PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus NEDD4L SENP2 19953087 biogrid exp GP GP G GP G GP GP G GP G GP P G GP GP GP GP G GP GP G G GP G GP G AGTRAP SENP2 25416956 biogrid,intact exp G GP G G GP GP G G GP G GP G GP G G G GP G GP G GP GP GP G G GP GP GP G SENP2 DAXX 17081986 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ARL6IP1 SENP2 25416956 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G TMEM17 SENP2 26638075 biogrid,intact exp P GP G P GP G P P G GP P P G G P GP P GP G P GP GP P P P P GP NUP133 SENP2 24927568 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CDCA5 SENP2 21988832 biogrid,intact exp P P G GP P P GP P P P GP P P GP P P P P GP P GP NUP107 SENP2 24927568,26496610 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HIPK2 SENP2 15958389 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TMEM239 SENP2 25416956 biogrid,intact exp G G G G G G G G G G TPD52 SENP2 21988832 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HNRNPK SENP2 23092970 biogrid,mint,intact exp P P P P P P P P P P P P P P P P P P P P P P ELAVL1 SENP2 19322201 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SENP2 TMEM216 26638075 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CCDC155 SENP2 25416956 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP P G GP GP GP GP G P P P GP GP G GP GP G APP SENP2 21244100,21832049 innatedb,biogrid exp G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP G FUNDC1 SENP2 25416956 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G TRIM63 SENP2 22626734 biogrid exp G G G G SENP2 FZR1 25483061 biogrid exp G GP G G G GP G GP GP G GP GP GP G G GP GP G P G G GP G GP GP G GP GP G NUP43 SENP2 24927568 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SMAD2 SENP2 20195357 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CDK5RAP2 SENP2 16169070 hprd,biogrid,i2d,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SYNE4 SENP2 25416956 biogrid,intact exp P GP P GP G GP GP G GP GP GP P G GP GP P GP G GP GP GP GP GP P GP P G SUMO1 SENP2 14673145,15296745,11997515,17099700,15896780,12192048, 25402006, 21836163 hprd,biogrid,i2d,intact,dip exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NUP153 SENP2 26496610,12192048,11896061, 25402006, 21836163 hprd,biogrid,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RANGAP1 SENP2 12192048, 25402006, 21836163 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G DVL2 SENP2 19888210, 23023127 i2d exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SUMO2 SENP2 25416956,17099700,19394292, 25402006, 23023127 biogrid,intact,dip exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SUMO3 SENP2 25416956,11997515,17099700,12192048, 25402006, 23023127, 21836163 hprd,biogrid,intact,dip exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PML SENP2 12419228, 25402006 hprd exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G AXIN1 SENP2 11997515, 23023127 hprd exp, pred GP GP G GP GP G P GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SENP2 IKBKG 21777808,20098747, 25402006 innatedb,biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MDM2 SENP2 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G DVL1 SENP2 23023127, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PIAS1 SENP2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ISG15 SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IPO7 SENP2 25402006, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G UBE2S SENP2 23023127 pred G G G G G G G G GP G G G GP G G G G G G G G G G G GP G BAP1 SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBXN7 SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SENP2 AXIN2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SENP2 ZMYM2 25402006 pred GP GP G G GP GP G GP GP G GP G G GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RDX SENP2 23023127 pred G GP G G G GP G G G G GP GP G GP G G GP GP GP G GP GP GP G G G GP GP G UBL4B SENP2 23023127 pred P P P P P P P P P P P P P P P P P P P P SENP2 USP20 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SENP2 TCF7L1 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FAU SENP2 23023127 pred GP G G G GP GP G GP GP G G GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G TRIM21 SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UFM1 SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G USP4 SENP2 23023127 pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G SRP14 SENP2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SENP2 MBD2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G UBXN1 SENP2 23023127 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G PIAS4 SENP2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G KPNB1 SENP2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBTD2 SENP2 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SENP2 USP16 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP GP GP GP G SENP2 DDX19B 21836163 pred P P P P P P P P P P P P P P P P P P P P P P EZR SENP2 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G FRZB SENP2 16082366 pred G GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G SENP2 TOPORS 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TMUB1 SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UCHL1 SENP2 23023127 pred G G G G G GP G G GP G GP G G G G G GP G GP G G G G G G G G GP G CSNK2B SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NUP214 SENP2 21836163 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP G G G GP G G GP G GP GP G SENP2 G3BP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PELP1 SENP2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G IQUB SENP2 23023127 pred P P P P P P GP P P P P P P P P P P P P P P GP RAD23A SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G EIF4E SENP2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G XPO1 SENP2 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ARNTL SENP2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G P GP GP GP GP GP GP GP G NFKB2 SENP2 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP G GP G GP GP GP GP G RAD23B SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2E3 SENP2 23023127 pred GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G GP GP G GP GP G TFG SENP2 25402006 pred G GP G G GP GP G GP GP G GP G G GP G GP GP GP GP G GP GP GP G GP G GP GP G PARK2 SENP2 23023127 pred P GP G P GP G GP GP G GP P P G P GP GP P G P GP GP GP P GP G SENP2 USP3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBXN11 SENP2 23023127 pred G GP G G G GP G GP P G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G DDI2 SENP2 23023127 pred P P P P P P P P P P P P P P P USP44 SENP2 23023127 pred P P P P P P P P P P P P P GP G P P P P P P GP PRKCI SENP2 23023127 pred GP GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G UBL4A SENP2 23023127 pred GP GP G G G GP G G GP G GP G G G G G GP G GP G GP G G G G G GP P G MYO7B SENP2 23023127 pred P P G G G P P P GP G GP G G G G P GP G GP G P G KHDRBS1 SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SENP2 EPB41L5 23023127 pred G GP G G GP GP G G G G GP GP G G G GP GP G GP G GP G G G GP P GP GP G UBTD1 SENP2 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G G GP GP GP G P G GP G G G GP G MYLIP SENP2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MYO1C SENP2 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RNF25 SENP2 23023127 pred P G P P P P P P P P P P P P P GP P P MEF2A SENP2 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP G GP G SETDB1 SENP2 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G G GP GP G GP GP G MAPK14 SENP2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G SENP2 DKK4 16082366 pred P P P P P P GP P P SENP2 WWOX 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G MAP3K1 SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBXN10 SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP GP GP GP G GP GP GP GP GP G GP GP G SENP2 SENP1 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SENP2 NXF1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HDAC4 SENP2 25402006 pred GP G G G GP GP G G GP G GP GP GP GP G GP GP GP GP G P GP GP GP GP GP GP GP G BAG6 SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G EPHB2 SENP2 25402006 pred P GP G G GP GP G GP GP G GP P GP P GP GP GP GP G GP P GP GP GP P P GP G RANBP2 SENP2 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G DDI1 SENP2 23023127 pred P P P P G GP GP P G P P GP SART1 SENP2 25402006 pred GP GP G G G GP G G GP G GP G G G G P GP G GP G GP G G G P G P GP G USP33 SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G TPR SENP2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SENP2 XPO7 25402006 pred G G G G GP GP G GP GP G GP G G G G G GP GP GP G G GP G GP G G G GP G SENP3 SENP2 25402006 pred GP GP G G G GP G GP GP G GP GP G G G GP GP G GP G GP G GP GP GP G GP GP G UBE2I SENP2 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CHD3 SENP2 25402006 pred GP GP G G G GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G CXXC4 SENP2 16082366 pred P G G G GP G GP GP G P GP G GP GP GP G G G P GP G G GP COPS5 SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G YOD1 SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G DVL3 SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBQLN3 SENP2 23023127 pred G G G G G G GP G SUMO4 SENP2 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G G GP GP GP G GP GP GP GP G GP GP GP G ZNF699 SENP2 21836163 pred P P P P P P SENP2 RASSF1 23023127 pred GP GP G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G TDG SENP2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SENP2 UBQLN1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SENP2 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP SENP2 UBA2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G G GP GP GP GP GP GP GP G RBCK1 SENP2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NEDD8 SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SENP2 UBE2T 23023127 pred G G G GP G GP P P P GP GP P GP P G GP P GP G TMUB2 SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP5 SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G UHRF2 SENP2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP11 SENP2 23023127 pred G GP G G G GP G G GP G GP G G G G G GP G G G G G G G G G G GP G SENP2 SAE1 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RAE1 SENP2 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G G GP GP GP GP GP G NEDD4 SENP2 23023127 pred GP GP G GP P G GP GP GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G UBXN2A SENP2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBC SENP2 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A0A024R3Z2 Q9HC62 - 15296745 - X 2 P05067-7 Q9HC62 pull down 21832049 direct interaction X 2 B7Z2P9 Q9HC62 pull down 19953087 direct interaction X 2 P55327 Q9HC62 two hybrid 21988832 direct interaction X 2 Q9HC62 affinity chromatography technology 21777808 physical association X 2 Q9HC62 enzymatic study 21777808 direct interaction X 2 Q9HC62 pull down 20098747 direct interaction X 2 Q9HC62 affinity chromatography technology 20098747 physical association X 2 Q9HC62 two hybrid 20098747 direct interaction X 2 P49790 Q9HC62 pull down 11896061 direct interaction X 2 P49790 Q9HC62 pull down 12192048 direct interaction X 2 P61956-2 Q9HC62 two hybrid 25416956 direct interaction X 2 P61956-2 Q9HC62 affinity chromatography technology 19394292 physical association X 2 Q6RW13 Q9HC62 two hybrid 25416956 direct interaction X 2 Q9HC62 two hybrid 25416956 direct interaction X 2 A0A024R5D6 Q9HC62 two hybrid 21988832 direct interaction X 2 A0A024R3Z2 Q9HC62 pull down 14673145 direct interaction X 2 A0A024R3Z2 Q9HC62 enzymatic study 12192048 direct interaction X 2 Q8N6L0 Q9HC62 two hybrid 25416956 direct interaction X 2 P61978 Q9HC62 affinity chromatography technology 23092970 physical association X 2 P61978 Q9HC62 affinity chromatography technology 23092970 physical association X 2 Q969Q1 Q9HC62 enzymatic study 22626734 direct interaction X 2 Q8N205 Q9HC62 two hybrid 25416956 direct interaction X 2 Q9H2X6-2 Q9HC62 affinity chromatography technology 15958389 physical association X 2 Q9H2X6-2 Q9HC62 affinity chromatography technology 15958389 physical association X 2 Q9H2X6-2 Q9HC62 imaging technique 15958389 colocalization X 2 P55854 Q9HC62 two hybrid 25416956 direct interaction X 2 P55854 Q9HC62 enzymatic study 12192048 direct interaction X 2 A0A024QYV7 Q9HC62 two hybrid 25416956 direct interaction X 2 Q9HC62 Q96SN8-2 two hybrid 16169070 direct interaction X 2 A0A024R1U0 Q9HC62 enzymatic study 12192048 direct interaction X 2 Q8IVP5 Q9HC62 two hybrid 25416956 direct interaction X 2 Q9HC62 affinity chromatography technology 17081986 physical association X 2 Q9HC62 enzymatic study 17081986 direct interaction X 2 Q9HC62 enzymatic study 17099700 physical association C 3 Q9HC62 enzymatic study 17099700 physical association C 3 Q9HC62 molecular sieving 17099700 physical association C 3 Q9HC62 enzymatic study 17099700 direct interaction X 2 Q9HC62 x-ray crystallography 17099700 direct interaction X 2 A0A024R3Z2 Q9HC62 enzymatic study 17099700 direct interaction X 2 Q9HC62 x-ray crystallography 17099700 physical association C 3 Q9HC62 enzymatic study 17099700 physical association C 3 Q9HC62 molecular sieving 17099700 physical association C 3 P55854 Q9HC62 x-ray crystallography 17099700 direct interaction X 2 P55854 Q9HC62 enzymatic study 17099700 direct interaction X 2 P29590-14 Q9HC62 in vitro 12419228 - X 2 P29590-14 Q9HC62 in vivo 12419228 - X 2 P29590-14 Q9HC62 in vitro 12419228 - X 2 P29590-14 Q9HC62 in vivo 12419228 - X 2 P49790 Q9HC62 in vivo 11896061,12192048 - X 2 P49790 Q9HC62 in vivo 11896061,12192048 - X 2 O15169-2 Q9HC62 in vitro 11997515 - X 2 O15169-2 Q9HC62 in vitro 11997515 - X 2 A0A024R3Z2 Q9HC62 in vitro 11997515,15296745,15896780 - X 2 A0A024R3Z2 Q9HC62 in vivo 11997515,15296745,15896780 - X 2 A0A024R3Z2 Q9HC62 in vivo 11997515,15296745,15896780 - X 2 A0A024R3Z2 Q9HC62 in vitro 11997515,15296745,15896780 - X 2 Q96SN8-4 Q9HC62 two hybrid 16169070 - X 2 Q96SN8-4 Q9HC62 two hybrid 16169070 - X 2 P55854 Q9HC62 in vivo 11997515 - X 2 P55854 Q9HC62 in vitro 11997515 - X 2 P55854 Q9HC62 in vitro 11997515 - X 2 P55854 Q9HC62 in vivo 11997515 - X 2 Q9Y6K9 Q9HC62 pull down 20098747 physical association X 2 Q9Y6K9 Q9HC62 anti tag coimmunoprecipitation 20098747 physical association X 2 Q9Y6K9 Q9HC62 two hybrid 20098747 physical association X 2 Q6RW13 Q9HC62 two hybrid prey pooling approach 25416956 physical association X 2 Q6RW13 Q9HC62 two hybrid array 25416956 physical association X 2 Q6RW13 Q9HC62 validated two hybrid 25416956 physical association X 2 Q8WW34 Q9HC62 two hybrid prey pooling approach 25416956 physical association X 2 Q8WW34 Q9HC62 two hybrid array 25416956 physical association X 2 Q8WW34 Q9HC62 validated two hybrid 25416956 physical association X 2 Q15796 Q9HC62 display technology 20195357 physical association X 2 A0A024R5D6 Q9HC62 two hybrid array 21988832 physical association X 2 A0A024R3Z2 Q9HC62 x-ray crystallography 15296745 direct interaction X 2 Q8N6L0 Q9HC62 two hybrid prey pooling approach 25416956 physical association X 2 Q8N6L0 Q9HC62 two hybrid array 25416956 physical association X 2 Q8N6L0 Q9HC62 validated two hybrid 25416956 physical association X 2 P61978 Q9HC62 anti bait coimmunoprecipitation 23092970 physical association X 2 Q96SN8 Q9HC62 two hybrid pooling approach 16169070 physical association X 2 A0A024R8S3 Q9HC62 two hybrid prey pooling approach 25416956 physical association X 2 A0A024R8S3 Q9HC62 two hybrid array 25416956 physical association X 2 A0A024R8S3 Q9HC62 validated two hybrid 25416956 physical association X 2 Q8N205 Q9HC62 two hybrid prey pooling approach 25416956 physical association X 2 Q8N205 Q9HC62 two hybrid array 25416956 physical association X 2 Q8N205 Q9HC62 validated two hybrid 25416956 physical association X 2 P55854 Q9HC62 anti tag coimmunoprecipitation 25416956 physical association X 2 P55854 Q9HC62 two hybrid prey pooling approach 25416956 physical association X 2 P55854 Q9HC62 two hybrid array 25416956 physical association X 2 P55854 Q9HC62 validated two hybrid 25416956 physical association X 2 A0A024QYV7 Q9HC62 two hybrid prey pooling approach 25416956 physical association X 2 A0A024QYV7 Q9HC62 two hybrid array 25416956 physical association X 2 A0A024QYV7 Q9HC62 validated two hybrid 25416956 physical association X 2 Q8IVP5 Q9HC62 two hybrid prey pooling approach 25416956 physical association X 2 Q8IVP5 Q9HC62 two hybrid array 25416956 physical association X 2 Q8IVP5 Q9HC62 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B TPD52 SENP2 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_119918|BIOGRID_288504 unspecified role|prey unspecified role|bait HIPK2 SENP2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15958389 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid)|(biogrid) BIOGRID_197807|BIOGRID_197806|BIOGRID_197809 prey|bait|bait bait|prey|prey NEDD4L SENP2 MI:0415(enzymatic study) 19953087 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_165798 bait prey AXIN1 SENP2 MI:0493(in vivo) 11997515 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_12680 - - SENP2 DAXX MI:0018(two hybrid)|MI:0018(two hybrid) 17081986 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_199854|BIOGRID_199855 bait|bait prey|prey ELAVL1 SENP2 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_186347 bait prey SUMO3 SENP2 MI:0096(pull down)|MI:0493(in vivo)|MI:0415(enzymatic study) 11997515,12192048,17099700 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|MI:0465(dip) BIOGRID_110292|HPRD_10503|DIP_53656 prey|-|- bait|-|- APP SENP2 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_227984 prey bait NRF1 SENP2 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295705 bait prey SUMO2 SENP2 MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0415(enzymatic study) 17099700,19394292 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|MI:0465(dip)|MI:0465(dip) BIOGRID_130995|DIP_53655|DIP_53654 bait|-|- prey|-|- SENP2 IKBKG MI:0089(protein array)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0089(protein array)|MI:0089(protein array)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0089(protein array) 20098747,21777808 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact)|(biogrid)|(biogrid)|(intact) UniProt_105664|BIOGRID_124001|BIOGRID_123995|BIOGRID_123986|UniProt_105660|UniProt_105673|BIOGRID_195377|BIOGRID_195376|UniProt_105642 prey|prey|prey|prey|prey|prey|prey|prey|null bait|bait|bait|bait|bait|bait|bait|bait|prey SMAD2 SENP2 MI:0034(display technology) 20195357 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_104996 bait prey CDCA5 SENP2 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_288791|UniProt_118456 bait|unspecified role prey|unspecified role NUP153 SENP2 MI:0096(pull down)|MI:0096(pull down)|MI:0493(in vivo) 11896061,12192048 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_107351|BIOGRID_110290|HPRD_12804 prey|prey|- bait|bait|- TRIM63 SENP2 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223012 bait prey PML SENP2 MI:0492(in vitro) 12419228 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_12310 - - HNRNPK SENP2 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23092970 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_126115|BIOGRID_247637|BIOGRID_247636 bait|prey|bait prey|bait|prey SUMO1 SENP2 MI:0096(pull down)|MI:0415(enzymatic study)|MI:0096(pull down)|MI:0114(x-ray crystallography)|MI:0493(in vivo)|MI:0415(enzymatic study) 11997515,12192048,14673145,15296745,17099700 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|-|MI:0915(physical association) (biogrid)|MI:0465(dip)|(biogrid)|(intact)|MI:0468(hprd)|MI:0465(dip) BIOGRID_110291|DIP_53657|BIOGRID_220465|UniProt_77770|HPRD_10063|DIP_53653 prey|-|bait|neutral component|-|- bait|-|prey|neutral component|-|- CDK5RAP2 SENP2 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0492(in vitro)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association) (intact)|(biogrid)|MI:0471(mint)|MI:0468(hprd)|MI:0471(mint) UniProt_155155|BIOGRID_94239|MINT_35624|HPRD_29862|MINT_64652 bait|bait|bait|-|bait prey|prey|prey|-|prey

PPI - HINT Gene A Gene B PMID Method Quality APP SENP2 21832049,21244100 0096,0096 LC NUP153 SENP2 12192048,26496610,26496610,11896061 0096,0004,0007,0096 LC,HT NUP107 SENP2 26496610,24927568,26496610 0007,1313,0004 HT,LC SUMO2 SENP2 19394292,19394292 0096,0004 LC SUMO1 SENP2 14673145 0096 LC TMEM17 SENP2 26638075,26638075 1314,1313 HT SENP2 TMEM216 26638075,26638075 1314,1313 HT SENP2 IKBKG 20098747,20098747,21777808,20098747,20098747,21777808 0007,0004,0415,0096,0018,0004 LC NUP153 SENP2 26496610,26496610 0004,0007 HT NUP107 SENP2 26496610,26496610 0007,0004 HT TMEM17 SENP2 26638075,26638075 1314,1313 HT SENP2 TMEM216 26638075,26638075 1314,1313 HT APP SENP2 21832049,21244100 0096,0096 LC NUP153 SENP2 12192048,11896061 0096,0096 LC NUP107 SENP2 24927568 1313 LC SUMO2 SENP2 19394292,19394292 0096,0004 LC SUMO1 SENP2 14673145 0096 LC SENP2 IKBKG 20098747,20098747,21777808,20098747,20098747,21777808 0007,0004,0415,0096,0018,0004 LC TPD52 SENP2 21988832 0018 HT SUMO3 SENP2 25416956,17099700,25944111,17099700,25416956,25416956,25416956,12192048,25416956 1112,0114,0415,0415,0397,0018,0007,0415,1356 HT,LC SUMO2 SENP2 25416956,17099700,24424631,17099700,25416956,25416956,25416956 1112,0114,0114,0415,0397,0018,1356 HT,LC SUMO1 SENP2 17099700,17099700,15296745,12192048 0114,0415,0114,0415 LC ARL6IP1 SENP2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT SMAD2 SENP2 20195357 0034 LC AGTRAP SENP2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT FUNDC1 SENP2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT SYNE4 SENP2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT CCDC155 SENP2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TMEM239 SENP2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIM63 SENP2 22626734 0415 HT CDCA5 SENP2 21988832,21988832 0397,0018 HT NACC1 SENP2 25891951 0415 LC CDK5RAP2 SENP2 16169070,16169070 0018,0398 HT Q9BSK3 SENP2 17099700,12192048 0114,0415 LC SENP2 SENP2 15296745 0114 LC SENP2 DAXX 17081986,17081986 0415,0004 LC SENP2 IKBKG 20098747,20098747,21777808,20098747,20098747,21777808 0007,0004,0415,0096,0018,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9HC62 P61978 SENP2 HNRNPK 0.507 23092970 Q9HC62 P05067 SENP2 APP 0.332 21244100,21832049 Q9HC62 P46060 SENP2 RANGAP1 0.309 12192048 Q9HC62 Q15796 SENP2 SMAD2 0.126 20195357 Q9HC62 Q8N205 SENP2 SYNE4 0.454 25416956 Q9HC62 Q8N6L0 SENP2 CCDC155 0.583 25416956,unassigned1304 Q9HC62 Q8WW34 SENP2 TMEM239 0.583 25416956,unassigned1304 Q9HC62 Q96RE7 SENP2 NACC1 0.309 25891951 Q9HC62 Q9H2X6 SENP2 HIPK2 0.454 15958389 Q9UER7 Q9HC62 DAXX SENP2 0.309 17081986 Q9HC62 Q8NFH3 SENP2 NUP43 0.126 24927568 Q9HC62 Q8IVP5 SENP2 FUNDC1 0.454 25416956 Q9HC62 Q6W2J9 SENP2 BCOR 0.126 26687479 Q9HC62 P03070 SENP2 P03070 0.126 22810586 Q9P0N5 Q9HC62 TMEM216 SENP2 0.236 26638075 Q9HC62 Q86VR2 SENP2 FAM134C 0.236 unassigned1304 Q9HC62 Q15041 SENP2 ARL6IP1 0.454 25416956 Q9HC62 P63165 SENP2 SUMO1 0.772 15296745,17099700,14673145,12192048 Q9HC62 P55327 SENP2 TPD52 0.332 21988832 Q9HC62 P49790 SENP2 NUP153 0.636 11896061,26496610,12192048 Q9Y6K9 Q9HC62 IKBKG SENP2 0.801 20098747,21777808 Q9NS64 Q9HC62 RPRM SENP2 0.236 unassigned1304 Q9HC62 Q96FF9 SENP2 CDCA5 0.286 21988832 Q9HC62 Q9ERU9 SENP2 RANBP2 0.236 26496610 Q9HC62 Q6PFD9 SENP2 NUP98 0.236 26496610 Q9HC62 Q86X19 SENP2 TMEM17 0.236 26638075 Q9HC62 Q8BH65 SENP2 DENND6A 0.236 26496610 Q9HC62 Q8BH74 SENP2 NUP107 0.236 26496610 Q9HC62 P53701 SENP2 HCCS 0.236 unassigned1304 Q9HC62 P63280 SENP2 UBE2I 0.236 26496610 Q9HC62 P57740 SENP2 NUP107 0.332 24927568,26496610 Q9HC62 P61956 SENP2 SUMO2 0.74 25416956,17099700 Q9HC62 P55854 SENP2 SUMO3 0.917 25416956,17099700,unassigned1304,12192048,25944111 Q9HC62 Q6RW13 SENP2 AGTRAP 0.583 25416956,unassigned1304 Q9HC62 Q8WUM0 SENP2 NUP133 0.126 24927568 Q9HC62 Q969Q1 SENP2 TRIM63 0.183 22626734 Q9HC62 Q96PU5 SENP2 NEDD4L 0.183 19953087 Q9HC62 Q96SN8 SENP2 CDK5RAP2 0.286 16169070 Q9UM11 Q9HC62 FZR1 SENP2 0.569 25483061 Q9HC62 Q15717 SENP2 ELAVL1 0.126 19322201

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 RGPD3 SENP2 MI:0362 inference MI:0461 interaction database RGPD8 SENP2 MI:0362 inference MI:0461 interaction database APP SENP2 MI:0045 experimental interaction detection MI:0461 interaction database RGPD1 SENP2 MI:0362 inference MI:0461 interaction database RGPD2 SENP2 MI:0362 inference MI:0461 interaction database PML SENP2 MI:0362 inference MI:0461 interaction database RANGAP1 SENP2 MI:0045 experimental interaction detection MI:0461 interaction database NUP153 SENP2 MI:0045 experimental interaction detection MI:0461 interaction database RANBP2 SENP2 MI:0362 inference MI:0461 interaction database NUP98 SENP2 MI:0362 inference MI:0461 interaction database TPD52 SENP2 MI:0045 experimental interaction detection MI:0461 interaction database SUMO3 SENP2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database NUP107 SENP2 MI:0045 experimental interaction detection MI:0461 interaction database SUMO2 SENP2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database HNRNPK SENP2 MI:0045 experimental interaction detection MI:0461 interaction database SUMO1 SENP2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UBE2I SENP2 MI:0362 inference MI:0461 interaction database MDM2 SENP2 MI:0362 inference MI:0461 interaction database ARL6IP1 SENP2 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 SENP2 MI:0045 experimental interaction detection MI:0461 interaction database SMAD2 SENP2 MI:0045 experimental interaction detection MI:0461 interaction database SUMO4 SENP2 MI:0362 inference MI:0461 interaction database AGTRAP SENP2 MI:0045 experimental interaction detection MI:0461 interaction database BCOR SENP2 MI:0045 experimental interaction detection MI:0461 interaction database RGPD4 SENP2 MI:0362 inference MI:0461 interaction database TMEM17 SENP2 MI:0045 experimental interaction detection MI:0461 interaction database FUNDC1 SENP2 MI:0045 experimental interaction detection MI:0461 interaction database DENND6A SENP2 MI:0362 inference MI:0461 interaction database SYNE4 SENP2 MI:0045 experimental interaction detection MI:0461 interaction database CCDC155 SENP2 MI:0045 experimental interaction detection MI:0461 interaction database NUP43 SENP2 MI:0045 experimental interaction detection MI:0461 interaction database NUP133 SENP2 MI:0045 experimental interaction detection MI:0461 interaction database TMEM239 SENP2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM63 SENP2 MI:0045 experimental interaction detection MI:0461 interaction database CDCA5 SENP2 MI:0045 experimental interaction detection MI:0461 interaction database NEDD4L SENP2 MI:0045 experimental interaction detection MI:0461 interaction database NACC1 SENP2 MI:0045 experimental interaction detection MI:0461 interaction database CDK5RAP2 SENP2 MI:0045 experimental interaction detection MI:0461 interaction database RGPD5 SENP2 MI:0362 inference MI:0461 interaction database HIPK2 SENP2 MI:0045 experimental interaction detection MI:0461 interaction database SENP2 TMEM216 MI:0045 experimental interaction detection MI:0461 interaction database SENP2 DAXX MI:0045 experimental interaction detection MI:0461 interaction database SENP2 FZR1 MI:0045 experimental interaction detection MI:0461 interaction database SENP2 IKBKG MI:0045 experimental interaction detection MI:0461 interaction database