PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus STX2 STXBP5 25244094 innatedb exp GP GP G G G GP G GP GP G P P GP GP G GP GP G GP G GP GP P G GP GP GP P STX6 STXBP5 26186194 biogrid exp GP GP G G G GP G G GP G P P GP GP G GP GP G GP G GP GP P G GP GP GP P STXBP5 VTI1B 26186194 biogrid exp GP GP G G G GP G GP GP G P P GP GP G GP GP G GP G GP GP P G GP GP GP P ARRB1 STXBP5 17620599 biogrid,intact exp GP G G G G GP G G GP G P GP G G GP GP G GP G GP GP P G GP GP GP P STXBP5 STX12 26186194 biogrid exp GP GP G G G GP G G GP G P P GP GP G GP GP G GP G GP GP P G GP G GP P STX3 STXBP5 26186194 biogrid exp GP GP G G G GP G GP GP G P P GP GP G GP GP G GP G GP GP P G GP GP GP P STX7 STXBP5 26186194 biogrid exp G G G G G G G G GP G P G GP G G G G G G G G G G GP GP P STXBP2 STXBP5 25244094 innatedb exp G GP G G P GP P P G G G GP GP G GP GP P G GP G GP SNAP29 STXBP5 26186194 biogrid exp, ortho GP GP G G G GP G GP GP G P P GP GP G GP GP G GP G GP GP P G GP GP GP P SNAP23 STXBP5 25244094,12832401, 25402006, 21836163 innatedb,hprd,biogrid exp, ortho, pred GP GP G G G GP G G GP G P P GP GP G GP GP G GP G GP GP P G GP GP GP P STX4 STXBP5 25244094,12832401, 25402006, 21836163 innatedb,hprd,biogrid exp, ortho, pred GP GP G G G GP G G GP G P P GP GP G GP GP G GP G GP GP P G GP GP GP P STX1A STXBP5 12832401,9620695, 25402006 hprd,biogrid exp, ortho, pred G G G GP G G P G G G GP GP GP G G G G GP GP STXBP5 STX19 26186194, 25402006 biogrid exp, pred P P P P P P P P P P P GP P P P P P P P STX11 STXBP5 25244094, 25402006 innatedb exp, pred GP P G G P P GP P P GP P G P P P GP P P P GP GP P STXBP5 INO80 ortho G G G G G G G G G G G G G G G G G G G G G G G G YWHAE STXBP5 ortho GP GP G G G GP G GP GP G P P GP GP G GP GP G GP G GP GP P G GP GP GP P STXBP5 NRCAM ortho GP GP G GP G P GP G GP GP P GP GP G GP GP GP GP P P ATP5B STXBP5 ortho GP GP G G G GP G GP GP G P P GP GP G GP GP G GP G GP GP P G GP GP GP P SUMO3 STXBP5 ortho GP GP G G G GP G GP GP G P P GP GP G GP GP G GP G GP GP P G GP GP GP P SUMO2 STXBP5 ortho GP GP G G G GP G GP GP G P P GP GP G GP GP G GP G GP GP P G GP GP GP P STXBP5 FTMT ortho P P P P P P P P P P P P P P P NTN1 STXBP5 ortho GP GP G GP G GP GP G P GP G G GP GP G GP G GP G P G GP GP P SNAP25 STXBP5 25402006, 21836163 ortho, pred G G G G GP G G GP G G G G G GP G G G G G G G G STXBP3 STXBP5 25402006 pred G GP G G G GP G G GP G P GP G G GP GP G GP G GP GP P G GP G GP P SLC6A1 STXBP5 25402006 pred G G G GP G G G G GP G G VAMP2 STXBP5 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G STXBP1 STXBP5 25402006 pred G G G G G GP G G GP G G G G G GP G GP G G G G G G G NAPA STXBP5 25402006 pred GP GP G G G GP G GP GP G P P GP GP G GP GP G GP G GP GP P G GP GP GP P SCNN1B STXBP5 25402006 pred GP GP G G P G GP G P P GP P G P P GP GP GP P GP GP GP P VAMP7 STXBP5 25402006 pred GP GP G G G GP G GP GP G P P GP GP G GP GP G GP G GP GP P G GP GP GP P STX1B STXBP5 25402006 pred G G G G G STXBP5 SLC6A5 25402006 pred P P G G P P P P P P P G GP GP P G P P GP P P P STXBP5 VAMP8 25402006 pred GP GP G G G G G GP GP G P P GP GP G GP G G GP G GP GP P G GP GP GP P STXBP5 STXBP4 25402006 pred P GP G G P P P P P P P G P P G GP G GP GP P GP P P P SCNN1G STXBP5 25402006 pred G G G STXBP5 TXLNB 25402006 pred GP P G G STXBP5 SYTL4 25402006 pred GP GP G G G GP G G GP G P P GP GP G P GP G GP G GP GP P GP G GP P SYT1 STXBP5 25402006 pred G G G G G GP G G G G G G G G GP G G G G G G G G G CPLX1 STXBP5 25402006 pred G G G G G G G G G G G G G G G G G SCNN1A STXBP5 25402006 pred GP GP P P GP P P GP GP G GP P GP G P GP P GP P GP P VAMP3 STXBP5 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B STXBP5 SIRT3 MI:0004(affinity chromatography technology) 22318606 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0796(suppressive genetic interaction defined by inequality) (biogrid) BIOGRID_193418 prey bait ARRB1 STXBP5 MI:0004(affinity chromatography technology) 17620599 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_188378 bait prey SNAP23 STXBP5 MI:0492(in vitro)|MI:0096(pull down) 12832401 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_11007|BIOGRID_88905 -|bait -|prey STX1A STXBP5 MI:0096(pull down)|MI:0492(in vitro)|MI:0096(pull down) 12832401,9620695 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_104082|HPRD_3286|BIOGRID_88903 bait|-|bait prey|-|prey STX4 STXBP5 MI:0096(pull down)|MI:0096(pull down)|MI:0492(in vitro) 12832401 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_88909|BIOGRID_88904|HPRD_3305 bait|bait|- prey|prey|-

PPI - HINT Gene A Gene B PMID Method Quality STX7 STXBP5 26186194 0004 HT STX6 STXBP5 26186194 0004 HT SNAP29 STXBP5 26186194 0004 HT STX1A STXBP5 9620695,12832401 0096,0096 LC STX3A STXBP5 26186194 0004 HT STXBP5 STX12 26186194 0004 HT STXBP5 STX19 26186194 0004 HT STXBP5 VTI1B 26186194 0004 HT STX7 STXBP5 26186194 0004 HT STX6 STXBP5 26186194 0004 HT SNAP29 STXBP5 26186194 0004 HT STX3A STXBP5 26186194 0004 HT STXBP5 STX12 26186194 0004 HT STXBP5 STX19 26186194 0004 HT STXBP5 VTI1B 26186194 0004 HT STX1A STXBP5 9620695,12832401 0096,0096 LC SNAP23 STXBP5 12832401,12832401 0018,0096 LC STX4 STXBP5 12832401,12832401 0018,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5T5C0 O43752 STXBP5 STX6 0.126 26186194 Q8N4C7 Q5T5C0 STX19 STXBP5 0.126 26186194 Q5T5C0 O15400 STXBP5 STX7 0.126 26186194 Q5T5C0 O95721 STXBP5 SNAP29 0.126 26186194 Q5T5C0 P49407 STXBP5 ARRB1 0.236 17620599 Q9UEU0 Q5T5C0 VTI1B STXBP5 0.126 26186194 Q5T5C0 Q13277 STXBP5 STX3 0.126 26186194 Q5T5C0 Q16623 STXBP5 STX1A 0.309 9620695

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SNAP23 STXBP5 MI:0045 experimental interaction detection MI:0461 interaction database NTN3 STXBP5 MI:0362 inference MI:0461 interaction database STX7 STXBP5 MI:0045 experimental interaction detection MI:0461 interaction database STX6 STXBP5 MI:0045 experimental interaction detection MI:0461 interaction database NTN1 STXBP5 MI:0362 inference MI:0461 interaction database SNAP29 STXBP5 MI:0045 experimental interaction detection MI:0461 interaction database ATP5B STXBP5 MI:0362 inference MI:0461 interaction database UBC STXBP5 MI:0045 experimental interaction detection MI:0461 interaction database ARRB1 STXBP5 MI:0045 experimental interaction detection MI:0461 interaction database SUMO3 STXBP5 MI:0362 inference MI:0461 interaction database SNAP25 STXBP5 MI:0362 inference MI:0461 interaction database SUMO2 STXBP5 MI:0362 inference MI:0461 interaction database SUMO1 STXBP5 MI:0362 inference MI:0461 interaction database STX4 STXBP5 MI:0045 experimental interaction detection MI:0461 interaction database STX3 STXBP5 MI:0045 experimental interaction detection MI:0461 interaction database STX1A STXBP5 MI:0045 experimental interaction detection MI:0461 interaction database STXBP5 SUMO4 MI:0362 inference MI:0461 interaction database STXBP5 STX12 MI:0045 experimental interaction detection MI:0461 interaction database STXBP5 STX19 MI:0045 experimental interaction detection MI:0461 interaction database STXBP5 VTI1B MI:0045 experimental interaction detection MI:0461 interaction database STXBP5 INO80 MI:0362 inference MI:0461 interaction database