Disease associated variation - ClinVar Allele ID Type Name RS#dbSNP Phenotype IDs Chromosome Start Stop Reference Alternate 158541 copy number gain GRCh38/hg38 10q24.32(chr10:101528556-101562006)x3 -1 - 10 103288313 103321763 na na 158541 copy number gain GRCh38/hg38 10q24.32(chr10:101528556-101562006)x3 -1 - 10 101528556 101562006 na na 158541 copy number gain GRCh38/hg38 10q24.32(chr10:101528556-101562006)x3 -1 - 10 103278303 103311753 na na 164723 copy number gain GRCh38/hg38 10q24.32(chr10:101528554-101556158)x3 -1 - 10 103288311 103315915 na na 164723 copy number gain GRCh38/hg38 10q24.32(chr10:101528554-101556158)x3 -1 - 10 101528554 101556158 na na 164723 copy number gain GRCh38/hg38 10q24.32(chr10:101528554-101556158)x3 -1 - 10 103278301 103305905 na na

Disease associated variation - GWASdb Chr Pos SNP ID(dbSNP 142) Ref Alt Ori SNP ID P-value Drug Name Drug Anno GWAS Trait HPO ID DO ID AA Type Trait or Drug 10 103113035 rs10883617 T C rs10883617 3.03E-05 GEMCITABINE ANTIMETABOLITES, ANTINEOPLASTIC|INTERLEUKIN-17|DEOXYCYTIDINE|IL17F PROTEIN, HUMAN Response to gemcitabine in pancreatic cancer HPOID:0006725 DOID:1793 T nearGene-5 GWASdb_drug 10 103113035 rs10883617 T C rs10883617 3.03E-05 Response to gemcitabine in pancreatic cancer HPOID:0006725 DOID:1793 T nearGene-5 GWASdb_trait 10 103124457 rs7090670 A C rs7090670 4.47E-04 Parkinson's disease HPOID:0001300 DOID:14330 A intron GWASdb_trait 10 103124457 rs7090670 A C rs7090670 8.64E-05 Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) HPOID:0001875|HPOID:0001882 DOID:1227 A intron GWASdb_trait 10 103133249 rs10450405 T C rs10450405 8.13E-05 Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) HPOID:0001875|HPOID:0001882 DOID:1227 T intron GWASdb_trait 10 103156416 rs17760784 G C rs17760784 4.10E-04 Nicotine smoking HPOID:0000707 DOID:0050742 G intron GWASdb_trait 10 103186838 rs7901883 G A rs7901883 8.13E-05 Adverse response to chemotherapy (neutropenia/leucopenia) (camptothecin) HPOID:0001875|HPOID:0001882 DOID:1227 A intron GWASdb_trait 10 103198642 rs4612729 T C rs4612729 4.48E-04 Parkinson's disease HPOID:0001300 DOID:14330 T intron GWASdb_trait 10 103199218 rs7900462 A G rs7900462 4.33E-04 Parkinson's disease HPOID:0001300 DOID:14330 A intron GWASdb_trait 10 103199432 rs7900747 A C rs7900747 4.48E-04 Parkinson's disease HPOID:0001300 DOID:14330 A intron GWASdb_trait 10 103207180 rs12765602 T A rs12765602 5.49E-04 Obesity (extreme) HPOID:0001513 DOID:9970 T intron GWASdb_trait 10 103228836 rs10786637 C T rs10786637 4.48E-04 Parkinson's disease HPOID:0001300 DOID:14330 C intron GWASdb_trait 10 103264187 rs9420843 T C rs9420843 1.60E-05 Bipolar disorder HPOID:0007302 DOID:3312 T intron GWASdb_trait

Disease associated variation - OMIM Ensembl_gene_ID Approved Gene Symbol MIM Number ENSG00000166167.17 BTRC 603482