PTM - CPLM Gene Name UniProt ID Type Position Code INPPL1; SHIP2 O15357 Ubiquitination 331 K INPPL1; SHIP2 O15357 Ubiquitination 224 K INPPL1; SHIP2 O15357 Ubiquitination 234 K INPPL1; SHIP2 O15357 Ubiquitination 376 K INPPL1; SHIP2 O15357 Ubiquitination 779 K INPPL1; SHIP2 O15357 Ubiquitination 315 K INPPL1; SHIP2 O15357 Ubiquitination 412 K INPPL1; SHIP2 O15357 Ubiquitination 267 K

PTM - dbPAF Gene Name UniProt ID Position Type Species INPPL1; SHIP2 O15357 1003 S Homo sapiens(Human) INPPL1; SHIP2 O15357 1011 S Homo sapiens(Human) INPPL1; SHIP2 O15357 1013 T Homo sapiens(Human) INPPL1; SHIP2 O15357 1038 S Homo sapiens(Human) INPPL1; SHIP2 O15357 1039 S Homo sapiens(Human) INPPL1; SHIP2 O15357 1040 S Homo sapiens(Human) INPPL1; SHIP2 O15357 1044 S Homo sapiens(Human) INPPL1; SHIP2 O15357 1047 T Homo sapiens(Human) INPPL1; SHIP2 O15357 1061 S Homo sapiens(Human) INPPL1; SHIP2 O15357 1068 S Homo sapiens(Human) INPPL1; SHIP2 O15357 1104 S Homo sapiens(Human) INPPL1; SHIP2 O15357 1129 T Homo sapiens(Human) INPPL1; SHIP2 O15357 1131 S Homo sapiens(Human) INPPL1; SHIP2 O15357 1135 Y Homo sapiens(Human) INPPL1; SHIP2 O15357 1160 S Homo sapiens(Human) INPPL1; SHIP2 O15357 1162 Y Homo sapiens(Human) INPPL1; SHIP2 O15357 1167 S Homo sapiens(Human) INPPL1; SHIP2 O15357 1176 S Homo sapiens(Human) INPPL1; SHIP2 O15357 1202 S Homo sapiens(Human) INPPL1; SHIP2 O15357 1213 Y Homo sapiens(Human) INPPL1; SHIP2 O15357 1253 T Homo sapiens(Human) INPPL1; SHIP2 O15357 1257 S Homo sapiens(Human) INPPL1; SHIP2 O15357 132 S Homo sapiens(Human) INPPL1; SHIP2 O15357 154 T Homo sapiens(Human) INPPL1; SHIP2 O15357 157 S Homo sapiens(Human) INPPL1; SHIP2 O15357 158 S Homo sapiens(Human) INPPL1; SHIP2 O15357 165 T Homo sapiens(Human) INPPL1; SHIP2 O15357 167 T Homo sapiens(Human) INPPL1; SHIP2 O15357 182 S Homo sapiens(Human) INPPL1; SHIP2 O15357 185 Y Homo sapiens(Human) INPPL1; SHIP2 O15357 189 S Homo sapiens(Human) INPPL1; SHIP2 O15357 190 Y Homo sapiens(Human) INPPL1; SHIP2 O15357 240 S Homo sapiens(Human) INPPL1; SHIP2 O15357 241 S Homo sapiens(Human) INPPL1; SHIP2 O15357 290 S Homo sapiens(Human) INPPL1; SHIP2 O15357 291 S Homo sapiens(Human) INPPL1; SHIP2 O15357 352 S Homo sapiens(Human) INPPL1; SHIP2 O15357 43 S Homo sapiens(Human) INPPL1; SHIP2 O15357 49 S Homo sapiens(Human) INPPL1; SHIP2 O15357 62 Y Homo sapiens(Human) INPPL1; SHIP2 O15357 622 Y Homo sapiens(Human) INPPL1; SHIP2 O15357 661 Y Homo sapiens(Human) INPPL1; SHIP2 O15357 663 Y Homo sapiens(Human) INPPL1; SHIP2 O15357 671 Y Homo sapiens(Human) INPPL1; SHIP2 O15357 827 S Homo sapiens(Human) INPPL1; SHIP2 O15357 831 Y Homo sapiens(Human) INPPL1; SHIP2 O15357 833 S Homo sapiens(Human) INPPL1; SHIP2 O15357 854 T Homo sapiens(Human) INPPL1; SHIP2 O15357 857 S Homo sapiens(Human) INPPL1; SHIP2 O15357 881 T Homo sapiens(Human) INPPL1; SHIP2 O15357 886 Y Homo sapiens(Human) INPPL1; SHIP2 O15357 890 S Homo sapiens(Human) INPPL1; SHIP2 O15357 958 T Homo sapiens(Human) INPPL1; SHIP2 O15357 980 S Homo sapiens(Human) INPPL1; SHIP2 O15357 986 Y Homo sapiens(Human) INPPL1; SHIP2 O15357 987 Y Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA O15357 K272-ac Acetylation VLKLSVLkDFLSGIQ O15357 R198-m1 Methylation GLDLEAVrGGASHLP O15357 R1080-m1 Methylation PGPVVRGrGGAEArG O15357 R1086-m1 Methylation GrGGAEArGPPPPKA O15357 R1096-m1 Methylation PPPKAHPrPPLPPGP O15357 R1142-m1 Methylation yAPAGPArSALLPGP O15357 S43-p Phosphorylation ARAGRDGsFLVRDsE O15357 S49-p Phosphorylation GsFLVRDsESVAGAF O15357 Y62-p Phosphorylation AFALCVLyQKHVHTY O15357 S132-p Phosphorylation PPDDRDAsDGEDEKP O15357 S158-p Phosphorylation SAPTGPSsPLPAPEt O15357 T165-p Phosphorylation sPLPAPEtPtAPAAE O15357 T167-p Phosphorylation LPAPEtPtAPAAESA O15357 S182-p Phosphorylation PNGLSTVsHDyLKGs O15357 Y185-p Phosphorylation LSTVsHDyLKGsyGL O15357 S189-p Phosphorylation sHDyLKGsyGLDLEA O15357 Y190-p Phosphorylation HDyLKGsyGLDLEAV O15357 S241-p Phosphorylation kVFDQQSsPMVTRLL O15357 T306-p Phosphorylation PSTRKAKtIPVQAFE O15357 S352-p Phosphorylation LLRRQRDsQEDWTTF O15357 Y622-p Phosphorylation DIQEILNyISRKEFE O15357 Y661-p Phosphorylation EISFPPTyRyERGSR O15357 Y663-p Phosphorylation SFPPTyRyERGSRDT O15357 Y671-p Phosphorylation ERGSRDTyAWHKQKP O15357 S827-p Phosphorylation HLLLTVKsMDGyEsY O15357 Y831-p Phosphorylation TVKsMDGyEsYGECV O15357 S833-p Phosphorylation KsMDGyEsYGECVVA O15357 T854-p Phosphorylation STAQQFLtFLsHRGE O15357 S857-p Phosphorylation QQFLtFLsHRGEETG O15357 T881-p Phosphorylation VPTERLGtRERLyEW O15357 Y886-p Phosphorylation LGtRERLyEWIsIDK O15357 S890-p Phosphorylation ERLyEWIsIDKDEAG O15357 T958-p Phosphorylation APREEPLtPRLKPEG O15357 S980-p Phosphorylation AAPPPKNsFNNPAyy O15357 Y986-p Phosphorylation NsFNNPAyyVLEGVP O15357 Y987-p Phosphorylation sFNNPAyyVLEGVPH O15357 S1003-p Phosphorylation LLPPEPPsPARAPVP O15357 S1011-p Phosphorylation PARAPVPsAtKNKVA O15357 T1013-p Phosphorylation RAPVPsAtKNKVAIT O15357 T1047-p Phosphorylation SDEESGGtLPPPDFP O15357 S1068-p Phosphorylation SAIFLPPsLDPLPGP O15357 S1104-p Phosphorylation PPLPPGPsPASTFLG O15357 T1129-p Phosphorylation SVLQMAKtLsEVDyA O15357 S1131-p Phosphorylation LQMAKtLsEVDyAPA O15357 Y1135-p Phosphorylation KtLsEVDyAPAGPAr O15357 S1160-p Phosphorylation QPPRGLPsDyGRPLs O15357 Y1162-p Phosphorylation PRGLPsDyGRPLsFP O15357 S1167-p Phosphorylation sDyGRPLsFPPPRIR O15357 S1176-p Phosphorylation PPPRIREsIQEDLAE O15357 S1202-p Phosphorylation GLGEAGMsAWLRAIG O15357 Y1213-p Phosphorylation RAIGLERyEEGLVHN O15357 T1253-p Phosphorylation HKRLLLDtLQLsK__ O15357 S1257-p Phosphorylation LLDtLQLsK______ O15357 K224-ub Ubiquitination RLHSEVDkVLSGLEI O15357 K234-ub Ubiquitination SGLEILSkVFDQQSs O15357 K315-ub Ubiquitination PVQAFEVkLDVTLGD O15357 K331-ub Ubiquitination TKIGKSQkFTLSVDV O15357 K376-ub Ubiquitination KSQRVQNkLGVVFEK O15357 K412-ub Ubiquitination CQLLQLMkNKHSKQD O15357 K741-ub Ubiquitination ISKKGLSkTSDQAYI O15357 K779-ub Ubiquitination TCLEEYKkSFENDAQ

PTM - dbPTM UniProt ID Position Code Type Resources References O15357 132 S Phosphorylation Swiss-Prot 1010711 17081983 O15357 158 S Phosphorylation Swiss-Prot 1010711 18669648 O15357 165 T Phosphorylation Swiss-Prot 1010711 18669648 O15357 241 S Phosphorylation Swiss-Prot 1010711 18669648;18691976 O15357 671 Y Phosphorylation Swiss-Prot 1010711 12522270 O15357 886 Y Phosphorylation Swiss-Prot 1010711 12522270;15592455;17389395;19534553 O15357 958 T Phosphorylation Swiss-Prot 1010711 17219406 O15357 986 Y Phosphorylation Swiss-Prot 1010711 11349134;12235291;12522270;15592455;15951569;17081983;17389395;18083107;19534553 O15357 987 Y Phosphorylation Swiss-Prot 1010711 19534553 O15357 1003 S Phosphorylation Swiss-Prot 1010711 12522270;15951569;17081983 O15357 1135 Y Phosphorylation Swiss-Prot 1010711 12522270;17081983;17389395;19534553 O15357 1162 Y Phosphorylation Swiss-Prot 1010711 11687594;12522270 O15357 132 S Phosphorylation PhosphoELM.10011 17081983 O15357 158 S Phosphorylation PhosphoELM.10011 18669648 O15357 241 S Phosphorylation PhosphoELM.10011 18669648 O15357 1003 S Phosphorylation PhosphoELM.10011 17081983;15951569 O15357 165 T Phosphorylation PhosphoELM.10011 18669648 O15357 167 T Phosphorylation PhosphoELM.10011 18669648 O15357 671 Y Phosphorylation PhosphoELM.10011 12522270 O15357 886 Y Phosphorylation PhosphoELM.10011 15592455;12522270 O15357 986 Y Phosphorylation PhosphoELM.10011 17081983 O15357 1135 Y Phosphorylation PhosphoELM.10011 17081983;12522270 O15357 1162 Y Phosphorylation PhosphoELM.10011 12522270 O15357 986 Y Phosphorylation PhosphoELM.10011 18669648;18083107;17081983;15592455;12522270;12235291 O15357 987 Y Phosphorylation PhosphoELM.10011 12235291 O15357 224 K Ubiquitylation Phosphositeplus.1010730 21890473 O15357 234 K Ubiquitylation Phosphositeplus.1010730 21890473 O15357 315 K Ubiquitylation Phosphositeplus.1010730 19880507 O15357 412 K Ubiquitylation Phosphositeplus.1010730 21906983 O15357 1003 S Phosphorylation Phosphositeplus.1010730 12522270;15951569;18180459;19534553;19901323;20007894 O15357 1104 S Phosphorylation Phosphositeplus.1010730 12522270 O15357 1257 S Phosphorylation Phosphositeplus.1010730 21770892 O15357 132 S Phosphorylation Phosphositeplus.1010730 17081983;21770892 O15357 158 S Phosphorylation Phosphositeplus.1010730 18669648 O15357 241 S Phosphorylation Phosphositeplus.1010730 18669648;18691976;20068231;22115753 O15357 890 S Phosphorylation Phosphositeplus.1010730 20068231 O15357 1253 T Phosphorylation Phosphositeplus.1010730 21770892 O15357 165 T Phosphorylation Phosphositeplus.1010730 18669648 O15357 167 T Phosphorylation Phosphositeplus.1010730 18669648 O15357 958 T Phosphorylation Phosphositeplus.1010730 17219406 O15357 1135 Y Phosphorylation Phosphositeplus.1010730 12522270;16464493;16497976;16858728;17016520;17389395;17646646;17870612;18083107;18180459;18776048;19534553;19901323;20007894;20090780;20562096;20736484;21403953;21447384 O15357 1162 Y Phosphorylation Phosphositeplus.1010730 11687594;12522270;16497976;18083107;18180459;20736484;21447384 O15357 663 Y Phosphorylation Phosphositeplus.1010730 20090780 O15357 671 Y Phosphorylation Phosphositeplus.1010730 12522270 O15357 831 Y Phosphorylation Phosphositeplus.1010730 21403953;21447384 O15357 886 Y Phosphorylation Phosphositeplus.1010730 12522270;15592455;17016520;17389395;18083107;18180459;19534553;19901323;20007894;20068231;20562096;20736484;21394647;21403953;21447384;22322096 O15357 986 Y Phosphorylation Phosphositeplus.1010730 12522270;15592455;15951569;16464493;16497976;17016520;17219406;17360941;17389395;18083107;18180459;18669648;19410646;19534553;19658100;19901323;20007894;20090780;20736484;21394647;21403953;21447384 O15357 987 Y Phosphorylation Phosphositeplus.1010730 17219406;18083107;18180459;19534553;20007894;20736484 O15357 132 S Phosphorylation HPRD 9.0 19651622,18452278 O15357 158 S Phosphorylation HPRD 9.0 18669648 O15357 240 S Phosphorylation HPRD 9.0 18691976 O15357 241 S Phosphorylation HPRD 9.0 18669648,18691976,20068231 O15357 290 S Phosphorylation HPRD 9.0 20068231 O15357 291 S Phosphorylation HPRD 9.0 20068231 O15357 890 S Phosphorylation HPRD 9.0 20068231 O15357 1003 S Phosphorylation HPRD 9.0 12522270,19901323 O15357 1038 S Phosphorylation HPRD 9.0 20068231 O15357 1039 S Phosphorylation HPRD 9.0 20068231 O15357 1061 S Phosphorylation HPRD 9.0 20068231 O15357 1068 S Phosphorylation HPRD 9.0 20068231 O15357 165 T Phosphorylation HPRD 9.0 18669648 O15357 167 T Phosphorylation HPRD 9.0 18669648 O15357 671 Y Phosphorylation HPRD 9.0 12522270 O15357 886 Y Phosphorylation HPRD 9.0 12522270,17389395,19901323,20068231 O15357 1135 Y Phosphorylation HPRD 9.0 12522270,17389395,16497976,19901323 O15357 1162 Y Phosphorylation HPRD 9.0 12522270,16497976 O15357 986 Y Phosphorylation (SRC) HPRD 9.0 12235291,17389395,16497976,19901323,18669648 O15357 987 Y Phosphorylation (SRC) HPRD 9.0 12235291,16497976 O15357 132 S Phosphorylation SysPTM 1.1 17081983 O15357 158 S Phosphorylation SysPTM 1.1 18669648 O15357 165 T Phosphorylation SysPTM 1.1 18669648 O15357 1135 Y Phosphorylation SysPTM 1.1 17081983

PTM - HPRD Symbol Position Code Type References INPPL1 1003 S Phosphorylation 12522270,19901323 INPPL1 1038 S Phosphorylation 20068231 INPPL1 1039 S Phosphorylation 20068231 INPPL1 1061 S Phosphorylation 20068231 INPPL1 1068 S Phosphorylation 20068231 INPPL1 1134 Y Phosphorylation 17016520 INPPL1 1135 Y Phosphorylation 12522270,17389395,16497976,19901323 INPPL1 1162 Y Phosphorylation 12522270,16497976 INPPL1 132 S Phosphorylation 19651622,18452278 INPPL1 158 S Phosphorylation 18669648 INPPL1 165 T Phosphorylation 18669648 INPPL1 167 T Phosphorylation 18669648 INPPL1 240 S Phosphorylation 18691976 INPPL1 241 S Phosphorylation 18669648,18691976,20068231 INPPL1 290 S Phosphorylation 20068231 INPPL1 291 S Phosphorylation 20068231 INPPL1 671 Y Phosphorylation 12522270 INPPL1 885 Y Phosphorylation 17016520 INPPL1 886 Y Phosphorylation 12522270,17389395,19901323,20068231 INPPL1 890 S Phosphorylation 20068231 INPPL1 985 Y Phosphorylation 17016520 INPPL1 986 Y Phosphorylation 12235291,17389395,16497976,19901323,18669648 INPPL1 987 Y Phosphorylation 12235291,16497976

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type O15357 132 S 17081983 HTP Phosphorylation O15357 671 Y 12522270 HTP Phosphorylation O15357 1162 Y 12522270 HTP Phosphorylation O15357 1003 S 17081983 HTP Phosphorylation O15357 1003 S 15951569 HTP Phosphorylation O15357 1135 Y 17081983 HTP Phosphorylation O15357 1135 Y 12522270 HTP Phosphorylation O15357 886 Y 15592455 HTP Phosphorylation O15357 886 Y 12522270 HTP Phosphorylation O15357 986 Y 18669648 HTP Phosphorylation O15357 986 Y 18083107 HTP Phosphorylation O15357 986 Y 17081983 HTP Phosphorylation O15357 986 Y 15592455 HTP Phosphorylation O15357 986 Y 12522270 HTP Phosphorylation O15357 986 Y 12235291 SRC LTP Phosphorylation O15357 987 Y 12235291 SRC LTP Phosphorylation O15357 986 Y 17081983 HTP Phosphorylation O15357 241 S 18669648 HTP Phosphorylation O15357 165 T 18669648 HTP Phosphorylation O15357 167 T 18669648 HTP Phosphorylation O15357 158 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs O15357 132 Phosphoserine 23186163 O15357 165 Phosphothreonine 18669648 O15357 241 Phosphoserine 18669648;20068231 O15357 352 Phosphoserine 23186163 O15357 886 Phosphotyrosine 23186163 O15357 890 Phosphoserine 23186163 O15357 958 Phosphothreonine 23186163;17219406 O15357 986 Phosphotyrosine; by SRC 11349134;12235291 O15357 1131 Phosphoserine 23186163 O15357 1135 Phosphotyrosine 17081983;23186163 O15357 1162 Phosphotyrosine 23186163;11687594 O15357 1257 Phosphoserine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type INPPL1 IPI00013838 S 1004 AIFLPPpSLDPLPG phosphorylation INPPL1 IPI00013838 S 177 VFDQQSpSPMVTRL phosphorylation INPPL1 IPI00016932 S 1003 LPPEPPpSPARAPV phosphorylation INPPL1 IPI00016932 S 132 PDDRDApSDGEDEK phosphorylation INPPL1 IPI00016932 Y 1135 TLSEVDpYAPAGPA phosphorylation INPPL1 IPI00016932 Y 986 SFNNPApYYVLEGV phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 3636 109848 - K Ubiquitination 19880507 3636 109848 - K Ubiquitination 21139048 3636 109848 - K Ubiquitination 21890473 3636 109848 - K Ubiquitination 21906983 3636 109848 - K Ubiquitination 22053931 3636 109848 - K Ubiquitination 23000965

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID INPPL1 Homo sapiens (Human) 170 "170,QLLQLMKNKHSKQ" 170:21906983 INPPL1 Homo sapiens (Human) 234; 412; 224 "234,GLEILSKVFDQQS; 412,QLLQLMKNKHSKQ; 224,LHSEVDKVLSGLE" 234:21890473; 412:21906983; 224:21890473 INPPL1 Homo sapiens (Human) 331 "331,KIGKSQKFTLSVD" 331:22053931 INPPL1 Homo sapiens (Human) 331 "331,KIGKSQKFTLSVD" 331:21139048