PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RNF149 TMEM231 26186194 biogrid exp GP GP G GP G GP GP G GP P GP G P GP G P G GP P P GP GP GP G BTNL8 RNF149 26186194 biogrid exp P G G P P P P P GP P P P GP P P TSPAN3 RNF149 26186194 biogrid exp G GP G G G GP G GP GP G GP G GP G G GP GP G GP G G G GP G GP G GP GP G RNF149 TSPAN17 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TNFRSF10B RNF149 26186194 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G G GP GP GP GP G GP GP G HEPACAM2 RNF149 26186194 biogrid exp P G G P P GP GP P P G GP P GP G P GP GP GP RNF149 PRRG3 26186194 biogrid exp G P G GP G GP GP G P P G P GP GP P G GP GP P G GP P G RNF149 AGO2 17932509 intact exp GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G G GP GP GP GP G GP GP G RNF149 GINM1 26186194 biogrid exp GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G G G GP GP GP G GP GP G ELAVL1 RNF149 19322201 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G G GP GP GP GP G GP GP G RNF149 TMEM30A 26186194 biogrid exp G GP G G G GP G GP GP G GP GP GP G G GP GP G G G G GP GP GP GP G GP GP G ACVR1 RNF149 26186194 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G G GP G GP GP G GP GP G BRAF RNF149 22628551 biogrid exp GP GP G G G GP G GP GP G GP GP GP G P GP GP GP G G GP GP GP P G GP GP G PLCG2 RNF149 23023127 pred G GP G G G GP G GP GP G GP G GP G G GP GP GP G G G G G GP GP G GP GP G HCLS1 RNF149 23023127 pred G G G G G GP G G G G G G GP G G G GP G G G G G G G G G G G G RNF149 SAMSN1 23023127 pred G GP G G P G P GP P P GP G GP GP P P P GP G GP P CUL4A RNF149 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MYL12A RNF149 23023127 pred P P P P P P PRKCD RNF149 23023127 pred GP GP G G G GP G GP GP GP P GP G G GP GP GP GP G GP GP P GP G GP GP G SASH3 RNF149 23023127 pred GP G G G G GP G G GP G G G GP G G G GP G GP G G GP GP G G G GP GP G S100A11 RNF149 23023127 pred GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G G GP GP G GP G GP G G UBE2D3 RNF149 23023127 pred GP G G G G GP G G GP G GP GP GP G G G GP GP GP G G GP G GP G G GP GP G RNF149 TRIM6 23023127 pred G GP G G G GP GP G G G G G G G G G G G G GP G RNF149 UBE2F 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G G GP GP GP GP G GP GP G RNF149 TRIM56 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G G GP G P GP G GP GP G RNF149 UXT 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G G GP GP GP GP G GP GP G UBE2D2 RNF149 23023127 pred GP G G G G GP G G GP G GP GP GP G G G GP GP GP G G GP G GP G G GP GP G PLAU RNF149 23023127 pred G G G G P G G GP GP GP G G GP GP GP GP G G GP G G GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8NC42 P15056 affinity chromatography technology 22628551 physical association X 2 P0CG48 Q8NC42 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q8NC42 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q8NC42 affinity chromatography technology 25147182 physical association X 2 P0CG48 Q8NC42 affinity chromatography technology 21987572 physical association X 2 P0CG48 Q8NC42 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q8NC42 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q8NC42 affinity chromatography technology 21906983 physical association X 2 Q81LA6 Q8NC42 two hybrid pooling approach 20711500 physical association X 2 Q8NC42 anti tag coimmunoprecipitation 17932509 association C 68 Q5NGW4 Q8NC42 two hybrid pooling approach 20711500 physical association X 2 P17778 Q8NC42 two hybrid pooling approach 20711500 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality HEPACAM2 RNF149 26186194 0004 HT TSPAN3 RNF149 26186194 0004 HT ACVR1 RNF149 26186194 0004 HT BTNL8 RNF149 26186194 0004 HT DKFZP686A24188 RNF149 26186194 0004 HT RNF149 TSPAN17 26186194 0004 HT RNF149 PRRG3 26186194 0004 HT RNF149 TMEM231 26186194 0004 HT RNF149 GINM1 26186194 0004 HT RNF149 TMEM30A 26186194 0004 HT HEPACAM2 RNF149 26186194 0004 HT TSPAN3 RNF149 26186194 0004 HT ACVR1 RNF149 26186194 0004 HT BTNL8 RNF149 26186194 0004 HT DKFZP686A24188 RNF149 26186194 0004 HT RNF149 TSPAN17 26186194 0004 HT RNF149 PRRG3 26186194 0004 HT RNF149 TMEM231 26186194 0004 HT RNF149 GINM1 26186194 0004 HT RNF149 TMEM30A 26186194 0004 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8NC42 O14763 RNF149 TNFRSF10B 0.126 26186194 Q8NC42 Q5NGW4 RNF149 TDH 0.126 20711500 Q8NC42 Q04771 RNF149 ACVR1 0.126 26186194 Q8NC42 Q81LA6 RNF149 Q81LA6 0.126 20711500 Q8NC42 O60637 RNF149 TSPAN3 0.126 26186194 Q9H6L2 Q8NC42 TMEM231 RNF149 0.126 26186194 Q9NU53 Q8NC42 GINM1 RNF149 0.126 26186194 Q9NV96 Q8NC42 TMEM30A RNF149 0.126 26186194 Q8NC42 Q6UX41 RNF149 BTNL8 0.126 26186194 Q8NC42 P0CK58 RNF149 P0CK58 0.126 22810586 Q96FV3 Q8NC42 TSPAN17 RNF149 0.126 26186194 Q9BZD7 Q8NC42 PRRG3 RNF149 0.126 26186194 Q9UKV8 Q8NC42 AGO2 RNF149 0.126 17932509 Q8NC42 P17778 RNF149 YOPM 0.126 20711500 Q8NC42 P15056 RNF149 BRAF 0.21 22628551 Q8NC42 Q15717 RNF149 ELAVL1 0.126 19322201 Q8NC42 A8MVW5 RNF149 HEPACAM2 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 HEPACAM2 RNF149 MI:0045 experimental interaction detection MI:0461 interaction database TNFRSF10B RNF149 MI:0045 experimental interaction detection MI:0461 interaction database TSPAN3 RNF149 MI:0045 experimental interaction detection MI:0461 interaction database UBC RNF149 MI:0045 experimental interaction detection MI:0461 interaction database BRAF RNF149 MI:0045 experimental interaction detection MI:0461 interaction database ACVR1 RNF149 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 RNF149 MI:0045 experimental interaction detection MI:0461 interaction database BTNL8 RNF149 MI:0045 experimental interaction detection MI:0461 interaction database RNF149 TSPAN17 MI:0045 experimental interaction detection MI:0461 interaction database RNF149 PRRG3 MI:0045 experimental interaction detection MI:0461 interaction database RNF149 TMEM231 MI:0045 experimental interaction detection MI:0461 interaction database RNF149 GINM1 MI:0045 experimental interaction detection MI:0461 interaction database RNF149 TMEM30A MI:0045 experimental interaction detection MI:0461 interaction database RNF149 AGO2 MI:0045 experimental interaction detection MI:0461 interaction database