440 T Phosphorylation Phosphositeplus.1010730 19690332 Q6ZNJ1 2748 Y Phosphorylation Phosphositeplus.1010730 21253578 Q6ZNJ1 757 S Phosphorylation HPRD 9.0 18669648 Q6ZNJ1 1301 S Phosphorylation HPRD 9.0 20058876 Q6ZNJ1 1410 S Phosphorylation HPRD 9.0 20058876 Q6ZNJ1 1503 S Phosphorylation HPRD 9.0 20068231 Q6ZNJ1 1647 S Phosphorylation HPRD 9.0 18669648,18691976,20068231 Q6ZNJ1 2012 S Phosphorylation HPRD 9.0 18691976 Q6ZNJ1 2013 S Phosphorylation HPRD 9.0 18691976 Q6ZNJ1 2739 S Phosphorylation HPRD 9.0 18669648,19651622 Q6ZNJ1 1298 T Phosphorylation HPRD 9.0 20058876 Q6ZNJ1 1322 T Phosphorylation HPRD 9.0 20058876 Q6ZNJ1 1867 T Phosphorylation HPRD 9.0 18669648,18691976,20058876

PTM - HPRD Symbol Position Code Type References NBEAL2 105 S Phosphorylation 18691976 NBEAL2 106 S Phosphorylation 18691976 NBEAL2 1298 T Phosphorylation 20058876 NBEAL2 1301 S Phosphorylation 20058876 NBEAL2 1322 T Phosphorylation 20058876 NBEAL2 1410 S Phosphorylation 20058876 NBEAL2 1503 S Phosphorylation 20068231 NBEAL2 1647 S Phosphorylation 18669648,18691976,20068231 NBEAL2 1867 T Phosphorylation 18669648,18691976,20058876 NBEAL2 2012 S Phosphorylation 18691976 NBEAL2 2013 S Phosphorylation 18691976 NBEAL2 2739 S Phosphorylation 18669648,19651622 NBEAL2 757 S Phosphorylation 18669648 NBEAL2 832 S Phosphorylation 18669648,19651622

PTM - UniProt UniProt ID Position Type PMIDs Q6ZNJ1 1647 Phosphoserine 18669648;18691976 Q6ZNJ1 1867 Phosphothreonine 19690332 Q6ZNJ1 2739 Phosphoserine 18669648;19690332;23186163 Q6ZNJ1 2742 Phosphoserine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type NBEAL2 IPI00297242 S 1726 ATDEAGpSPLAAAA phosphorylation NBEAL2 IPI00297242 S 1934 DPHLEApSALRDNL phosphorylation NBEAL2 IPI00297242 S 2091 VGTTPVpSSPSQTP phosphorylation NBEAL2 IPI00297242 S 2092 GTTPVSpSPSQTPR phosphorylation NBEAL2 IPI00297242 T 1946 LGEVPLpTPTEEAS phosphorylation NBEAL2 IPI00432423 T 146 LGEVPLpTPTEEAS phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 23218 116825 - K Ubiquitination 21906983 23218 116825 - K Ubiquitination 22505724 23218 116825 - K Ubiquitination 21963094

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID NBEAL2 Homo sapiens (Human) 1883; 1956 "1883,ASGLTQKWVQREI; 1956,AQLVREKYESFED" 1883:21906983; 1956:21906983 NBEAL2 Homo sapiens (Human) 2067; 2140 "2067,ASGLTQKWVQREI; 2140,AQLVREKYESFED" 2067:21906983; 2140:21906983 NBEAL2 Homo sapiens (Human) 419; 346 "419,AQLVREKYESFED; 346,ASGLTQKWVQREI" 419:21906983; 346:21906983 NBEAL2 Homo sapiens (Human) 10 "10,ASGLTQKWVQREI" 10:21906983 NBEAL2 Homo sapiens (Human) 1355; 1428 "1355,ASGLTQKWVQREI; 1428,AQLVREKYESFED" 1355:21906983; 1428:21906983