PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ACTA2 UBAP1 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G XPO1 UBAP1 26673895 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TSG101 UBAP1 22405001,26344197,24284069,21757351 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SHMT2 UBAP1 22658674 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MAP3K1 UBAP1 25260751 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBC UBAP1 19285159,21757351 innatedb,biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ENO1 UBAP1 22658674 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MOV10 UBAP1 22658674 biogrid exp G G G G G G G G G G G G G G G G G G G G G G VPS37A UBAP1 22405001,24284069,21757351 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBAP1 VPS28 22405001,26186194,24284069,21757351 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PTPN23 UBAP1 21757351 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CDC37L1 UBAP1 22863883 biogrid exp GP GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G UBAP1 UBAP1 22405001 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PPIC UBAP1 25416956 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G UBAP1 KIAA1468 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBAP1 NXF1 22658674 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G YWHAE UBAP1 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9NZ09 P88991 two hybrid 22028648 direct interaction X 2 Q9NZ09 ubiquitinase assay 25260751 ubiquitination reaction C 5 Q9NZ09 P88991 two hybrid array 22028648 physical association X 2 P45877 Q9NZ09 two hybrid prey pooling approach 25416956 physical association X 2 P45877 Q9NZ09 two hybrid array 25416956 physical association X 2 P45877 Q9NZ09 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBAP1 VPS28 MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology) 21757351,22405001,24284069 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_195305|BIOGRID_221861|BIOGRID_307563 prey|bait|prey bait|prey|bait TSG101 UBAP1 MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21757351,22405001,24284069 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_221860|BIOGRID_307570|BIOGRID_221858|BIOGRID_195302|BIOGRID_307562|BIOGRID_195312|BIOGRID_307564 prey|bait|bait|bait|bait|prey|prey bait|prey|prey|prey|prey|bait|bait ACTA2 UBAP1 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240146 bait prey CDC37L1 UBAP1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304748 bait prey UBAP1 VPS37C MI:0004(affinity chromatography technology) 21757351 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_195311 bait prey VPS37A UBAP1 MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21757351,22405001,24284069 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_221862|BIOGRID_195310|BIOGRID_307569|BIOGRID_307565 prey|prey|bait|prey bait|bait|prey|bait UBAP1 KIAA1468 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_300756 bait prey UBC UBAP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 19285159,21139048,21757351,21890473,21906983,21963094,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_195309|BIOGRID_267830|BIOGRID_179330|BIOGRID_170071|BIOGRID_264159|BIOGRID_200656|BIOGRID_174210 prey|bait|bait|bait|bait|bait|bait bait|prey|prey|prey|prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality UBC UBAP1 21757351,26456826,19285159,21757351 0096,0096,0096,0004 LC ACTA2 UBAP1 22939629 0401 HT CDC37L1 UBAP1 22863883 0401 HT VPS37A UBAP1 22405001,24284069,21757351 0004,0004,0004 LC TSG101 UBAP1 24284069,26456826,24284069,22405001,26344197,21757351 0004,0004,0096,0004,0401,0004 LC,HT UBAP1 KIAA1468 22863883 0401 HT UBAP1 VPS28 26186194,22405001,24284069,21757351 0004,0004,0004,0004 HT,LC ACTA2 UBAP1 22939629 0401 HT CDC37L1 UBAP1 22863883 0401 HT TSG101 UBAP1 26344197 0401 HT UBAP1 KIAA1468 22863883 0401 HT UBAP1 VPS28 26186194 0004 HT UBC UBAP1 21757351,26456826,19285159,21757351 0096,0096,0096,0004 LC VPS37A UBAP1 22405001,24284069,21757351 0004,0004,0004 LC TSG101 UBAP1 24284069,26456826,24284069,22405001,21757351 0004,0004,0096,0004,0004 LC UBAP1 VPS28 22405001,24284069,21757351 0004,0004,0004 LC PPIC UBAP1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT ACTA2 UBAP1 22939629 0401 LC MAP3K1 UBAP1 25260751 0415 LC CDC37L1 UBAP1 22863883 0401 LC TSG101 UBAP1 26344197 0401 LC PTPN23 UBAP1 21757351 0018 LC UBAP1 UBAP1 22405001 0114 LC UBAP1 KIAA1468 22863883 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NZ09 Q9HCE1 UBAP1 MOV10 0.126 22658674 Q9NZ09 P08648 UBAP1 ITGA5 0.309 26456826 Q9NZ09 P0CG48 UBAP1 UBC 0.671 26456826,21757351,19285159 Q9NZ09 P88991 UBAP1 BQRF1 0.126 22028648 Q9NZ09 Q9NZ09 UBAP1 UBAP1 0.332 22405001 Q9P260 Q9NZ09 KIAA1468 UBAP1 0.081 22863883 Q9UK41 Q9NZ09 VPS28 UBAP1 0.569 22405001,21757351,26186194,24284069 Q9NZ09 Q62925 UBAP1 MAP3K1 0.033 25260751 Q9NZ09 Q7L3B6 UBAP1 CDC37L1 0.081 22863883 Q9NZ09 Q6P5F9 UBAP1 XPO1 0.126 26673895 Q9NZ09 P06733 UBAP1 ENO1 0.126 22658674 Q9NZ09 Q8NEZ2 UBAP1 VPS37A 0.692 22405001,21757351,24284069 Q9NZ09 Q9D1C8 UBAP1 VPS28 0.236 26496610 Q9NZ09 Q9H3S7 UBAP1 PTPN23 0.454 26456826,21757351 Q9NZ09 Q61187 UBAP1 TSG101 0.236 26496610 Q9NZ09 Q99816 UBAP1 TSG101 0.878 21757351,24284069,26344197,26456826,22405001 Q9UBU9 Q9NZ09 NXF1 UBAP1 0.126 22658674 Q9NZ09 P34897 UBAP1 SHMT2 0.126 22658674 Q9NZ09 P45877 UBAP1 PPIC 0.454 25416956 Q9NZ09 P62736 UBAP1 ACTA2 0.081 22939629 Q9NZ09 Q13233 UBAP1 MAP3K1 0.183 25260751

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 VPS37C UBAP1 MI:0045 experimental interaction detection MI:0461 interaction database XPO1 UBAP1 MI:0045 experimental interaction detection MI:0461 interaction database ENO1 UBAP1 MI:0045 experimental interaction detection MI:0461 interaction database ITGA5 UBAP1 MI:0045 experimental interaction detection MI:0461 interaction database UBC UBAP1 MI:0045 experimental interaction detection MI:0461 interaction database SHMT2 UBAP1 MI:0045 experimental interaction detection MI:0461 interaction database PPIC UBAP1 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K1 UBAP1 MI:0045 experimental interaction detection MI:0461 interaction database VPS37A UBAP1 MI:0045 experimental interaction detection MI:0461 interaction database TSG101 UBAP1 MI:0045 experimental interaction detection MI:0461 interaction database PTPN23 UBAP1 MI:0045 experimental interaction detection MI:0461 interaction database MOV10 UBAP1 MI:0045 experimental interaction detection MI:0461 interaction database UBAP1 NXF1 MI:0045 experimental interaction detection MI:0461 interaction database UBAP1 VPS28 MI:0045 experimental interaction detection MI:0461 interaction database