PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CDC5L LRWD1 20467437 intact exp P P P P P P P P P P P P P P P P RNF126 LRWD1 26186194 biogrid exp P P P P P P P P P P P P P P ORC5 LRWD1 22939629,26496610 biogrid,intact exp P P P P P P P P P P P P P P P P DDB1 LRWD1 22935713 biogrid exp P P P P P P P P P P P P P P P P FOXE1 LRWD1 25609649 intact exp SNW1 LRWD1 20467437 intact exp P P P P P P P P P P P P P P P P PRR3 LRWD1 26496610 biogrid,intact exp ORC1 LRWD1 26496610 biogrid,intact exp P P P P P P P P P P P P P P P THBS3 LRWD1 26186194 biogrid exp P P P P P P P P P P P P P CUL7 LRWD1 24711643 biogrid exp P P P P P P P P P P P P P P P P ORC2 LRWD1 20850016,22935713,26344197,22939629,26496610 biogrid,intact exp P P P P P P P P P P P P ADD1 LRWD1 26496610 biogrid,intact exp P P P P P P P P P P P P P P P P NTRK1 LRWD1 25921289 biogrid exp P P P P P P P P P P P P P P GGH LRWD1 26186194 biogrid exp P P P P P P P P P P P P P P P P TEAD2 LRWD1 25609649 intact exp EGFR LRWD1 24797263 biogrid exp P P P P P P P P P P P CC2D1A LRWD1 26344197 biogrid exp P P P P P P P P P P P P P P P P FOXS1 LRWD1 25609649 intact exp P P P P P P P P P P P P P P ORC3 LRWD1 22939629,26496610 biogrid,intact exp P P P P P P P P P P P P P P P P LRWD1 TSC22D4 26186194 biogrid exp P P P P P P P P P P P P P CUL4A LRWD1 22935713 biogrid exp ORC4 LRWD1 26496610 biogrid,intact exp P P P P P P P P P P P P P P P P LRWD1 ORC6 26186194 biogrid exp P P P P P P P P P P P P P FOXG1 LRWD1 25609649 intact exp LRWD1 NUDC 25036637 intact exp P P P P P P P P P P P P P P P P TUBGCP6 LRWD1 26496610 biogrid,intact exp P P P P P P P P P P P P P P P TUBGCP3 LRWD1 26496610 biogrid,intact exp P P P P P P P P P P P P P P P P HIST3H3 LRWD1 20850016 biogrid exp P P P P P P P P P P P P P P P P MZT2A LRWD1 26496610 biogrid,intact exp P P P P P P P P P P P P P P P FOXQ1 LRWD1 25609649 intact exp P P P P P P P P P P P P FXR1 LRWD1 24778252 biogrid exp P P P P P P P P P P P P P P P P HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4 LRWD1 20850016 biogrid exp P P P P P P P P P P P P P P P P TUBG1 LRWD1 26496610 biogrid,intact exp P P P P P P P P P P P P P P P P OBFC1 LRWD1 26186194 biogrid exp P P P P P P P P P P TUBGCP2 LRWD1 26496610 biogrid,intact exp P P P P P P P P P P P P P P P P LCOR LRWD1 26496610 biogrid,intact exp P P P P P P P P P P P P P P P P FOXB1 LRWD1 25609649 intact exp MPHOSPH8 LRWD1 26496610 biogrid,intact exp P P P P P P P P P P P P P P P P FOXM1 LRWD1 25609649 intact exp P P P P P P P P P P P P P P P P LRWD1 SUGT1 25036637 intact exp P P P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9UFC0 A0A024R411 affinity chromatography technology 22935713 physical association X 2 Q9UFC0 A0A024R411 affinity chromatography technology 22935713 physical association X 2 Q9UFC0 Q16531 affinity chromatography technology 22935713 physical association X 2 Q9UFC0 Q16531 affinity chromatography technology 22935713 physical association X 2 Q9UFC0 A0A024R411 biochemical 22939629 colocalization X 2 Q9UFC0 biochemical 22939629 colocalization X 2 Q9UFC0 P51114-3 affinity chromatography technology 24778252 physical association X 2 Q9UFC0 A0A024R411 affinity chromatography technology 20850016 physical association X 2 P00533 Q9UFC0 affinity chromatography technology 24797263 physical association X 2 Q9Z1N2 Q9UFC0 affinity chromatography technology 20360068 physical association X 2 B2R4R0 Q9UFC0 unspecified method 20850016 direct interaction X 2 Q16695 Q9UFC0 unspecified method 20850016 direct interaction X 2 Q9UFC0 B2RBV7 affinity chromatography technology 22935713 physical association X 2 Q9UFC0 B2RBV7 affinity chromatography technology 22935713 physical association X 2 Q9UFC0 O43913-2 biochemical 22939629 colocalization X 2 Q9UFC0 affinity chromatography technology 24711643 physical association X 2 P0CG48 Q9UFC0 affinity chromatography technology 22935713 physical association X 2 P0CG48 Q9UFC0 affinity chromatography technology 22935713 physical association X 2 P0CG48 Q9UFC0 affinity chromatography technology 24816145 physical association X 2 P0CG48 Q9UFC0 affinity chromatography technology 21139048 physical association X 2 Q9Y266 Q9UFC0 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q9UFC0 tandem affinity purification 20360068 physical association C 6

PPI - HINT Gene A Gene B PMID Method Quality FOXE1 LRWD1 25609649,25609649 0676,0004 HT FOXS1 LRWD1 25609649,25609649 0676,0004 HT ORC5 LRWD1 26496610 0007 HT ORC4 LRWD1 26496610 0007 HT NFATC1 LRWD1 25609649 0004 HT TUBG1 LRWD1 26496610,26496610 0007,0004 HT ADD1 LRWD1 26496610,26496610 0007,0004 HT THBS3 LRWD1 26186194 0004 HT FOXG1 LRWD1 25609649,25609649 0676,0004 HT PRR3 LRWD1 26496610 0007 HT FOXM1 LRWD1 25609649,25609649 0676,0004 HT ORC1 LRWD1 26496610 0007 HT ORC2 LRWD1 26344197,26496610,26496610,20850016,22935713,22939629 0401,0004,0007,0004,0004,0401 HT,LC TEAD2 LRWD1 25609649,25609649 0676,0004 HT Q53FC8 LRWD1 26496610,22939629 0004,0401 HT CC2D1A LRWD1 26344197 0401 HT MZT2A LRWD1 26496610,26496610 0007,0004 HT GGH LRWD1 26186194 0004 HT Q96B14 LRWD1 26496610 0004 HT TUBGCP3 LRWD1 26496610,26496610 0007,0004 HT ORC1L LRWD1 26496610 0004 HT LCOR LRWD1 26496610,26496610 0007,0004 HT CAT56 LRWD1 26496610 0004 HT TUBGCP6 LRWD1 26496610,26496610 0007,0004 HT MPHOSPH8 LRWD1 26496610,26496610 0007,0004 HT FOXB1 LRWD1 25609649,25609649 0676,0004 HT TUBGCP2 LRWD1 26496610,26496610 0007,0004 HT RNF126 LRWD1 26186194 0004 HT FOXQ1 LRWD1 25609649,25609649 0676,0004 HT OBFC1 LRWD1 26186194 0004 HT ORC3 LRWD1 26496610,26496610,22939629 0007,0004,0401 HT LRWD1 TSC22D4 26186194 0004 HT LRWD1 ORC6 26186194 0004 HT FOXE1 LRWD1 25609649,25609649 0676,0004 HT FOXS1 LRWD1 25609649,25609649 0676,0004 HT ORC5 LRWD1 26496610 0007 HT ORC4 LRWD1 26496610 0007 HT NFATC1 LRWD1 25609649 0004 HT TUBG1 LRWD1 26496610,26496610 0007,0004 HT ADD1 LRWD1 26496610,26496610 0007,0004 HT THBS3 LRWD1 26186194 0004 HT FOXG1 LRWD1 25609649,25609649 0676,0004 HT PRR3 LRWD1 26496610 0007 HT FOXM1 LRWD1 25609649,25609649 0676,0004 HT ORC1 LRWD1 26496610 0007 HT ORC2 LRWD1 26344197,26496610,26496610,22939629 0401,0004,0007,0401 HT TEAD2 LRWD1 25609649,25609649 0676,0004 HT Q53FC8 LRWD1 26496610,22939629 0004,0401 HT CC2D1A LRWD1 26344197 0401 HT MZT2A LRWD1 26496610,26496610 0007,0004 HT GGH LRWD1 26186194 0004 HT Q96B14 LRWD1 26496610 0004 HT TUBGCP3 LRWD1 26496610,26496610 0007,0004 HT ORC1L LRWD1 26496610 0004 HT LCOR LRWD1 26496610,26496610 0007,0004 HT CAT56 LRWD1 26496610 0004 HT TUBGCP6 LRWD1 26496610,26496610 0007,0004 HT MPHOSPH8 LRWD1 26496610,26496610 0007,0004 HT FOXB1 LRWD1 25609649,25609649 0676,0004 HT TUBGCP2 LRWD1 26496610,26496610 0007,0004 HT RNF126 LRWD1 26186194 0004 HT FOXQ1 LRWD1 25609649,25609649 0676,0004 HT OBFC1 LRWD1 26186194 0004 HT ORC3 LRWD1 26496610,26496610,22939629 0007,0004,0401 HT LRWD1 TSC22D4 26186194 0004 HT LRWD1 ORC6 26186194 0004 HT ORC2 LRWD1 20850016,22935713 0004,0004 LC B4DYC6 LRWD1 25036637 0729 HT ORC2 LRWD1 26344197,22939629 0401,0401 LC Q53FC8 LRWD1 22939629 0401 LC CC2D1A LRWD1 26344197 0401 LC ORC3 LRWD1 22939629 0401 LC LRWD1 NUDC 25036637 0729 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9UFC0 Q9H668 LRWD1 OBFC1 0.126 26186194 Q9Y5N6 Q9UFC0 ORC6 LRWD1 0.126 26186194 Q9Y266 Q9UFC0 NUDC LRWD1 0.126 25036637 Q9Y3Q8 Q9UFC0 TSC22D4 LRWD1 0.126 26186194 Q9UFC0 Q6P1N0 LRWD1 CC2D1A 0.081 26344197 Q9UFC0 O95644 LRWD1 NFATC1 0.126 25609649 Q9UFC0 P04629 LRWD1 NTRK1 0.126 25921289 Q9UFC0 P00533 LRWD1 EGFR 0.126 24797263 Q9Z1N2 Q9UFC0 ORC1 LRWD1 0.236 20360068 Q9UFC0 Q13416 LRWD1 ORC2 0.531 26344197,20850016,26496610 Q9UFC0 O43929 LRWD1 ORC4 0.236 26496610 Q9UFC0 Q13415 LRWD1 ORC1 0.416 26496610 Q9UFC0 P35611 LRWD1 ADD1 0.236 26496610 Q9UFC0 P79522 LRWD1 PRR3 0.236 26496610 Q9UFC0 Q96RT7 LRWD1 TUBGCP6 0.236 26496610 Q9UFC0 Q6P582 LRWD1 MZT2A 0.236 26496610 Q9UFC0 Q96JN0 LRWD1 LCOR 0.236 26496610 Q9UFC0 Q9BSJ2 LRWD1 TUBGCP2 0.236 26496610 Q9UFC0 Q13573 LRWD1 SNW1 0.236 20467437 Q9UFC0 Q99459 LRWD1 CDC5L 0.236 20467437 Q9UFC0 Q99549 LRWD1 MPHOSPH8 0.236 26496610 Q9UFC0 Q99853 LRWD1 FOXB1 0.236 25609649 Q9UFC0 Q9C009 LRWD1 FOXQ1 0.236 25609649 Q9UFC0 Q15562 LRWD1 TEAD2 0.236 25609649 Q9UFC0 P83917 LRWD1 CBX1 0.236 26496610 Q9UFC0 Q08050 LRWD1 FOXM1 0.236 25609649 Q9UFC0 O00358 LRWD1 FOXE1 0.236 25609649 Q9UFC0 Q60862 LRWD1 ORC2 0.236 26496610 Q9UFC0 O43638 LRWD1 FOXS1 0.236 25609649 Q9UFC0 P55316 LRWD1 FOXG1 0.236 25609649 Q9UFC0 O43913 LRWD1 ORC5 0.298 22939629,26496610 Q9UFC0 Q92820 LRWD1 GGH 0.126 26186194 Q9UFC0 Q9BV68 LRWD1 RNF126 0.126 26186194 Q9UFC0 B4DYC6 LRWD1 B4DYC6 0.126 25036637 Q9UFC0 P23258 LRWD1 TUBG1 0.126 26496610 Q9UFC0 Q96CW5 LRWD1 TUBGCP3 0.126 26496610 Q9UFC0 Q9UBD5 LRWD1 ORC3 0.126 26496610 Q9UFC0 P62805 LRWD1 HIST4H4 0.183 20850016 Q9UFC0 P49746 LRWD1 THBS3 0.126 26186194 Q9UFC0 Q14999 LRWD1 CUL7 0.126 24711643 Q9UFC0 P51114 LRWD1 FXR1 0.126 24778252 Q9UFC0 Q16695 LRWD1 HIST3H3 0.183 20850016

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 FOXE1 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database FOXS1 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database ORC5 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database ORC4 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database NFATC1 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database EGFR LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database NTRK1 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database UBC LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database TUBG1 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database ADD1 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database THBS3 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database FXR1 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database FOXG1 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database HIST1H4A LRWD1 MI:0362 inference MI:0461 interaction database PRR3 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database CBX1 LRWD1 MI:0362 inference MI:0461 interaction database FOXM1 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database ORC1 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database ORC2 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database SNW1 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database CUL4A LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database CUL7 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database TEAD2 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database DDB1 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database HIST3H3 LRWD1 MI:0362 inference MI:0461 interaction database MZT2A LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database GGH LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database TUBGCP3 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database LCOR LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database TUBGCP6 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database CDC5L LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database MPHOSPH8 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database FOXB1 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database TUBGCP2 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database RNF126 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database FOXQ1 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database OBFC1 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database ORC3 LRWD1 MI:0045 experimental interaction detection MI:0461 interaction database LRWD1 NUDC MI:0045 experimental interaction detection MI:0461 interaction database LRWD1 TSC22D4 MI:0045 experimental interaction detection MI:0461 interaction database LRWD1 ORC6 MI:0045 experimental interaction detection MI:0461 interaction database