Disease associated variation - GWASdb Chr Pos SNP ID(dbSNP 142) Ref Alt Ori SNP ID P-value Drug Name Drug Anno GWAS Trait HPO ID DO ID AA Type Trait or Drug 1 55546696 rs17111584 T C rs17111584 5.80E-04 ROSUVASTATIN FLUOROBENZENES|CHOLESTEROL, LDL|PYRIMIDINES|SULFONAMIDES|ANTICHOLESTEREMIC AGENTS Response to statin therapy (LDL-C) HPOID:0001677 DOID:3393|DOID:1936 T intron GWASdb_drug 1 55590465 rs17111652 C T rs17111652 9.36E-05 HYDROCHLOROTHIAZIDE|CANDESARTAN EPITHELIAL SODIUM CHANNELS|DIURETICS|ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS|BENZIMIDAZOLES|GPR83 PROTEIN, HUMAN|TETRAZOLES|RECEPTORS, G-PROTEIN-COUPLED|SCNN1G PROTEIN, HUMAN Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy) HPOID:0000847 DOID:10763 C intron GWASdb_drug 1 55537198 rs17111568 G A rs17111568 1.74E-04 Multiple complex diseases HPOID:0000118 NA G intron GWASdb_trait 1 55546696 rs17111584 T C rs17111584 5.80E-04 Response to statin therapy (LDL-C) HPOID:0001677 DOID:3393|DOID:1936 T intron GWASdb_trait 1 55546895 rs683880 T C rs683880 5.67E-04 Substance dependence HPOID:0000707 DOID:9973 T intron GWASdb_trait 1 55590465 rs17111652 C T rs17111652 9.36E-05 Response to angiotensin II receptor blocker therapy (opposite direction w/ diuretic therapy) HPOID:0000847 DOID:10763 C intron GWASdb_trait 1 55591283 rs17111657 C A rs17111657 8.89E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 A intron GWASdb_trait 1 55625548 rs17111684 C T rs17111684 2.00E-17 LDL cholesterol HPOID:0010979 DOID:1936|DOID:3393 C intron GWASdb_trait 1 55627525 rs17111689 C G rs17111689 5.07E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 C intron GWASdb_trait 1 55653588 rs1115058 C T rs1115058 8.79E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 G intron GWASdb_trait 1 55662680 rs4926670 C T rs4926670 3.07E-05 LDL lipoproteins HPOID:0003119|HPOID:0002621 DOID:1936 C intron GWASdb_trait 1 55670896 rs6671533 G C rs6671533 3.94E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 G intron GWASdb_trait 1 55673420 rs6703366 T G rs6703366 6.08E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 T intron GWASdb_trait

Disease associated variation - GWAS Central Study Name Source Marker Accession Chromosome Marker Start Marker Stop Alleles Gene Section P-value -log(p-value) GWAS of prostate cancer rs1165237 1 55599219 55599219 intronic 0.955671 0.0196915925316486 GWAS of prostate cancer rs6703366 1 55673420 55673420 intronic 0.945832 0.0241859967402109 GWAS of prostate cancer rs497159 1 55553554 55553554 intronic 0.944231 0.0249217453706261 GWAS of prostate cancer rs1165222 1 55638075 55638075 exonic 0.940165 0.0267959205481043 GWAS of prostate cancer rs4926670 1 55662680 55662680 intronic 0.79218 0.10117612633374899 GWAS of prostate cancer rs12130799 1 55663372 55663372 intronic 0.759718 0.119347583733841 GWAS of prostate cancer rs17111584 1 55546696 55546696 intronic 0.310802 0.507516195192329 GWAS of prostate cancer rs287234 1 55666520 55666520 intronic 0.255812 0.592079086864613 GWAS of prostate cancer rs1165284 1 55557067 55557067 intronic 0.214528 0.668516016057874 GWAS of prostate cancer rs487230 1 55541174 55541174 exonic 0.188009 0.7258213605406709 GWAS of prostate cancer rs1024305 1 55630204 55630204 intronic 0.186751 0.728737063979396 GWAS of prostate cancer rs1165221 1 55637620 55637620 intronic 0.185924 0.7306645457052081 GWAS of prostate cancer rs1165238 1 55646006 55646006 intronic 0.175864 0.754823053103478 GWAS of prostate cancer rs1165226 1 55608005 55608005 intronic 0.173196 0.761462142330149 GWAS of prostate cancer rs17111652 1 55590465 55590465 intronic 0.125721 0.9005921732100199

Disease associated variation - OMIM Ensembl_gene_ID Approved Gene Symbol MIM Number ENSG00000162402.13 USP24 610569