PTM - CPLM Gene Name UniProt ID Type Position Code RNF25 Q96BH1 Ubiquitination 334 K RNF25 Q96BH1 Ubiquitination 341 K RNF25 Q96BH1 Ubiquitination 120 K RNF25 Q96BH1 Ubiquitination 456 K RNF25 Q96BH1 Ubiquitination 364 K RNF25 Q96BH1 Ubiquitination 356 K RNF25 Q96BH1 Ubiquitination 318 K RNF25 Q96BH1 Ubiquitination 386 K

PTM - dbPAF Gene Name UniProt ID Position Type Species RNF25 Q96BH1 295 S Homo sapiens(Human) RNF25 Q96BH1 296 T Homo sapiens(Human) RNF25 Q96BH1 297 S Homo sapiens(Human) RNF25 Q96BH1 302 S Homo sapiens(Human) RNF25 Q96BH1 303 T Homo sapiens(Human) RNF25 Q96BH1 391 S Homo sapiens(Human) RNF25 Q96BH1 405 S Homo sapiens(Human) RNF25 Q96BH1 432 Y Homo sapiens(Human) RNF25 Q96BH1 442 Y Homo sapiens(Human) RNF25 Q96BH1 450 S Homo sapiens(Human) RNF25 Q96BH1 455 S Homo sapiens(Human) RNF25 Q96BH1 459 S Homo sapiens(Human) RNF25 Q96BH1 90 S Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type RNF25 rs11686957 CGC->TGC R->C 432 Y GRTPGSSYPRLPRGQ 432 Phosphorylation TypeIII- RNF25 rs59377638 CGG->TGG R->W 432 Y GRTPGSSYPRLPRGQ 432 Phosphorylation TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q96BH1 K213-ac Acetylation VYDLASLkAAPEPQQ Q96BH1 R348-m1 Methylation kPSRGPWrQPERRHP Q96BH1 R434-m1 Methylation TPGSSyPrLPrGQGA Q96BH1 R437-m1 Methylation SSyPrLPrGQGAyRP Q96BH1 S90-p Phosphorylation IRNPRGLsDEQIHTI Q96BH1 S297-p Phosphorylation LAAELSTsPAVQSTL Q96BH1 S391-p Phosphorylation DLkPEPHsQGVEGPP Q96BH1 S405-p Phosphorylation PQEKGPGsWQGPPPR Q96BH1 Y432-p Phosphorylation GRTPGSSyPrLPrGQ Q96BH1 Y442-p Phosphorylation LPrGQGAyRPGTRRE Q96BH1 S450-p Phosphorylation RPGTRREsLGLEskD Q96BH1 S455-p Phosphorylation REsLGLEskDGs___ Q96BH1 S459-p Phosphorylation GLEskDGs_______ Q96BH1 K120-ub Ubiquitination MLYELIEkGKEILTD Q96BH1 K318-ub Ubiquitination ATQHICEkIPGTRSN Q96BH1 K334-ub Ubiquitination QRLGETQkAMLDPPk Q96BH1 K341-ub Ubiquitination kAMLDPPkPSRGPWr Q96BH1 K356-ub Ubiquitination QPERRHPkGGECHAP Q96BH1 K364-ub Ubiquitination GGECHAPkGTRDTQE Q96BH1 K386-ub Ubiquitination LKEPMDLkPEPHsQG Q96BH1 K456-ub Ubiquitination EsLGLEskDGs____

PTM - dbPTM UniProt ID Position Code Type Resources References Q96BH1 450 S Phosphorylation Swiss-Prot 1010711 17924679 Q96BH1 120 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q96BH1 334 K Ubiquitylation Phosphositeplus.1010730 20639865;21890473;21906983 Q96BH1 341 K Ubiquitylation Phosphositeplus.1010730 16196087;20639865;21890473 Q96BH1 386 K Ubiquitylation Phosphositeplus.1010730 21906983 Q96BH1 456 K Ubiquitylation Phosphositeplus.1010730 21906983 Q96BH1 405 S Phosphorylation Phosphositeplus.1010730 16674116 Q96BH1 450 S Phosphorylation Phosphositeplus.1010730 20068231;22115753 Q96BH1 450 S Phosphorylation HPRD 9.0 17924679,18212344,20068231 Q96BH1 450 S Phosphorylation SysPTM 1.1 18212344 Q96BH1 341 K Ubiquitylation UbiProtDB 1.0 16196087

PTM - HPRD Symbol Position Code Type References RNF25 450 S Phosphorylation 17924679,18212344,20068231

PTM - UniProt UniProt ID Position Type PMIDs Q96BH1 450 Phosphoserine 20068231;23186163

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 64320 122133 - K Ubiquitination 20639865 64320 122133 - K Ubiquitination 22118674 64320 122133 - K Ubiquitination 21987572 64320 122133 - K Ubiquitination 21139048 64320 122133 - K Ubiquitination 21890473 64320 122133 - K Ubiquitination 21906983 64320 122133 - K Ubiquitination 17203973 64320 122133 - K Ubiquitination 22053931 64320 122133 - K Ubiquitination 23000965 64320 122133 - K Ubiquitination 24816145

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID RNF25 Homo sapiens (Human) 341; 334; 120 "341,AMLDPPKPSRGPW; 334,RLGETQKAMLDPP; 120,LYELIEKGKEILT" 341:21890473; 334:21890473; 120:21890473 RNF25 Homo sapiens (Human) 356; 341; 456; 364; 334; 386; 120 "356,PERRHPKGGECHA; 341,AMLDPPKPSRGPW; 456,SLGLESKDGS; 364,GECHAPKGTRDTQ; 334,RLGETQKAMLDPP; 386,KEPMDLKPEPHSQ; 120,LYELIEKGKEILT" "356:22053931; 341:21890473,16196087,22053931; 456:21906983,22053931; 364:22053931; 334:21890473,21906983,22053931; 386:21906983; 120:21890473,21906983,21139048"