PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus GABARAP ATG16L2 20562859 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G XPO1 ATG16L2 26673895 biogrid exp GP G G G G GP G GP GP G GP G G G G G GP G P G GP G G G G G GP GP G ATG16L2 MAP1LC3B 20562859 intact exp G G G G G GP G GP GP G GP G G G G G GP G G G G G G G G GP GP G TK1 ATG16L2 21900206 biogrid,mint,intact exp GP G G G P G G GP G G G G G P G G GP G G G GP G CHUK ATG16L2 23563314 biogrid exp, ortho GP G G G G GP G GP GP G GP G G G G G GP G P G GP G G G G G GP GP G ATG16L2 ATG5 20562859,21575909, 25402006 innatedb,intact exp, pred GP G G G G GP G GP GP G GP G G G G G GP G P G GP G G G G G GP GP G ATG12 ATG16L2 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP G P G GP G G G G G GP GP G WDFY3 ATG16L2 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP G P G GP G G G G G GP GP G ATG16L2 RAB24 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G ATG16L2 MAP1LC3C 25402006 pred G G G ATG16L2 NUP37 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G ATG16L2 ATG10 25402006 pred GP G G G G GP G GP GP G GP G G G GP G P G GP G G G G P P G TAGLN2 ATG16L2 25402006 pred G G G G G GP G G G G GP G G G G G GP G P G G G G G G G GP G G HSPE1 ATG16L2 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP G P G GP G G G G G GP GP G RPS16 ATG16L2 25402006 pred GP G G G G GP G G GP G GP G G G G G GP G P G GP G G G G G GP GP G EEF1B2 ATG16L2 25402006 pred P P P P P P P P P HPRT1 ATG16L2 25402006 pred GP G G G G GP G G GP G GP G G G G G GP G P G GP G G G G G GP GP G IMPDH2 ATG16L2 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP G P G GP G G G G G GP GP G RBBP4 ATG16L2 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP G P G GP G G G G G GP GP G ATG16L2 IFIH1 25402006 pred GP G P G GP GP G G G G G P G P G GP G G G G GP P GNGT1 ATG16L2 23023127 pred P G P ATG16L1 ATG16L2 25402006, 23023127 pred G G G GP G G G G G G G GP G G G G G G G G G ATG16L2 AMBRA1 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP G P G GP G G G G G GP GP G SQSTM1 ATG16L2 23023127 pred GP G G G G G G G GP G GP G G G G G G G P G GP G G G G G GP GP G GOT2 ATG16L2 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP G P G GP G G G G G GP GP G WIPI1 ATG16L2 23023127 pred GP G G G G GP G GP GP G GP G G G G G GP G P G GP G G G G G GP GP G RGS19 ATG16L2 23023127 pred GP G G G G GP G G GP G GP G G G G G GP G P G GP G G G G G GP GP G TECPR1 ATG16L2 25402006 pred GP G G G G GP G GP GP G GP G G G G G GP G P G GP G G G G G GP GP G RGS9 ATG16L2 23023127 pred G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O15111 Q8NAA4 affinity chromatography technology 23563314 physical association X 2 O15111 Q8NAA4 affinity chromatography technology 23563314 physical association X 2 P04183 Q8NAA4 two hybrid 21900206 direct interaction X 2 Q8NAA4 anti tag coimmunoprecipitation 20562859 association C 12 Q8NAA4 Q658J6 pull down 20562859 direct interaction X 2 P04183 Q8NAA4 two hybrid 21900206 physical association X 2 Q8NAA4 anti tag coimmunoprecipitation 20562859 association C 13 O95166 Q8NAA4 pull down 20562859 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ATG16L2 MAP1LC3B MI:0007(anti tag coimmunoprecipitation) 20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (intact) UniProt_106669 prey bait TK1 ATG16L2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(intact) UniProt_178063|BIOGRID_157290|UniProt_157465 bait|bait|bait prey|prey|prey STK4 ATG16L2 MI:0004(affinity chromatography technology) 23455922 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_277668 bait prey GABARAP ATG16L2 MI:0007(anti tag coimmunoprecipitation) 20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (intact) UniProt_106561 bait prey CHUK ATG16L2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23563314 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_279650|BIOGRID_279651 prey|bait bait|prey

PPI - HINT Gene A Gene B PMID Method Quality PCID2 ATG16L2 20562859 0096 HT DKFZP762B153 ATG16L2 20562859 0096 HT ATG16L2 MAP1LC3B 20562859 0096 HT ATG16L2 ATG5 20562859 0007 HT PCID2 ATG16L2 20562859 0096 HT DKFZP762B153 ATG16L2 20562859 0096 HT ATG16L2 MAP1LC3B 20562859 0096 HT ATG16L2 ATG5 20562859 0007 HT TK1 ATG16L2 21900206 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8NAA4 O15111 ATG16L2 CHUK 0.376 23563314 Q9GZQ8 Q8NAA4 MAP1LC3B ATG16L2 0.183 20562859 Q9H1Y0 Q8NAA4 ATG5 ATG16L2 0.126 20562859 Q8NAA4 Q6P5F9 ATG16L2 XPO1 0.126 26673895 Q8NAA4 O95166 ATG16L2 GABARAP 0.183 20562859 Q8NAA4 P04183 ATG16L2 TK1 0.332 21900206 Q969H0 Q8NAA4 FBXW7 ATG16L2 0.126 25720964

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 XPO1 ATG16L2 MI:0045 experimental interaction detection MI:0461 interaction database CHUK ATG16L2 MI:0045 experimental interaction detection MI:0461 interaction database GABARAP ATG16L2 MI:0045 experimental interaction detection MI:0461 interaction database TK1 ATG16L2 MI:0045 experimental interaction detection MI:0461 interaction database ATG16L2 FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database ATG16L2 MAP1LC3B MI:0045 experimental interaction detection MI:0461 interaction database ATG16L2 ATG5 MI:0045 experimental interaction detection MI:0461 interaction database