PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ZC3H12A CYFIP2 21988832 biogrid,intact exp G GP G G P G GP GP GP GP GP GP G G P GP GP G GP GP GP GP G GP GP GP G XPO1 ZC3H12A 26673895 biogrid exp G GP G G P G GP GP GP G GP GP G G P GP GP G GP GP GP GP G GP GP GP G KPNA2 ZC3H12A 21988832 biogrid,intact exp G GP G G P G GP GP GP GP GP GP G G P G GP G GP G GP GP G GP GP GP G ZC3H12A TANK 16189514 hprd,biogrid,intact exp G GP G G P G GP GP GP GP GP GP G G P GP GP G GP GP GP GP G GP GP GP G SHBG ZC3H12A 15862967 hprd,i2d exp ZC3H12A P4HA3 25416956 biogrid,intact exp P P P P P P P P G GP P P P P P G ZC3H12A ZC3H12A 23355615 biogrid exp G GP G G P G GP GP GP GP GP GP G G P GP GP G GP GP GP GP G GP GP GP G UBC ZC3H12A 24270572,21115689 biogrid exp G GP G G P G GP GP GP GP GP GP G G P GP GP G GP GP GP GP G GP GP GP G ZC3H12A AHSP 25416956,16189514 hprd,biogrid,intact exp G G G G G G G GP G G G G G G G P G G SMAD3 ZC3H12A 21988832 innatedb,biogrid,intact exp G GP G G P G G G G G GP GP G G P G GP G GP G G G G G G G G AIMP2 ZC3H12A 21900206 biogrid,mint,intact exp G GP G G P G GP GP GP GP GP GP G G P GP GP G GP GP GP GP G GP GP GP G IRAK2 ZC3H12A 21903422 innatedb,biogrid,intact exp G GP G G P G P P GP GP GP GP G P G G G GP GP G G GP P EP300 ZC3H12A 21988832 biogrid,intact exp G GP G G P G GP GP GP GP GP GP G G P GP GP G GP GP GP GP G GP GP GP G USP10 ZC3H12A 24270572 biogrid,intact exp G GP G G P G GP GP GP GP GP GP G G P GP GP G GP GP GP GP G GP GP GP G IKBKB ZC3H12A 22037600 intact exp G GP G G P G G GP GP G GP GP G G P GP GP G GP GP GP G G GP GP GP G ZC3H12A BTRC 24270572,21988832,21900206 biogrid,mint,intact exp G GP G G P G GP GP GP GP GP GP G G P GP GP G GP GP GP GP G G GP GP G ZC3H12A IKBKG 24270572 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G FN1 ZC3H12A 23023127 pred G G G G P G GP GP GP GP G G G G P GP G G GP G G G G G G G G GFAP ZC3H12A 21836163 pred P G G P G G CCL2 ZC3H12A 21836163 pred G GP P G G GP GP GP GP GP G G P GP GP G GP GP P G G GP GP P G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q5D1E8 affinity chromatography technology 21988832 physical association X 2 Q5D1E8 Q09472 two hybrid 21988832 direct interaction X 2 Q5D1E8 P52292 two hybrid 21988832 direct interaction X 2 Q5D1E8 two hybrid 21988832 direct interaction X 2 Q5D1E8 Q7Z4N8 two hybrid 25416956 direct interaction X 2 Q5D1E8 O43187 affinity chromatography technology 21903422 physical association X 2 Q5D1E8 O43187 pull down 21903422 direct interaction X 2 Q5D1E8 A0A024QZY1 two hybrid 21900206 direct interaction X 2 Q5D1E8 Q549J4 two hybrid 16189514 direct interaction X 2 Q5D1E8 P0CG48 affinity chromatography technology 22505724 physical association X 2 Q5D1E8 two hybrid 21988832 direct interaction X 2 Q5D1E8 Q96F07-2 two hybrid 21988832 direct interaction X 2 Q5D1E8 affinity chromatography technology 24270572 physical association X 2 Q5D1E8 P0CG48 enzymatic study 21115689 direct interaction X 2 Q5D1E8 enzymatic study 24270572 direct interaction X 2 Q5D1E8 P0CG48 pull down 24270572 direct interaction X 2 Q5D1E8 Q14694 affinity chromatography technology 24270572 physical association X 2 Q5D1E8 Q14694 affinity chromatography technology 24270572 physical association X 2 Q5D1E8 P0CG48 affinity chromatography technology 21115689 physical association X 2 Q5D1E8 Q549J4 two hybrid 25416956 direct interaction X 2 Q5D1E8 Q5D1E8 affinity chromatography technology 23355615 physical association X 2 Q5D1E8 two hybrid 21900206 direct interaction X 2 Q5D1E8 two hybrid 16189514 direct interaction X 2 Q5D1E8 P04278 two hybrid 15862967 - X 2 Q5D1E8 Q92844-3 two hybrid 16189514 - X 2 Q5D1E8 P04278 two hybrid 15862967 - X 2 Q5D1E8 Q92844-3 two hybrid 16189514 - X 2 Q5D1E8 Q549J4 two hybrid 16189514 - X 2 Q5D1E8 Q549J4 two hybrid 16189514 - X 2 Q5D1E8 anti bait coimmunoprecipitation 24270572 association C 3 Q5D1E8 A0A024QZY1 two hybrid 21900206 physical association X 2 Q5D1E8 O43187 anti tag coimmunoprecipitation 21903422 physical association X 2 Q5D1E8 A0A024R5Z3 anti tag coimmunoprecipitation 21988832 physical association X 2 Q5D1E8 O14920 anti bait coimmunoprecipitation 22037600 physical association X 2 Q5D1E8 Q7Z4N8 two hybrid prey pooling approach 25416956 physical association X 2 Q5D1E8 Q7Z4N8 two hybrid array 25416956 physical association X 2 Q5D1E8 Q7Z4N8 validated two hybrid 25416956 physical association X 2 Q5D1E8 anti tag coimmunoprecipitation 21903422 association C 17 Q5D1E8 anti tag coimmunoprecipitation 24270572 association C 3 Q5D1E8 Q92844 two hybrid pooling approach 16189514 physical association X 2 Q5D1E8 Q549J4 two hybrid pooling approach 16189514 physical association X 2 Q5D1E8 Q9Y297 two hybrid 21900206 physical association X 2 Q5D1E8 Q9Y6K9 anti tag coimmunoprecipitation 24270572 physical association X 2 Q5D1E8 Q14694 anti tag coimmunoprecipitation 24270572 physical association X 2 Q5D1E8 Q14694 anti tag coimmunoprecipitation 24270572 physical association X 2 Q5D1E8 Q14694 anti tag coimmunoprecipitation 24270572 physical association X 2 Q5D1E8 Q9Y6K9 anti bait coimmunoprecipitation 24270572 physical association X 2 Q5D1E8 Q549J4 two hybrid prey pooling approach 25416956 physical association X 2 Q5D1E8 Q549J4 two hybrid array 25416956 physical association X 2 Q5D1E8 Q549J4 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ZC3H12A TANK MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|- (intact)|(biogrid)|MI:0468(hprd) UniProt_152637|BIOGRID_79793|HPRD_22269 unspecified role|prey|- unspecified role|bait|- IRAK2 ZC3H12A MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21903422 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(intact)|(intact)|(biogrid)|(biogrid) UniProt_115746|UniProt_172488|UniProt_115883|UniProt_172619|BIOGRID_155526|BIOGRID_155907 bait|bait|prey|prey|bait|bait prey|prey|bait|bait|prey|prey IKBKB ZC3H12A MI:0424(protein kinase assay) 22037600 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_120648 prey bait UBC ZC3H12A MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 21115689,22505724 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_310367|BIOGRID_225181 prey|bait bait|prey SMAD3 ZC3H12A MI:0397(two hybrid array)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(intact) UniProt_119812|BIOGRID_288364|BIOGRID_285334|UniProt_120292 unspecified role|bait|bait|unspecified role unspecified role|prey|prey|unspecified role ZC3H12A IKBKG MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 24270572 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_131970|UniProt_131966|UniProt_177724 prey|prey|prey bait|bait|bait SHBG ZC3H12A MI:0018(two hybrid) 15862967 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_18240 - - ZC3H12A BTRC MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206,21988832,24270572 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(intact)|(intact)|(biogrid)|(intact) UniProt_131976|BIOGRID_285854|UniProt_158045|UniProt_119954|BIOGRID_157614|UniProt_178643 bait|prey|prey|unspecified role|prey|prey prey|bait|bait|unspecified role|bait|bait ZC3H12A AHSP MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0407(direct interaction) (intact)|MI:0468(hprd)|(biogrid) UniProt_153325|HPRD_23139|BIOGRID_80491 unspecified role|-|prey unspecified role|-|bait AIMP2 ZC3H12A MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_158855|UniProt_179453|BIOGRID_157184 bait|bait|bait prey|prey|prey EP300 ZC3H12A MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_286052|UniProt_119617 bait|unspecified role prey|unspecified role KPNA2 ZC3H12A MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_288346|UniProt_119790 bait|unspecified role prey|unspecified role ZC3H12A CYFIP2 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_288734|UniProt_120139 prey|unspecified role bait|unspecified role USP10 ZC3H12A MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 24270572 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_131972|UniProt_177726|UniProt_131976|UniProt_131969|UniProt_131968|UniProt_131967 bait|bait|prey|prey|prey|bait prey|prey|bait|bait|bait|prey

PPI - HINT Gene A Gene B PMID Method Quality UBC ZC3H12A 24270572,21115689,21115689 0096,0004,0415 LC USP10 ZC3H12A 24270572,24270572,24270572,25861989 0006,0004,0007,0004 LC ZC3H12A ZC3H12A 19909337,23355615 0004,0004 LC ZC3H12A IKBKG 24270572,24270572,24270572,24270572,25861989 0006,0007,0004,0415,0004 LC UBC ZC3H12A 24270572,21115689,21115689 0096,0004,0415 LC USP10 ZC3H12A 24270572,24270572,24270572,25861989 0006,0004,0007,0004 LC ZC3H12A ZC3H12A 19909337,23355615 0004,0004 LC ZC3H12A IKBKG 24270572,24270572,24270572,24270572,25861989 0006,0007,0004,0415,0004 LC ZC3H12D ZC3H12A 26134560,26134560 0004,0018 LC SHBG ZC3H12A 15862967 0018 LC UBC ZC3H12A 21115689,21115689 0004,0415 LC KPNA2 ZC3H12A 21988832 0018 HT SMAD3 ZC3H12A 21988832,21988832 0007,0018 HT EP300 ZC3H12A 21988832 0018 HT AIMP2 ZC3H12A 21900206 0018 HT HIF1A ZC3H12A 24048733 0415 LC ERAF ZC3H12A 16189514,16189514 0398,0018 HT ZC3H12A ZC3H12A 22561375 0114 LC ZC3H12A P4HA3 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT ZC3H12A TANK 16189514,16189514 0398,0018 HT ZC3H12A CYFIP2 21988832 0018 HT ZC3H12A AHSP 16189514,25416956,25416956,25416956,16189514,25416956 0398,1112,0397,0018,0018,1356 HT ZC3H12A Q9P0T0 21988832,21988832 0004,0018 HT ZC3H12A BTRC 21900206,21988832 0018,0018 HT ZC3H12A IKBKG 24270572,24270572,24270572,24270572 0006,0007,0004,0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5D1E8 P01584 ZC3H12A IL1B 0.21 19909337 Q5D1E8 P53829 ZC3H12A CAF40 0.332 27107014 Q5D1E8 Q02793 ZC3H12A SKI8 0.332 27107014 Q5D1E8 Q16665 ZC3H12A HIF1A 0.309 24048733 Q9Y4K3 Q5D1E8 TRAF6 ZC3H12A 0.21 25861989 Q5D1E8 P0CG48 ZC3H12A UBC 0.623 21115689,24270572 Q6P5F9 Q5D1E8 XPO1 ZC3H12A 0.126 26673895 Q9Y6K9 Q5D1E8 IKBKG ZC3H12A 0.731 24270572,25861989 Q9NZD4 Q5D1E8 AHSP ZC3H12A 0.61 25416956,16189514 Q8TBB1 Q5D1E8 LNX1 ZC3H12A 0.236 unassigned1304 Q5D1E8 Q09472 ZC3H12A EP300 0.332 21988832 Q5D1E8 Q13155 ZC3H12A AIMP2 0.332 21900206 Q9Y297 Q5D1E8 BTRC ZC3H12A 0.648 21900206,24270572,21988832 Q5D1E8 A2A288 ZC3H12A ZC3H12D 0.702 26134560 Q92844 Q5D1E8 TANK ZC3H12A 0.731 16189514,25861989 Q5D1E8 Q5D1E8 ZC3H12A ZC3H12A 0.416 19909337,23355615 Q5D1E8 P59910 ZC3H12A DNAJB13 0.236 unassigned1304 Q7Z4N8 Q5D1E8 P4HA3 ZC3H12A 0.583 25416956,unassigned1304 Q5D1E8 P20095 ZC3H12A PRP2 0.332 27107014 Q5D1E8 Q14694 ZC3H12A USP10 0.808 24270572,25861989 Q5D1E8 O43187 ZC3H12A IRAK2 0.454 21903422 Q5D1E8 P84022 ZC3H12A SMAD3 0.49 21988832 Q96F07 Q5D1E8 CYFIP2 ZC3H12A 0.332 21988832 Q5D1E8 P52292 ZC3H12A KPNA2 0.332 21988832

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 ZC3H12D ZC3H12A MI:0045 experimental interaction detection MI:0461 interaction database IKBKB ZC3H12A MI:0045 experimental interaction detection MI:0461 interaction database XPO1 ZC3H12A MI:0045 experimental interaction detection MI:0461 interaction database IRAK2 ZC3H12A MI:0045 experimental interaction detection MI:0461 interaction database IL1B ZC3H12A MI:0045 experimental interaction detection MI:0461 interaction database SHBG ZC3H12A MI:0045 experimental interaction detection MI:0461 interaction database UBC ZC3H12A MI:0045 experimental interaction detection MI:0461 interaction database IRAK1 ZC3H12A MI:0362 inference MI:0461 interaction database KPNA2 ZC3H12A MI:0045 experimental interaction detection MI:0461 interaction database PPP1CB ZC3H12A MI:0362 inference MI:0461 interaction database SMAD3 ZC3H12A MI:0045 experimental interaction detection MI:0461 interaction database EP300 ZC3H12A MI:0045 experimental interaction detection MI:0461 interaction database AIMP2 ZC3H12A MI:0045 experimental interaction detection MI:0461 interaction database PIN1 ZC3H12A MI:0362 inference MI:0461 interaction database USP10 ZC3H12A MI:0045 experimental interaction detection MI:0461 interaction database HIF1A ZC3H12A MI:0045 experimental interaction detection MI:0461 interaction database ZC3H12A P4HA3 MI:0045 experimental interaction detection MI:0461 interaction database ZC3H12A RQCD1 MI:0362 inference MI:0461 interaction database ZC3H12A TANK MI:0045 experimental interaction detection MI:0461 interaction database ZC3H12A CYFIP2 MI:0045 experimental interaction detection MI:0461 interaction database ZC3H12A AHSP MI:0045 experimental interaction detection MI:0461 interaction database ZC3H12A BTRC MI:0045 experimental interaction detection MI:0461 interaction database ZC3H12A TRAF6 MI:0045 experimental interaction detection MI:0461 interaction database ZC3H12A IKBKG MI:0045 experimental interaction detection MI:0461 interaction database