PTM - CPLM Gene Name UniProt ID Type Position Code CUL5; VACM1 Q93034 Ubiquitination 384 K CUL5; VACM1 Q93034 Ubiquitination 529 K CUL5; VACM1 Q93034 Ubiquitination 724 K CUL5; VACM1 Q93034 Ubiquitination 10 K CUL5; VACM1 Q93034 Ubiquitination 620 K

PTM - dbPAF Gene Name UniProt ID Position Type Species CUL5; VACM1 Q93034 124 S Homo sapiens(Human) CUL5; VACM1 Q93034 128 S Homo sapiens(Human) CUL5; VACM1 Q93034 210 T Homo sapiens(Human) CUL5; VACM1 Q93034 34 S Homo sapiens(Human) CUL5; VACM1 Q93034 346 T Homo sapiens(Human) CUL5; VACM1 Q93034 373 Y Homo sapiens(Human) CUL5; VACM1 Q93034 539 S Homo sapiens(Human) CUL5; VACM1 Q93034 633 T Homo sapiens(Human) CUL5; VACM1 Q93034 695 T Homo sapiens(Human) CUL5; VACM1 Q93034 730 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q93034 K286-ac Acetylation AECQGMIkRNETEKL Q93034 K447-ac Acetylation VLKYVQNkDVFMRYH Q93034 K455-ac Acetylation DVFMRYHkAHLTRRL Q93034 R631-m1 Methylation ELPDAELrRTLWSLV Q93034 S34-p Phosphorylation LKLLRQEsVTKQQWF Q93034 S124-p Phosphorylation TLMGKQGsNKKsNVE Q93034 S128-p Phosphorylation KQGsNKKsNVEDSIV Q93034 T210-p Phosphorylation EKAYLDStERFYRTQ Q93034 T346-p Phosphorylation KYVEQLLtLFNRFSK Q93034 Y373-p Phosphorylation LTARDKAyKAVVNDA Q93034 S539-p Phosphorylation NAGAWSRsSEKVFVS Q93034 S656-p Phosphorylation LYEPQVNsPKDFTEG Q93034 T695-p Phosphorylation LIGRLQLtTERMREE Q93034 S730-p Phosphorylation MkMRKKIsNAQLQTE Q93034 Y765-p Phosphorylation EWLIEHKyIRRDESD Q93034 K384-ub Ubiquitination VNDATIFkLELPLKQ Q93034 K529-ub Ubiquitination PADSVNIkILNAGAW Q93034 K724-ub Ubiquitination EAIIQIMkMRKKIsN

PTM - dbPTM UniProt ID Position Code Type Resources References Q93034 210 T Phosphorylation Swiss-Prot 1010711 18669648 Q93034 730 S Phosphorylation PhosphoELM.10011 10898738 Q93034 210 T Phosphorylation PhosphoELM.10011 18669648 Q93034 373 Y Phosphorylation PhosphoELM.10011 16497976 Q93034 384 K Ubiquitylation Phosphositeplus.1010730 21890473 Q93034 529 K Ubiquitylation Phosphositeplus.1010730 21890473 Q93034 724 K Ubiquitylation Phosphositeplus.1010730 20972266;21890473;21906983 Q93034 724 K Neddylation Phosphositeplus.1010730 18247557 Q93034 539 S Phosphorylation Phosphositeplus.1010730 19562805 Q93034 730 S Phosphorylation Phosphositeplus.1010730 10898738;12917106;19917606;21635549 Q93034 210 T Phosphorylation Phosphositeplus.1010730 18669648 Q93034 346 T Phosphorylation Phosphositeplus.1010730 20068231 Q93034 373 Y Phosphorylation Phosphositeplus.1010730 16497976 Q93034 724 K Neddylation HPRD 9.0 10092517 Q93034 539 S Phosphorylation HPRD 9.0 19562805 Q93034 210 T Phosphorylation HPRD 9.0 18669648 Q93034 346 T Phosphorylation HPRD 9.0 20068231 Q93034 373 Y Phosphorylation HPRD 9.0 16497976 Q93034 730 S Phosphorylation (PRKACA) HPRD 9.0 10898738 Q93034 210 T Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References CUL5 210 T Phosphorylation 18669648 CUL5 346 T Phosphorylation 20068231 CUL5 373 Y Phosphorylation 16497976 CUL5 539 S Phosphorylation 19562805 CUL5 724 K Neddylation 10092517 CUL5 730 S Phosphorylation 10898738

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q93034 730 S 10898738 PKA_group LTP Phosphorylation Q93034 210 T 18669648 HTP Phosphorylation Q93034 373 Y 16497976 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q93034 34 Phosphoserine 23186163 Q93034 210 Phosphothreonine 18669648

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 8065 113743 - K Neddylation 18805092 8065 113743 - K Neddylation 20847044 8065 113743 - K Neddylation 18274552 8065 113743 - K Neddylation 21119685 8065 113743 - K Ubiquitination 21987572 8065 113743 - K Ubiquitination 20972266 8065 113743 - K Ubiquitination 21963094 8065 113743 - K Ubiquitination 21139048 8065 113743 - K Ubiquitination 21890473 8065 113743 - K Ubiquitination 21906983 8065 113743 - K Neddylation 18247557 8065 113743 - K Ubiquitination 22505724 8065 113743 - K Ubiquitination 23000965 8065 113743 - K Neddylation 24654937 8065 113743 - K Ubiquitination 24816145 8065 113743 - K Ubiquitination 25015289 8065 113743 - K Ubiquitination 25147182 8065 113743 - K Neddylation 19617556 8065 113743 - K Neddylation 21145461

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID CUL5 Homo sapiens (Human) 528; 383; 723 "528,ADSVNIKILNAGA; 383,NDATIFKLELPLK; 723,AIIQIMKMRKKIS" 528:21890473; 383:21890473; 723:21890473