PTM - CPLM Gene Name UniProt ID Type Position Code SENP3; SSP3; SUSP3 Q9H4L4 Ubiquitination 43 K SENP3; SSP3; SUSP3 Q9H4L4 Ubiquitination 446 K SENP3; SSP3; SUSP3 Q9H4L4 Ubiquitination 520 K SENP3; SSP3; SUSP3 Q9H4L4 Ubiquitination 497 K SENP3; SSP3; SUSP3 Q9H4L4 Ubiquitination 558 K SENP3; SSP3; SUSP3 Q9H4L4 Ubiquitination 357 K SENP3; SSP3; SUSP3 Q9H4L4 Ubiquitination 516 K SENP3; SSP3; SUSP3 Q9H4L4 Ubiquitination 541 K SENP3; SSP3; SUSP3 Q9H4L4 Ubiquitination 565 K SENP3; SSP3; SUSP3 Q9H4L4 Ubiquitination 231 K SENP3; SSP3; SUSP3 Q9H4L4 Ubiquitination 505 K SENP3; SSP3; SUSP3 Q9H4L4 Ubiquitination 506 K

PTM - dbPAF Gene Name UniProt ID Position Type Species SENP3; SSP3; SUSP3 Q9H4L4 169 S Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 176 T Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 181 S Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 188 S Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 212 S Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 229 T Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 232 S Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 24 Y Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 242 S Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 25 S Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 253 S Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 26 S Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 307 S Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 353 T Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 4 T Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 44 S Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 54 S Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 57 T Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 69 S Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 73 S Homo sapiens(Human) SENP3; SSP3; SUSP3 Q9H4L4 75 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q9H4L4 K120-ac Acetylation PSRPTHRkTCSQRRR Q9H4L4 K2-m1 Methylation ______MkETIQGTG Q9H4L4 K43-m1 Methylation PPPKPRLksGGGFGP Q9H4L4 R190-m1 Methylation CCRFDsPrGPPPPRL Q9H4L4 Y24-p Phosphorylation GPGIPPAyssPRRER Q9H4L4 S25-p Phosphorylation PGIPPAyssPRRERL Q9H4L4 S26-p Phosphorylation GIPPAyssPRRERLR Q9H4L4 S44-p Phosphorylation PPKPRLksGGGFGPD Q9H4L4 S54-p Phosphorylation GFGPDPGsGTTVPAR Q9H4L4 S69-p Phosphorylation RLPVPRPsFDAsAsE Q9H4L4 S73-p Phosphorylation PRPsFDAsAsEEEEE Q9H4L4 S75-p Phosphorylation PsFDAsAsEEEEEEE Q9H4L4 S139-p Phosphorylation AFRMLLYsKstsLtF Q9H4L4 S141-p Phosphorylation RMLLYsKstsLtFHW Q9H4L4 T142-p Phosphorylation MLLYsKstsLtFHWK Q9H4L4 S143-p Phosphorylation LLYsKstsLtFHWKL Q9H4L4 T145-p Phosphorylation YsKstsLtFHWKLWG Q9H4L4 S169-p Phosphorylation AHPKNHLsPQQGGAt Q9H4L4 T176-p Phosphorylation sPQQGGAtPQVPsPC Q9H4L4 S181-p Phosphorylation GAtPQVPsPCCRFDs Q9H4L4 S188-p Phosphorylation sPCCRFDsPrGPPPP Q9H4L4 S212-p Phosphorylation AEDGVRGsPPVPsGP Q9H4L4 S217-p Phosphorylation RGsPPVPsGPPMEED Q9H4L4 T229-p Phosphorylation EEDGLRWtPksPLDP Q9H4L4 S232-p Phosphorylation GLRWtPksPLDPDsG Q9H4L4 S238-p Phosphorylation ksPLDPDsGLLsCTL Q9H4L4 S242-p Phosphorylation DPDsGLLsCTLPNGF Q9H4L4 S307-p Phosphorylation GEKAGQHsPLREEHV Q9H4L4 T353-p Phosphorylation IFQQEFStPSRKGLV Q9H4L4 T477-p Phosphorylation SVDVRRRtITYFDsQ Q9H4L4 S483-p Phosphorylation RtITYFDsQRTLNRR Q9H4L4 Y498-p Phosphorylation CPKHIAKyLQAEAVK Q9H4L4 K43-ub Ubiquitination PPPKPRLksGGGFGP Q9H4L4 K231-ub Ubiquitination DGLRWtPksPLDPDs Q9H4L4 K446-ub Ubiquitination DGVKRWTkNVDIFNK

PTM - dbPTM UniProt ID Position Code Type Resources References Q9H4L4 73 S Phosphorylation Swiss-Prot 1010711 18691976 Q9H4L4 75 S Phosphorylation Swiss-Prot 1010711 18691976 Q9H4L4 169 S Phosphorylation Swiss-Prot 1010711 17081983;18220336;18669648;18691976;19413330 Q9H4L4 176 T Phosphorylation Swiss-Prot 1010711 18669648 Q9H4L4 181 S Phosphorylation Swiss-Prot 1010711 18220336;18669648;18691976;19413330 Q9H4L4 188 S Phosphorylation Swiss-Prot 1010711 18669648 Q9H4L4 212 S Phosphorylation Swiss-Prot 1010711 18669648;18691976;19007248;19690332 Q9H4L4 232 S Phosphorylation Swiss-Prot 1010711 17081983;18691976 Q9H4L4 253 S Phosphorylation Swiss-Prot 1010711 19007248 Q9H4L4 307 S Phosphorylation Swiss-Prot 1010711 18691976 Q9H4L4 353 T Phosphorylation Swiss-Prot 1010711 16565220 Q9H4L4 25 S Phosphorylation PhosphoELM.10011 18220336 Q9H4L4 169 S Phosphorylation PhosphoELM.10011 18669648;18220336;17081983 Q9H4L4 181 S Phosphorylation PhosphoELM.10011 18669648;18220336 Q9H4L4 188 S Phosphorylation PhosphoELM.10011 18669648 Q9H4L4 212 S Phosphorylation PhosphoELM.10011 18669648 Q9H4L4 232 S Phosphorylation PhosphoELM.10011 18669648;17081983 Q9H4L4 242 S Phosphorylation PhosphoELM.10011 18669648 Q9H4L4 176 T Phosphorylation PhosphoELM.10011 18669648 Q9H4L4 229 T Phosphorylation PhosphoELM.10011 18669648 Q9H4L4 353 T Phosphorylation PhosphoELM.10011 18669648;16565220 Q9H4L4 43 K Ubiquitylation Phosphositeplus.1010730 21890473 Q9H4L4 446 K Ubiquitylation Phosphositeplus.1010730 21890473 Q9H4L4 169 S Phosphorylation Phosphositeplus.1010730 18220336;18491316;18669648;18691976;19276368;19664994;20068231;20164059;20363803;21406692;21659604;22115753 Q9H4L4 181 S Phosphorylation Phosphositeplus.1010730 18220336;18669648;18691976;19276368;19664994;22115753 Q9H4L4 188 S Phosphorylation Phosphositeplus.1010730 18669648 Q9H4L4 212 S Phosphorylation Phosphositeplus.1010730 18669648;18691976;19690332;19691289 Q9H4L4 232 S Phosphorylation Phosphositeplus.1010730 18691976;19276368;19690332;20068231;21406692;21659604;22115753 Q9H4L4 242 S Phosphorylation Phosphositeplus.1010730 18669648 Q9H4L4 25 S Phosphorylation Phosphositeplus.1010730 18220336;19276368;19664995 Q9H4L4 26 S Phosphorylation Phosphositeplus.1010730 19664995 Q9H4L4 307 S Phosphorylation Phosphositeplus.1010730 18691976;21406692 Q9H4L4 73 S Phosphorylation Phosphositeplus.1010730 18691976 Q9H4L4 75 S Phosphorylation Phosphositeplus.1010730 18691976 Q9H4L4 176 T Phosphorylation Phosphositeplus.1010730 18669648;19276368 Q9H4L4 229 T Phosphorylation Phosphositeplus.1010730 19276368 Q9H4L4 353 T Phosphorylation Phosphositeplus.1010730 16565220;18669648;21659604 Q9H4L4 24 Y Phosphorylation Phosphositeplus.1010730 19664995 Q9H4L4 25 S Phosphorylation HPRD 9.0 19664995 Q9H4L4 26 S Phosphorylation HPRD 9.0 19664995 Q9H4L4 73 S Phosphorylation HPRD 9.0 18691976 Q9H4L4 75 S Phosphorylation HPRD 9.0 18691976 Q9H4L4 169 S Phosphorylation HPRD 9.0 17081983,18669648,18691976,18491316,19664994,20068231 Q9H4L4 181 S Phosphorylation HPRD 9.0 18669648,18691976,19664994,20068231 Q9H4L4 188 S Phosphorylation HPRD 9.0 18669648 Q9H4L4 212 S Phosphorylation HPRD 9.0 18669648,18691976,19007248,19691289 Q9H4L4 232 S Phosphorylation HPRD 9.0 17081983,18669648,18691976,19651622,18452278,20068231 Q9H4L4 242 S Phosphorylation HPRD 9.0 18669648 Q9H4L4 253 S Phosphorylation HPRD 9.0 19007248 Q9H4L4 307 S Phosphorylation HPRD 9.0 18691976 Q9H4L4 176 T Phosphorylation HPRD 9.0 18669648 Q9H4L4 229 T Phosphorylation HPRD 9.0 18669648 Q9H4L4 353 T Phosphorylation HPRD 9.0 16565220,18669648,20068231 Q9H4L4 24 Y Phosphorylation HPRD 9.0 19664995 Q9H4L4 73 S Phosphorylation SysPTM 1.1 18691976 Q9H4L4 75 S Phosphorylation SysPTM 1.1 18691976 Q9H4L4 169 S Phosphorylation SysPTM 1.1 18691976;18669648;17081983;18491316 Q9H4L4 181 S Phosphorylation SysPTM 1.1 18691976;18669648 Q9H4L4 188 S Phosphorylation SysPTM 1.1 18669648 Q9H4L4 212 S Phosphorylation SysPTM 1.1 18691976;18669648 Q9H4L4 232 S Phosphorylation SysPTM 1.1 18691976;17081983 Q9H4L4 307 S Phosphorylation SysPTM 1.1 18691976 Q9H4L4 176 T Phosphorylation SysPTM 1.1 18669648 Q9H4L4 353 T Phosphorylation SysPTM 1.1 16565220

PTM - HPRD Symbol Position Code Type References SENP3 169 S Phosphorylation 17081983,18669648,18691976,18491316,19664994,20068231 SENP3 176 T Phosphorylation 18669648 SENP3 181 S Phosphorylation 18669648,18691976,19664994,20068231 SENP3 188 S Phosphorylation 18669648 SENP3 212 S Phosphorylation 18669648,18691976,19007248,19691289 SENP3 229 T Phosphorylation 18669648 SENP3 232 S Phosphorylation 17081983,18669648,18691976,19651622,18452278,20068231 SENP3 24 Y Phosphorylation 19664995 SENP3 242 S Phosphorylation 18669648 SENP3 25 S Phosphorylation 19664995 SENP3 253 S Phosphorylation 19007248 SENP3 26 S Phosphorylation 19664995 SENP3 307 S Phosphorylation 18691976 SENP3 353 T Phosphorylation 16565220,18669648,20068231 SENP3 73 S Phosphorylation 18691976 SENP3 75 S Phosphorylation 18691976

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q9H4L4 232 S 18669648 HTP Phosphorylation Q9H4L4 232 S 17081983 HTP Phosphorylation Q9H4L4 229 T 18669648 HTP Phosphorylation Q9H4L4 353 T 18669648 HTP Phosphorylation Q9H4L4 353 T 16565220 HTP Phosphorylation Q9H4L4 242 S 18669648 HTP Phosphorylation Q9H4L4 176 T 18669648 HTP Phosphorylation Q9H4L4 169 S 18669648 HTP Phosphorylation Q9H4L4 169 S 18220336 HTP Phosphorylation Q9H4L4 169 S 17081983 HTP Phosphorylation Q9H4L4 212 S 18669648 HTP Phosphorylation Q9H4L4 188 S 18669648 HTP Phosphorylation Q9H4L4 25 S 18220336 HTP Phosphorylation Q9H4L4 181 S 18669648 HTP Phosphorylation Q9H4L4 181 S 18220336 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q9H4L4 54 Phosphoserine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type SENP3 IPI00171525 S 169 HPKNHLpSPQQGGA phosphorylation SENP3 IPI00171525 S 181 ATPQVPpSPCCRFD phosphorylation SENP3 IPI00171525 S 212 EDGVRGpSPPVPSG phosphorylation SENP3 IPI00171525 S 232 LRWTPKpSPLDPDS phosphorylation SENP3 IPI00171525 S 307 EKAGQHpSPLREEH phosphorylation SENP3 IPI00171525 S 355 QEFSTPpSRKGLVL phosphorylation SENP3 IPI00171525 S 73 RPSFDApSASEEEE phosphorylation SENP3 IPI00171525 S 75 SFDASApSEEEEEE phosphorylation SENP3 IPI00171525 T 176 PQQGGApTPQVPSP phosphorylation SENP3 IPI00171525 T 353 FQQEFSpTPSRKGL phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 26168 117594 - K Ubiquitination 20924358 26168 117594 - K Ubiquitination 21139048 26168 117594 - K Ubiquitination 21890473 26168 117594 - K Ubiquitination 18948745 26168 117594 - K Ubiquitination 22505724 26168 117594 - K Ubiquitination 24816145 26168 117594 - K Sumoylation 25027693 26168 117594 - K Ubiquitination 25147182 26168 117594 - K Ubiquitination 19680224 26168 117594 - K Neddylation 18247557

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID SENP3 Homo sapiens (Human) 445; 43 "445,GVKRWTKNVDIFN; 43,PPKPRLKSGGGFG" 445:21890473; 43:21890473 SENP3 Homo sapiens (Human) 446; 43 "446,GVKRWTKNVDIFN; 43,PPKPRLKSGGGFG" 446:21890473; 43:21890473