PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RNF187 MOV10 22658674 biogrid exp G G G G G G G G G G G G G G G G G G G G G G RNF187 NXF1 22658674 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF187 LHX6 26186194 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP P GP GP G RNF187 ZNF562 26186194 biogrid exp GP GP G G G GP G GP G G GP G G G G GP GP GP GP G GP G G GP GP G GP GP G NEDD8 RNF187 21145461 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF187 PRMT1 23624934 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G G G GP GP GP GP GP G GP GP G CUL2 RNF187 21145461 biogrid exp GP GP G G G GP G G GP G GP GP GP GP G G GP GP GP G GP GP GP G G G GP GP G RNF187 XRN1 15231747 biogrid exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G RNF187 RNF187 23624934 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF187 WDR83 26186194 biogrid exp GP GP G G G GP G GP P G GP GP GP GP GP GP G GP G GP GP G P GP GP GP GP G JUN RNF187 23624934,20852630 biogrid exp, ortho GP GP G G G GP G G GP G GP G GP G G GP GP G G G GP G GP G GP G GP G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q5TA31 Q13617 affinity chromatography technology 21145461 physical association X 2 Q5TA31 Q15843 affinity chromatography technology 21145461 physical association X 2 Q5TA31 P0CG48 affinity chromatography technology 21963094 physical association X 2 Q5TA31 A0A087X1W2 affinity chromatography technology 23624934 physical association X 2 Q5TA31 A0A087X1W2 affinity chromatography technology 23624934 physical association X 2 Q5TA31 A0A087X1W2 enzymatic study 23624934 direct interaction X 2 Q5TA31 two hybrid 15231747 direct interaction X 2 Q5TA31 P55854 affinity chromatography technology 25391492 physical association X 2 Q5TA31 P0CG48 affinity chromatography technology 20852630 physical association X 2 Q5TA31 P0CG48 affinity chromatography technology 20852630 physical association X 2 Q5TA31 P0CG48 affinity chromatography technology 18781797 physical association X 2 Q5TA31 P0CG48 affinity chromatography technology 21906983 physical association X 2 Q5TA31 P05412 affinity chromatography technology 23624934 physical association X 2 Q5TA31 Q5TA31 affinity chromatography technology 23624934 physical association X 2 Q5TA31 Q5TA31 pull down 23624934 direct interaction X 2 Q5TA31 P05412 pull down 20852630 direct interaction X 2 Q5TA31 P05412 affinity chromatography technology 20852630 physical association X 2 Q5TA31 Q5TA31 comigration in non denaturing gel electrophoresis 23624934 physical association Y 1

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B RNF187 XRN1 MI:0018(two hybrid) 15231747 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_290130 prey bait UBC RNF187 MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18781797,20852630,21906983,21963094 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_146454|BIOGRID_146453|BIOGRID_265971|BIOGRID_177921|BIOGRID_162191 bait|prey|bait|bait|bait prey|bait|prey|prey|prey c-Jun RNF187 MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down) 20852630,23624934 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_272733|BIOGRID_146451|BIOGRID_146452 bait|prey|bait prey|bait|prey CUL2 RNF187 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_203937 bait prey NEDD8 RNF187 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_206854 bait prey RNF187 PRMT1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23624934 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_272736|BIOGRID_272737|BIOGRID_272738 prey|bait|prey bait|prey|bait

PPI - HINT Gene A Gene B PMID Method Quality JUN RNF187 20852630,20852630,23624934 0096,0004,0004 LC CUL2 RNF187 21145461 0004 HT NEDD8 RNF187 21145461 0004 HT RNF187 ZNF562 26186194 0004 HT RNF187 WDR83 26186194 0004 HT RNF187 LHX6 26186194 0004 HT CUL2 RNF187 21145461 0004 HT NEDD8 RNF187 21145461 0004 HT RNF187 ZNF562 26186194 0004 HT RNF187 WDR83 26186194 0004 HT RNF187 LHX6 26186194 0004 HT JUN RNF187 20852630,20852630,23624934 0096,0004,0004 LC RNF187 RNF187 23624934,23624934,23624934 0096,0404,0004 LC RNF187 XRN1 15231747 0018 HT RNF187 PRMT1 23624934,23624934 0004,0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5TA31 P05412 RNF187 JUN 0.569 20852630,23624934 Q99873 Q5TA31 PRMT1 RNF187 0.569 23624934 Q8IZH2 Q5TA31 XRN1 RNF187 0.183 15231747 Q9HCE1 Q5TA31 MOV10 RNF187 0.126 22658674 Q6V9R5 Q5TA31 ZNF562 RNF187 0.126 26186194 Q5TA31 Q5TA31 RNF187 RNF187 0.61 23624934 Q9BRX9 Q5TA31 WDR83 RNF187 0.126 26186194 Q9UBU9 Q5TA31 NXF1 RNF187 0.126 22658674 Q9UPM6 Q5TA31 LHX6 RNF187 0.126 26186194 Q5TA31 Q13617 RNF187 CUL2 0.126 21145461 Q5TA31 Q15843 RNF187 NEDD8 0.126 21145461

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 JUN RNF187 MI:0045 experimental interaction detection MI:0461 interaction database UBC RNF187 MI:0045 experimental interaction detection MI:0461 interaction database SUMO3 RNF187 MI:0045 experimental interaction detection MI:0461 interaction database CUL2 RNF187 MI:0045 experimental interaction detection MI:0461 interaction database NEDD8 RNF187 MI:0045 experimental interaction detection MI:0461 interaction database RNF187 ZNF562 MI:0045 experimental interaction detection MI:0461 interaction database RNF187 XRN1 MI:0045 experimental interaction detection MI:0461 interaction database RNF187 PRMT1 MI:0045 experimental interaction detection MI:0461 interaction database RNF187 WDR83 MI:0045 experimental interaction detection MI:0461 interaction database RNF187 MOV10 MI:0045 experimental interaction detection MI:0461 interaction database RNF187 NXF1 MI:0045 experimental interaction detection MI:0461 interaction database RNF187 LHX6 MI:0045 experimental interaction detection MI:0461 interaction database