PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ACTN1 FXN 16713569 hprd,biogrid,mint,intact exp G G G G G GP G G G G G GP GP GP G G GP G G G GP G GP G G GP G G G FXN PASK 21418524 mint,intact exp GP P G G G GP G P GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP PMPCB FXN 9700204 hprd,biogrid,bci exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G SDHA FXN 15961414 intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G FXN PICK1 16713569 hprd,biogrid,mint,intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G SDHB FXN 15961414, 21836163 intact exp, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G YWHAE FXN ortho GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G NDUFA2 FXN 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G UQCRC1 FXN 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G IGFBP1 FXN 23023127 pred GP G G G GP G FXN NFS1 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G PRSS2 FXN 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G FXN PCSK9 23023127 pred G G G G G G GP P G G G G HP FXN 23023127 pred G G G G G G G G G G GP G G G G G G G G G G G KLKB1 FXN 23023127 pred GP GP G GP P G GP GP P GP GP GP GP G P P P G GP P P GP TTPA FXN 21836163 pred G G G G G G PARP1 FXN 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G LCN2 FXN 23023127 pred GP G G G G G GP G G G G G G G G G G G G G GP GP G G APBA1 FXN 23023127, 21836163 pred P GP G GP G GP P G GP GP P GP G GP GP G P G P P GP G GP GP GP GP G NTF4 FXN 23023127 pred P P P P G P G P ABL2 FXN 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G CGA FXN 23023127 pred G G G G G GP G G G ETFA FXN 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G F12 FXN 23023127 pred G G G G P G P GP G G G G G G G P G G G G G P G FXN APBA2 23023127 pred P P G G G GP G P P G P P P GP P GP P P P P P GP P P PRSS3 FXN 23023127 pred P P P FXN ISLR2 23023127 pred G G G G G G G G G G FXN KLK6 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UQCRC2 FXN 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G PARK2 FXN 23023127 pred P GP G GP G GP GP G GP P P G P GP G P G P GP G GP P GP G RBP4 FXN 23023127 pred G G G G G G G GP GP G G G G G GP G G G G G G P ATXN7 FXN 21836163 pred GP G G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP G G FXN ISCU 23023127, 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G F11 FXN 23023127 pred G G G G G G G G G G G G G KRAS FXN 23023127 pred G G G G G GP G G GP G GP G G GP G GP GP G GP G G GP GP G GP G GP GP G FXN SPTBN4 23023127 pred P G GP G P GP G P P P P GP G P P G P P GP KLK8 FXN 23023127 pred GP G G G G G G G G G GP G G G G G G G G G G G G G G G G G C8B FXN 23023127 pred GP G G G GP G GP P GP GP G GP G G G G G G GP G FGF7 FXN 23023127 pred G G G G P GP G G G GP P GP GP G GP G FXN FGD4 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G DNM2 FXN 23023127 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G FXN KLK13 23023127 pred G G G G G GP G G GP G GP G G GP G GP GP G GP G GP GP GP G GP GP GP GP G AVP FXN 23023127 pred G G G G G GAA FXN 21836163 pred GP GP G G G GP G G GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G NTN1 FXN 23023127 pred GP GP G GP G GP GP G P G GP G G GP GP G GP G GP G GP G GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O75439 Q16595 two hybrid 9700204 direct interaction X 2 O75439 Q16595 pull down 9700204 direct interaction X 2 P0CG48 Q16595 affinity chromatography technology 21890473 physical association X 2 Q16595 P12814-2 two hybrid 16713569 direct interaction X 2 Q16595 A0A024R1J5 two hybrid 16713569 direct interaction X 2 Q16595 coimmunoprecipitation 17331979 association C 7 P21912 Q16595 anti tag coimmunoprecipitation 15961414 physical association X 2 Q16595 A0A024R1J5 two hybrid 16713569 physical association X 2 P31040 Q16595 anti tag coimmunoprecipitation 15961414 physical association X 2 Q16595 A0A024R694 two hybrid 16713569 physical association X 2 Q96RG2 Q16595 protein kinase assay 21418524 phosphorylation reaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SDHA FXN MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 15961414 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_79735|UniProt_194560 prey|prey bait|bait FXN PASK MI:0424(protein kinase assay) 21418524 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0217(phosphorylation reaction) (intact) UniProt_113307 neutral component neutral component PMPCB FXN MI:0492(in vitro)|MI:0018(two hybrid)|MI:0018(two hybrid) 9700204 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0468(hprd)|(biogrid)|(biogrid) HPRD_13998|BIOGRID_98892|BIOGRID_98891 -|bait|bait -|prey|prey SDHB FXN MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 15961414 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_79736|UniProt_194561 prey|prey bait|bait ACTN1 FXN MI:0397(two hybrid array)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association) (intact)|MI:0471(mint)|(biogrid)|MI:0468(hprd)|MI:0471(mint) UniProt_86369|MINT_50048|BIOGRID_215805|HPRD_27229|MINT_82336 prey|prey|prey|-|prey bait|bait|bait|-|bait FXN PICK1 MI:0096(pull down)|MI:0397(two hybrid array)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0471(mint)|MI:0468(hprd)|(biogrid) MINT_50454|UniProt_86370|MINT_82742|HPRD_5184|BIOGRID_215806 bait|bait|bait|-|bait prey|prey|prey|-|prey UBC FXN MI:0004(affinity chromatography technology) 21890473 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_173692 bait prey FXN NRF1 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295239 prey bait

PPI - HINT Gene A Gene B PMID Method Quality FXN LYRM4 27499296 0004 HT FXN LYRM4 27499296 0004 HT PMPCB FXN 9700204,9700204 0018,0096 LC ACTN1 FXN 16713569 0018 HT FXN FXN 21671584,21776984 0114,0114 LC FXN PASK 21418524 0424 LC FXN PICK1 16713569 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9HD34 Q16595 LYRM4 FXN 0.126 27499296 Q16595 A6NEM1 FXN GOLGA6L9 {ECO:0000312|HGNC:HGNC:37229} 0.236 unassigned1304 Q16595 O75439 FXN PMPCB 0.523 9700204 Q9NRD5 Q16595 PICK1 FXN 0.332 16713569 Q96RG2 Q16595 PASK FXN 0.033 21418524 Q16595 P12814 FXN ACTN1 0.332 16713569

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PMPCB FXN MI:0045 experimental interaction detection MI:0461 interaction database UBC FXN MI:0045 experimental interaction detection MI:0461 interaction database ACTN1 FXN MI:0045 experimental interaction detection MI:0461 interaction database ETFA FXN MI:0362 inference MI:0461 interaction database SDHB FXN MI:0045 experimental interaction detection MI:0461 interaction database FECH FXN MI:0362 inference MI:0461 interaction database SDHA FXN MI:0045 experimental interaction detection MI:0461 interaction database ETFB FXN MI:0362 inference MI:0461 interaction database LMNB2 FXN MI:0362 inference MI:0461 interaction database FXN TBC1D5 MI:0362 inference MI:0461 interaction database FXN CMTM5 MI:0362 inference MI:0461 interaction database FXN PASK MI:0045 experimental interaction detection MI:0461 interaction database FXN ACO2 MI:0362 inference MI:0461 interaction database FXN ISCU MI:0362 inference MI:0461,MI:1106 interaction database,pathways database FXN LYRM4 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FXN PICK1 MI:0045 experimental interaction detection MI:0461 interaction database FXN NFS1 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database