PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus MAPK14 NOD2 19349988 innatedb exp P G GP P P P GP P P P P P P P P GP P TRAF4 NOD2 21097508 biogrid exp P P P P GP P P P P P P P G P SHARPIN NOD2 23818254,22607974 biogrid exp P G G P P P GP P P P P P P P P P GP P TLE1 NOD2 21699783 biogrid,intact exp P G GP P P P GP P P P P P P P P P GP P NOD2 NOD2 19337385,23437331,16492792 innatedb,biogrid exp P G GP P P P GP P P P P P P P P P GP P NOD2 FIS1 21699783 biogrid,intact exp P G GP P P P GP P P P P P P P P P GP P NOD2 NDUFA13 15753091 innatedb,intact exp P G GP P P P GP P P P P P P P P P GP P SLC15A3 NOD2 24695226 dip exp G GP P P P GP P P P P P GP P RNF31 NOD2 23818254,22607974 biogrid exp P G GP P P P GP P P P P P P P P P GP P RAC1 NOD2 18684957,17356065 innatedb exp P G GP P GP P P P P P P G P UBC NOD2 23300079 biogrid exp P G GP P P P GP P P P P P P P P P GP P TRIM27 NOD2 22829933 innatedb,biogrid,intact exp P G GP P P P GP P P P P P P P P P GP P ATG16L1 NOD2 19898471,23376921 innatedb,biogrid,intact exp P G GP P GP P GP DDX58 NOD2 21690088 innatedb exp P G GP P P GP P P P P P P P P P GP P RBCK1 NOD2 23818254,22607974 biogrid exp P G GP P P P GP P P P P P P P P P GP P TRIM8 NOD2 22829933 intact exp P G GP P P P GP P P P P P P P P P GP P CAD NOD2 22387394 innatedb exp P G GP P P P GP P P P P P P P P GP P RELA NOD2 20436512 intact exp P G GP P P P GP P P P P P P P P P GP P PPP2R5E NOD2 21699783 biogrid,intact exp P G GP P P P GP P P P P P P P P P GP P ANKRD17 NOD2 23711367 intact exp P G G P P P GP P P P P P P P P P GP P SLC15A4 NOD2 24695226 dip exp P G G P P P GP P P P P P P P P P GP P GALNT2 NOD2 21699783 biogrid,intact exp P G GP P P GP P P P P P P P P GP P KAT5 NOD2 21699783 biogrid,intact exp P G GP P P P GP P P P P P P P P P GP P NAT16 NOD2 22607974 biogrid exp P G GP P P P GP P P P P P P P P P P P TRIM50 NOD2 22829933 intact exp P P P P P P P P P P P P P P P COPS6 NOD2 17337451 innatedb,biogrid exp P G GP P P P GP P P P P P P P P GP P ARHGEF7 NOD2 18684957 innatedb exp P G GP P P P GP P P P P P P P P GP P AAMP NOD2 19535145 innatedb exp P G GP P P P GP P P P P P P P P GP P HSPA1A, HSPA1B NOD2 24790089 innatedb exp P P P P P P P P P P P P P P P P P HNRNPA1 NOD2 19349988 innatedb exp P G GP P P P GP P P P P P P P P P GP P OLFM4 NOD2 20534456 dip exp, ortho G G CASP1 NOD2 18511561,15107016, 25402006, 23023127, 16082366 innatedb,biogrid,dip exp, ortho, pred P G GP P P P GP P P P P P P P P P G P CARD9 NOD2 24960071,17187069, 23023127, 16082366 innatedb exp, ortho, pred G GP P P P P P GP P RIPK2 NOD2 19337385,17054981,19464198,21097508,11087742,22607974,21123652,15620648,22829933,19592251,16714539,16552041,24790089,19667203,19266573,16492792, 25402006, 23023127, 21836163, 16082366 innatedb,hprd,biogrid,i2d,mint,intact exp, ortho, pred P G GP P P P GP P P P P P P P P P G NOD2 SUGT1 17435760,17420470, 25402006 innatedb,biogrid,dip exp, pred G G P P G P P P P G P CASP12 NOD2 18329614, 25402006 biogrid exp, pred P P P P P P P P P P P P P P NOD2 NOD1 19898471, 25402006, 23023127, 16082366 biogrid exp, pred G G G G BID NOD2 21552281, 25402006 innatedb exp, pred G GP P P GP P P P P P P GP P MAP3K7 NOD2 17348859,17965022,17965022 ,15075345, 25402006 innatedb,biogrid exp, pred P G G P P GP P P P P G P ERBB2IP NOD2 19853919,16714539,18684957,19266573,16203728, 25402006 innatedb,hprd exp, pred P G GP P P P G P P P P P P P GP P NOD2 TRAF6 23437331, 25402006 biogrid exp, pred P G GP P P GP P P P P P GP P ACAP1 NOD2 17005562, 25402006, 21836163 innatedb exp, pred P G GP P P P P P P P P P P P P P GP P NOD2 NLRC4 11472070,15107016, 25402006, 23023127, 21836163, 16082366 innatedb,hprd,biogrid,i2d exp, pred P G GP P P P GP P P P P P P P G P NOD2 CARD8 20385562, 25402006, 23023127, 16082366 innatedb exp, pred P G GP P P P GP P P P P P P P P P GP P XIAP NOD2 22607974,19667203, 25402006 innatedb,biogrid,dip exp, pred P G G P P P GP P P P P P P P G P RIPK1 NOD2 22607974, 25402006, 23023127 biogrid exp, pred P G GP P P P GP P P P P P P P P P GP P NLRP1 NOD2 19337385,18511561, 25402006, 23023127 innatedb,dip exp, pred P G G P P GP P P P P P P P G P NOD2 IKBKG 22607974, 25402006 biogrid exp, pred G G G G MAP3K14 NOD2 16552041, 23023127 innatedb exp, pred G G G G OAS2 NOD2 19853919, 25402006 innatedb exp, pred P G GP P P P GP P P P P P P P P P GP P BIRC3 NOD2 22607974, 25402006, 23023127, 16082366 biogrid exp, pred G GP P G P P P P P P GP P NOD2 DUOX2 19759286, 25402006 innatedb exp, pred SQSTM1 NOD2 23437331, 23023127 innatedb,biogrid exp, pred P G GP P GP P P P P P P P P GP P NLRP3 NOD2 19337385, 25402006, 23023127, 16082366 innatedb exp, pred G GP P P P P P P BIRC2 NOD2 22607974, 23023127, 16082366 biogrid exp, pred P G GP P P P GP P P P P P P P P GP P VIM NOD2 21699783,22684479, 25402006 biogrid,intact exp, pred P G GP P P GP P P P GP CASP4 NOD2 18511561, 25402006, 23023127, 21836163, 16082366 innatedb,dip exp, pred P G GP P P GP P P P P P P P P G P HSP90AB1 NOD2 ortho P G GP P P P GP P P P P P P P P P GP P SOCS3 NOD2 ortho P G GP P P P GP P P P P P P P G P TRPM7 NOD2 ortho P G GP P P P GP P P P P P P P P P GP P PYDC1 NOD2 23023127 pred MYO1D NOD2 25402006 pred P P P P P G P P P P P GP P ALB NOD2 23023127 pred P P P P P P P P P P P KAZALD1 NOD2 23023127 pred P G GP P P P P P P P P P P P P P GP P NOD2 SEL1L 21836163 pred P G G P P GP P P P P P P P P GP P P2RY2 NOD2 23023127 pred P P P P P P CD40 NOD2 23023127 pred G G G P GP CALM1, CALM2, CALM3 NOD2 25402006 pred P G GP P P P GP P P P P P P P P P GP P BCL2 NOD2 25402006 pred G GP P P G P P P P GP TUBB4A NOD2 25402006 pred P G GP P P P GP P P P P P P P P P GP P LIF NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P MRPS26 NOD2 23023127 pred P G GP P P P GP P P P P P P P P GP P UNC13D NOD2 23023127 pred G G G ABL1 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P CRADD NOD2 23023127, 16082366 pred P G GP P P P GP P P P P P P P P G P TRIM21 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P NAIP NOD2 16082366 pred P G GP P P P GP P P P P P P P P P GP P PIM1 NOD2 23023127 pred P G GP P P G P P P P P G P CTLA4 NOD2 23023127 pred PF4 NOD2 23023127 pred G GP G G CD83 NOD2 23023127 pred G GP GP P GP AXIN1 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P CXCL3 NOD2 23023127 pred G APOA2 NOD2 23023127 pred P P P HOXA7 NOD2 23023127 pred G G G NCOR1 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P F7 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P G P HCK NOD2 23023127 pred G GP P GP P P P P P P P P GP P NFAM1 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P KLHL6 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P PVRL2 NOD2 23023127 pred P G GP P P GP P P P P P P P P GP P IGF1 NOD2 23023127 pred G GP G G CXCL8 NOD2 23023127 pred P G GP P P G P P P GP P CD74 NOD2 23023127 pred P G GP P P GP P P P P P P P P GP P TRIM16 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P TFG NOD2 23023127 pred P G GP P P P G P P P P P P P P G P CXCL12 NOD2 23023127 pred P G GP P P P GP P P P P P P GP SPP1 NOD2 23023127 pred P G GP P GP P P P P P P MNDA NOD2 23023127 pred G GP GP P GP STAT3 NOD2 25402006 pred P G GP P P P GP P P P P P P P P P GP P TLR3 NOD2 23023127 pred P P P P GP P P P P P P G P IL7 NOD2 23023127 pred P P P P P GP P P P P P P P P P G P SLC2A4 NOD2 25402006 pred P P P P P P P P P PGLYRP2 NOD2 21836163 pred P P P P P P P P P P P P P P MICA NOD2 23023127 pred G G G G MGST1 NOD2 23023127 pred P G G P P P GP P P P P P P P P GP P POU2F2 NOD2 23023127 pred G GP P G P G CR1 NOD2 23023127 pred G GP G P GP IL13 NOD2 23023127 pred P P P P P P P P P P P P P P P P P C1QA NOD2 23023127 pred G G G G TRIM24 NOD2 23023127 pred G G P GP P P P P P P P G P TICAM1 NOD2 21836163 pred P P P P GP P P P P P P P P P GP P NOD2 PSME2 23023127 pred G G G G FAS NOD2 23023127 pred P G G P P GP P P P P P P P G P CARD18 NOD2 25402006, 16082366 pred G G P P P P P P P TRAF3 NOD2 25402006 pred P G GP P GP P P P P P P P G P C3 NOD2 23023127 pred G P P G P NLRP11 NOD2 25402006 pred P P P P P P SUMO1 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P APOA1 NOD2 23023127 pred CARD6 NOD2 25402006, 23023127, 16082366 pred P G GP P P GP P P P P P G P APOL1 NOD2 23023127 pred G G P G P P P P G P UHRF2 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P LY9 NOD2 23023127 pred G GP P P GP P P P P GP P BCL10 NOD2 25402006, 23023127, 16082366 pred P G GP P P P GP P P P P P P P P P GP P OAS1 NOD2 25402006 pred P G GP P P P GP P P P P P P P P P GP P NOD2 PACSIN2 23023127 pred P G GP P P GP P P P P P P P P GP P LTC4S NOD2 23023127 pred G SMO NOD2 23023127 pred P G GP P P P GP P P P P P P P P G P CD2 NOD2 23023127 pred G G G P GP S100A4 NOD2 23023127 pred G GP GP P P GP FLT1 NOD2 23023127 pred P P P G P P P G CYB5R4 NOD2 23023127 pred P G GP P P P GP P P P P P P P P GP P CARD17 NOD2 25402006, 23023127 pred BCL6 NOD2 23023127 pred G GP G P P GP MICB NOD2 23023127 pred G G G G TRAF3IP2 NOD2 25402006 pred P P P P P GP P P P P P P P P P GP P NGFR NOD2 25402006, 23023127 pred P P G NOD2 PYCARD 25402006, 23023127, 16082366 pred P G GP P P GP P P P P P P P P P GP P IRAK1 NOD2 25402006, 23023127 pred P G GP P P P GP P P P P P P P P GP P VEGFC NOD2 23023127 pred G G G G APOC1 NOD2 23023127 pred P G G P P P G P P G A2M NOD2 23023127 pred G G P P G P P G B2M NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P IFI16 NOD2 23023127 pred G GP P P G P P GP C1R NOD2 23023127 pred G GP P GP P P P P P P GP IL2 NOD2 23023127 pred P P P P P P P P P P P P P P SLIT2 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P NOD2 NLK 25402006 pred P G GP P P G P P P G DVL2 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P PCBP2 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P CIDEA NOD2 23023127 pred IL12A NOD2 23023127 pred P P P P P P P P P P P P P P P P EPS15 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P CBL NOD2 23023127 pred P G GP P P GP P P GP IL18 NOD2 25402006 pred G GP P GP P P P P P P GP P RNASE3 NOD2 23023127 pred G GP P P G P P P P G P NOD2 SHOC2 25402006 pred G GP P P GP P P P P GP P NOD2 TNFSF13B 23023127 pred P G GP P P P GP P P P P P P P P P GP P FOXM1 NOD2 23023127 pred P G GP P P P P P P P P P P P P P P P NOD2 CLCF1 23023127 pred P P P P P P P P P P P P P GP P CD276 NOD2 23023127 pred P G GP P P GP P P P P P P P P GP P CD4 NOD2 23023127 pred G GP G P GP C5AR1 NOD2 23023127 pred G GP P P GP P P P P P P P P GP P IL10 NOD2 23023127 pred P P P P P P P P P P P DMD NOD2 23023127 pred G G P P G P P HIF1A NOD2 23023127 pred P G GP P P GP P P P P P P P GP P NOD2 LY96 23023127 pred G G G G S100A8 NOD2 23023127 pred G GP G P GP BCAR1 NOD2 23023127 pred P P P P P GP P P P P P P P P P GP P IGF2BP3 NOD2 23023127 pred P P P P P P P P P P P P P P P INS NOD2 23023127 pred P VEGFA NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P CARD10 NOD2 23023127, 16082366 pred P G GP P P P GP P P P P P P P P P GP P NCF2 NOD2 23023127 pred G GP GP P GP PTPRC NOD2 23023127 pred G GP G P GP NOD2 TACC3 23023127 pred G GP P P P P P P P P P P GP P TRIM22 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P RIN3 NOD2 23023127 pred P G G P P P GP P P P GP CD1D NOD2 23023127 pred P G G P P P P P P P GP P PDCD1LG2 NOD2 23023127 pred P P P P P P P P P P P P P P P P P C1S NOD2 23023127 pred G G G G VCAM1 NOD2 23023127 pred G G G P GP NLRP12 NOD2 23023127 pred G GP P P P GP P P P P P P P P P GP P IFNB1 NOD2 23023127 pred P P P P P P P P P P P P P P P P P AGER NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P UNC5C NOD2 23023127 pred P P P P GP P P P P G P OSMR NOD2 23023127 pred P P P P GP P P P P P P P P P P STX11 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P NOD2 ITSN2 23023127 pred G G P P G P P P P P P G P PPARG NOD2 23023127 pred P P P P GP P P P P P P P P COL18A1 NOD2 23023127 pred P G GP P P P GP P P P P P P GP P NOD2 FAF1 25402006 pred P G GP P P P GP P P P P P P P P P GP P TUBB NOD2 25402006 pred P G GP P P P GP P P P P P P P P P GP P VWF NOD2 23023127 pred G GP P P G P G C3AR1 NOD2 23023127 pred G GP P P GP P P P P P P G P VRK2 NOD2 25402006 pred P G G P P GP P P P P P P P G P POLR3G NOD2 23023127 pred P P P P P NOD2 IRAK3 23023127 pred P G GP P P P GP P P P P P P P P P GP P C1QC NOD2 23023127 pred P G GP P P GP P P P P P P GP P TLR4 NOD2 23023127 pred P G GP P G P P P GP RGS1 NOD2 23023127 pred G G G G IL16 NOD2 23023127 pred G GP G P GP ITGB2 NOD2 23023127 pred P G GP P GP P P GP NOD2 S100A14 23023127 pred G G P P GP P P P P P P G P TLR1 NOD2 23023127 pred G G G G IL7R NOD2 23023127 pred G GP P P GP P P P P P P P P GP P BMP4 NOD2 23023127 pred P P P P P P P P P P P P P P PGLYRP3 NOD2 21836163 pred P P P P P P P P NOD2 CD93 23023127 pred G GP P P GP P GP NOD2 IFNK 23023127 pred NFATC2IP NOD2 23023127 pred G G G G IL6 NOD2 23023127 pred G GP G P P G CASP9 NOD2 25402006, 16082366 pred P G GP P P P GP P P P P P P P P P GP P PSME1 NOD2 23023127 pred P G GP P P P GP P P P P P P P P GP P PLCB2 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P CASP7 NOD2 16082366 pred P G G P P GP P P P P P P P P G P CNTF NOD2 23023127 pred P G GP P P P P P P P P P P P P P P P NOD2 NUB1 23023127 pred P G GP P P GP P P P P P P P GP P OSM NOD2 23023127 pred P G GP P P GP P P P P P P P P P P IL11 NOD2 23023127 pred CFB NOD2 23023127 pred P GP P P G P CASP5 NOD2 25402006, 23023127, 16082366 pred P P P P P P P P P P P P P P P P P TARBP2 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P GIMAP5 NOD2 23023127 pred P P P P P P P P P P P P P P P P P NOD2 TLR9 23023127 pred G GP P P P GP P P P P P P P P P GP P CTSG NOD2 23023127 pred G GP G P P NFKB1 NOD2 23023127 pred G GP P GP P P P P P P GP CARD14 NOD2 16082366 pred P P P P P P P P P P P P P P CNKSR3 NOD2 23023127 pred P P P P G P P P P P P P G P NOD2 TNFRSF11A 23023127 pred P G GP P P P P P P P P P P P STAT5B NOD2 23023127 pred P G GP P P P GP P P P P P P P GP P NOD2 VSIG4 23023127 pred G G P GP P P P G P ACTG1 NOD2 25402006 pred P G GP P P P GP P P P P P P P P P GP P TFRC NOD2 25402006 pred P G GP P P P GP P P P P P P P G P EREG NOD2 23023127 pred P G G P P P P P P P P P P P P P P MAP2K7 NOD2 25402006 pred P G GP P P P GP P P P P P P P P GP P DLG5 NOD2 21836163 pred P G P G PANX1 NOD2 23023127 pred P G GP P P P GP P P P P P P GP P S100A9 NOD2 23023127 pred G GP GP P P GP S100A7 NOD2 23023127 pred TRADD NOD2 23023127 pred P G GP P P GP P P P P P GP P TP63 NOD2 23023127 pred G G G P P REL NOD2 23023127 pred G GP P P GP P P P P P P P P GP P DPEP1 NOD2 21836163 pred G G P G P P P NFKBIA NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P TIRAP NOD2 25402006 pred P G G P P P G P P P P P P P G P MGST2 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P G P NOD2 IL19 23023127 pred G G G TRIM16L NOD2 25402006 pred P P P IRAK2 NOD2 23023127 pred P G GP P P P GP P P P P P P G P IL27RA NOD2 23023127 pred G G G G LYN NOD2 23023127 pred G GP P P GP P P P P P P P P GP P ZFYVE16 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P G P ATN1 NOD2 21836163 pred P G GP P P P G P P P P P P P P GP P RP1 NOD2 23023127 pred P CLTC NOD2 25402006 pred P G GP P P P GP P P P P P P P P GP P CHUK NOD2 25402006 pred P G GP P P P GP P P P P P P P P P GP P LEP NOD2 23023127 pred P P P P P P P P P P P P CAV1 NOD2 23023127 pred G G P P P GP P P P G FOXP3 NOD2 23023127 pred P P P IGFBP7 NOD2 23023127 pred G G G P G IL6R NOD2 23023127 pred G G G G PGLYRP1 NOD2 21836163 pred G GP P P MASP1 NOD2 23023127 pred P G G P GP RIN2 NOD2 23023127 pred P G GP P P P GP P P P P P P P P GP P BCL2L1 NOD2 25402006 pred P G GP P G P P P P P G P PIDD1 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P C2 NOD2 23023127 pred G G P G G CXCR2 NOD2 23023127 pred G GP P G P GP NCR3 NOD2 23023127 pred G G G IL4 NOD2 23023127 pred CFI NOD2 23023127 pred P G G DNTT NOD2 21836163 pred G G P P P P P P CD86 NOD2 23023127 pred G GP P P GP P P P P P P P P GP P PLA2G2A NOD2 23023127 pred P G GP P P P G P P P P P P P G P PLEK NOD2 23023127 pred G GP P GP P P G ITGA1 NOD2 23023127 pred P P P P P P P P P P P P P P G P NCF4 NOD2 23023127 pred G GP GP P GP NCF4 NOD2 23023127 pred G GP GP P GP ITSN1 NOD2 23023127 pred P G G P P P GP P P P P P P P G P NLRP4 NOD2 25402006, 21836163 pred P P P P P P P P P P P P P P ALOX5AP NOD2 23023127 pred G GP P GP P P GP SH2D1A NOD2 23023127 pred G IL5 NOD2 23023127 pred P P P P P P P P P P NOD2 ROBO2 23023127 pred P P P P P GP P P P P P P P P P GP P CASP10 NOD2 23023127 pred P G GP P P P GP P P P P P P P GP P CASP2 NOD2 16082366 pred P G GP P P P GP P P P P P P P P P GP P CCL2 NOD2 23023127 pred P P P P GP P P P P P P P P GP P MYD88 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P FLNA NOD2 23023127 pred G GP P P GP P P P P G P NOD2 TAB2 23023127 pred G G G G PLAU NOD2 23023127 pred G GP P P GP P P P P P P P GP P TUBB2B NOD2 25402006 pred P P P P P P P P P P P P P P USP14 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P NOD2 TREM2 23023127 pred P P P P P GP P P P P P P P P CD80 NOD2 23023127 pred G GP P G P P P GP NOL3 NOD2 16082366 pred P P P P GP P P P P P P P G P ELANE NOD2 23023127 pred G GP HSPA8 NOD2 25402006 pred P P P P P P P P P P P P P HLX NOD2 23023127 pred P G GP P P P GP P P P P P P P GP P THBS1 NOD2 23023127 pred P G GP P P P GP P P P P P P P P GP P NOD2 DICER1 23023127 pred G GP P P P G P P P P P P P P GP P NOD2 SPINK5 23023127 pred G NOD2 CD274 23023127 pred P G GP P P P GP P P P P P P P GP P NOD2 NCOA3 23023127 pred P G GP P P P GP P P P P P P P P P GP P BTK NOD2 23023127 pred G GP GP P GP ARHGEF1 NOD2 23023127 pred G GP P GP P P P P P GP P F3 NOD2 23023127 pred P P P GP P P P P P P P GP P NOD2 TLR7 23023127 pred P P P P P P P P NOD2 ZAK 23023127 pred P G G P P P GP P P P P P P P G P AIM2 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P EBI3 NOD2 23023127 pred P P P P P P P P P G P S100A6 NOD2 25402006 pred P G GP P P GP P P P P P P P P P GP P CBLB NOD2 23023127 pred P G G P P GP P P P P P P P GP P IRF1 NOD2 23023127 pred P G GP P P P GP P P P P P P P G P APOE NOD2 23023127 pred P G GP P P P GP P P P P GP P FN1 NOD2 23023127 pred G GP P P P G P P G DCC NOD2 23023127 pred P P P P P P P P P P P P P P P P NOD2 MALT1 23023127, 16082366 pred G GP G P G NOD2 TLR8 23023127 pred G GP GP P P GP P CD14 NOD2 23023127 pred G GP GP P GP CD28 NOD2 23023127 pred G LTB NOD2 23023127 pred G GP P P GP P P P P P P GP P TGFB2 NOD2 23023127 pred G G G G DVL3 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P RGS14 NOD2 23023127 pred P G G P P P GP P P P P P P P P P GP P GPR183 NOD2 23023127 pred G G P P P GP P P P P P P P P P GP P VAV1 NOD2 23023127 pred P G GP P P P GP P P P P P P P P GP P NFKBID NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P SNX2 NOD2 23023127 pred P G GP P P GP P P P P P P P GP P MSN NOD2 23023127 pred P G GP P P GP P P P P P P GP TP73 NOD2 23023127 pred FES NOD2 23023127 pred P G GP P P P GP P P P P P P P P GP P JAK2 NOD2 23023127 pred P G GP P P P GP P P P P P P P GP P MAPK8IP2 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P STAT1 NOD2 23023127 pred G GP P P GP P P P P P P P GP CADM1 NOD2 23023127 pred P P P GP P P P P P P P G P DGKD NOD2 23023127 pred P G GP P P P GP P P P P P P P P G P S100A13 NOD2 23023127 pred P G G P P GP P P P P P GP MID1 NOD2 23023127 pred P P P G P P P P P P G P NLRP8 NOD2 25402006 pred G G P P P G P P P P P G P STAT5A NOD2 23023127 pred P G GP P GP P P P GP CARD16 NOD2 25402006, 23023127, 16082366 pred G G P P G P P P P P P G MZB1 NOD2 23023127 pred G GP P GP NOD2 ROBO1 23023127 pred P P P P P GP P P P P P P P P P GP P C4BPA NOD2 23023127 pred G GP P P G P NLRP7 NOD2 25402006 pred P G GP P P P P P P P P P P P P P P P HERPUD1 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P FCER1A NOD2 23023127 pred G GP P P P GP P P P P P GP P MEFV NOD2 25402006 pred G G EPB41 NOD2 23023127 pred G G G G CASP3 NOD2 25402006, 16082366 pred G GP P GP P P P P P GP P KRT20 NOD2 23023127 pred P P P P CFLAR NOD2 23023127, 16082366 pred P G GP P P P GP P P P P P P P P P GP P MYO7A NOD2 23023127 pred P G GP P P P G P P P P P P P G P TLR5 NOD2 23023127 pred P G GP P P P GP P P P P P P P P GP P ROBO4 NOD2 23023127 pred G G G G KCNN4 NOD2 23023127 pred G G P G P G NOD2 SLAMF7 23023127 pred G GP GP P G AZU1 NOD2 23023127 pred G GP P P P P P P P P P ICAM1 NOD2 23023127 pred G GP P P GP P P GP NOD2 C1RL 23023127 pred G GP P P P G P P P P GP P CD8B NOD2 23023127 pred P P P P P P P P P P P P P P P P P HSPA1L NOD2 25402006 pred P G G P G CASP6 NOD2 16082366 pred G GP P G P P P P P P P G P CD37 NOD2 23023127 pred G G G P GP P TNFRSF25 NOD2 23023127 pred G G NLRP13 NOD2 25402006 pred P P P P P P P P P P P P P P P P TAB3 NOD2 25402006 pred P G GP P P P GP P P P P P P P P P GP P CEBPB NOD2 23023127 pred P G GP P P GP P P P P P P P P P GP P S100A12 NOD2 23023127 pred G GP G P GP MOG NOD2 23023127 pred G G P P G P P G RNF135 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P G P CCL5 NOD2 23023127 pred G G G G CARD11 NOD2 25402006, 23023127 pred P G G P P P P P P P P P P P P GP P APAF1 NOD2 25402006, 23023127, 16082366 pred P G GP P P P GP P P P P P P P P P GP P THOC1 NOD2 23023127 pred P G GP P P P GP P P P P P P P P G P NOD2 TCF7L2 23023127 pred P G GP P P P GP P P P P P P P P P GP P SCGB1A1 NOD2 23023127 pred G G G FOXJ1 NOD2 23023127 pred P GP P P PKN1 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P FGR NOD2 23023127 pred P G GP P P P GP P P P P P P P P GP P HSP90B1 NOD2 25402006 pred P G GP P P P GP P P P P P P P P P GP P TNFRSF4 NOD2 23023127 pred P P GP HSP90AA1 NOD2 25402006 pred P G G P P G P P G C8A NOD2 23023127 pred BCL3 NOD2 23023127 pred G GP P P G P P P P G P CXCL10 NOD2 23023127 pred G G G G CASP8 NOD2 23023127, 16082366 pred P G GP P P P GP P P P P P P P P P GP P CASP14 NOD2 16082366 pred PVR NOD2 23023127 pred P G G P P P GP P P P P P P P G P NOD2 NLRP2 25402006, 23023127 pred P P P P P GP P P P P P P P P P GP P IRF3 NOD2 23023127 pred P G GP P P P GP P P P P P P P P GP P NOD2 TREM1 23023127 pred P G GP P P P GP P P P P P P P P GP P HSPA4 NOD2 25402006 pred P G GP P P GP P P P P P P P P P GP P IL15 NOD2 23023127 pred P P P P GP P P P P P P P P GP P PRRX1 NOD2 23023127 pred G GP P P G P P P P P P GP P ARFIP1 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P CRTAM NOD2 23023127 pred P P P P P GP P P P P P P P P P G P TGFB1 NOD2 23023127 pred G GP G P P P GP P ABL2 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P EDA2R NOD2 23023127 pred P P P P P P P P P CD3E NOD2 23023127 pred G GP G P GP LRRC1 NOD2 25402006 pred P P P GP P P P P P P P P P NOD2 SWAP70 23023127 pred P G GP P P GP P P P P P P P GP P STAT6 NOD2 23023127 pred P G GP P P GP P P P P P P P GP P TUBA3C, TUBA3D NOD2 25402006 pred P P P P P P P P P P JAK3 NOD2 23023127 pred G G G G EP300 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P FADD NOD2 23023127 pred P G G P P P GP P P P P P P P P GP P ANK1 NOD2 23023127 pred G GP P P P P P P PARK2 NOD2 23023127 pred P P P P P P P P P P P P P P KDR NOD2 23023127 pred P G G P GP G HSF1 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P SP100 NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P NOD2 KCNMB3 23023127 pred P G G P P P P P P G P HMOX1 NOD2 23023127 pred G GP P GP P P P P GP ITGA2 NOD2 23023127 pred P P P P P GP P P P P P P P GP P PELI2 NOD2 25402006 pred P G GP P P P GP P P P P P P P P GP P NOD2 FBXO4 23023127 pred G G G G C7 NOD2 23023127 pred P G G P P GP P P P P P P P GP P TLR2 NOD2 23023127 pred G G G G TNFRSF1A NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P ENO1 NOD2 25402006 pred P G GP P P P GP P P P P P P P P P GP P S100B NOD2 23023127 pred P P GP P P P P P P ITGAM NOD2 23023127 pred G GP P GP P P GP IKBKB NOD2 25402006 pred P G GP P P GP P P P P P P P P GP P NOD2 TLR6 23023127 pred G G G CMTM7 NOD2 23023127 pred G G G G PTX3 NOD2 23023127 pred G G G G TIGIT NOD2 23023127 pred G G G G IL20RB NOD2 23023127 pred P P P P P GP P P P P P P P P P P MASP2 NOD2 23023127 pred P G G P P P P P P P P P P P P P CD8A NOD2 23023127 pred G GP GP P GP PRKCD NOD2 23023127 pred P G GP P P P GP P P P P P P P P P GP P STIM1 NOD2 23023127 pred P G GP P P GP P P P P P P P P P GP P TNFRSF10A NOD2 23023127 pred G G P P P GP P P P P P G P SRGN NOD2 23023127 pred G GP P GP P P P GP SYK NOD2 23023127 pred G GP P P GP P P P P P GP P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9HC29 O43353 - 11087742 - X 2 Q13490 Q9HC29 affinity chromatography technology 22607974 physical association X 2 A0A024QZ59 Q9HC29 affinity chromatography technology 21097508 physical association X 2 A0A024QZ59 Q9HC29 affinity chromatography technology 21097508 physical association X 2 Q9HC29 O43353 affinity chromatography technology 22607974 physical association X 2 Q9HC29 affinity chromatography technology 22607974 physical association X 2 Q9HC29 Q10471 two hybrid 21699783 direct interaction X 2 Q9HC29 Q04724 two hybrid 21699783 direct interaction X 2 Q9HC29 Q16537 two hybrid 21699783 direct interaction X 2 Q9HC29 Q10471 affinity chromatography technology 21699783 physical association X 2 Q9HC29 Q04724 affinity chromatography technology 21699783 physical association X 2 Q9HC29 Q16537 affinity chromatography technology 21699783 physical association X 2 Q9HC29 P14373 affinity chromatography technology 22829933 physical association X 2 Q9HC29 P14373 affinity chromatography technology 22829933 physical association X 2 Q9HC29 O43353 affinity chromatography technology 21097508 physical association X 2 Q9HC29 O43318-4 affinity chromatography technology 17965022 physical association X 2 Q9HC29 O43318-4 affinity chromatography technology 15075345 physical association X 2 Q9HC29 O43318-4 affinity chromatography technology 15075345 physical association X 2 Q9HC29 O43318-4 pull down 15075345 direct interaction X 2 Q9HC29 O43318-4 pull down 15075345 direct interaction X 2 Q9HC29 O43318-4 pull down 17348859 direct interaction X 2 Q9HC29 Q9Y4K3 affinity chromatography technology 23437331 physical association X 2 Q9HC29 affinity chromatography technology 23818254 physical association X 2 Q9HC29 P29466-5 affinity chromatography technology 15107016 physical association X 2 Q9HC29 O43353 affinity chromatography technology 11087742 physical association X 2 Q9HC29 O43353 affinity chromatography technology 19592251 physical association X 2 Q9HC29 O43353 affinity chromatography technology 15620648 physical association X 2 Q9HC29 O43353 affinity chromatography technology 15620648 physical association X 2 Q9HC29 O43353 affinity chromatography technology 21123652 physical association X 2 Q9HC29 O43353 affinity chromatography technology 21123652 physical association X 2 Q8N8M0 Q9HC29 affinity chromatography technology 22607974 physical association X 2 Q9HC29 affinity chromatography technology 18329614 physical association X 2 Q92993-4 Q9HC29 two hybrid 21699783 direct interaction X 2 Q92993-4 Q9HC29 affinity chromatography technology 21699783 physical association X 2 P08670 Q9HC29 two hybrid 21699783 direct interaction X 2 P08670 Q9HC29 affinity chromatography technology 21699783 physical association X 2 Q9NPP4 Q9HC29 affinity chromatography technology 15107016 physical association X 2 Q9NPP4 Q9HC29 affinity chromatography technology 11472070 physical association X 2 Q9Y2Z0 Q9HC29 affinity chromatography technology 17420470 physical association X 2 A0A024RA73 Q9HC29 affinity chromatography technology 19898471 physical association X 2 A0A024RA73 Q9HC29 affinity chromatography technology 19898471 physical association X 2 Q96EP0 Q9HC29 affinity chromatography technology 22607974 physical association X 2 Q96EP0 Q9HC29 affinity chromatography technology 23818254 physical association X 2 A0A024QZU0 Q9HC29 affinity chromatography technology 22607974 physical association X 2 Q9HC29 affinity chromatography technology 22607974 physical association X 2 Q9HC29 Q7L5N1 affinity chromatography technology 17337451 physical association X 2 Q9HC29 Q13501 affinity chromatography technology 23437331 physical association X 2 Q9HC29 Q9HC29 affinity chromatography technology 23437331 physical association X 2 Q9HC29 E7EVC7 affinity chromatography technology 23376921 physical association X 2 Q9HC29 E7EVC7 affinity chromatography technology 19898471 physical association X 2 Q9HC29 E7EVC7 affinity chromatography technology 19898471 physical association X 2 P98170 Q9HC29 affinity chromatography technology 22607974 physical association X 2 P98170 Q9HC29 pull down 19667203 direct interaction X 2 Q13489 Q9HC29 affinity chromatography technology 22607974 physical association X 2 P0CG48 Q9HC29 affinity chromatography technology 23019338 physical association X 2 P0CG48 Q9HC29 affinity chromatography technology 21906983 physical association X 2 Q9Y3D6 Q9HC29 two hybrid 21699783 direct interaction X 2 Q9Y3D6 Q9HC29 affinity chromatography technology 21699783 physical association X 2 Q9H0F6 Q9HC29 affinity chromatography technology 22607974 physical association X 2 Q9H0F6 Q9HC29 affinity chromatography technology 23818254 physical association X 2 Q9HC29 pull down 19667203 - C 3 Q8IY34 Q9HC29 anti tag coimmunoprecipitation 24695226 physical association X 2 Q8IY34 Q9HC29 anti tag coimmunoprecipitation 24695226 physical association X 2 Q9HC29 Q8N697 anti tag coimmunoprecipitation 24695226 physical association X 2 Q9HC29 Q8N697 anti tag coimmunoprecipitation 24695226 physical association X 2 Q9HC29 molecular sieving 18511561 physical association C 3 P49662 Q9HC29 anti tag coimmunoprecipitation 18511561 physical association X 2 Q9Y2Z0 Q9HC29 anti tag coimmunoprecipitation 17420470 physical association X 2 Q9HC29 P29466 anti bait coimmunoprecipitation 18511561 physical association X 2 Q9HC29 P29466 anti tag coimmunoprecipitation 18511561 physical association X 2 Q9HC29 P29466 anti tag coimmunoprecipitation 18511561 physical association X 2 Q9HC29 Q9C000 anti bait coimmunoprecipitation 18511561 physical association X 2 P98170 Q9HC29 pull down 19667203 physical association X 2 A0A024QZ95 Q9HC29 anti tag coimmunoprecipitation 20534456 physical association X 2 A0A024QZ95 Q9HC29 anti tag coimmunoprecipitation 20534456 physical association X 2 Q9HC29 O43353 in vivo 11087742 - X 2 Q9HC29 O43353 in vivo 11087742 - X 2 Q9HC29 Q96RT1-5 in vivo 16203728 - X 2 Q9HC29 Q96RT1-5 two hybrid 16203728 - X 2 Q9HC29 Q96RT1-5 in vivo 16203728 - X 2 Q9HC29 Q96RT1-5 two hybrid 16203728 - X 2 Q9NPP4 Q9HC29 in vivo 11472070 - X 2 Q9NPP4 Q9HC29 in vivo 11472070 - X 2 Q9HC29 O43353 coimmunoprecipitation 11087742 physical association X 2 Q9HC29 P14373 anti tag coimmunoprecipitation 22829933 physical association X 2 Q9HC29 P14373 anti tag coimmunoprecipitation 22829933 physical association X 2 Q9HC29 O43353 anti tag coimmunoprecipitation 22829933 physical association X 2 Q9HC29 P14373 anti tag coimmunoprecipitation 22829933 physical association X 2 Q9HC29 P14373 anti tag coimmunoprecipitation 22829933 physical association X 2 Q9HC29 P14373 anti tag coimmunoprecipitation 22829933 physical association X 2 Q9HC29 P14373 anti bait coimmunoprecipitation 22829933 physical association X 2 Q9HC29 P14373 pull down 22829933 direct interaction X 2 Q9HC29 P14373 two hybrid 22829933 physical association X 2 Q9HC29 P14373 fluorescence microscopy 22829933 colocalization X 2 Q9HC29 Q676U5 pull down 23376921 physical association X 2 Q9HC29 anti tag coimmunoprecipitation 22829933 association C 3 A2AIV8 Q9HC29 anti tag coimmunoprecipitation 24960071 physical association X 2 Q86XT4 Q9HC29 two hybrid 22829933 physical association X 2 Q9BZR9 Q9HC29 two hybrid 22829933 physical association X 2 Q9HC29 O75179 fluorescence microscopy 23711367 colocalization X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B GALNT2 NOD2 MI:0018(two hybrid)|MI:0018(two hybrid) 21699783 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_194948|BIOGRID_194942 prey|prey bait|bait ANKRD17 NOD2 MI:0416(fluorescence microscopy) 23711367 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (intact) UniProt_131887 neutral component neutral component TRAF4 NOD2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21097508 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_212993|BIOGRID_212990 prey|bait bait|prey RNF31 NOD2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22607974,23818254 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_282694|BIOGRID_187979 prey|prey bait|bait BIRC2 NOD2 MI:0004(affinity chromatography technology) 22607974 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187973 prey bait PPP2R5E NOD2 MI:0018(two hybrid)|MI:0018(two hybrid) 21699783 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_194947|BIOGRID_194953 prey|prey bait|bait NOD2 IKBKG MI:0004(affinity chromatography technology) 22607974 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187977 bait prey ERBB2IP NOD2 MI:0493(in vivo) 16203728 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_27701 - - NOD2 TRAF6 MI:0004(affinity chromatography technology) 23437331 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_258077 prey bait RIPK1 NOD2 MI:0004(affinity chromatography technology) 22607974 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187978 prey bait NOD2 SUGT1 MI:0004(affinity chromatography technology) 17420470 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_270553 prey bait XIAP NOD2 MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19667203,22607974 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|MI:0465(dip)|(biogrid)|(biogrid) DIP_55506|DIP_55515|BIOGRID_187976|BIOGRID_214408 -|-|prey|bait -|-|bait|prey COPS6 NOD2 MI:0004(affinity chromatography technology) 17337451 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_207565 prey bait TLE1 NOD2 MI:0018(two hybrid)|MI:0018(two hybrid) 21699783 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_194950|BIOGRID_194944 prey|prey bait|bait BIRC3 NOD2 MI:0004(affinity chromatography technology) 22607974 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187974 prey bait NOD2 NLRC4 MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 11472070,15107016 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(biogrid) HPRD_13858|BIOGRID_86619|BIOGRID_97955 -|prey|prey -|bait|bait NAT16 NOD2 MI:0004(affinity chromatography technology) 22607974 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187975 prey bait NLRP1 NOD2 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 18511561 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|MI:0465(dip) DIP_54281|DIP_54280 -|- -|- SQSTM1 NOD2 MI:0004(affinity chromatography technology) 23437331 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_258074 bait prey UBC NOD2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21906983,23019338 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_247711|BIOGRID_177639 prey|bait bait|prey RBCK1 NOD2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22607974,23818254 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_187980|BIOGRID_282695 prey|prey bait|bait CASP12 NOD2 MI:0004(affinity chromatography technology) 18329614 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_195950 prey bait KAT5 NOD2 MI:0018(two hybrid)|MI:0018(two hybrid) 21699783 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_194946|BIOGRID_194952 prey|prey bait|bait SHARPIN NOD2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22607974,23818254 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_187981|BIOGRID_282696 prey|prey bait|bait TRIM27 NOD2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22829933 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_199039|BIOGRID_199040 prey|bait bait|prey MAP3K7 NOD2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15075345,17348859,17965022 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_248438|BIOGRID_248439|BIOGRID_248437|BIOGRID_227646|BIOGRID_248440|BIOGRID_256352 prey|bait|bait|prey|prey|prey bait|prey|prey|bait|bait|bait CASP4 NOD2 MI:0006(anti bait coimmunoprecipitation) 18511561 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) MI:0465(dip) DIP_54279 - - CASP1 NOD2 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 15107016,18511561 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|MI:0465(dip) BIOGRID_86625|DIP_54278|DIP_54280 bait|-|- prey|-|- RIPK2 NOD2 MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation) 11087742,15620648,19592251,19667203,21097508,21123652,22607974 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|MI:0471(mint)|MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact) DIP_55506|BIOGRID_162572|BIOGRID_162651|HPRD_12384|BIOGRID_162650|MINT_56391|MINT_85410|BIOGRID_106738|BIOGRID_187972|BIOGRID_162571|BIOGRID_154585|BIOGRID_212991|UniProt_68629 -|bait|bait|-|prey|prey|prey|prey|prey|prey|prey|prey|prey -|prey|prey|-|bait|bait|bait|bait|bait|bait|bait|bait|bait VIM NOD2 MI:0018(two hybrid)|MI:0018(two hybrid) 21699783 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_194945|BIOGRID_194951 prey|prey bait|bait

PPI - HINT Gene A Gene B PMID Method Quality MAP3K7 NOD2 17348859,17965022,15075345,15075345 0096,0004,0096,0004 LC RIPK2 NOD2 19464198,22829933,16552041,17054981,26670046,21123652,22607974,11087742,19592251,19266573,16492792,15620648,11087742,21097508 0007,0007,0007,0007,0004,0004,0004,0004,0004,0007,0007,0004,0019,0004 LC VIM NOD2 22684479,22684479,22684479,21699783,22684479,21699783,21699783 0018,0007,0006,0006,0416,0018,0004 LC CASP1 NOD2 18511561,15107016,18511561,15107016,15107016 0006,0019,0007,0004,0007 LC XIAP NOD2 22607974,19667203 0004,0096 LC ATG16L1 NOD2 23376921,19898471,23376921,19898471 0096,0004,0004,0007 LC RNF31 NOD2 26670046,22607974,23818254 0004,0004,0004 LC ERBB2IP NOD2 16203728,16203728,16203728,16203728,16203728,19853919,19266573,16714539,16714539 0006,0007,0018,0663,0069,0676,0007,0018,0007 LC RBCK1 NOD2 26670046,22607974,23818254 0004,0004,0004 LC SHARPIN NOD2 26670046,22607974,23818254 0004,0004,0004 LC NOD2 NOD2 16492792,23437331 0007,0004 LC NOD2 NLRC4 15107016,15107016,11472070,15107016 0004,0019,0004,0007 LC NOD2 SUGT1 17420470,17435760,17420470 0004,0007,0007 LC MAP3K7 NOD2 17348859,17965022,15075345,15075345 0096,0004,0096,0004 LC RIPK2 NOD2 19464198,22829933,16552041,17054981,26670046,21123652,22607974,11087742,19592251,19266573,16492792,15620648,11087742,21097508 0007,0007,0007,0007,0004,0004,0004,0004,0004,0007,0007,0004,0019,0004 LC VIM NOD2 22684479,22684479,22684479,21699783,22684479,21699783,21699783 0018,0007,0006,0006,0416,0018,0004 LC CASP1 NOD2 18511561,15107016,18511561,15107016,15107016 0006,0019,0007,0004,0007 LC XIAP NOD2 22607974,19667203 0004,0096 LC ATG16L1 NOD2 23376921,19898471,23376921,19898471 0096,0004,0004,0007 LC RNF31 NOD2 26670046,22607974,23818254 0004,0004,0004 LC ERBB2IP NOD2 16203728,16203728,16203728,16203728,16203728,19853919,19266573,16714539,16714539 0006,0007,0018,0663,0069,0676,0007,0018,0007 LC RBCK1 NOD2 26670046,22607974,23818254 0004,0004,0004 LC SHARPIN NOD2 26670046,22607974,23818254 0004,0004,0004 LC NOD2 NOD2 16492792,23437331 0007,0004 LC NOD2 NLRC4 15107016,15107016,11472070,15107016 0004,0019,0004,0007 LC NOD2 SUGT1 17420470,17435760,17420470 0004,0007,0007 LC RIPK2 NOD2 11087742,11087742,16714539,19337385 0004,0019,0018,0018 LC ANKRD17 NOD2 23711367 0416 LC VIM NOD2 22684479,22684479,22684479,21699783,22684479,21699783,21699783 0018,0007,0006,0006,0416,0018,0004 LC UBC NOD2 23300079 0114 LC TRIM27 NOD2 22829933,22829933,22829933,22829933,22829933,22829933 0007,0006,0096,0018,0416,0004 LC CASP1 NOD2 15107016,15107016,15107016 0019,0004,0007 LC TLE1 NOD2 21699783,21699783,21699783 0004,0006,0018 LC GALNT2 NOD2 21699783,21699783,21699783 0004,0006,0018 LC ACAP1 NOD2 17005562,17005562 0018,0007 LC PPP2R5E NOD2 21699783,21699783,21699783 0004,0006,0018 LC Q59EF7 NOD2 21699783,21699783 0004,0018 LC Q59EK0 NOD2 21699783,21699783 0004,0018 LC TRIM50 NOD2 22829933 0018 LC KAT5 NOD2 21699783,21699783,21699783 0004,0006,0018 LC NLRP3 NOD2 19337385,19337385 0007,0018 LC ERBB2IP NOD2 16203728,16203728,16203728,16203728,16203728,16714539,16714539 0006,0007,0018,0663,0069,0018,0007 LC TRIM8 NOD2 22829933 0018 LC NOD2 NOD2 19337385 0018 LC NOD2 NLRC4 15107016,15107016,15107016 0004,0019,0007 LC NOD2 NDUFA13 15753091,15753091,15753091 0663,0007,0018 LC NOD2 FIS1 21699783,21699783,21699783 0004,0006,0018 LC NOD2 HEL113 21699783,21699783 0004,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9HC29 A1A4Y4 NOD2 IRGM 0.569 25891078 Q9HC29 A2AIV8 NOD2 CARD9 0.21 24960071 Q9HC29 O75179 NOD2 ANKRD17 0.126 23711367 Q9HC29 P0CG48 NOD2 UBC 0.309 23300079 Q9HC29 P21580 NOD2 TNFAIP3 0.21 26670046 Q9HC29 P98170 NOD2 XIAP 0.569 19667203,22607974 Q9HC29 Q13489 NOD2 BIRC3 0.21 22607974 Q9HC29 Q13490 NOD2 BIRC2 0.21 22607974 Q9HC29 Q13546 NOD2 RIPK1 0.21 22607974 Q9HC29 Q6UXS9 NOD2 CASP12 0.21 18329614 Q9HC29 Q7L5N1 NOD2 COPS6 0.21 17337451 Q9HC29 Q86XT4 NOD2 TRIM50 0.309 22829933 Q9HC29 Q8N8M0 NOD2 NAT16 0.21 22607974 Q9HC29 Q9BZR9 NOD2 TRIM8 0.309 22829933 Q9HC29 Q9HC29 NOD2 NOD2 0.236 23437331 Q9NQC7 Q9HC29 CYLD NOD2 0.21 26670046 Q9Y239 Q9HC29 NOD1 NOD2 0.376 19898471 Q9Y6K9 Q9HC29 IKBKG NOD2 0.21 22607974 Q9Y2Z0 Q9HC29 SUGT1 NOD2 0.21 17420470 Q9Y4K3 Q9HC29 TRAF6 NOD2 0.21 23437331 Q9HC29 P14373 NOD2 TRIM27 0.872 22829933 Q9HC29 Q676U5 NOD2 ATG16L1 0.61 23376921,19898471 Q9NPP4 Q9HC29 NLRC4 NOD2 0.376 11472070,15107016 Q9HC29 Q96RT1 NOD2 ERBB2IP 0.765 16203728 Q9HC29 O43353 NOD2 RIPK2 0.941 26670046,22829933,21097508,11087742,19592251,21123652,15620648,22607974 Q9HC29 O43318 NOD2 MAP3K7 0.837 17965022,17348859,15075345 Q9HC29 P29466 NOD2 CASP1 0.507 18511561,15107016 Q9HC29 Q96EP0 NOD2 RNF31 0.507 26670046,22607974,23818254 Q9HC29 Q9H0F6 NOD2 SHARPIN 0.507 26670046,22607974,23818254 Q9HC29 Q9BYM8 NOD2 RBCK1 0.507 26670046,22607974,23818254 Q9P0J0 Q9HC29 NDUFA13 NOD2 0.523 15753091 Q9HC29 Q92993 NOD2 KAT5 0.702 21699783 Q9HC29 Q04724 NOD2 TLE1 0.702 21699783 Q9HC29 Q10471 NOD2 GALNT2 0.702 21699783 Q9HC29 Q16537 NOD2 PPP2R5E 0.702 21699783 Q9Y3D6 Q9HC29 FIS1 NOD2 0.702 21699783 Q9HC29 P08670 NOD2 VIM 0.888 21699783,22684479 Q9HC29 Q9BUZ4 NOD2 TRAF4 0.376 21097508 Q9HC29 Q9C000 NOD2 NLRP1 0.21 18511561 Q9HC29 P49662 NOD2 CASP4 0.21 18511561 Q9HC29 Q13501 NOD2 SQSTM1 0.21 23437331

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 IRGM NOD2 MI:0045 experimental interaction detection MI:0461 interaction database SOCS3 NOD2 MI:0362 inference MI:0461 interaction database MAP2K7 NOD2 MI:0362 inference MI:1106 pathways database IKBKB NOD2 MI:0362 inference MI:1106 pathways database CHUK NOD2 MI:0362 inference MI:1106 pathways database MAP3K7 NOD2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RIPK2 NOD2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database HSP90AB1 NOD2 MI:0362 inference MI:0461 interaction database VIM NOD2 MI:0045 experimental interaction detection MI:0461 interaction database UBC NOD2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM27 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database TNFAIP3 NOD2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CASP1 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database HNF4A NOD2 MI:0045 experimental interaction detection MI:0461 interaction database MAP2K4 NOD2 MI:0362 inference MI:1106 pathways database MAP2K3 NOD2 MI:0362 inference MI:1106 pathways database CASP4 NOD2 MI:0362 inference MI:0461 interaction database MAP2K6 NOD2 MI:0362 inference MI:1106 pathways database UBE2N NOD2 MI:0362 inference MI:1106 pathways database XIAP NOD2 MI:0045 experimental interaction detection MI:0461 interaction database RELA NOD2 MI:0045 experimental interaction detection MI:0461 interaction database TLE1 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database GALNT2 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2V1 NOD2 MI:0362 inference MI:1106 pathways database BIRC3 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database BIRC2 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database SQSTM1 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database RIPK1 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database TAB1 NOD2 MI:0362 inference MI:1106 pathways database PPP2R5E NOD2 MI:0045 experimental interaction detection MI:0461 interaction database ATG16L1 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database OLFM4 NOD2 MI:0362 inference MI:0461 interaction database CASP12 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database COPS6 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM50 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database SLC15A3 NOD2 MI:0362 inference MI:0461 interaction database TAB3 NOD2 MI:0362 inference MI:1106 pathways database SLC15A4 NOD2 MI:0362 inference MI:0461 interaction database NAT16 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database KAT5 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database RNF31 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database ITCH NOD2 MI:0362 inference MI:1106 pathways database ERBIN NOD2 MI:0045 experimental interaction detection MI:0461 interaction database TRAF4 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database RBCK1 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM8 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database NLRP1 NOD2 MI:0362 inference MI:0461 interaction database SHARPIN NOD2 MI:0045 experimental interaction detection MI:0461 interaction database CARD9 NOD2 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database NOD2 NLRC4 MI:0045 experimental interaction detection MI:0461 interaction database NOD2 CYLD MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database NOD2 TAB2 MI:0362 inference MI:1106 pathways database NOD2 NDUFA13 MI:0045 experimental interaction detection MI:0461 interaction database NOD2 NOD1 MI:0045 experimental interaction detection MI:0461 interaction database NOD2 SUGT1 MI:0045 experimental interaction detection MI:0461 interaction database NOD2 FIS1 MI:0045 experimental interaction detection MI:0461 interaction database NOD2 TRAF6 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database NOD2 IKBKG MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database