PTM - CPLM Gene Name UniProt ID Type Position Code DTX3L; BBAP Q8TDB6 Acetylation 25 K DTX3L; BBAP Q8TDB6 Ubiquitination 675 K DTX3L; BBAP Q8TDB6 Ubiquitination 709 K DTX3L; BBAP Q8TDB6 Ubiquitination 728 K DTX3L; BBAP Q8TDB6 Ubiquitination 653 K DTX3L; BBAP Q8TDB6 Ubiquitination 593 K DTX3L; BBAP Q8TDB6 Ubiquitination 228 K DTX3L; BBAP Q8TDB6 Ubiquitination 401 K DTX3L; BBAP Q8TDB6 Ubiquitination 316 K DTX3L; BBAP Q8TDB6 Ubiquitination 668 K DTX3L; BBAP Q8TDB6 Ubiquitination 408 K DTX3L; BBAP Q8TDB6 Ubiquitination 456 K DTX3L; BBAP Q8TDB6 Ubiquitination 672 K DTX3L; BBAP Q8TDB6 Ubiquitination 306 K DTX3L; BBAP Q8TDB6 Ubiquitination 543 K DTX3L; BBAP Q8TDB6 Ubiquitination 232 K DTX3L; BBAP Q8TDB6 Ubiquitination 503 K DTX3L; BBAP Q8TDB6 Ubiquitination 607 K DTX3L; BBAP Q8TDB6 Ubiquitination 337 K DTX3L; BBAP Q8TDB6 Ubiquitination 558 K DTX3L; BBAP Q8TDB6 Ubiquitination 300 K DTX3L; BBAP Q8TDB6 Ubiquitination 322 K DTX3L; BBAP Q8TDB6 Ubiquitination 331 K DTX3L; BBAP Q8TDB6 Ubiquitination 354 K DTX3L; BBAP Q8TDB6 Ubiquitination 519 K DTX3L; BBAP Q8TDB6 Ubiquitination 415 K DTX3L; BBAP Q8TDB6 Ubiquitination 556 K DTX3L; BBAP Q8TDB6 Ubiquitination 469 K DTX3L; BBAP Q8TDB6 Ubiquitination 363 K DTX3L; BBAP Q8TDB6 Ubiquitination 463 K DTX3L; BBAP Q8TDB6 Ubiquitination 95 K DTX3L; BBAP Q8TDB6 Ubiquitination 521 K DTX3L; BBAP Q8TDB6 Ubiquitination 356 K DTX3L; BBAP Q8TDB6 Ubiquitination 508 K DTX3L; BBAP Q8TDB6 Ubiquitination 423 K DTX3L; BBAP Q8TDB6 Ubiquitination 412 K DTX3L; BBAP Q8TDB6 Ubiquitination 253 K DTX3L; BBAP Q8TDB6 Ubiquitination 259 K

PTM - dbPAF Gene Name UniProt ID Position Type Species DTX3L; BBAP Q8TDB6 195 S Homo sapiens(Human) DTX3L; BBAP Q8TDB6 202 S Homo sapiens(Human) DTX3L; BBAP Q8TDB6 204 S Homo sapiens(Human) DTX3L; BBAP Q8TDB6 206 T Homo sapiens(Human) DTX3L; BBAP Q8TDB6 212 S Homo sapiens(Human) DTX3L; BBAP Q8TDB6 218 S Homo sapiens(Human) DTX3L; BBAP Q8TDB6 221 S Homo sapiens(Human) DTX3L; BBAP Q8TDB6 223 S Homo sapiens(Human) DTX3L; BBAP Q8TDB6 235 Y Homo sapiens(Human) DTX3L; BBAP Q8TDB6 248 Y Homo sapiens(Human) DTX3L; BBAP Q8TDB6 256 S Homo sapiens(Human) DTX3L; BBAP Q8TDB6 28 S Homo sapiens(Human) DTX3L; BBAP Q8TDB6 3 S Homo sapiens(Human) DTX3L; BBAP Q8TDB6 311 S Homo sapiens(Human) DTX3L; BBAP Q8TDB6 373 Y Homo sapiens(Human) DTX3L; BBAP Q8TDB6 385 Y Homo sapiens(Human) DTX3L; BBAP Q8TDB6 513 S Homo sapiens(Human) DTX3L; BBAP Q8TDB6 514 S Homo sapiens(Human) DTX3L; BBAP Q8TDB6 532 S Homo sapiens(Human) DTX3L; BBAP Q8TDB6 535 S Homo sapiens(Human) DTX3L; BBAP Q8TDB6 539 S Homo sapiens(Human) DTX3L; BBAP Q8TDB6 547 S Homo sapiens(Human) DTX3L; BBAP Q8TDB6 548 S Homo sapiens(Human) DTX3L; BBAP Q8TDB6 592 Y Homo sapiens(Human) DTX3L; BBAP Q8TDB6 603 Y Homo sapiens(Human) DTX3L; BBAP Q8TDB6 623 S Homo sapiens(Human) DTX3L; BBAP Q8TDB6 719 Y Homo sapiens(Human) DTX3L; BBAP Q8TDB6 721 Y Homo sapiens(Human) DTX3L; BBAP Q8TDB6 9 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q8TDB6 K25-ac Acetylation sGPRVRRkLEsYFQS Q8TDB6 K518-ac Acetylation GMssLAGkKLKEGHE Q8TDB6 S3-p Phosphorylation _____MAsHLRPPsP Q8TDB6 S9-p Phosphorylation AsHLRPPsPLLVRVy Q8TDB6 Y16-p Phosphorylation sPLLVRVyKsGPRVR Q8TDB6 S18-p Phosphorylation LLVRVyKsGPRVRRk Q8TDB6 S28-p Phosphorylation RVRRkLEsYFQSSKs Q8TDB6 S35-p Phosphorylation sYFQSSKsSGGGECT Q8TDB6 S202-p Phosphorylation SEQKQQFsPsMtERK Q8TDB6 S204-p Phosphorylation QKQQFsPsMtERKPL Q8TDB6 T206-p Phosphorylation QQFsPsMtERKPLsQ Q8TDB6 S212-p Phosphorylation MtERKPLsQQERDsC Q8TDB6 S218-p Phosphorylation LsQQERDsCIsPSEP Q8TDB6 S221-p Phosphorylation QERDsCIsPSEPETK Q8TDB6 S233-p Phosphorylation ETKAEQKsNyFEVPL Q8TDB6 Y235-p Phosphorylation KAEQKsNyFEVPLPY Q8TDB6 Y248-p Phosphorylation PYFEYFKyICPDKIN Q8TDB6 S256-p Phosphorylation ICPDKINsIEKRFGV Q8TDB6 S311-p Phosphorylation PLKQECVsLADskQA Q8TDB6 S315-p Phosphorylation ECVsLADskQANKFK Q8TDB6 S513-p Phosphorylation VLKGGGMssLAGkKL Q8TDB6 S514-p Phosphorylation LKGGGMssLAGkKLK Q8TDB6 T526-p Phosphorylation KLKEGHEtPMDIDsD Q8TDB6 S532-p Phosphorylation EtPMDIDsDDsKAAs Q8TDB6 S535-p Phosphorylation MDIDsDDsKAAsPPL Q8TDB6 S539-p Phosphorylation sDDsKAAsPPLKGsV Q8TDB6 S545-p Phosphorylation AsPPLKGsVsSEAsE Q8TDB6 S547-p Phosphorylation PPLKGsVsSEAsELD Q8TDB6 S551-p Phosphorylation GsVsSEAsELDKKEK Q8TDB6 T567-p Phosphorylation ICVICMDtISNKKVL Q8TDB6 S591-p Phosphorylation PCINKAMsyKPICPT Q8TDB6 Y592-p Phosphorylation CINKAMsyKPICPTC Q8TDB6 Y603-p Phosphorylation CPTCQTSyGIQKGNQ Q8TDB6 S614-p Phosphorylation KGNQPEGsMVFTVSR Q8TDB6 S623-p Phosphorylation VFTVSRDsLPGYESF Q8TDB6 S698-p Phosphorylation YSRVLGVsDVITWND Q8TDB6 Y719-p Phosphorylation RFGGPEMyGyPDPSY Q8TDB6 Y721-p Phosphorylation GGPEMyGyPDPSYLk Q8TDB6 K316-ub Ubiquitination CVsLADskQANKFKQ Q8TDB6 K337-ub Ubiquitination TKLLIKEkGGELTLL Q8TDB6 K363-ub Ubiquitination KISEAFVkIPVKLFA Q8TDB6 K423-ub Ubiquitination TCILFESkDRQVDLS Q8TDB6 K456-ub Ubiquitination MREVLLLkSLGKERK Q8TDB6 K653-ub Ubiquitination EEHPNPGkRYPGIQR Q8TDB6 K668-ub Ubiquitination TAYLPDNkEGRKVLk Q8TDB6 K675-ub Ubiquitination kEGRKVLkLLYRAFD Q8TDB6 K709-ub Ubiquitination TWNDIHHkTSRFGGP Q8TDB6 K728-ub Ubiquitination yPDPSYLkRVKEELK

PTM - dbPTM UniProt ID Position Code Type Resources References Q8TDB6 9 S Phosphorylation Swiss-Prot 1010711 18691976;19369195 Q8TDB6 202 S Phosphorylation Swiss-Prot 1010711 18691976 Q8TDB6 221 S Phosphorylation Swiss-Prot 1010711 18669648 Q8TDB6 221 S Phosphorylation PhosphoELM.10011 18669648 Q8TDB6 675 K Ubiquitylation Phosphositeplus.1010730 21890473 Q8TDB6 709 K Ubiquitylation Phosphositeplus.1010730 21890473 Q8TDB6 728 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q8TDB6 202 S Phosphorylation Phosphositeplus.1010730 18691976;20068231;20164059;22115753 Q8TDB6 218 S Phosphorylation Phosphositeplus.1010730 20058876 Q8TDB6 221 S Phosphorylation Phosphositeplus.1010730 16964243;18669648;20058876 Q8TDB6 532 S Phosphorylation Phosphositeplus.1010730 20068231;20166139;22115753 Q8TDB6 9 S Phosphorylation Phosphositeplus.1010730 18691976;19369195;20058876;20068231;22115753 Q8TDB6 248 Y Phosphorylation Phosphositeplus.1010730 18083107 Q8TDB6 373 Y Phosphorylation Phosphositeplus.1010730 18083107 Q8TDB6 385 Y Phosphorylation Phosphositeplus.1010730 18083107 Q8TDB6 592 Y Phosphorylation Phosphositeplus.1010730 20090780 Q8TDB6 3 S Phosphorylation HPRD 9.0 20068231 Q8TDB6 9 S Phosphorylation HPRD 9.0 18691976,20068231,20058876 Q8TDB6 202 S Phosphorylation HPRD 9.0 18691976,20068231 Q8TDB6 218 S Phosphorylation HPRD 9.0 20058876 Q8TDB6 221 S Phosphorylation HPRD 9.0 18669648,20058876 Q8TDB6 532 S Phosphorylation HPRD 9.0 18452278,20166139,20068231 Q8TDB6 535 S Phosphorylation HPRD 9.0 18452278 Q8TDB6 9 S Phosphorylation SysPTM 1.1 18691976 Q8TDB6 202 S Phosphorylation SysPTM 1.1 18691976 Q8TDB6 221 S Phosphorylation SysPTM 1.1 18669648;16964243

PTM - HPRD Symbol Position Code Type References DTX3L 202 S Phosphorylation 18691976,20068231 DTX3L 218 S Phosphorylation 20058876 DTX3L 221 S Phosphorylation 18669648,20058876 DTX3L 3 S Phosphorylation 20068231 DTX3L 532 S Phosphorylation 18452278,20166139,20068231 DTX3L 535 S Phosphorylation 18452278 DTX3L 9 S Phosphorylation 18691976,20068231,20058876

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q8TDB6 221 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q8TDB6 2 N-acetylalanine 19369195 Q8TDB6 9 Phosphoserine 18691976;19369195;23186163 Q8TDB6 202 Phosphoserine 20068231;23186163 Q8TDB6 221 Phosphoserine 18669648 Q8TDB6 532 Phosphoserine 20068231;23186163;24275569 Q8TDB6 539 Phosphoserine 24275569

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type DTX3L IPI00152503 S 202 EQKQQFpSPSMTER phosphorylation DTX3L IPI00152503 S 3 ____MApSHLRPPS phosphorylation DTX3L IPI00152503 S 532 TPMDIDpSDDSKAA phosphorylation DTX3L IPI00152503 S 9 SHLRPPpSPLLVRV phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 151636 127392 - K Ubiquitination 21139048 151636 127392 - K Ubiquitination 21890473 151636 127392 - K Ubiquitination 21906983 151636 127392 - K Sumoylation 19471022 151636 127392 - K Ubiquitination 22505724 151636 127392 - K Ubiquitination 21963094 151636 127392 - K Ubiquitination 23000965 151636 127392 - K Ubiquitination 25147182

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID DTX3L Homo sapiens (Human) 728 "728,PDPSYLKRVKEEL" 728:21906983 DTX3L Homo sapiens (Human) 728; 675; 709 "728,PDPSYLKRVKEEL; 675,EGRKVLKLLYRAF; 709,WNDIHHKTSRFGG" 728:21890473; 675:21890473; 709:21890473 DTX3L Homo sapiens (Human) 216; 163; 197 "216,PDPSYLKRVKEEL; 163,EGRKVLKLLYRAF; 197,WNDIHHKTSRFGG" 216:21890473; 163:21890473; 197:21890473