PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus FAAP100 FAAP20 22705371,22343915 biogrid exp GP G G G G G G G GP G GP GP G G G GP G G GP G GP GP GP G GP G GP G G FAAP20 FANCD2 22266823 dip exp G G GP G G GP G GP P GP G GP G UBC FAAP20 22705371,22343915,25414354,25799058 biogrid exp GP G G G G G G G GP G GP GP G G G GP G G GP G GP GP GP G GP G GP G G CEP170 FAAP20 26638075 biogrid,intact exp GP G G G G G G G GP G GP GP G G G GP G G GP G GP GP GP G GP G GP G G FANCA FAAP20 22705371,22343915,22396592,24910428,22266823 biogrid,dip exp G G G G G G G G G G G G G G G G G G G G G G G FANCC FAAP20 22343915,22266823 biogrid,dip exp GP G G G G G G G GP G GP GP G G G GP G G GP G GP GP GP G GP G GP G G FAAP20 FANCB 22705371,22343915 biogrid exp P G G P G P P P P G GP P P P P G FAAP20 FANCL 22705371,22343915,24910428 biogrid exp GP G G G G G G G GP G GP GP G G G GP G G GP G GP GP GP G GP G GP G G FAAP20 FANCI 26496610 biogrid,intact exp GP G G G G GP G GP GP G G GP G G P G GP GP GP GP G GP G G FAAP20 REV1 26318859,22266823 biogrid,intact exp GP G G G G G G G GP G GP GP G G G GP G G GP G GP GP GP G GP G GP G G FAAP20 FANCF 22705371,22343915 biogrid exp G G G G G G G G G G G G G G G G G G G G G G FAAP20 FANCE 22343915,22266823 biogrid,dip exp GP G G G P P G G G GP G G GP G GP GP GP G GP G P G G UBA52 FAAP20 22266823 dip exp GP G G G G G G G GP G GP GP G G G GP G G GP G GP GP GP G GP G GP G G FAAP20 APITD1 22705371 biogrid exp SOD1 FAAP20 26496610 biogrid,intact exp GP G G G G G G G GP G GP GP G G G GP G G GP G GP GP GP G GP G GP G G FANCG FAAP20 22705371,22343915 biogrid exp G G G G G G G G GP G GP G G G G GP G G GP G GP GP GP G GP G GP G G FAAP20 FANCM 22705371,22343915 biogrid exp G G G G G G G G G G G G G G G FAAP20 FAAP24 22705371 biogrid exp GP G G G G G G G GP G GP GP G G G GP G G GP G GP GP GP G GP G GP G G FAAP20 GAR1 26496610 biogrid,intact exp GP G G G G G G G GP G GP GP G G G GP G G GP G GP GP GP G GP G GP G G ELAVL1 FAAP20 19322201 biogrid exp GP G G G G G G G GP G GP GP G G G GP G G GP G GP GP GP G GP G GP G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6NZ36 Q7CLA7 two hybrid pooling approach 20711500 physical association X 2 Q81K51 Q6NZ36 two hybrid pooling approach 20711500 physical association X 2 Q8ZDJ2 Q6NZ36 two hybrid pooling approach 20711500 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality FANCA FAAP20 22266823,22266823,22705371,22266823 0096,0007,0004,0004 LC SOD1 FAAP20 26496610 0007 HT UBC FAAP20 22266823,22705371 0096,0004 LC CEP170 FAAP20 26638075 1314 HT FAAP20 FANCI 26496610 0007 HT FAAP20 GAR1 26496610 0007 HT SOD1 FAAP20 26496610 0007 HT CEP170 FAAP20 26638075 1314 HT FAAP20 FANCI 26496610 0007 HT FAAP20 GAR1 26496610 0007 HT FANCA FAAP20 22266823,22266823,22705371,22266823 0096,0007,0004,0004 LC UBC FAAP20 22266823,22705371 0096,0004 LC UBA52 FAAP20 25414354 0114 LC FAAP20 REV1 26318859 0077 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q6NZ36 Q0VG06 FAAP20 FAAP100 0.396 22705371,22343915 Q9NVI1 Q6NZ36 FANCI FAAP20 0.126 26496610 Q9NW38 Q6NZ36 FANCL FAAP20 0.472 24910428,22705371,22343915 Q9NY12 Q6NZ36 GAR1 FAAP20 0.126 26496610 Q9BTP7 Q6NZ36 FAAP24 FAAP20 0.21 22705371 Q8N2Z9 Q6NZ36 APITD1 FAAP20 0.21 22705371 Q7CLA7 Q6NZ36 Q7CLA7 FAAP20 0.126 20711500 Q81K51 Q6NZ36 Q81K51 FAAP20 0.126 20711500 Q6P5D4 Q6NZ36 CEP135 FAAP20 0.126 26496610 Q6NZ36 P00441 FAAP20 SOD1 0.126 26496610 Q9NQX1 Q6NZ36 PRDM5 FAAP20 0.236 unassigned1304 Q9UBZ9 Q6NZ36 REV1 FAAP20 0.702 22266823,26318859 Q9UJW9 Q6NZ36 SERTAD3 FAAP20 0.236 unassigned1304 Q8NI38 Q6NZ36 NFKBID FAAP20 0.236 unassigned1304 Q96NS8 Q6NZ36 CLUHP3 FAAP20 0.236 unassigned1304 Q9GZU7 Q6NZ36 CTDSP1 FAAP20 0.236 unassigned1304 Q6NZ36 A4D127 FAAP20 MEOX2 {ECO:0000313|EMBL:EAL24289.1} 0.236 unassigned1304 Q6NZ36 O15287 FAAP20 FANCG 0.561 22705371,22343915 Q6NZ36 Q0VD86 FAAP20 INCA1 0.236 unassigned1304 Q6NZ36 Q04864 FAAP20 REL 0.236 unassigned1304 Q6NZ36 Q5SW79 FAAP20 CEP170 0.236 26638075 Q6NZ36 A0A087WVE9 FAAP20 ARNT2 {ECO:0000313|ENSEMBL:ENSP00000479393} 0.236 unassigned1304 Q6NZ36 A6NEM1 FAAP20 GOLGA6L9 {ECO:0000312|HGNC:HGNC:37229} 0.236 unassigned1304 Q6NZ36 O43186 FAAP20 CRX 0.236 unassigned1304 Q6NZ36 O76011 FAAP20 KRT34 0.236 unassigned1304 Q6NZ36 P25791 FAAP20 LMO2 0.236 unassigned1304 Q6NZ36 P80188 FAAP20 LCN2 0.236 unassigned1304 Q6NZ36 Q00597 FAAP20 FANCC 0.309 22343915,22266823 Q8IWF7 Q6NZ36 UBE2DNL FAAP20 0.236 unassigned1304 Q8IYD8 Q6NZ36 FANCM FAAP20 0.309 22705371,22343915 Q8IYF3 Q6NZ36 TEX11 FAAP20 0.236 unassigned1304 Q8NB91 Q6NZ36 FANCB FAAP20 0.309 22705371,22343915 Q96D03 Q6NZ36 DDIT4L FAAP20 0.236 unassigned1304 Q99471 Q6NZ36 PFDN5 FAAP20 0.236 unassigned1304 Q9HB96 Q6NZ36 FANCE FAAP20 0.309 22343915,22266823 Q9NPI8 Q6NZ36 FANCF FAAP20 0.309 22705371,22343915 Q9UHV2 Q6NZ36 SERTAD1 FAAP20 0.236 unassigned1304 Q8IUC2 Q6NZ36 KRTAP8-1 FAAP20 0.236 unassigned1304 Q6NZ36 O15360 FAAP20 FANCA 0.936 24910428,25751062,22343915,22266823,22396592,22705371 Q6NZ36 P0CG48 FAAP20 UBC 0.872 22343915,25799058,25414354,26318859 Q8ZDJ2 Q6NZ36 Q8ZDJ2 FAAP20 0.126 20711500 Q921T2 Q6NZ36 TOR1AIP1 FAAP20 0.126 26496610 Q9QY36 Q6NZ36 NAA10 FAAP20 0.126 26496610 Q6NZ36 Q15717 FAAP20 ELAVL1 0.126 19322201 Q6NZ36 O08901 FAAP20 BUB1 0.126 26496610

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 STRA13 FAAP20 MI:0362 inference MI:1106 pathways database FANCG FAAP20 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FANCA FAAP20 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database BUB1 FAAP20 MI:0362 inference MI:0461 interaction database USP1 FAAP20 MI:0362 inference MI:1106 pathways database SOD1 FAAP20 MI:0045 experimental interaction detection MI:0461 interaction database ERCC1 FAAP20 MI:0362 inference MI:1106 pathways database UBB FAAP20 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBC FAAP20 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RPA2 FAAP20 MI:0362 inference MI:1106 pathways database RPA1 FAAP20 MI:0362 inference MI:1106 pathways database RPA3 FAAP20 MI:0362 inference MI:1106 pathways database NAA10 FAAP20 MI:0362 inference MI:0461 interaction database RPS27A FAAP20 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBA52 FAAP20 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database FANCC FAAP20 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FAAP100 FAAP20 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ATR FAAP20 MI:0362 inference MI:1106 pathways database ELAVL1 FAAP20 MI:0045 experimental interaction detection MI:0461 interaction database TOR1AIP1 FAAP20 MI:0362 inference MI:0461 interaction database CEP170 FAAP20 MI:0045 experimental interaction detection MI:0461 interaction database CEP135 FAAP20 MI:0362 inference MI:0461 interaction database FAAP20 DCLRE1A MI:0362 inference MI:1106 pathways database FAAP20 POLN MI:0362 inference MI:1106 pathways database FAAP20 SLX4 MI:0362 inference MI:1106 pathways database FAAP20 FANCM MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FAAP20 APITD1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FAAP20 FANCB MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FAAP20 ATRIP MI:0362 inference MI:1106 pathways database FAAP20 ERCC4 MI:0362 inference MI:1106 pathways database FAAP20 EME1 MI:0362 inference MI:1106 pathways database FAAP20 MUS81 MI:0362 inference MI:1106 pathways database FAAP20 SLX1A MI:0362 inference MI:1106 pathways database FAAP20 FAAP24 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FAAP20 FANCD2 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database FAAP20 FANCE MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FAAP20 UBE2T MI:0362 inference MI:1106 pathways database FAAP20 FANCF MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FAAP20 FANCI MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FAAP20 FANCL MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FAAP20 GAR1 MI:0045 experimental interaction detection MI:0461 interaction database FAAP20 REV1 MI:0045 experimental interaction detection MI:0461 interaction database FAAP20 FAN1 MI:0362 inference MI:1106 pathways database FAAP20 ZBTB32 MI:0362 inference MI:1106 pathways database