PTM - CPLM Gene Name UniProt ID Type Position Code WDFY3; KIAA0993 Q8IZQ1 Ubiquitination 1353 K WDFY3; KIAA0993 Q8IZQ1 Ubiquitination 521 K

PTM - dbPAF Gene Name UniProt ID Position Type Species WDFY3; KIAA0993 Q8IZQ1 1011 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 1015 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 1016 T Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 1020 T Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 1364 T Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 1648 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 1696 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 1699 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 17 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 1709 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 1940 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 1942 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 1944 Y Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 2083 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 2177 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 2184 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 2185 Y Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 2190 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 2277 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 2278 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 2283 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 234 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 241 T Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 2490 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 2492 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 262 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 271 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 2807 T Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 3305 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 3306 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 3307 T Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 3308 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 3319 T Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 3324 T Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 3326 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 3328 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 3335 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 3339 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 3500 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 3501 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 465 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 467 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 474 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 524 T Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 653 Y Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 779 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 81 T Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 813 Y Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 815 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 817 S Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 818 T Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 82 T Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 822 Y Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 963 Y Homo sapiens(Human) WDFY3; KIAA0993 Q8IZQ1 970 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q8IZQ1 R3472-m1 Methylation VRFSLTErRHHCRNC Q8IZQ1 S17-p Phosphorylation RPRQEECsPQDNALG Q8IZQ1 T81-p Phosphorylation FSDLLQFttQVSRLM Q8IZQ1 T82-p Phosphorylation SDLLQFttQVSRLMV Q8IZQ1 S234-p Phosphorylation YNLPWRKsAGEVLMt Q8IZQ1 T241-p Phosphorylation sAGEVLMtISRHGLS Q8IZQ1 S262-p Phosphorylation IHEKECLsTCVQNMQ Q8IZQ1 S271-p Phosphorylation CVQNMQQsDDLSPLE Q8IZQ1 S465-p Phosphorylation IPCKELIsVsILLKS Q8IZQ1 S467-p Phosphorylation CKELIsVsILLKSSs Q8IZQ1 S474-p Phosphorylation sILLKSSsSYHCSII Q8IZQ1 T524-p Phosphorylation AALLkDPtQALNEQG Q8IZQ1 Y653-p Phosphorylation RKVGGFVyITSLLVA Q8IZQ1 Y813-p Phosphorylation LSRKRHAyHsVstPP Q8IZQ1 S815-p Phosphorylation RKRHAyHsVstPPVy Q8IZQ1 S817-p Phosphorylation RHAyHsVstPPVyPP Q8IZQ1 T818-p Phosphorylation HAyHsVstPPVyPPK Q8IZQ1 Y822-p Phosphorylation sVstPPVyPPKNVAD Q8IZQ1 Y963-p Phosphorylation DKKLLKQyRVHKPSs Q8IZQ1 S970-p Phosphorylation yRVHKPSsLSYEPEM Q8IZQ1 T1020-p Phosphorylation EGSTVPLtRVKCLVS Q8IZQ1 T1364-p Phosphorylation ISSHENAtPVKLIHN Q8IZQ1 S1648-p Phosphorylation LLKLIYTsKEKTSIN Q8IZQ1 S1696-p Phosphorylation RILVVLLsNQsILIK Q8IZQ1 S1699-p Phosphorylation VVLLsNQsILIKFKE Q8IZQ1 S1709-p Phosphorylation IKFKEGLsGGGWLEQ Q8IZQ1 S1940-p Phosphorylation ADTGMNRsQsEyCNV Q8IZQ1 S1942-p Phosphorylation TGMNRsQsEyCNVGT Q8IZQ1 Y1944-p Phosphorylation MNRsQsEyCNVGTKT Q8IZQ1 S2083-p Phosphorylation IAQSKRRsQGLSLDA Q8IZQ1 S2177-p Phosphorylation TWHIMIPsDIEPDGs Q8IZQ1 S2184-p Phosphorylation sDIEPDGsySQDIsE Q8IZQ1 Y2185-p Phosphorylation DIEPDGsySQDIsEG Q8IZQ1 S2190-p Phosphorylation GsySQDIsEGRQLLI Q8IZQ1 S2277-p Phosphorylation QSKLSRVssGFGLsK Q8IZQ1 S2278-p Phosphorylation SKLSRVssGFGLsKL Q8IZQ1 S2283-p Phosphorylation VssGFGLsKLTGSRR Q8IZQ1 S2434-p Phosphorylation ARYRRAVsYDSKEYY Q8IZQ1 S2490-p Phosphorylation VKPPLKRsRsAPDGG Q8IZQ1 S2492-p Phosphorylation PPLKRsRsAPDGGDE Q8IZQ1 T2573-p Phosphorylation DGFTMTAtREIRDIE Q8IZQ1 T2807-p Phosphorylation LVRMEPFtQIFLRLQ Q8IZQ1 S3308-p Phosphorylation PSQPSSTsHRPRAAS Q8IZQ1 T3319-p Phosphorylation RAASCRAtAAWCtDs Q8IZQ1 T3324-p Phosphorylation RAtAAWCtDsGsDDS Q8IZQ1 S3326-p Phosphorylation tAAWCtDsGsDDSRR Q8IZQ1 S3328-p Phosphorylation AWCtDsGsDDSRRWs Q8IZQ1 S3335-p Phosphorylation sDDSRRWsDQLsLDE Q8IZQ1 S3339-p Phosphorylation RRWsDQLsLDEKDGF Q8IZQ1 S3501-p Phosphorylation IKRLKISsPVRVCQN Q8IZQ1 S3519-p Phosphorylation NLQHERGsEDGPRNC Q8IZQ1 K45-ub Ubiquitination PPRHMTQkEQEEKLY Q8IZQ1 K521-ub Ubiquitination HKYAALLkDPtQALN Q8IZQ1 K1353-ub Ubiquitination LDSKAIAkQLGISSH

PTM - dbPTM UniProt ID Position Code Type Resources References Q8IZQ1 653 Y Phosphorylation Swiss-Prot 1010711 17053785 Q8IZQ1 813 Y Phosphorylation Swiss-Prot 1010711 18669648 Q8IZQ1 815 S Phosphorylation Swiss-Prot 1010711 18669648 Q8IZQ1 817 S Phosphorylation Swiss-Prot 1010711 18669648 Q8IZQ1 818 T Phosphorylation Swiss-Prot 1010711 18669648 Q8IZQ1 822 Y Phosphorylation Swiss-Prot 1010711 18669648 Q8IZQ1 1696 S Phosphorylation Swiss-Prot 1010711 18187866 Q8IZQ1 1699 S Phosphorylation Swiss-Prot 1010711 18187866 Q8IZQ1 815 S Phosphorylation PhosphoELM.10011 18669648 Q8IZQ1 817 S Phosphorylation PhosphoELM.10011 18669648 Q8IZQ1 1011 S Phosphorylation PhosphoELM.10011 17081983 Q8IZQ1 2490 S Phosphorylation PhosphoELM.10011 18669648 Q8IZQ1 2492 S Phosphorylation PhosphoELM.10011 18669648 Q8IZQ1 818 T Phosphorylation PhosphoELM.10011 18669648 Q8IZQ1 813 Y Phosphorylation PhosphoELM.10011 18669648 Q8IZQ1 822 Y Phosphorylation PhosphoELM.10011 18669648 Q8IZQ1 1353 K Ubiquitylation Phosphositeplus.1010730 21890473 Q8IZQ1 45 K Ubiquitylation Phosphositeplus.1010730 21906983 Q8IZQ1 521 K Ubiquitylation Phosphositeplus.1010730 21906983 Q8IZQ1 1696 S Phosphorylation Phosphositeplus.1010730 18187866 Q8IZQ1 1699 S Phosphorylation Phosphositeplus.1010730 18187866 Q8IZQ1 2278 S Phosphorylation Phosphositeplus.1010730 20363803 Q8IZQ1 2490 S Phosphorylation Phosphositeplus.1010730 18669648 Q8IZQ1 262 S Phosphorylation Phosphositeplus.1010730 20562096 Q8IZQ1 271 S Phosphorylation Phosphositeplus.1010730 20562096 Q8IZQ1 3339 S Phosphorylation Phosphositeplus.1010730 19664994 Q8IZQ1 465 S Phosphorylation Phosphositeplus.1010730 19276368 Q8IZQ1 467 S Phosphorylation Phosphositeplus.1010730 19276368 Q8IZQ1 474 S Phosphorylation Phosphositeplus.1010730 19276368 Q8IZQ1 815 S Phosphorylation Phosphositeplus.1010730 18669648 Q8IZQ1 817 S Phosphorylation Phosphositeplus.1010730 18669648 Q8IZQ1 818 T Phosphorylation Phosphositeplus.1010730 18669648 Q8IZQ1 653 Y Phosphorylation Phosphositeplus.1010730 17053785 Q8IZQ1 813 Y Phosphorylation Phosphositeplus.1010730 18669648 Q8IZQ1 822 Y Phosphorylation Phosphositeplus.1010730 18669648 Q8IZQ1 779 S Phosphorylation HPRD 9.0 18452278 Q8IZQ1 815 S Phosphorylation HPRD 9.0 18669648 Q8IZQ1 817 S Phosphorylation HPRD 9.0 18669648 Q8IZQ1 1015 S Phosphorylation HPRD 9.0 17081983 Q8IZQ1 2277 S Phosphorylation HPRD 9.0 18691976 Q8IZQ1 2490 S Phosphorylation HPRD 9.0 18669648 Q8IZQ1 2492 S Phosphorylation HPRD 9.0 18669648 Q8IZQ1 3339 S Phosphorylation HPRD 9.0 19664994 Q8IZQ1 818 T Phosphorylation HPRD 9.0 18669648 Q8IZQ1 1016 T Phosphorylation HPRD 9.0 17081983 Q8IZQ1 1020 T Phosphorylation HPRD 9.0 17081983 Q8IZQ1 813 Y Phosphorylation HPRD 9.0 18669648 Q8IZQ1 822 Y Phosphorylation HPRD 9.0 18669648 Q8IZQ1 815 S Phosphorylation SysPTM 1.1 18669648 Q8IZQ1 817 S Phosphorylation SysPTM 1.1 18669648 Q8IZQ1 1015 S Phosphorylation SysPTM 1.1 17081983 Q8IZQ1 818 T Phosphorylation SysPTM 1.1 18669648 Q8IZQ1 1016 T Phosphorylation SysPTM 1.1 17081983 Q8IZQ1 1020 T Phosphorylation SysPTM 1.1 17081983 Q8IZQ1 813 Y Phosphorylation SysPTM 1.1 18669648 Q8IZQ1 822 Y Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References WDFY3 1015 S Phosphorylation 17081983 WDFY3 1016 T Phosphorylation 17081983 WDFY3 1020 T Phosphorylation 17081983 WDFY3 2277 S Phosphorylation 18691976 WDFY3 2490 S Phosphorylation 18669648 WDFY3 2492 S Phosphorylation 18669648 WDFY3 3339 S Phosphorylation 19664994 WDFY3 779 S Phosphorylation 18452278 WDFY3 813 Y Phosphorylation 18669648 WDFY3 815 S Phosphorylation 18669648 WDFY3 817 S Phosphorylation 18669648 WDFY3 818 T Phosphorylation 18669648 WDFY3 822 Y Phosphorylation 18669648 WDFY3 94 S Phosphorylation 19664994

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q8IZQ1 813 Y 18669648 HTP Phosphorylation Q8IZQ1 815 S 18669648 HTP Phosphorylation Q8IZQ1 2490 S 18669648 HTP Phosphorylation Q8IZQ1 822 Y 18669648 HTP Phosphorylation Q8IZQ1 817 S 18669648 HTP Phosphorylation Q8IZQ1 1011 S 17081983 HTP Phosphorylation Q8IZQ1 818 T 18669648 HTP Phosphorylation Q8IZQ1 2492 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q8IZQ1 2278 Phosphoserine 23186163 Q8IZQ1 3339 Phosphoserine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type WDFY3 IPI00218052 S 1011 SKSLVKpSAEGSTV phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 23001 116647 - K Ubiquitination 21139048 23001 116647 - K Ubiquitination 21890473 23001 116647 - K Ubiquitination 21906983

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID WDFY3 Homo sapiens (Human) 1353 "1353,DSKAIAKQLGISS" 1353:21890473 WDFY3 Homo sapiens (Human) 1353; 521; 45 "1353,DSKAIAKQLGISS; 521,KYAALLKDPTQAL; 45,PRHMTQKEQEEKL" 1353:21890473; 521:21906983; 45:21906983 WDFY3 Homo sapiens (Human) 1353; 521; 45 "1353,DSKAIAKQLGISS; 521,KYAALLKDPTQAL; 45,PRHMTQKEQEEKL" 1353:21890473; 521:21906983; 45:21906983 WDFY3 Homo sapiens (Human) 521; 45 "521,KYAALLKDPTQAL; 45,PRHMTQKEQEEKL" 521:21906983; 45:21906983 WDFY3 Homo sapiens (Human) 521; 45 "521,KYAALLKDPTQAL; 45,PRHMTQKEQEEKL" 521:21906983; 45:21906983