Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change BLCA 7 150779267 150779267 + Silent SNP C C T TCGA-FD-A6TC-01A-21D-A339-08 TCGA-FD-A6TC-10A-21D-A339-08 g.chr7:150779267C>T c.384G>A c.(382-384)ttG>ttA p.L128L BLCA 7 150779321 150779321 + Silent SNP G G C TCGA-FD-A43P-01A-31D-A23U-08 TCGA-FD-A43P-10A-01D-A23U-08 g.chr7:150779321G>C c.330C>G c.(328-330)ctC>ctG p.L110L BLCA 7 150779421 150779421 + Missense_Mutation SNP C C T TCGA-XF-A9T5-01A-11D-A42E-08 TCGA-XF-A9T5-10A-01D-A42H-08 g.chr7:150779421C>T c.230G>A c.(229-231)aGa>aAa p.R77K BLCA 7 150779465 150779465 + Missense_Mutation SNP C C A TCGA-BT-A3PK-01A-21D-A21Z-08 TCGA-BT-A3PK-10A-01D-A21Z-08 g.chr7:150779465C>A c.186G>T c.(184-186)atG>atT p.M62I CHOL 7 150778815 150778815 + Missense_Mutation SNP G G A TCGA-W5-AA2X-01A-11D-A417-09 TCGA-W5-AA2X-10A-01D-A41A-09 g.chr7:150778815G>A c.562C>T c.(562-564)Ccc>Tcc p.P188S GBMLGG 7 150779522 150779522 + Silent SNP C C T TCGA-TQ-A7RP-01A-21D-A34A-08 TCGA-TQ-A7RP-10A-01D-A34A-08 g.chr7:150779522C>T c.129G>A c.(127-129)ccG>ccA p.P43P HNSC 7 150778971 150778971 + Missense_Mutation SNP G G A TCGA-CV-A6JE-01A-11D-A31L-08 TCGA-CV-A6JE-10A-01D-A31J-08 g.chr7:150778971G>A c.406C>T c.(406-408)Cgg>Tgg p.R136W HNSC 7 150779330 150779330 + Silent SNP C C T TCGA-CQ-5327-01A-01D-1683-08 TCGA-CQ-5327-10A-01D-1683-08 g.chr7:150779330C>T c.321G>A c.(319-321)ctG>ctA p.L107L KIPAN 7 150779559 150779559 + Missense_Mutation SNP G G C TCGA-UZ-A9Q1-01A-11D-A42J-10 TCGA-UZ-A9Q1-10A-01D-A42M-10 g.chr7:150779559G>C c.92C>G c.(91-93)aCg>aGg p.T31R KIRP 7 150779559 150779559 + Missense_Mutation SNP G G C TCGA-UZ-A9Q1-01A-11D-A42J-10 TCGA-UZ-A9Q1-10A-01D-A42M-10 g.chr7:150779559G>C c.92C>G c.(91-93)aCg>aGg p.T31R LGG 7 150779522 150779522 + Silent SNP C C T TCGA-TQ-A7RP-01A-21D-A34A-08 TCGA-TQ-A7RP-10A-01D-A34A-08 g.chr7:150779522C>T c.129G>A c.(127-129)ccG>ccA p.P43P LIHC 7 150778970 150778970 + Missense_Mutation SNP C C G TCGA-DD-AADI-01A-11D-A40R-10 TCGA-DD-AADI-10A-01D-A40U-10 g.chr7:150778970C>G c.407G>C c.(406-408)cGg>cCg p.R136P LIHC 7 150778972 150778972 + Silent SNP G G T TCGA-DD-AADI-01A-11D-A40R-10 TCGA-DD-AADI-10A-01D-A40U-10 g.chr7:150778972G>T c.405C>A c.(403-405)ggC>ggA p.G135G LIHC 7 150779558 150779558 + Silent SNP C C T TCGA-DD-AAEK-01A-11D-A40R-10 TCGA-DD-AAEK-10A-01D-A40U-10 g.chr7:150779558C>T c.93G>A c.(91-93)acG>acA p.T31T LUAD 7 150779461 150779461 + Missense_Mutation SNP C C T TCGA-95-7562-01A-11D-2238-08 TCGA-95-7562-10B-01D-2238-08 g.chr7:150779461C>T c.190G>A c.(190-192)Ggg>Agg p.G64R LUAD 7 150779566 150779566 + Missense_Mutation SNP C C A TCGA-05-4382-01A-01D-1931-08 TCGA-05-4382-10A-01D-1265-08 g.chr7:150779566C>A c.85G>T c.(85-87)Gtc>Ttc p.V29F PAAD 7 150779321 150779321 + Silent SNP G G T TCGA-OE-A75W-01A-12D-A32N-08 TCGA-OE-A75W-10A-01D-A32N-08 g.chr7:150779321G>T c.330C>A c.(328-330)ctC>ctA p.L110L SKCM 7 150778904 150778904 + Missense_Mutation SNP C C T TCGA-EE-A29T-06A-11D-A197-08 TCGA-EE-A29T-10A-01D-A199-08 g.chr7:150778904C>T c.473G>A c.(472-474)aGc>aAc p.S158N SKCM 7 150779298 150779298 + Missense_Mutation SNP C C T TCGA-EE-A29T-06A-11D-A197-08 TCGA-EE-A29T-10A-01D-A199-08 g.chr7:150779298C>T c.353G>A c.(352-354)aGg>aAg p.R118K

Mutation - ICGC Project Code Chromosome Chromosome Start Chromosome End Mutation Type Mutated from Allele Mutated to Allele Consequence Type AA Mutation CDS Mutation BLCA-US 7 150777000 150777000 single base substitution G A downstream_gene_variant BLCA-US 7 150779465 150779465 single base substitution C A missense_variant M62I 186G>T BRCA-EU 7 150773488 150773488 single base substitution C T downstream_gene_variant BRCA-EU 7 150776428 150776428 single base substitution C G downstream_gene_variant BRCA-EU 7 150777354 150777354 single base substitution G A downstream_gene_variant BRCA-EU 7 150780017 150780017 single base substitution C T 5_prime_UTR_variant BRCA-EU 7 150780017 150780017 single base substitution C T intron_variant BRCA-EU 7 150780017 150780017 single base substitution C T upstream_gene_variant BRCA-EU 7 150780240 150780240 single base substitution G A intron_variant BRCA-EU 7 150780240 150780240 single base substitution G A upstream_gene_variant BRCA-EU 7 150781075 150781075 single base substitution G T upstream_gene_variant BRCA-EU 7 150781076 150781076 single base substitution A T upstream_gene_variant BRCA-EU 7 150782129 150782129 single base substitution T G upstream_gene_variant BRCA-EU 7 150785463 150785463 insertion of <=200bp - A upstream_gene_variant BRCA-EU 7 150785616 150785616 single base substitution T A upstream_gene_variant BRCA-UK 7 150782129 150782129 single base substitution T G upstream_gene_variant BRCA-US 7 150773425 150773425 single base substitution G A downstream_gene_variant BRCA-US 7 150774051 150774051 single base substitution C G downstream_gene_variant BRCA-US 7 150774052 150774052 single base substitution G C downstream_gene_variant BRCA-US 7 150774081 150774081 single base substitution G A downstream_gene_variant BRCA-US 7 150774317 150774317 single base substitution A T downstream_gene_variant BTCA-JP 7 150775845 150775845 single base substitution C G downstream_gene_variant BTCA-JP 7 150775878 150775878 insertion of <=200bp - T downstream_gene_variant BTCA-JP 7 150776955 150776955 deletion of <=200bp G - downstream_gene_variant BTCA-JP 7 150776981 150776981 single base substitution T G downstream_gene_variant BTCA-JP 7 150779670 150779670 single base substitution G A 5_prime_UTR_variant CESC-US 7 150774001 150774001 single base substitution G A downstream_gene_variant COAD-US 7 150773255 150773255 single base substitution C T downstream_gene_variant COAD-US 7 150773835 150773835 single base substitution G A downstream_gene_variant COAD-US 7 150774459 150774459 single base substitution C T downstream_gene_variant COAD-US 7 150774464 150774464 deletion of <=200bp C - downstream_gene_variant COCA-CN 7 150773972 150773972 single base substitution C T downstream_gene_variant COCA-CN 7 150775306 150775306 single base substitution G A downstream_gene_variant COCA-CN 7 150776733 150776733 single base substitution C T downstream_gene_variant COCA-CN 7 150779673 150779673 single base substitution C A 5_prime_UTR_variant COCA-CN 7 150784101 150784101 single base substitution G T upstream_gene_variant COCA-CN 7 150784513 150784513 single base substitution C T upstream_gene_variant ESAD-UK 7 150773772 150773772 deletion of <=200bp C - downstream_gene_variant ESAD-UK 7 150774201 150774201 single base substitution C T downstream_gene_variant ESAD-UK 7 150778574 150778574 single base substitution G T 3_prime_UTR_variant ESAD-UK 7 150778574 150778574 single base substitution G T downstream_gene_variant KIRC-US 7 150773915 150773915 single base substitution G C downstream_gene_variant KIRC-US 7 150784022 150784022 single base substitution A C upstream_gene_variant KIRP-US 7 150773354 150773354 single base substitution C T downstream_gene_variant LAML-KR 7 150773807 150773807 single base substitution A T downstream_gene_variant LICA-CN 7 150776865 150776865 single base substitution C A downstream_gene_variant LICA-FR 7 150774405 150774405 single base substitution T G downstream_gene_variant LICA-FR 7 150776096 150776096 single base substitution T A downstream_gene_variant LIHC-US 7 150773389 150773389 single base substitution G A downstream_gene_variant LIHC-US 7 150774867 150774867 single base substitution C T downstream_gene_variant LIHC-US 7 150774997 150774997 single base substitution A G downstream_gene_variant LINC-JP 7 150773306 150773306 single base substitution C G downstream_gene_variant LINC-JP 7 150774602 150774602 single base substitution T G downstream_gene_variant LINC-JP 7 150776581 150776581 single base substitution C A downstream_gene_variant LINC-JP 7 150778908 150778908 single base substitution C A downstream_gene_variant LINC-JP 7 150778908 150778908 single base substitution C A missense_variant G157C 469G>T LINC-JP 7 150779590 150779590 single base substitution G A missense_variant L21F 61C>T LIRI-JP 7 150774478 150774478 single base substitution T A downstream_gene_variant LIRI-JP 7 150776741 150776741 single base substitution C T downstream_gene_variant LIRI-JP 7 150779363 150779363 single base substitution C A synonymous_variant P96P 288G>T LIRI-JP 7 150782573 150782573 single base substitution G A upstream_gene_variant LIRI-JP 7 150784483 150784483 single base substitution G C upstream_gene_variant LUSC-KR 7 150773287 150773287 single base substitution T C downstream_gene_variant LUSC-KR 7 150774051 150774051 single base substitution C T downstream_gene_variant LUSC-KR 7 150774308 150774308 single base substitution G A downstream_gene_variant LUSC-KR 7 150778752 150778752 single base substitution G A downstream_gene_variant LUSC-KR 7 150778752 150778752 single base substitution G A synonymous_variant L209L 625C>T LUSC-KR 7 150783124 150783124 single base substitution G A upstream_gene_variant LUSC-US 7 150784082 150784082 single base substitution C A upstream_gene_variant MALY-DE 7 150778089 150778089 single base substitution C T downstream_gene_variant MALY-DE 7 150781724 150781724 single base substitution C T upstream_gene_variant MALY-DE 7 150782044 150782044 single base substitution G A upstream_gene_variant MALY-DE 7 150784880 150784880 single base substitution T C upstream_gene_variant MELA-AU 7 150774396 150774396 single base substitution C T downstream_gene_variant MELA-AU 7 150775345 150775345 single base substitution G A downstream_gene_variant MELA-AU 7 150776078 150776078 single base substitution G A downstream_gene_variant MELA-AU 7 150777407 150777407 single base substitution G A downstream_gene_variant MELA-AU 7 150777742 150777742 single base substitution C T downstream_gene_variant MELA-AU 7 150778015 150778015 single base substitution G A downstream_gene_variant MELA-AU 7 150779496 150779496 single base substitution G A missense_variant P52L 155C>T MELA-AU 7 150780562 150780562 single base substitution C T 5_prime_UTR_variant MELA-AU 7 150780562 150780562 single base substitution C T upstream_gene_variant MELA-AU 7 150780806 150780806 single base substitution C T upstream_gene_variant MELA-AU 7 150781980 150781980 single base substitution C T upstream_gene_variant MELA-AU 7 150782258 150782258 single base substitution A G upstream_gene_variant MELA-AU 7 150782291 150782291 single base substitution G A upstream_gene_variant MELA-AU 7 150782480 150782480 single base substitution G C upstream_gene_variant MELA-AU 7 150783063 150783063 single base substitution A C upstream_gene_variant MELA-AU 7 150784432 150784432 single base substitution C T upstream_gene_variant MELA-AU 7 150784432 150784433 multiple base substitution (>=2bp and <=200bp) CC TT upstream_gene_variant OV-AU 7 150774479 150774479 single base substitution G A downstream_gene_variant OV-AU 7 150775132 150775132 single base substitution G A downstream_gene_variant OV-AU 7 150775454 150775454 single base substitution G A downstream_gene_variant OV-AU 7 150777981 150777981 single base substitution G A downstream_gene_variant PACA-AU 7 150775665 150775665 single base substitution G A downstream_gene_variant PACA-AU 7 150775837 150775837 single base substitution G C downstream_gene_variant PACA-AU 7 150776884 150776884 deletion of <=200bp C - downstream_gene_variant PACA-AU 7 150780353 150780353 single base substitution G A intron_variant PACA-AU 7 150780353 150780353 single base substitution G A upstream_gene_variant PACA-AU 7 150782670 150782670 deletion of <=200bp G - upstream_gene_variant PACA-AU 7 150784645 150784645 insertion of <=200bp - C upstream_gene_variant PACA-CA 7 150783961 150783963 deletion of <=200bp GGC - upstream_gene_variant PACA-CA 7 150783997 150783997 deletion of <=200bp C - upstream_gene_variant PBCA-DE 7 150776315 150776315 single base substitution T C downstream_gene_variant PBCA-DE 7 150778792 150778792 single base substitution G A downstream_gene_variant PBCA-DE 7 150778792 150778792 single base substitution G A synonymous_variant I195I 585C>T PBCA-DE 7 150780132 150780132 single base substitution A C 5_prime_UTR_variant PBCA-DE 7 150780132 150780132 single base substitution A C intron_variant PBCA-DE 7 150780132 150780132 single base substitution A C upstream_gene_variant PBCA-DE 7 150780772 150780772 single base substitution T C upstream_gene_variant PBCA-DE 7 150782034 150782034 deletion of <=200bp C - upstream_gene_variant PBCA-DE 7 150782617 150782617 single base substitution G A upstream_gene_variant PRAD-US 7 150773232 150773232 single base substitution G A downstream_gene_variant RECA-EU 7 150773972 150773972 single base substitution C T downstream_gene_variant RECA-EU 7 150782420 150782420 single base substitution C A upstream_gene_variant RECA-EU 7 150782475 150782475 single base substitution G T upstream_gene_variant SKCA-BR 7 150773521 150773521 single base substitution T C downstream_gene_variant SKCA-BR 7 150773670 150773670 single base substitution A G downstream_gene_variant SKCA-BR 7 150773759 150773759 single base substitution T C downstream_gene_variant SKCA-BR 7 150774860 150774860 single base substitution A G downstream_gene_variant SKCA-BR 7 150775534 150775534 single base substitution G A downstream_gene_variant SKCA-BR 7 150778058 150778058 single base substitution T G downstream_gene_variant SKCA-BR 7 150778085 150778085 single base substitution A C downstream_gene_variant SKCA-BR 7 150778117 150778117 single base substitution A G downstream_gene_variant SKCA-BR 7 150778129 150778129 single base substitution T C downstream_gene_variant SKCA-BR 7 150780138 150780138 single base substitution G C 5_prime_UTR_variant SKCA-BR 7 150780138 150780138 single base substitution G C intron_variant SKCA-BR 7 150780138 150780138 single base substitution G C upstream_gene_variant SKCA-BR 7 150780741 150780741 insertion of <=200bp - CG upstream_gene_variant SKCA-BR 7 150780747 150780747 single base substitution C G upstream_gene_variant SKCA-BR 7 150780759 150780759 single base substitution T G upstream_gene_variant SKCA-BR 7 150784408 150784408 single base substitution T G upstream_gene_variant SKCA-BR 7 150784611 150784611 single base substitution T G upstream_gene_variant SKCM-US 7 150773192 150773192 single base substitution C T downstream_gene_variant SKCM-US 7 150773331 150773331 insertion of <=200bp - C downstream_gene_variant SKCM-US 7 150775013 150775013 single base substitution C T downstream_gene_variant SKCM-US 7 150775018 150775018 single base substitution G A downstream_gene_variant SKCM-US 7 150776715 150776715 single base substitution C T downstream_gene_variant SKCM-US 7 150776809 150776809 single base substitution G A downstream_gene_variant SKCM-US 7 150776851 150776851 single base substitution G A downstream_gene_variant STAD-US 7 150774091 150774091 single base substitution C T downstream_gene_variant STAD-US 7 150774416 150774416 single base substitution C T downstream_gene_variant STAD-US 7 150774416 150774417 deletion of <=200bp CA - downstream_gene_variant STAD-US 7 150775020 150775020 single base substitution G A downstream_gene_variant STAD-US 7 150775086 150775086 single base substitution C T downstream_gene_variant STAD-US 7 150775740 150775740 single base substitution T C downstream_gene_variant STAD-US 7 150776883 150776883 single base substitution T C downstream_gene_variant STAD-US 7 150779570 150779570 single base substitution G T synonymous_variant A27A 81C>A STAD-US 7 150779627 150779627 single base substitution A G synonymous_variant G8G 24T>C STAD-US 7 150783997 150783997 insertion of <=200bp - C upstream_gene_variant THCA-SA 7 150774308 150774308 single base substitution G A downstream_gene_variant THCA-SA 7 150783911 150783911 single base substitution A G upstream_gene_variant THCA-SA 7 150783917 150783917 single base substitution T G upstream_gene_variant THCA-SA 7 150783922 150783922 insertion of <=200bp - GGGG upstream_gene_variant THCA-US 7 150773217 150773217 single base substitution G A downstream_gene_variant THCA-US 7 150774839 150774839 single base substitution G C downstream_gene_variant THCA-US 7 150775088 150775088 single base substitution C A downstream_gene_variant UCEC-US 7 150774819 150774819 single base substitution G A downstream_gene_variant UCEC-US 7 150775156 150775156 single base substitution G T downstream_gene_variant UCEC-US 7 150776649 150776649 single base substitution C T downstream_gene_variant UCEC-US 7 150779405 150779405 single base substitution C T synonymous_variant Q82Q 246G>A UCEC-US 7 150784185 150784185 single base substitution G A upstream_gene_variant

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand HCC58 COSM1622566 c.469G>T p.G157C Substitution - Missense 7:151081821-151081821 - CSCC-42-T COSM4500661 c.570C>T p.P190P Substitution - coding silent 7:151081720-151081720 - TCGA-HU-A4GU-01 COSM3879383 c.81C>A p.A27A Substitution - coding silent 7:151082483-151082483 - TCGA-BT-A3PK-01 COSM3778243 c.186G>T p.M62I Substitution - Missense 7:151082378-151082378 - PT46 COSM5928989 c.328C>T p.L110F Substitution - Missense 7:151082236-151082236 - T407 COSM4734817 c.313C>T p.L105L Substitution - coding silent 7:151082251-151082251 - ICGC_MB57 COSM3765338 c.585C>T p.I195I Substitution - coding silent 7:151081705-151081705 - SNUH_G38_S1 COSM3685112 c.659T>C p.F220S Substitution - Missense 7:151081631-151081631 - HCC64 COSM1622567 c.61C>T p.L21F Substitution - Missense 7:151082503-151082503 - CHEWS024 COSM4587263 c.317G>A p.R106Q Substitution - Missense 7:151082247-151082247 - C125 COSM4616942 c.309C>T p.L103L Substitution - coding silent 7:151082255-151082255 - 392 COSM4428322 c.47C>A p.S16* Substitution - Nonsense 7:151082517-151082517 - KM12 COSM1673680 c.80C>T p.A27V Substitution - Missense 7:151082484-151082484 - TCGA-B5-A0JR-01 COSM1087383 c.246G>A p.Q82Q Substitution - coding silent 7:151082318-151082318 - KM12 COSM4639216 c.538C>T p.P180S Substitution - Missense 7:151081752-151081752 - KM12 COSM1673681 c.79G>T p.A27S Substitution - Missense 7:151082485-151082485 - CCK81 COSM3261579 c.156C>A p.P52P Substitution - coding silent 7:151082408-151082408 - HCC64T COSM1622567 c.61C>T p.L21F Substitution - Missense 7:151082503-151082503 - CAKI-1 COSM1683643 c.302_303insGCCCCTCGT p.V104_L105insPLV Insertion - In frame 7:151082261-151082262 - 92 COSM5014765 c.210G>T p.E70D Substitution - Missense 7:151082354-151082354 - 388 COSM3723910 c.519G>C p.T173T Substitution - coding silent 7:151081771-151081771 - T3152 COSM4734818 c.168G>T p.M56I Substitution - Missense 7:151082396-151082396 - TCGA-BR-4366-01 COSM3879384 c.24T>C p.G8G Substitution - coding silent 7:151082540-151082540 - KM12 COSM1673680 c.80C>T p.A27V Substitution - Missense 7:151082484-151082484 - PTC-10C COSM4161966 c.293C>G p.S98C Substitution - Missense 7:151082271-151082271 - RKO COSM3261581 c.15A>G p.E5E Substitution - coding silent 7:151082549-151082549 - KM12 COSM1673681 c.79G>T p.A27S Substitution - Missense 7:151082485-151082485 - HCC58T COSM1622566 c.469G>T p.G157C Substitution - Missense 7:151081821-151081821 - 4_PRE-TREATMENT COSM1724349 c.667_668insC p.L223fs*>25 Insertion - Frameshift 7:151081622-151081623 -

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.726188;Hs.726209;Hs.726213;Hs.726215 7q36.1 614792

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer A G Synonymous p.G8G c.24T>C 7 150779627 STAD C A Missense p.M62I c.186G>T 7 150779465 BLCA C A Missense p.V29F c.85G>T 7 150779566 LUAD C T Missense p.R118K c.353G>A 7 150779298 CM C T Missense p.S158N c.473G>A 7 150778904 CM C T Synonymous p.L107L c.321G>A 7 150779330 HNSC C T Synonymous p.Q82Q c.246G>A 7 150779405 UCEC G A Synonymous p.I195I c.585C>T 7 150778792 MB