PTM - CPLM Gene Name UniProt ID Type Position Code CRK P46108 Acetylation 253 K

PTM - dbPAF Gene Name UniProt ID Position Type Species CRK P46108 108 Y Homo sapiens(Human) CRK P46108 111 T Homo sapiens(Human) CRK P46108 112 T Homo sapiens(Human) CRK P46108 113 T Homo sapiens(Human) CRK P46108 119 S Homo sapiens(Human) CRK P46108 121 S Homo sapiens(Human) CRK P46108 125 S Homo sapiens(Human) CRK P46108 136 Y Homo sapiens(Human) CRK P46108 190 Y Homo sapiens(Human) CRK P46108 194 S Homo sapiens(Human) CRK P46108 196 S Homo sapiens(Human) CRK P46108 198 S Homo sapiens(Human) CRK P46108 208 S Homo sapiens(Human) CRK P46108 221 Y Homo sapiens(Human) CRK P46108 225 S Homo sapiens(Human) CRK P46108 228 T Homo sapiens(Human) CRK P46108 239 Y Homo sapiens(Human) CRK P46108 251 Y Homo sapiens(Human) CRK P46108 254 T Homo sapiens(Human) CRK P46108 304 S Homo sapiens(Human) CRK P46108 40 S Homo sapiens(Human) CRK P46108 41 S Homo sapiens(Human) CRK P46108 42 T Homo sapiens(Human) CRK P46108 43 S Homo sapiens(Human) CRK P46108 47 Y Homo sapiens(Human) CRK P46108 74 S Homo sapiens(Human) CRK P46108 83 S Homo sapiens(Human) CRK P46108 85 S Homo sapiens(Human) CRK P46108 96 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P46108 K154-ac Acetylation DEEDLPFkKGDILRI P46108 K253-ac Acetylation RVPNAyDktALALEV P46108 R122-m1 Methylation IEPVSRsrQGsGVIL P46108 S40-p Phosphorylation GVFLVRDsstsPGDy P46108 S41-p Phosphorylation VFLVRDsstsPGDyV P46108 T42-p Phosphorylation FLVRDsstsPGDyVL P46108 S43-p Phosphorylation LVRDsstsPGDyVLS P46108 Y47-p Phosphorylation sstsPGDyVLSVSEN P46108 S74-p Phosphorylation PRPPVPPsPAQPPPG P46108 S83-p Phosphorylation AQPPPGVsPsRLRIG P46108 S85-p Phosphorylation PPPGVsPsRLRIGDQ P46108 S96-p Phosphorylation IGDQEFDsLPALLEF P46108 Y108-p Phosphorylation LEFYKIHyLDtttLI P46108 T111-p Phosphorylation YKIHyLDtttLIEPV P46108 T112-p Phosphorylation KIHyLDtttLIEPVS P46108 T113-p Phosphorylation IHyLDtttLIEPVSR P46108 S121-p Phosphorylation LIEPVSRsrQGsGVI P46108 S125-p Phosphorylation VSRsrQGsGVILRQE P46108 Y136-p Phosphorylation LRQEEAEyVRALFDF P46108 S175-p Phosphorylation QWWNAEDsEGKRGMI P46108 Y190-p Phosphorylation PVPYVEKyRPAsAsV P46108 S194-p Phosphorylation VEKyRPAsAsVsALI P46108 S196-p Phosphorylation KyRPAsAsVsALIGG P46108 S198-p Phosphorylation RPAsAsVsALIGGNQ P46108 S208-p Phosphorylation IGGNQEGsHPQPLGG P46108 Y221-p Phosphorylation GGPEPGPyAQPsVNt P46108 S225-p Phosphorylation PGPyAQPsVNtPLPN P46108 T228-p Phosphorylation yAQPsVNtPLPNLQN P46108 Y239-p Phosphorylation NLQNGPIyARVIQKR P46108 Y251-p Phosphorylation QKRVPNAyDktALAL P46108 T254-p Phosphorylation VPNAyDktALALEVG P46108 S304-p Phosphorylation QNPDEDFs_______

PTM - dbPTM UniProt ID Position Code Type Resources References P46108 2 A Acetylation Swiss-Prot 1010711 19413330 P46108 74 S Phosphorylation Swiss-Prot 1010711 18669648 P46108 83 S Phosphorylation Swiss-Prot 1010711 18669648 P46108 136 Y Phosphorylation Swiss-Prot 1010711 19534553 P46108 221 Y Phosphorylation Swiss-Prot 1010711 17081983;19534553 P46108 239 Y Phosphorylation Swiss-Prot 1010711 15592455 P46108 251 Y Phosphorylation Swiss-Prot 1010711 19534553 P46108 74 S Phosphorylation PhosphoELM.10011 18669648 P46108 83 S Phosphorylation PhosphoELM.10011 18669648 P46108 221 Y Phosphorylation PhosphoELM.10011 9480991;9642287;12198159;8194526 P46108 125 S Phosphorylation Phosphositeplus.1010730 20068231 P46108 194 S Phosphorylation Phosphositeplus.1010730 17016520;20166139 P46108 40 S Phosphorylation Phosphositeplus.1010730 19415658;20736484 P46108 41 S Phosphorylation Phosphositeplus.1010730 20068231;20736484 P46108 74 S Phosphorylation Phosphositeplus.1010730 18669648;20068231 P46108 83 S Phosphorylation Phosphositeplus.1010730 18669648 P46108 42 T Phosphorylation Phosphositeplus.1010730 20068231;20736484 P46108 108 Y Phosphorylation Phosphositeplus.1010730 18083107;18180459 P46108 136 Y Phosphorylation Phosphositeplus.1010730 18083107;18180459;19534553;20736484 P46108 190 Y Phosphorylation Phosphositeplus.1010730 17016520 P46108 221 Y Phosphorylation Phosphositeplus.1010730 11314030;11380621;12198159;12799422;12955086;16187300;16522685;17016520;18180459;19534553;20007894;20736484;20837138;21049007;21403953;21602891;8194526;9642287 P46108 239 Y Phosphorylation Phosphositeplus.1010730 15592455;20736484 P46108 251 Y Phosphorylation Phosphositeplus.1010730 18083107;18180459;19534553;20090780;20736484;21403953;21602891 P46108 40 S Phosphorylation HPRD 9.0 19415658,20068231 P46108 41 S Phosphorylation HPRD 9.0 15345747,19651622,20068231 P46108 74 S Phosphorylation HPRD 9.0 18669648,20068231 P46108 83 S Phosphorylation HPRD 9.0 18669648,20068231 P46108 85 S Phosphorylation HPRD 9.0 20068231 P46108 125 S Phosphorylation HPRD 9.0 20068231 P46108 194 S Phosphorylation HPRD 9.0 20166139,20068231 P46108 196 S Phosphorylation HPRD 9.0 20068231 P46108 304 S Phosphorylation HPRD 9.0 19651622 P46108 42 T Phosphorylation HPRD 9.0 19651622,20068231 P46108 239 Y Phosphorylation HPRD 9.0 15592455,20068231 P46108 221 Y Phosphorylation (ABL1) HPRD 9.0 12198159,11956190,9642287,8875975,9480911,17016520,20068231 P46108 221 Y Phosphorylation (ABL2) HPRD 9.0 12198159,11956190,9642287,8875975,9480911,17016520,20068231 P46108 221 Y Phosphorylation (EGFR) HPRD 9.0 12198159,11956190,9642287,8875975,9480911,17016520,20068231 P46108 221 Y Phosphorylation (IGF1R) HPRD 9.0 12198159,11956190,9642287,8875975,9480911,17016520,20068231 P46108 74 S Phosphorylation SysPTM 1.1 18669648 P46108 83 S Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References CRK 125 S Phosphorylation 20068231 CRK 194 S Phosphorylation 20166139,20068231 CRK 196 S Phosphorylation 20068231 CRK 221 Y Phosphorylation 12198159,11956190,9642287,8875975,9480911,17016520,20068231 CRK 239 Y Phosphorylation 15592455,20068231 CRK 304 S Phosphorylation 19651622 CRK 40 S Phosphorylation 19415658,20068231 CRK 41 S Phosphorylation 15345747,19651622,20068231 CRK 42 T Phosphorylation 19651622,20068231 CRK 74 S Phosphorylation 18669648,20068231 CRK 83 S Phosphorylation 18669648,20068231 CRK 85 S Phosphorylation 20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P46108 221 Y 9480991 LTP Phosphorylation P46108 221 Y 9642287 LTP Phosphorylation P46108 221 Y 12198159 LTP Phosphorylation P46108 221 Y 8194526 Abl LTP Phosphorylation P46108 74 S 18669648 HTP Phosphorylation P46108 83 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P46108 2 N-acetylalanine 22223895;22814378 P46108 40 Phosphoserine 23186163 P46108 41 Phosphoserine 20068231;23186163 P46108 74 Phosphoserine 18669648;20068231 P46108 83 Phosphoserine 18669648 P46108 108 Phosphotyrosine 23186163 P46108 125 Phosphoserine 23186163;24275569 P46108 221 Phosphotyrosine; by ABL1 17515907 P46108 239 Phosphotyrosine 15592455

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type CRK IPI00305469 S 194 EKYRPApSASVSAL phosphorylation CRK IPI00305469 S 196 YRPASApSVSALIG phosphorylation CRK IPI00399054 Y 221 GPEPGPpYAQPSVN phosphorylation CRK IPI00399054 Y 239 LQNGPIpYARVIQK phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 1398 107788 - K Ubiquitination 21139048

PTM - PhosphoBase Gene Name PB Accession PROT ID Serine Threonine Tyrosine Peptide CRK A056 Proto-oncogene c-Crk - - 221 [A056-A] A056-A - EPGPYAQPS;!