PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus GRB10 KCTD5 20007894 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PTPN11 KCTD5 20007894 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD5 POLK 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NCK1 KCTD5 20007894 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EP300 KCTD5 21988832 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NPM1 KCTD5 23402259 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD5 NXF1 21988832 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ILK KCTD5 17353931 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SHC1 KCTD5 20007894 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SMURF1 KCTD5 23184937 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ARRDC1 KCTD5 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NEK6 KCTD5 21988832 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G CD1A KCTD5 21988832 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G YES1 KCTD5 20007894 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIP6 KCTD5 17353931 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GRK5 KCTD5 22952844 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SOX2 KCTD5 23667531 biogrid exp G G G G G G G G G G G G G G CNRIP1 KCTD5 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FRS2 KCTD5 20007894 i2d exp G G G G G G G G G G G G G G G G G G G G G G G PAN2 KCTD5 23398456 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PRKAB2 KCTD5 21988832 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DVL3 KCTD5 20007894 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD5 RAPGEF2 25332235 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G XPO1 KCTD5 26673895 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PTK2 KCTD5 20007894 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ELF3 KCTD5 17353931 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DVL2 KCTD5 20007894 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G APC KCTD5 20007894 i2d exp G G G G G G G G G G G G G G G G G G G G G G G G G G G GIT2 KCTD5 21988832 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD5 KCTD5 19361449,16501559,18573101 hprd,biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL3 KCTD5 24747150,18573101,21145461, 21836163 biogrid exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GORASP2 KCTD5 19361449,16501559, 16082366 hprd,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL2 KCTD5 17353931, 21836163 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD17 KCTD5 26186194, 25402006, 16082366 biogrid exp, pred G G G G G G G FYN KCTD5 20007894, 23023127 i2d exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FLNA KCTD5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GGPS1 KCTD5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD5 FEM1B ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2I KCTD5 16082366 ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCNA4 KCTD5 23023127, 16082366 pred G G G KCNJ15 KCTD5 16082366 pred G G G G G G G G G G G G G G KCTD7 KCTD5 23023127, 16082366 pred KCTD5 KCNK7 16082366 pred G KCNQ4 KCTD5 16082366 pred G G G G G G G G G G G G G G G KCNB1 KCTD5 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCNA1 KCTD5 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G KCNQ3 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MIDN KCTD5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GRIA4 KCTD5 16082366 pred G G G G G G G G G KCNA2 KCTD5 23023127, 16082366 pred G G G G G G G G G G G G KCTD5 KCND2 23023127, 16082366 pred G G G G G G KCND1 KCTD5 23023127 pred G CNGA3 KCTD5 16082366 pred G KCNQ2 KCTD5 16082366 pred G G G G G G G G G KCNJ2 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GRIA3 KCTD5 16082366 pred G G G G G BTBD17 KCTD5 23023127 pred CACNB4 KCTD5 16082366 pred G G G G G G G KCNJ13 KCTD5 16082366 pred G GRIA2 KCTD5 16082366 pred G G G G G G KCNH6 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G KCNA7 KCTD5 23023127, 16082366 pred G KCTD5 KCTD3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G TARDBP KCTD5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KLHL17 KCTD5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G ALYREF KCTD5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCNJ3 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G CNGA2 KCTD5 16082366 pred KCNK5 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G GRIK4 KCTD5 16082366 pred KLHL23 KCTD5 23023127 pred G G G G G G G G G G G G G KCNC3 KCTD5 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G KCTD16 KCTD5 23023127, 16082366 pred G G G G G G G G KCTD10 KCTD5 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCNJ5 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G RBM15 KCTD5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD2 KCTD5 25402006, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCNA6 KCTD5 23023127, 16082366 pred G G G G G G G G G G G KCNS3 KCTD5 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G KCTD14 KCTD5 23023127, 16082366 pred KCTD5 IVNS1ABP 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD5 KCNN3 16082366 pred G G G G G G G KLHL24 KCTD5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD6 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCNJ8 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G KCNK10 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G KCNJ10 KCTD5 16082366 pred G G G G G G G G KCNA3 KCTD5 23023127, 16082366 pred G G G G G G KCTD5 KCNK6 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD1 KCTD5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G kcnj12x KCTD5 16082366 pred KCNK15 KCTD5 16082366 pred KCTD5 KCNS2 16082366 pred G G G G G G G G G G G G G G KCTD5 KCNG1 23023127, 16082366 pred G G G G CNGB3 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G G KCTD5 KCND3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCNF1 KCTD5 23023127, 16082366 pred G G G G G G KCNN2 KCTD5 16082366 pred G G G G G G G G G G G G G KCTD12 KCTD5 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCNV2 KCTD5 23023127, 16082366 pred G KCNH1 KCTD5 16082366 pred KCNJ16 KCTD5 16082366 pred G G G G G G G G G G G G G G KCTD15 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCNG3 KCTD5 23023127, 16082366 pred G G KCNRG KCTD5 23023127 pred G G G G G KCNT1 KCTD5 16082366 pred G G G G G CACNB1 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G KCTD5 KCNIP1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G KCNK9 KCTD5 16082366 pred G G G G KCTD5 KCNH4 16082366 pred G G G G G G G G G G KCTD20 KCTD5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD5 KCNH3 16082366 pred G G G G G G G G G G G G G G G G G KCTD5 KCNK4 16082366 pred KCNJ1 KCTD5 16082366 pred G KCNA5 KCTD5 23023127, 16082366 pred G G KCNG4 KCTD5 23023127, 16082366 pred G G G G G G G G G G G G G G G KCNQ1 KCTD5 16082366 pred G G G G G G G G G G G G G G NUP35 KCTD5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HCN1 KCTD5 16082366 pred G G G G G KCNMA1 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCNQ5 KCTD5 16082366 pred G G G G G G G G G KCTD21 KCTD5 23023127 pred G G G G G G G G G G G G G KCNH5 KCTD5 16082366 pred G G G G G G G KCNH2 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RBM12B KCTD5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCNJ6 KCTD5 16082366 pred G G G G G G HNRNPK KCTD5 23023127 pred KCTD5 KCNJ14 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCNV1 KCTD5 23023127, 16082366 pred G G G SYNCRIP KCTD5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCNC1 KCTD5 23023127, 16082366 pred G G G G G G G G G G G G G G G G KCNK3 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G KCTD5 KCNG2 23023127, 16082366 pred KCTD18 KCTD5 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD5 HCN2 16082366 pred G G G G G G KCNJ4 KCTD5 16082366 pred G G G G G G G KCNB2 KCTD5 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G KCTD9 KCTD5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KLHL28 KCTD5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCNK13 KCTD5 16082366 pred G CACNB2 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G KCNC4 KCTD5 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCNJ11 KCTD5 16082366 pred G G KCNK12 KCTD5 16082366 pred G G G G G G KCNJ9 KCTD5 16082366 pred G G G G G G G G G KCNN1 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G KCTD11 KCTD5 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G KCNK17 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GRIK1 KCTD5 16082366 pred G G G G G G G G G G KCTD8 KCTD5 23023127 pred KCNK1 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TNFAIP1 KCTD5 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SHKBP1 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G KCNK16 KCTD5 16082366 pred G G G G G G G G G G G G G G GRIA1 KCTD5 16082366 pred G G G G G G RBM15B KCTD5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CNGA1 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G CNGA4 KCTD5 16082366 pred G G G G KEAP1 KCTD5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCNS1 KCTD5 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCNK2 KCTD5 16082366 pred G CACNB3 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G KCNC2 KCTD5 23023127 pred KCNH8 KCTD5 16082366 pred G G G G G G G G G G G G KCNN4 KCTD5 16082366 pred G G G G G G G G G G G G G G G G G G G G G G KCNA10 KCTD5 23023127, 16082366 pred KCTD13 KCTD5 23023127, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q09472 Q9NXV2 two hybrid 21988832 direct interaction X 2 Q9NXV2 Q9H8Y8 affinity chromatography technology 19361449 physical association X 2 Q9NXV2 P34947 affinity chromatography technology 22952844 physical association X 2 Q9NXV2 affinity chromatography technology 23184937 physical association X 2 Q9NXV2 P06748-2 affinity chromatography technology 23402259 physical association X 2 Q9NXV2 Q14161-2 two hybrid 21988832 direct interaction X 2 Q9NXV2 two hybrid 21988832 direct interaction X 2 P0CG48 Q9NXV2 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q9NXV2 affinity chromatography technology 24816145 physical association X 2 P0CG48 Q9NXV2 affinity chromatography technology 18573101 physical association X 2 P0CG48 Q9NXV2 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q9NXV2 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q9NXV2 affinity chromatography technology 21906983 physical association X 2 Q9Y4G8 Q9NXV2 affinity chromatography technology 25332235 physical association X 2 Q15654 Q9NXV2 affinity chromatography technology 17353931 physical association X 2 Q9NXV2 A0A024R475 affinity chromatography technology 21145461 physical association X 2 Q9NXV2 Q9NXV2 x-ray crystallography 19361449 association X 2 Q9NXV2 Q9NXV2 pull down 19361449 direct interaction X 2 Q9NXV2 Q504Q3-3 affinity chromatography technology 23398456 physical association X 2 Q9NXV2 P48431 affinity chromatography technology 23667531 physical association X 2 Q9NXV2 two hybrid 21988832 direct interaction X 2 Q9NXV2 A0A024R475 pull down 24747150 direct interaction X 2 Q9NXV2 Q13617 affinity chromatography technology 17353931 physical association X 2 Q9NXV2 A0A024R475 affinity chromatography technology 18573101 physical association X 2 Q9NXV2 A0A024R475 pull down 18573101 direct interaction X 2 Q9NXV2 Q9NXV2 pull down 18573101 direct interaction X 2 Q9NXV2 affinity chromatography technology 20360068 physical association X 2 O43741 Q9NXV2 two hybrid 21988832 direct interaction X 2 P06126 Q9NXV2 two hybrid 21988832 direct interaction X 2 Q9NXV2 Q9H8Y8 in vivo 16501559 - X 2 Q9NXV2 Q9H8Y8 in vivo 16501559 - X 2 Q9NXV2 Q9NXV2 in vivo 16501559 - X 2 Q89268 Q9NXV2 anti bait coimmunoprecipitation 17239418 physical association X 2 Q89268 Q9NXV2 fluorescence microscopy 17239418 physical association X 2 Q13418 Q9NXV2 anti bait coimmunoprecipitation 17353931 physical association X 2 Q09472 Q9NXV2 two hybrid array 21988832 physical association X 2 Q9NXV2 A0A024R974 anti bait coimmunoprecipitation 17353931 physical association X 2 Q9NXV2 A0A024R8A6 two hybrid array 21988832 physical association X 2 P03132 Q9NXV2 anti bait coimmunoprecipitation 17239418 physical association X 2 P03132 Q9NXV2 two hybrid 17239418 physical association X 2 P03132 Q9NXV2 two hybrid 17239418 physical association X 2 Q15654 Q9NXV2 anti bait coimmunoprecipitation 17353931 physical association X 2 Q9NXV2 tandem affinity purification 20360068 physical association C 4 Q9NXV2 Q13617 anti bait coimmunoprecipitation 17353931 physical association X 2 Q9NXV2 Q14161 two hybrid array 21988832 physical association X 2 Q9NXV2 Q9UBU9 two hybrid array 21988832 physical association X 2 O43741 Q9NXV2 two hybrid array 21988832 physical association X 2 P06126 Q9NXV2 two hybrid array 21988832 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ELF3 KCTD5 MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_148455 bait prey NPM1 KCTD5 MI:0004(affinity chromatography technology) 23402259 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_274491 bait prey EP300 KCTD5 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_117778|BIOGRID_286047 unspecified role|bait unspecified role|prey TRIP6 KCTD5 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_148057|BIOGRID_82744 bait|bait prey|prey GRK5 KCTD5 MI:0004(affinity chromatography technology) 22952844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_218537 bait prey SMURF1 KCTD5 MI:0004(affinity chromatography technology) 23184937 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_248795 bait prey KCTD5 NXF1 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(intact) UniProt_120016|BIOGRID_288594|UniProt_118215 unspecified role|bait|unspecified role unspecified role|prey|unspecified role PAN2 KCTD5 MI:0004(affinity chromatography technology) 23398456 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_273374 bait prey GIT2 KCTD5 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_118050|BIOGRID_288440 unspecified role|bait unspecified role|prey NEK6 KCTD5 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_286696|UniProt_118236 prey|unspecified role bait|unspecified role ILK KCTD5 MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_149818 bait prey CUL3 KCTD5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18573101,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_202090|BIOGRID_116868|BIOGRID_116869 bait|prey|prey prey|bait|bait GORASP2 KCTD5 MI:0493(in vivo)|MI:0114(x-ray crystallography) 16501559,19361449 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_20200|BIOGRID_213397 -|prey -|bait CD1A KCTD5 MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_117376 unspecified role unspecified role PRKAB2 KCTD5 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_118049|BIOGRID_288439 unspecified role|prey unspecified role|bait CUL2 KCTD5 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_83445|UniProt_150018 bait|bait prey|prey SOX2 KCTD5 MI:0004(affinity chromatography technology) 23667531 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_275039 bait prey UBC KCTD5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18573101,21139048,21890473,21906983,22505724 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_174856|BIOGRID_116870|BIOGRID_167904|BIOGRID_177338|BIOGRID_224439 bait|prey|bait|bait|bait prey|bait|prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality C21ORF2 KCTD5 27173435 0676 HT PRDX2 KCTD5 27173435 0676 HT ELF3 KCTD5 17353931 0006 HT ILK KCTD5 17353931 0006 HT CUL2 KCTD5 17353931,17353931 0006,0004 HT CUL3 KCTD5 18573101,24747150,18573101,21145461,26334369 0004,0096,0096,0004,0096 LC,HT SLC9A3R2 KCTD5 27173435 0676 HT TRIP6 KCTD5 17353931,17353931 0006,0004 HT ARRDC1 KCTD5 26186194 0004 HT KCTD17 KCTD5 26186194 0004 HT CNRIP1 KCTD5 26186194 0004 HT KCTD5 KCTD5 19361449,18573101,19361449 0096,0096,0114 LC KCTD5 POLK 26496610,26496610 0007,0004 HT C21ORF2 KCTD5 27173435 0676 HT PRDX2 KCTD5 27173435 0676 HT ELF3 KCTD5 17353931 0006 HT ILK KCTD5 17353931 0006 HT CUL2 KCTD5 17353931,17353931 0006,0004 HT CUL3 KCTD5 21145461 0004 HT SLC9A3R2 KCTD5 27173435 0676 HT TRIP6 KCTD5 17353931,17353931 0006,0004 HT ARRDC1 KCTD5 26186194 0004 HT KCTD17 KCTD5 26186194 0004 HT CNRIP1 KCTD5 26186194 0004 HT KCTD5 POLK 26496610,26496610 0007,0004 HT CUL3 KCTD5 18573101,24747150,18573101,26334369 0004,0096,0096,0096 LC KCTD5 KCTD5 19361449,18573101,19361449 0096,0096,0114 LC PRKAB2 KCTD5 21988832,21988832 0397,0018 HT CD1A KCTD5 21988832,21988832 0397,0018 HT MCM7 KCTD5 26188516,26188516 0004,0018 LC EP300 KCTD5 21988832,21988832 0397,0018 HT GIT2 KCTD5 21988832,21988832 0397,0018 HT FAM193B KCTD5 26188516,26188516 0004,0018 LC NEK6 KCTD5 21988832,21988832 0397,0018 HT KCTD5 KCTD5 19361449,19361449 0096,0114 LC KCTD5 NXF1 21988832,21988832 0397,0018 HT KCTD5 ZNF711 26188516,26188516 0004,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NXV2 Q09472 KCTD5 EP300 0.286 21988832 Q9NXV2 O14980 KCTD5 XPO1 0.126 26673895 Q9NXV2 O43741 KCTD5 PRKAB2 0.286 21988832 Q9NXV2 Q8N5I2 KCTD5 ARRDC1 0.126 26186194 Q9NXV2 Q8N5Z5 KCTD5 KCTD17 0.126 26186194 Q9NXV2 Q9HC98 KCTD5 NEK6 0.286 21988832 Q9NXV2 Q9HCE7 KCTD5 SMURF1 0.126 23184937 Q9NXV2 Q13418 KCTD5 ILK 0.126 17353931 Q9NXV2 Q13617 KCTD5 CUL2 0.332 17353931 Q9NXV2 Q15654 KCTD5 TRIP6 0.332 17353931 Q9NXV2 Q9H8Y8 KCTD5 GORASP2 0.21 19361449 Q9NXV2 Q9H2C0 KCTD5 GAN 0.126 26460568 Q9Y462 Q9NXV2 ZNF711 KCTD5 0.569 26188516 Q9Y4G8 Q9NXV2 RAPGEF2 KCTD5 0.126 25332235 Q9NXV2 Q6P5F9 KCTD5 XPO1 0.126 26673895 Q9NXV2 P06748 KCTD5 NPM1 0.126 23402259 Q9NXV2 Q13618 KCTD5 CUL3 0.772 24747150,21145461,18573101,26334369 Q9UBT6 Q9NXV2 POLK KCTD5 0.236 26496610 Q9NXV2 Q8VC57 KCTD5 KCTD5 0.236 20360068 Q9NXV2 P06126 KCTD5 CD1A 0.286 21988832 Q9NXV2 Q14161 KCTD5 GIT2 0.286 21988832 Q9NXV2 Q15599 KCTD5 SLC9A3R2 0.236 27173435,unassigned1312 Q9NXV2 O43822 KCTD5 C21ORF2 0.236 27173435,unassigned1312 Q9UBU9 Q9NXV2 NXF1 KCTD5 0.416 21988832 Q9NXV2 Q9NXV2 KCTD5 KCTD5 0.867 19361449,27152988,18573101 Q9NXV2 Q96F85 KCTD5 CNRIP1 0.126 26186194 Q9NXV2 P32119 KCTD5 PRDX2 0.236 27173435,unassigned1312 Q9NXV2 Q96PV7 KCTD5 FAM193B 0.569 26188516 Q9NXV2 P33993 KCTD5 MCM7 0.569 26188516 Q9NXV2 P34947 KCTD5 GRK5 0.126 22952844 Q9NXV2 P78545 KCTD5 ELF3 0.236 17353931 Q9NXV2 P48431 KCTD5 SOX2 0.126 23667531 Q9NXV2 Q504Q3 KCTD5 PAN2 0.126 23398456

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 POLRMT KCTD5 MI:0362 inference MI:0461 interaction database PSMA7 KCTD5 MI:0362 inference MI:0461 interaction database XPO1 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database SEC16A KCTD5 MI:0362 inference MI:0461 interaction database PDPK1 KCTD5 MI:0362 inference MI:0461 interaction database TET3 KCTD5 MI:0362 inference MI:0461 interaction database TLX3 KCTD5 MI:0362 inference MI:0461 interaction database PRKAB2 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database C21orf2 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database HPGDS KCTD5 MI:0362 inference MI:0461 interaction database SEC22B KCTD5 MI:0362 inference MI:0461 interaction database NDUFB4 KCTD5 MI:0362 inference MI:0461 interaction database GGPS1 KCTD5 MI:0362 inference MI:0461 interaction database BAG2 KCTD5 MI:0362 inference MI:0461 interaction database ALB KCTD5 MI:0362 inference MI:0461 interaction database HSPB1 KCTD5 MI:0362 inference MI:0461 interaction database CD1A KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database NPM1 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database TUBB KCTD5 MI:0362 inference MI:0461 interaction database UBC KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database TAF1 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database LAMA1 KCTD5 MI:0362 inference MI:0461 interaction database CALR KCTD5 MI:0362 inference MI:0461 interaction database SSFA2 KCTD5 MI:0362 inference MI:0461 interaction database PRDX2 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database MCM7 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database GRK5 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database RFC1 KCTD5 MI:0362 inference MI:0461 interaction database HADHA KCTD5 MI:0362 inference MI:0461 interaction database LRPPRC KCTD5 MI:0362 inference MI:0461 interaction database SLC1A3 KCTD5 MI:0362 inference MI:0461 interaction database SOX2 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database CSNK1E KCTD5 MI:0362 inference MI:0461 interaction database RAB5C KCTD5 MI:0362 inference MI:0461 interaction database PLXNA3 KCTD5 MI:0362 inference MI:0461 interaction database COPB1 KCTD5 MI:0362 inference MI:0461 interaction database SUB1 KCTD5 MI:0362 inference MI:0461 interaction database ATP6V0D1 KCTD5 MI:0362 inference MI:0461 interaction database GNB1 KCTD5 MI:0362 inference MI:0461 interaction database GNB2 KCTD5 MI:0362 inference MI:0461 interaction database UBE2I KCTD5 MI:0362 inference MI:0461 interaction database TUBA1B KCTD5 MI:0362 inference MI:0461 interaction database ELF3 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database CDC42EP1 KCTD5 MI:0362 inference MI:0461 interaction database TFAP4 KCTD5 MI:0362 inference MI:0461 interaction database GBE1 KCTD5 MI:0362 inference MI:0461 interaction database LGALS3BP KCTD5 MI:0362 inference MI:0461 interaction database EP300 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database AHNAK KCTD5 MI:0362 inference MI:0461 interaction database PSMD2 KCTD5 MI:0362 inference MI:0461 interaction database MTA1 KCTD5 MI:0362 inference MI:0461 interaction database ILK KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database PKD2 KCTD5 MI:0362 inference MI:0461 interaction database CUL2 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database CUL3 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database RAPSN KCTD5 MI:0362 inference MI:0461 interaction database CKAP5 KCTD5 MI:0362 inference MI:0461 interaction database GIT2 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database DCTN1 KCTD5 MI:0362 inference MI:0461 interaction database PDE3A KCTD5 MI:0362 inference MI:0461 interaction database ITPR1 KCTD5 MI:0362 inference MI:0461 interaction database KCTD2 KCTD5 MI:0362 inference MI:0461 interaction database ARID5B KCTD5 MI:0362 inference MI:0461 interaction database RCN1 KCTD5 MI:0362 inference MI:0461 interaction database SLC9A3R2 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database TRAM1 KCTD5 MI:0362 inference MI:0461 interaction database TRIP13 KCTD5 MI:0362 inference MI:0461 interaction database TRIP6 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database PAN2 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database PHLDA2 KCTD5 MI:0362 inference MI:0461 interaction database GORAB KCTD5 MI:0362 inference MI:0461 interaction database RNF219 KCTD5 MI:0362 inference MI:0461 interaction database FBXO31 KCTD5 MI:0362 inference MI:0461 interaction database FAM91A1 KCTD5 MI:0362 inference MI:0461 interaction database JMJD6 KCTD5 MI:0362 inference MI:0461 interaction database PKN3 KCTD5 MI:0362 inference MI:0461 interaction database FAM111B KCTD5 MI:0362 inference MI:0461 interaction database CYFIP1 KCTD5 MI:0362 inference MI:0461 interaction database IQGAP3 KCTD5 MI:0362 inference MI:0461 interaction database SIRT2 KCTD5 MI:0362 inference MI:0461 interaction database ARRDC1 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database KCTD17 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database SIRT6 KCTD5 MI:0362 inference MI:0461 interaction database PSMA8 KCTD5 MI:0362 inference MI:0461 interaction database RAB3IL1 KCTD5 MI:0362 inference MI:0461 interaction database SNX29 KCTD5 MI:0362 inference MI:0461 interaction database TMEM263 KCTD5 MI:0362 inference MI:0461 interaction database SYNE2 KCTD5 MI:0362 inference MI:0461 interaction database GCN1 KCTD5 MI:0362 inference MI:0461 interaction database TNPO1 KCTD5 MI:0362 inference MI:0461 interaction database PRKCDBP KCTD5 MI:0362 inference MI:0461 interaction database MRPL24 KCTD5 MI:0362 inference MI:0461 interaction database CNRIP1 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database FAM193B KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database RAB3IP KCTD5 MI:0362 inference MI:0461 interaction database TCF12 KCTD5 MI:0362 inference MI:0461 interaction database PHB2 KCTD5 MI:0362 inference MI:0461 interaction database FEM1A KCTD5 MI:0362 inference MI:0461 interaction database DERL2 KCTD5 MI:0362 inference MI:0461 interaction database SLIRP KCTD5 MI:0362 inference MI:0461 interaction database GAN KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database KCTD10 KCTD5 MI:0362 inference MI:0461 interaction database CDC42EP4 KCTD5 MI:0362 inference MI:0461 interaction database RBKS KCTD5 MI:0362 inference MI:0461 interaction database EPB41L1 KCTD5 MI:0362 inference MI:0461 interaction database THAP9 KCTD5 MI:0362 inference MI:0461 interaction database GORASP2 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database SLC25A22 KCTD5 MI:0362 inference MI:0461 interaction database NEK6 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database SMURF1 KCTD5 MI:0045 experimental interaction detection MI:0461 interaction database SMC4 KCTD5 MI:0362 inference MI:0461 interaction database POLR3E KCTD5 MI:0362 inference MI:0461 interaction database TMEM45A KCTD5 MI:0362 inference MI:0461 interaction database THUMPD1 KCTD5 MI:0362 inference MI:0461 interaction database KCTD5 ANAPC11 MI:0362 inference MI:0461 interaction database KCTD5 MYOF MI:0362 inference MI:0461 interaction database KCTD5 SENP1 MI:0362 inference MI:0461 interaction database KCTD5 KLHL13 MI:0362 inference MI:0461 interaction database KCTD5 GNG12 MI:0362 inference MI:0461 interaction database KCTD5 POLK MI:0045 experimental interaction detection MI:0461 interaction database KCTD5 NXF1 MI:0045 experimental interaction detection MI:0461 interaction database KCTD5 ZMYM2 MI:0362 inference MI:0461 interaction database KCTD5 SEPT9 MI:0362 inference MI:0461 interaction database KCTD5 TRPS1 MI:0362 inference MI:0461 interaction database KCTD5 ATP6V1H MI:0362 inference MI:0461 interaction database KCTD5 FEM1B MI:0362 inference MI:0461 interaction database KCTD5 TBC1D24 MI:0362 inference MI:0461 interaction database KCTD5 HIGD1A MI:0362 inference MI:0461 interaction database KCTD5 GIT1 MI:0362 inference MI:0461 interaction database KCTD5 ZNF711 MI:0045 experimental interaction detection MI:0461 interaction database KCTD5 RAPGEF2 MI:0045 experimental interaction detection MI:0461 interaction database KCTD5 AFG3L2 MI:0362 inference MI:0461 interaction database KCTD5 COX11 MI:0362 inference MI:0461 interaction database