PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus APP PEX2 21832049 biogrid exp G GP G G G GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP G PEX2 UBE2B 19410543 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX2 TLE4 16169070 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX2 TLE1 16169070 hprd,biogrid,mint,intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PEX2 CDKN1A 19410543 intact exp GP GP G G G G G G GP G G G GP G G GP G G G G GP G G G GP G G GP G PEX2 UBE2A 19410543 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX2 C14orf1 16169070 hprd,biogrid,i2d,mint,intact exp G GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PEX2 PEX19 20531392, 21836163, 16082366 mint,intact,bci exp, ortho, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PEX14 PEX2 21525035, 21836163 biogrid,intact exp, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PEX2 PEX5 22002062, 21836163 biogrid exp, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ABCD3 PEX2 21836163 bci exp, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G PEX10 PEX2 10837480, 23023127, 21836163 hprd,biogrid,bci exp, pred G G G G G GP G G GP G GP G G G G G GP G G G G G G G G G GP G PEX2 SUMO1 25402006 ortho, pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PEX2 SLC6A1 21836163 pred G G G GP G G G G G GP G G G PEX2 PDCD11 16082366 pred GP GP G G G GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G PEX2 LEO1 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP FYN PEX2 23023127 pred G GP G G G GP G G GP G GP GP G GP G G GP G G G G G G G G GP G G G PEX12 PEX2 23023127, 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GPI PEX2 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PEX2 KLC2 16082366 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PEX2 HDLBP 23023127 pred GP GP G G G GP G GP GP G GP GP G GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PEX2 BRCA1 23023127 pred P P G G P P P P P P P GP P P P P P P P P P P GP PEX2 HCFC1 21836163 pred GP GP G G G GP G GP G G GP GP GP G G G GP G G G G GP GP GP G G GP GP G PEX2 ABCD1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX2 WDR5 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX7 PEX2 21836163 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G G G GP GP GP GP GP GP G MEN1 PEX2 21836163 pred G GP G G G GP G G GP G GP GP GP GP G G GP G G G GP GP GP GP G G GP GP G RPLP1 PEX2 16082366 pred G G G G G GP G G GP G GP G G G G GP GP G GP G GP G GP G GP GP GP GP G SLC25A17 PEX2 21836163 pred GP GP G G G GP G GP GP G GP GP GP G G G GP GP GP G GP GP G GP G G GP GP G PEX2 EZH2 21836163 pred GP P G G GP P GP G GP G P P P GP GP GP GP PEX2 MBD1 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PEX2 PEX11G 21836163 pred G G G G G G G G G G G G G G G G G GP G G PEX2 MNX1 21836163 pred G G G G G G G G PEX1 PEX2 21836163 pred GP G G G G G G GP GP G GP G G G G GP G GP GP G GP GP GP GP GP G GP G EED PEX2 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G PEX11B PEX2 16082366 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G PRC1 PEX2 21836163 pred GP P G G G GP G GP GP G P P P GP G GP GP G GP GP P P P GP GP G GP PEX2 ESPL1 16082366 pred GP GP G G G GP GP GP G GP GP GP GP G GP GP GP GP G GP P GP GP GP GP GP GP G PEX2 ACADL 21836163 pred G P P G P P GP GP GP P G P P G GP G P G GP GP GP P P GP PEX2 PEX13 23023127, 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PEX2 ASCL2 21836163 pred G G G G G G PEX2 COX4I2 21836163 pred G GP G G G G G GP GP G GP G GP G G G G GP GP G GP GP GP GP G G GP GP G PEX2 CEP70 16082366 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G P GP GP GP GP GP GP GP G PEX2 UBE2D2 21836163 pred GP G G G G GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G PEX2 KLC1 16082366 pred GP GP G G G GP G GP GP G GP P GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G PEX2 RBBP5 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP PEX2 CDC73 21836163 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G PEX2 PEX6 21836163 pred P GP G GP G G GP G GP G P GP GP GP G GP G GP GP GP G GP GP P GP G PEX2 SORBS1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G PEX2 SHPRH 16082366 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PEX2 SUZ12 21836163 pred G G G G G G G G GP G GP G G GP G GP G G G G GP G G G GP G GP G G PEX2 STUB1 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PEX2 MYLIP 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PEX2 SCAP 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PEX2 CXXC1 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G XPO1 PEX2 16082366 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SETD1A PEX2 21836163 pred GP GP G G P GP GP GP P GP G P P P P G GP P P P GP GP GP GP G SEC14L2 PEX2 23023127 pred P P G GP P P G P GP P P G P GP P GP P GP P P P P P P G PEX2 TTC1 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP G G GP GP GP GP GP G GP GP G PEX2 PEX3 21836163 pred G GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PEX2 GABRA3 21836163 pred P P P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P28328 P05067-7 pull down 21832049 direct interaction X 2 P28328 affinity chromatography technology 22002062 physical association X 2 P28328 Q04724 two hybrid 16169070 direct interaction X 2 O75381 P28328 biochemical 21525035 association X 2 A0A024R068 P28328 pull down 10837480 direct interaction X 2 Q6FII3 P28328 two hybrid 16169070 direct interaction X 2 P28328 pull down 19410543 association C 9 P28328 anti tag coimmunoprecipitation 22002062 association C 21 P28328 pull down 19410543 association C 9 P28328 Q04724 two hybrid pooling approach 16169070 physical association X 2 P28328 P40855 peptide array 20531392 direct interaction X 2 P28328 P40855 peptide array 20531392 direct interaction X 2 P28328 P40855 peptide array 20531392 direct interaction X 2 Q8D192 P28328 two hybrid pooling approach 20711500 physical association X 2 Q6FII3 P28328 two hybrid pooling approach 16169070 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B PEX2 PEX5 MI:0004(affinity chromatography technology) 22002062 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255174 prey bait PEX2 TLE1 MI:0018(two hybrid)|MI:0492(in vitro)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0468(hprd)|MI:0471(mint)|(intact)|MI:0471(mint) BIOGRID_95328|HPRD_20869|MINT_33793|UniProt_154858|MINT_62734 bait|-|bait|bait|bait prey|-|prey|prey|prey PEX10 PEX2 MI:0018(two hybrid)|MI:0493(in vivo) 10837480 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_97612|HPRD_676 prey|- bait|- PEX2 C14orf1 MI:0492(in vitro)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|MI:0471(mint)|MI:0471(mint)|(intact) HPRD_20870|BIOGRID_95327|MINT_33794|MINT_62735|UniProt_154857 -|bait|bait|bait|bait -|prey|prey|prey|prey APP PEX2 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229283 prey bait PEX14 PEX2 MI:0096(pull down)|MI:0401(biochemical) 21525035 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association) (intact)|(biogrid) UniProt_113581|BIOGRID_257427 bait|bait prey|prey PEX2 PEX19 MI:0081(peptide array)|MI:0081(peptide array)|MI:0081(peptide array) 20531392 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(intact)|(intact) UniProt_107489|UniProt_107488|UniProt_107481 bait|bait|bait prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality PEX10 PEX2 10837480,10837480 0018,0096 LC PEX14 PEX2 21525035,21525035 0401,0096 LC PEX2 PEX19 20531392 0081 LC PEX2 TLE1 16169070,16169070 0018,0398 HT PEX2 Q59EF7 16169070 0018 HT PEX2 C14ORF1 16169070,16169070 0018,0398 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q04724 P28328 TLE1 PEX2 0.126 16169070 Q9GZS3 P28328 WDR61 PEX2 0.126 19410543 Q6P1J9 P28328 CDC73 PEX2 0.126 19410543 P49459 P28328 UBE2A PEX2 0.236 19410543 P28328 O75381 PEX2 PEX14 0.236 21525035 Q8WVC0 P28328 LEO1 PEX2 0.126 19410543 Q920N5 P28328 PEX5 PEX2 0.126 22002062 Q92541 P28328 RTF1 PEX2 0.126 19410543 P40855 P28328 PEX19 PEX2 0.523 20531392 Q8D192 P28328 CIRA2 PEX2 0.126 20711500 P28328 P05067 PEX2 APP 0.183 21832049 P28328 O60683 PEX2 PEX10 0.309 10837480 Q6PD62 P28328 CTR9 PEX2 0.126 19410543 P63146 P28328 UBE2B PEX2 0.236 19410543 Q9UKR5 P28328 C14ORF1 PEX2 0.126 16169070 P50542 P28328 PEX5 PEX2 0.126 22002062

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PEX10 PEX2 MI:0045 experimental interaction detection MI:0461 interaction database PEX14 PEX2 MI:0045 experimental interaction detection MI:0461 interaction database APP PEX2 MI:0045 experimental interaction detection MI:0461 interaction database PEX2 CDKN1A MI:0045 experimental interaction detection MI:0461 interaction database PEX2 PEX19 MI:0045 experimental interaction detection MI:0461 interaction database PEX2 UBE2A MI:0045 experimental interaction detection MI:0461 interaction database PEX2 PEX5 MI:0045 experimental interaction detection MI:0461 interaction database PEX2 UBE2B MI:0045 experimental interaction detection MI:0461 interaction database PEX2 SUMO1 MI:0362 inference MI:0461 interaction database PEX2 TLE1 MI:0045 experimental interaction detection MI:0461 interaction database PEX2 SUMO4 MI:0362 inference MI:0461 interaction database PEX2 C14orf1 MI:0045 experimental interaction detection MI:0461 interaction database PEX2 FOXA2 MI:0362 inference MI:0461 interaction database