Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change ACC 10 22618192 22618192 + Missense_Mutation SNP G G T TCGA-OR-A5JA-01A-11D-A29I-10 TCGA-OR-A5JA-10A-01D-A29L-10 g.chr10:22618192G>T c.702G>T c.(700-702)atG>atT p.M234I BLCA 10 22616526 22616526 + Nonsense_Mutation SNP C C G TCGA-BT-A20R-01A-12D-A16O-08 TCGA-BT-A20R-11A-11D-A16O-08 g.chr10:22616526C>G c.212C>G c.(211-213)tCa>tGa p.S71* BLCA 10 22616718 22616718 + Missense_Mutation SNP G G A TCGA-K4-A5RH-01A-11D-A30E-08 TCGA-K4-A5RH-10A-01D-A30H-08 g.chr10:22616718G>A c.313G>A c.(313-315)Gat>Aat p.D105N BLCA 10 22616891 22616891 + Missense_Mutation SNP C C G TCGA-BT-A20Q-01A-11D-A14W-08 TCGA-BT-A20Q-11A-11D-A14W-08 g.chr10:22616891C>G c.329C>G c.(328-330)tCt>tGt p.S110C BLCA 10 22617548 22617548 + Missense_Mutation SNP T T C TCGA-UY-A78K-01A-11D-A339-08 TCGA-UY-A78K-10A-01D-A339-08 g.chr10:22617548T>C c.491T>C c.(490-492)tTa>tCa p.L164S BRCA 10 22615839 22615839 + Missense_Mutation SNP C C T TCGA-AN-A046-01A-21W-A050-09 TCGA-AN-A046-10A-01W-A055-09 g.chr10:22615839C>T c.133C>T c.(133-135)Cgt>Tgt p.R45C BRCA 10 22616543 22616543 + Missense_Mutation SNP G G C TCGA-A2-A0YK-01A-22D-A117-09 TCGA-A2-A0YK-10A-01D-A117-09 g.chr10:22616543G>C c.229G>C c.(229-231)Gat>Cat p.D77H BRCA 10 22618336 22618336 + Silent SNP T T G TCGA-E2-A1LA-01A-11D-A142-09 TCGA-E2-A1LA-10A-01D-A142-09 g.chr10:22618336T>G c.846T>G c.(844-846)ccT>ccG p.P282P CESC 10 22616899 22616899 + Missense_Mutation SNP G G C TCGA-FU-A3HY-01A-11D-A21Q-09 TCGA-FU-A3HY-10A-01D-A21Q-09 g.chr10:22616899G>C c.337G>C c.(337-339)Gat>Cat p.D113H CESC 10 22618232 22618232 + Missense_Mutation SNP G G A TCGA-DR-A0ZM-01A-12D-A10S-08 TCGA-DR-A0ZM-10A-01D-A10S-08 g.chr10:22618232G>A c.742G>A c.(742-744)Gaa>Aaa p.E248K CESC 10 22618337 22618337 + Missense_Mutation SNP C C T TCGA-IR-A3LI-01A-11D-A20U-09 TCGA-IR-A3LI-10A-01D-A20U-09 g.chr10:22618337C>T c.847C>T c.(847-849)Cat>Tat p.H283Y CESC 10 22618360 22618360 + Silent SNP C C T TCGA-C5-A2LZ-01A-11D-A20U-09 TCGA-C5-A2LZ-10B-01D-A20U-09 g.chr10:22618360C>T c.870C>T c.(868-870)tcC>tcT p.S290S COAD 10 22615392 22615392 + Missense_Mutation SNP C C T TCGA-AA-3864-01A-01W-0995-10 TCGA-AA-3864-10A-01W-0995-10 g.chr10:22615392C>T c.14C>T c.(13-15)aCg>aTg p.T5M COAD 10 22615476 22615476 + Missense_Mutation SNP A A T TCGA-AA-3715-01A-01W-0900-09 TCGA-AA-3715-10A-01W-0900-09 g.chr10:22615476A>T c.98A>T c.(97-99)gAa>gTa p.E33V COAD 10 22616535 22616535 + Missense_Mutation SNP C C G TCGA-AA-3866-01A-01W-0995-10 TCGA-AA-3866-10A-01W-0995-10 g.chr10:22616535C>G c.221C>G c.(220-222)aCt>aGt p.T74S COADREAD 10 22615392 22615392 + Missense_Mutation SNP C C T TCGA-AA-3864-01A-01W-0995-10 TCGA-AA-3864-10A-01W-0995-10 g.chr10:22615392C>T c.14C>T c.(13-15)aCg>aTg p.T5M COADREAD 10 22615476 22615476 + Missense_Mutation SNP A A T TCGA-AA-3715-01A-01W-0900-09 TCGA-AA-3715-10A-01W-0900-09 g.chr10:22615476A>T c.98A>T c.(97-99)gAa>gTa p.E33V COADREAD 10 22616535 22616535 + Missense_Mutation SNP C C G TCGA-AA-3866-01A-01W-0995-10 TCGA-AA-3866-10A-01W-0995-10 g.chr10:22616535C>G c.221C>G c.(220-222)aCt>aGt p.T74S ESCA 10 22615824 22615824 + Frame_Shift_Del DEL A A - TCGA-L5-A4OI-01A-11D-A27G-09 TCGA-L5-A4OI-11A-11D-A27G-09 g.chr10:22615824delA c.118delA c.(118-120)aaafs p.K40fs GBM 10 22615480 22615480 + Missense_Mutation SNP T T G TCGA-28-5211-01C-11D-1845-08 TCGA-28-5211-10B-01D-1845-08 g.chr10:22615480T>G c.102T>G c.(100-102)tgT>tgG p.C34W GBM 10 22615862 22615862 + Nonsense_Mutation SNP T T G TCGA-06-0166-01A-01D-1491-08 TCGA-06-0166-10A-01D-1491-08 g.chr10:22615862T>G c.156T>G c.(154-156)taT>taG p.Y52* GBM 10 22617609 22617609 + Silent SNP C C T TCGA-06-2565-01A-01D-1494-08 TCGA-06-2565-10A-01D-1494-08 g.chr10:22617609C>T c.552C>T c.(550-552)gaC>gaT p.D184D GBMLGG 10 22615480 22615480 + Missense_Mutation SNP T T G TCGA-28-5211-01C-11D-1845-08 TCGA-28-5211-10B-01D-1845-08 g.chr10:22615480T>G c.102T>G c.(100-102)tgT>tgG p.C34W GBMLGG 10 22615862 22615862 + Nonsense_Mutation SNP T T G TCGA-06-0166-01A-01D-1491-08 TCGA-06-0166-10A-01D-1491-08 g.chr10:22615862T>G c.156T>G c.(154-156)taT>taG p.Y52* GBMLGG 10 22616921 22616925 + Frame_Shift_Del DEL AAGAT AAGAT - TCGA-DU-A76K-01A-11D-A33T-08 TCGA-DU-A76K-10A-01D-A33W-08 g.chr10:22616921_22616925delAAGAT c.359_363delAAGAT c.(358-363)gaagatfs p.ED120fs GBMLGG 10 22617609 22617609 + Silent SNP C C T TCGA-06-2565-01A-01D-1494-08 TCGA-06-2565-10A-01D-1494-08 g.chr10:22617609C>T c.552C>T c.(550-552)gaC>gaT p.D184D GBMLGG 10 22618234 22618234 + Silent SNP A A G TCGA-FG-A4MY-01A-11D-A26M-08 TCGA-FG-A4MY-10A-01D-A26K-08 g.chr10:22618234A>G c.744A>G c.(742-744)gaA>gaG p.E248E HNSC 10 22618334 22618334 + Missense_Mutation SNP C C A TCGA-CN-6023-01A-11D-1683-08 TCGA-CN-6023-10A-01D-1683-08 g.chr10:22618334C>A c.844C>A c.(844-846)Cct>Act p.P282T HNSC 10 22618352 22618352 + Missense_Mutation SNP C C T TCGA-D6-A6ES-01A-12D-A31L-08 TCGA-D6-A6ES-10A-01D-A31J-08 g.chr10:22618352C>T c.862C>T c.(862-864)Cac>Tac p.H288Y HNSC 10 22618452 22618452 + Missense_Mutation SNP C C T TCGA-CR-7394-01A-11D-2012-08 TCGA-CR-7394-10A-01D-2013-08 g.chr10:22618452C>T c.962C>T c.(961-963)tCa>tTa p.S321L KIPAN 10 22618246 22618246 + Missense_Mutation SNP C C G TCGA-IA-A40Y-01A-11D-A25F-10 TCGA-IA-A40Y-10A-01D-A25F-10 g.chr10:22618246C>G c.756C>G c.(754-756)gaC>gaG p.D252E KIRP 10 22618246 22618246 + Missense_Mutation SNP C C G TCGA-IA-A40Y-01A-11D-A25F-10 TCGA-IA-A40Y-10A-01D-A25F-10 g.chr10:22618246C>G c.756C>G c.(754-756)gaC>gaG p.D252E LGG 10 22616921 22616925 + Frame_Shift_Del DEL AAGAT AAGAT - TCGA-DU-A76K-01A-11D-A33T-08 TCGA-DU-A76K-10A-01D-A33W-08 g.chr10:22616921_22616925delAAGAT c.359_363delAAGAT c.(358-363)gaagatfs p.ED120fs LGG 10 22618234 22618234 + Silent SNP A A G TCGA-FG-A4MY-01A-11D-A26M-08 TCGA-FG-A4MY-10A-01D-A26K-08 g.chr10:22618234A>G c.744A>G c.(742-744)gaA>gaG p.E248E LIHC 10 22616563 22616563 + Silent SNP T T C TCGA-DD-A39X-01A-11D-A20W-10 TCGA-DD-A39X-11A-11D-A20W-10 g.chr10:22616563T>C c.249T>C c.(247-249)gtT>gtC p.V83V LIHC 10 22618024 22618024 + Silent SNP A A G TCGA-BC-A10U-01A-11D-A12Z-10 TCGA-BC-A10U-11A-11D-A12Z-10 g.chr10:22618024A>G c.618A>G c.(616-618)ctA>ctG p.L206L LIHC 10 22618054 22618054 + Silent SNP A A G TCGA-G3-A3CG-01A-11D-A20W-10 TCGA-G3-A3CG-10A-01D-A20W-10 g.chr10:22618054A>G c.648A>G c.(646-648)agA>agG p.R216R LIHC 10 22618212 22618212 + Missense_Mutation SNP A A G TCGA-DD-A3A0-01A-11D-A20W-10 TCGA-DD-A3A0-11A-11D-A20W-10 g.chr10:22618212A>G c.722A>G c.(721-723)gAt>gGt p.D241G LUAD 10 22615878 22615878 + Missense_Mutation SNP G G T TCGA-69-7765-01A-11D-2167-08 TCGA-69-7765-10A-01D-2167-08 g.chr10:22615878G>T c.172G>T c.(172-174)Gtc>Ttc p.V58F LUAD 10 22616706 22616706 + Missense_Mutation SNP C C T TCGA-99-8025-01A-11D-2238-08 TCGA-99-8025-10A-01D-2238-08 g.chr10:22616706C>T c.301C>T c.(301-303)Cat>Tat p.H101Y LUAD 10 22616918 22616918 + Missense_Mutation SNP A A T TCGA-50-5946-01A-11D-1753-08 TCGA-50-5946-10A-01D-1753-08 g.chr10:22616918A>T c.356A>T c.(355-357)gAt>gTt p.D119V LUAD 10 22617985 22617985 + Silent SNP C C T TCGA-55-A4DF-01A-11D-A24D-08 TCGA-55-A4DF-10A-01D-A24F-08 g.chr10:22617985C>T c.579C>T c.(577-579)gtC>gtT p.V193V LUAD 10 22618355 22618355 + Missense_Mutation SNP A A T TCGA-78-8662-01A-11D-2393-08 TCGA-78-8662-10A-01D-2393-08 g.chr10:22618355A>T c.865A>T c.(865-867)Att>Ttt p.I289F LUSC 10 22615393 22615393 + Silent SNP G G T TCGA-85-6561-01A-11D-1817-08 TCGA-85-6561-10A-01D-1817-08 g.chr10:22615393G>T c.15G>T c.(13-15)acG>acT p.T5T OV 10 22615464 22615464 + Missense_Mutation SNP C C A TCGA-24-1567-01A-01W-0615-10 TCGA-24-1567-10A-01W-0615-10 g.chr10:22615464C>A c.86C>A c.(85-87)aCa>aAa p.T29K PAAD 10 22618434 22618434 + Nonsense_Mutation SNP C C A TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr10:22618434C>A c.944C>A c.(943-945)tCa>tAa p.S315* PRAD 10 22615874 22615874 + Nonsense_Mutation SNP T T A TCGA-VP-A876-01A-11D-A34U-08 TCGA-VP-A876-10A-01D-A34X-08 g.chr10:22615874T>A c.168T>A c.(166-168)tgT>tgA p.C56* SKCM 10 22615839 22615839 + Missense_Mutation SNP C C T TCGA-EE-A29C-06A-21D-A197-08 TCGA-EE-A29C-10A-01D-A199-08 g.chr10:22615839C>T c.133C>T c.(133-135)Cgt>Tgt p.R45C SKCM 10 22616968 22616968 + Missense_Mutation SNP G G A TCGA-FW-A3R5-06A-11D-A23B-08 TCGA-FW-A3R5-10A-01D-A23B-08 g.chr10:22616968G>A c.406G>A c.(406-408)Gaa>Aaa p.E136K SKCM 10 22617070 22617070 + Missense_Mutation SNP C C T TCGA-GF-A6C9-06A-11D-A30X-08 TCGA-GF-A6C9-10A-01D-A30X-08 g.chr10:22617070C>T c.433C>T c.(433-435)Cgg>Tgg p.R145W SKCM 10 22618322 22618322 + Missense_Mutation SNP C C T TCGA-EE-A2A0-06A-11D-A196-08 TCGA-EE-A2A0-10A-01D-A198-08 g.chr10:22618322C>T c.832C>T c.(832-834)Cca>Tca p.P278S

Mutation - ICGC Project Code Chromosome Chromosome Start Chromosome End Mutation Type Mutated from Allele Mutated to Allele Consequence Type AA Mutation CDS Mutation BLCA-CN 10 22607095 22607095 single base substitution C T upstream_gene_variant BLCA-CN 10 22607749 22607749 single base substitution T C upstream_gene_variant BLCA-US 10 22616526 22616526 single base substitution C G downstream_gene_variant BLCA-US 10 22616526 22616526 single base substitution C G intron_variant BLCA-US 10 22616526 22616526 single base substitution C G splice_region_variant BLCA-US 10 22616526 22616526 single base substitution C G stop_gained S71* 212C>G BLCA-US 10 22616526 22616526 single base substitution C G upstream_gene_variant BLCA-US 10 22616891 22616891 single base substitution C G downstream_gene_variant BLCA-US 10 22616891 22616891 single base substitution C G exon_variant BLCA-US 10 22616891 22616891 single base substitution C G intron_variant BLCA-US 10 22616891 22616891 single base substitution C G missense_variant S110C 329C>G BRCA-EU 10 22605807 22605807 single base substitution C T upstream_gene_variant BRCA-EU 10 22607014 22607014 deletion of <=200bp T - upstream_gene_variant BRCA-EU 10 22608158 22608158 single base substitution T A upstream_gene_variant BRCA-EU 10 22608322 22608322 single base substitution G C upstream_gene_variant BRCA-EU 10 22609117 22609132 deletion of <=200bp AAGTATTTGAATCGTT - upstream_gene_variant BRCA-EU 10 22609162 22609162 single base substitution G T upstream_gene_variant BRCA-EU 10 22611554 22611554 single base substitution C G intron_variant BRCA-EU 10 22611554 22611554 single base substitution C G upstream_gene_variant BRCA-EU 10 22615738 22615738 single base substitution C T exon_variant BRCA-EU 10 22615738 22615738 single base substitution C T intron_variant BRCA-EU 10 22615738 22615738 single base substitution C T upstream_gene_variant BRCA-EU 10 22616200 22616200 single base substitution G C downstream_gene_variant BRCA-EU 10 22616200 22616200 single base substitution G C intron_variant BRCA-EU 10 22616200 22616200 single base substitution G C upstream_gene_variant BRCA-EU 10 22616673 22616673 single base substitution G A downstream_gene_variant BRCA-EU 10 22616673 22616673 single base substitution G A exon_variant BRCA-EU 10 22616673 22616673 single base substitution G A intron_variant BRCA-EU 10 22616673 22616673 single base substitution G A missense_variant E90K 268G>A BRCA-EU 10 22616673 22616673 single base substitution G A splice_region_variant BRCA-EU 10 22616673 22616673 single base substitution G A upstream_gene_variant BRCA-EU 10 22617065 22617065 single base substitution T C downstream_gene_variant BRCA-EU 10 22617065 22617065 single base substitution T C exon_variant BRCA-EU 10 22617065 22617065 single base substitution T C missense_variant L143S 428T>C BRCA-EU 10 22617065 22617065 single base substitution T C missense_variant L48S 143T>C BRCA-EU 10 22617065 22617065 single base substitution T C splice_region_variant BRCA-EU 10 22617661 22617661 single base substitution T A downstream_gene_variant BRCA-EU 10 22617661 22617661 single base substitution T A intron_variant BRCA-EU 10 22618835 22618835 single base substitution T G 3_prime_UTR_variant BRCA-EU 10 22618835 22618835 single base substitution T G downstream_gene_variant BRCA-EU 10 22618895 22618895 single base substitution T G 3_prime_UTR_variant BRCA-EU 10 22618895 22618895 single base substitution T G downstream_gene_variant BRCA-EU 10 22619404 22619404 single base substitution T C 3_prime_UTR_variant BRCA-EU 10 22619404 22619404 single base substitution T C downstream_gene_variant BRCA-EU 10 22620174 22620174 single base substitution T C 3_prime_UTR_variant BRCA-EU 10 22620174 22620174 single base substitution T C downstream_gene_variant BRCA-EU 10 22621362 22621362 single base substitution C A downstream_gene_variant BRCA-EU 10 22621816 22621816 single base substitution A G downstream_gene_variant BRCA-EU 10 22623062 22623062 single base substitution A C downstream_gene_variant BRCA-EU 10 22623734 22623734 single base substitution C T downstream_gene_variant BRCA-EU 10 22623793 22623793 single base substitution C A downstream_gene_variant BRCA-EU 10 22625152 22625152 single base substitution G A downstream_gene_variant BRCA-FR 10 22615738 22615738 single base substitution C T exon_variant BRCA-FR 10 22615738 22615738 single base substitution C T intron_variant BRCA-FR 10 22615738 22615738 single base substitution C T upstream_gene_variant BRCA-FR 10 22618329 22618329 single base substitution A C downstream_gene_variant BRCA-FR 10 22618329 22618329 single base substitution A C exon_variant BRCA-FR 10 22618329 22618329 single base substitution A C missense_variant Q280P 839A>C BRCA-FR 10 22621736 22621736 single base substitution T G downstream_gene_variant BRCA-KR 10 22607647 22607647 single base substitution A C upstream_gene_variant BRCA-US 10 22606826 22606826 single base substitution G A upstream_gene_variant BRCA-US 10 22608896 22608896 single base substitution C T upstream_gene_variant BRCA-US 10 22615839 22615839 single base substitution C T downstream_gene_variant BRCA-US 10 22615839 22615839 single base substitution C T exon_variant BRCA-US 10 22615839 22615839 single base substitution C T missense_variant R22C 64C>T BRCA-US 10 22615839 22615839 single base substitution C T missense_variant R45C 133C>T BRCA-US 10 22615839 22615839 single base substitution C T upstream_gene_variant BRCA-US 10 22616543 22616543 single base substitution G C downstream_gene_variant BRCA-US 10 22616543 22616543 single base substitution G C exon_variant BRCA-US 10 22616543 22616543 single base substitution G C intron_variant BRCA-US 10 22616543 22616543 single base substitution G C missense_variant D77H 229G>C BRCA-US 10 22616543 22616543 single base substitution G C upstream_gene_variant BRCA-US 10 22618336 22618336 single base substitution T G downstream_gene_variant BRCA-US 10 22618336 22618336 single base substitution T G exon_variant BRCA-US 10 22618336 22618336 single base substitution T G synonymous_variant P282P 846T>G BTCA-JP 10 22606903 22606903 single base substitution G C upstream_gene_variant CESC-US 10 22606984 22606984 single base substitution C T upstream_gene_variant CESC-US 10 22607675 22607675 single base substitution T G upstream_gene_variant CESC-US 10 22616899 22616899 single base substitution G C downstream_gene_variant CESC-US 10 22616899 22616899 single base substitution G C exon_variant CESC-US 10 22616899 22616899 single base substitution G C intron_variant CESC-US 10 22616899 22616899 single base substitution G C missense_variant D113H 337G>C CESC-US 10 22618232 22618232 single base substitution G A downstream_gene_variant CESC-US 10 22618232 22618232 single base substitution G A exon_variant CESC-US 10 22618232 22618232 single base substitution G A missense_variant E153K 457G>A CESC-US 10 22618232 22618232 single base substitution G A missense_variant E248K 742G>A CESC-US 10 22618337 22618337 single base substitution C T downstream_gene_variant CESC-US 10 22618337 22618337 single base substitution C T exon_variant CESC-US 10 22618337 22618337 single base substitution C T missense_variant H283Y 847C>T CESC-US 10 22618360 22618360 single base substitution C T downstream_gene_variant CESC-US 10 22618360 22618360 single base substitution C T exon_variant CESC-US 10 22618360 22618360 single base substitution C T synonymous_variant S290S 870C>T CLLE-ES 10 22624579 22624579 single base substitution G A downstream_gene_variant COAD-US 10 22608897 22608897 single base substitution G A upstream_gene_variant COCA-CN 10 22607138 22607138 single base substitution C A upstream_gene_variant COCA-CN 10 22607157 22607157 single base substitution G T upstream_gene_variant COCA-CN 10 22607182 22607182 single base substitution C A upstream_gene_variant COCA-CN 10 22607716 22607716 single base substitution G A upstream_gene_variant COCA-CN 10 22607822 22607822 single base substitution A G upstream_gene_variant COCA-CN 10 22607914 22607914 single base substitution G T upstream_gene_variant COCA-CN 10 22608898 22608898 single base substitution A G upstream_gene_variant COCA-CN 10 22608913 22608913 single base substitution G T upstream_gene_variant COCA-CN 10 22615366 22615366 single base substitution T G 5_prime_UTR_premature_start_codon_gain_variant COCA-CN 10 22615366 22615366 single base substitution T G exon_variant COCA-CN 10 22615366 22615366 single base substitution T G upstream_gene_variant COCA-CN 10 22615578 22615578 single base substitution C A exon_variant COCA-CN 10 22615578 22615578 single base substitution C A intron_variant COCA-CN 10 22615578 22615578 single base substitution C A upstream_gene_variant COCA-CN 10 22616830 22616830 single base substitution T G downstream_gene_variant COCA-CN 10 22616830 22616830 single base substitution T G exon_variant COCA-CN 10 22616830 22616830 single base substitution T G intron_variant COCA-CN 10 22616830 22616830 single base substitution T G upstream_gene_variant COCA-CN 10 22616861 22616861 single base substitution T G downstream_gene_variant COCA-CN 10 22616861 22616861 single base substitution T G exon_variant COCA-CN 10 22616861 22616861 single base substitution T G intron_variant COCA-CN 10 22616861 22616861 single base substitution T G upstream_gene_variant COCA-CN 10 22617485 22617485 single base substitution T C downstream_gene_variant COCA-CN 10 22617485 22617485 single base substitution T C intron_variant COCA-CN 10 22617729 22617729 single base substitution T G downstream_gene_variant COCA-CN 10 22617729 22617729 single base substitution T G intron_variant COCA-CN 10 22618257 22618257 single base substitution A G downstream_gene_variant COCA-CN 10 22618257 22618257 single base substitution A G exon_variant COCA-CN 10 22618257 22618257 single base substitution A G missense_variant D161G 482A>G COCA-CN 10 22618257 22618257 single base substitution A G missense_variant D256G 767A>G ESAD-UK 10 22605820 22605820 single base substitution T A upstream_gene_variant ESAD-UK 10 22607160 22607160 deletion of <=200bp G - upstream_gene_variant ESAD-UK 10 22607901 22607901 single base substitution C A upstream_gene_variant ESAD-UK 10 22609364 22609364 single base substitution G A upstream_gene_variant ESAD-UK 10 22614055 22614055 single base substitution C T intron_variant ESAD-UK 10 22614055 22614055 single base substitution C T upstream_gene_variant ESAD-UK 10 22614830 22614830 single base substitution G C intron_variant ESAD-UK 10 22614830 22614830 single base substitution G C upstream_gene_variant ESAD-UK 10 22615155 22615158 deletion of <=200bp AAGT - intron_variant ESAD-UK 10 22615155 22615158 deletion of <=200bp AAGT - upstream_gene_variant ESAD-UK 10 22616079 22616079 single base substitution G A downstream_gene_variant ESAD-UK 10 22616079 22616079 single base substitution G A intron_variant ESAD-UK 10 22616079 22616079 single base substitution G A upstream_gene_variant ESAD-UK 10 22616999 22616999 single base substitution A C downstream_gene_variant ESAD-UK 10 22616999 22616999 single base substitution A C exon_variant ESAD-UK 10 22616999 22616999 single base substitution A C intron_variant ESAD-UK 10 22619348 22619348 single base substitution A G 3_prime_UTR_variant ESAD-UK 10 22619348 22619348 single base substitution A G downstream_gene_variant ESAD-UK 10 22619750 22619750 single base substitution C A 3_prime_UTR_variant ESAD-UK 10 22619750 22619750 single base substitution C A downstream_gene_variant ESAD-UK 10 22620032 22620032 single base substitution G C 3_prime_UTR_variant ESAD-UK 10 22620032 22620032 single base substitution G C downstream_gene_variant ESAD-UK 10 22620199 22620199 single base substitution C G 3_prime_UTR_variant ESAD-UK 10 22620199 22620199 single base substitution C G downstream_gene_variant ESAD-UK 10 22622522 22622522 single base substitution G A downstream_gene_variant ESAD-UK 10 22623468 22623468 single base substitution G A downstream_gene_variant ESAD-UK 10 22623538 22623538 single base substitution A C downstream_gene_variant ESAD-UK 10 22624023 22624023 single base substitution G C downstream_gene_variant ESAD-UK 10 22624269 22624269 single base substitution G A downstream_gene_variant ESAD-UK 10 22624428 22624428 single base substitution C T downstream_gene_variant ESAD-UK 10 22625172 22625172 single base substitution C T downstream_gene_variant ESCA-CN 10 22616944 22616944 single base substitution G A downstream_gene_variant ESCA-CN 10 22616944 22616944 single base substitution G A exon_variant ESCA-CN 10 22616944 22616944 single base substitution G A intron_variant ESCA-CN 10 22616944 22616944 single base substitution G A missense_variant D128N 382G>A GBM-US 10 22615480 22615480 single base substitution T G exon_variant GBM-US 10 22615480 22615480 single base substitution T G missense_variant C11W 33T>G GBM-US 10 22615480 22615480 single base substitution T G missense_variant C34W 102T>G GBM-US 10 22615480 22615480 single base substitution T G upstream_gene_variant GBM-US 10 22615862 22615862 single base substitution T G downstream_gene_variant GBM-US 10 22615862 22615862 single base substitution T G exon_variant GBM-US 10 22615862 22615862 single base substitution T G stop_gained Y29* 87T>G GBM-US 10 22615862 22615862 single base substitution T G stop_gained Y52* 156T>G GBM-US 10 22615862 22615862 single base substitution T G upstream_gene_variant GBM-US 10 22617609 22617609 single base substitution C T downstream_gene_variant GBM-US 10 22617609 22617609 single base substitution C T exon_variant GBM-US 10 22617609 22617609 single base substitution C T synonymous_variant D184D 552C>T GBM-US 10 22617609 22617609 single base substitution C T synonymous_variant D89D 267C>T KIRC-US 10 22605369 22605369 single base substitution A G upstream_gene_variant KIRP-US 10 22618246 22618246 single base substitution C G downstream_gene_variant KIRP-US 10 22618246 22618246 single base substitution C G exon_variant KIRP-US 10 22618246 22618246 single base substitution C G missense_variant D157E 471C>G KIRP-US 10 22618246 22618246 single base substitution C G missense_variant D252E 756C>G LGG-US 10 22618234 22618234 single base substitution A G downstream_gene_variant LGG-US 10 22618234 22618234 single base substitution A G exon_variant LGG-US 10 22618234 22618234 single base substitution A G synonymous_variant E153E 459A>G LGG-US 10 22618234 22618234 single base substitution A G synonymous_variant E248E 744A>G LICA-FR 10 22607254 22607254 single base substitution G A upstream_gene_variant LICA-FR 10 22612497 22612497 single base substitution G T intron_variant LICA-FR 10 22612497 22612497 single base substitution G T upstream_gene_variant LICA-FR 10 22613471 22613471 single base substitution T A intron_variant LICA-FR 10 22613471 22613471 single base substitution T A upstream_gene_variant LICA-FR 10 22617995 22617995 single base substitution G C downstream_gene_variant LICA-FR 10 22617995 22617995 single base substitution G C exon_variant LICA-FR 10 22617995 22617995 single base substitution G C missense_variant E102Q 304G>C LICA-FR 10 22617995 22617995 single base substitution G C missense_variant E197Q 589G>C LICA-FR 10 22618251 22618251 single base substitution G A downstream_gene_variant LICA-FR 10 22618251 22618251 single base substitution G A exon_variant LICA-FR 10 22618251 22618251 single base substitution G A missense_variant G159E 476G>A LICA-FR 10 22618251 22618251 single base substitution G A missense_variant G254E 761G>A LIHC-US 10 22606855 22606855 single base substitution A G upstream_gene_variant LIHC-US 10 22606865 22606865 insertion of <=200bp - G upstream_gene_variant LIHC-US 10 22607754 22607754 single base substitution T G upstream_gene_variant LIHC-US 10 22618024 22618024 single base substitution A G downstream_gene_variant LIHC-US 10 22618024 22618024 single base substitution A G exon_variant LIHC-US 10 22618024 22618024 single base substitution A G synonymous_variant L111L 333A>G LIHC-US 10 22618024 22618024 single base substitution A G synonymous_variant L206L 618A>G LIHC-US 10 22618212 22618212 single base substitution A G downstream_gene_variant LIHC-US 10 22618212 22618212 single base substitution A G exon_variant LIHC-US 10 22618212 22618212 single base substitution A G missense_variant D146G 437A>G LIHC-US 10 22618212 22618212 single base substitution A G missense_variant D241G 722A>G LINC-JP 10 22607161 22607161 deletion of <=200bp T - upstream_gene_variant LINC-JP 10 22607747 22607747 single base substitution C A upstream_gene_variant LINC-JP 10 22612810 22612810 single base substitution G A intron_variant LINC-JP 10 22612810 22612810 single base substitution G A upstream_gene_variant LINC-JP 10 22615591 22615591 single base substitution G A exon_variant LINC-JP 10 22615591 22615591 single base substitution G A intron_variant LINC-JP 10 22615591 22615591 single base substitution G A upstream_gene_variant LINC-JP 10 22616563 22616563 single base substitution T A downstream_gene_variant LINC-JP 10 22616563 22616563 single base substitution T A exon_variant LINC-JP 10 22616563 22616563 single base substitution T A intron_variant LINC-JP 10 22616563 22616563 single base substitution T A synonymous_variant V83V 249T>A LINC-JP 10 22616563 22616563 single base substitution T A upstream_gene_variant LINC-JP 10 22617502 22617502 single base substitution A T downstream_gene_variant LINC-JP 10 22617502 22617502 single base substitution A T intron_variant LIRI-JP 10 22606950 22606950 single base substitution T G upstream_gene_variant LIRI-JP 10 22608126 22608126 single base substitution G A upstream_gene_variant LIRI-JP 10 22611889 22611889 single base substitution C T intron_variant LIRI-JP 10 22611889 22611889 single base substitution C T upstream_gene_variant LIRI-JP 10 22612453 22612453 single base substitution G T intron_variant LIRI-JP 10 22612453 22612453 single base substitution G T upstream_gene_variant LIRI-JP 10 22613413 22613413 single base substitution A G intron_variant LIRI-JP 10 22613413 22613413 single base substitution A G upstream_gene_variant LIRI-JP 10 22614098 22614098 single base substitution A G intron_variant LIRI-JP 10 22614098 22614098 single base substitution A G upstream_gene_variant LIRI-JP 10 22614726 22614726 single base substitution G T intron_variant LIRI-JP 10 22614726 22614726 single base substitution G T upstream_gene_variant LIRI-JP 10 22616639 22616639 single base substitution G A downstream_gene_variant LIRI-JP 10 22616639 22616639 single base substitution G A exon_variant LIRI-JP 10 22616639 22616639 single base substitution G A intron_variant LIRI-JP 10 22616639 22616639 single base substitution G A upstream_gene_variant LIRI-JP 10 22616876 22616876 single base substitution T C downstream_gene_variant LIRI-JP 10 22616876 22616876 single base substitution T C exon_variant LIRI-JP 10 22616876 22616876 single base substitution T C intron_variant LIRI-JP 10 22616876 22616876 single base substitution T C splice_region_variant LIRI-JP 10 22618334 22618334 single base substitution C T downstream_gene_variant LIRI-JP 10 22618334 22618334 single base substitution C T exon_variant LIRI-JP 10 22618334 22618334 single base substitution C T missense_variant P282S 844C>T LIRI-JP 10 22620276 22620276 single base substitution G A 3_prime_UTR_variant LIRI-JP 10 22620276 22620276 single base substitution G A downstream_gene_variant LIRI-JP 10 22625267 22625267 single base substitution A G downstream_gene_variant LIRI-JP 10 22625324 22625324 single base substitution G A downstream_gene_variant LUSC-KR 10 22606067 22606067 single base substitution G T upstream_gene_variant LUSC-KR 10 22610288 22610288 single base substitution C G 5_prime_UTR_variant LUSC-KR 10 22610288 22610288 single base substitution C G upstream_gene_variant LUSC-KR 10 22611207 22611207 single base substitution G C intron_variant LUSC-KR 10 22611207 22611207 single base substitution G C upstream_gene_variant LUSC-KR 10 22619023 22619023 single base substitution C T 3_prime_UTR_variant LUSC-KR 10 22619023 22619023 single base substitution C T downstream_gene_variant LUSC-KR 10 22619232 22619232 single base substitution G A 3_prime_UTR_variant LUSC-KR 10 22619232 22619232 single base substitution G A downstream_gene_variant LUSC-KR 10 22621226 22621226 single base substitution A T downstream_gene_variant LUSC-KR 10 22621958 22621958 single base substitution A G downstream_gene_variant LUSC-KR 10 22624275 22624275 single base substitution C T downstream_gene_variant LUSC-KR 10 22625147 22625147 single base substitution G T downstream_gene_variant LUSC-KR 10 22625230 22625230 single base substitution C G downstream_gene_variant LUSC-US 10 22615393 22615393 single base substitution G T exon_variant LUSC-US 10 22615393 22615393 single base substitution G T synonymous_variant T5T 15G>T LUSC-US 10 22615393 22615393 single base substitution G T upstream_gene_variant MALY-DE 10 22606211 22606211 single base substitution T C upstream_gene_variant MALY-DE 10 22619893 22619893 single base substitution T C 3_prime_UTR_variant MALY-DE 10 22619893 22619893 single base substitution T C downstream_gene_variant MELA-AU 10 22605833 22605833 single base substitution G A upstream_gene_variant MELA-AU 10 22606322 22606322 single base substitution C T upstream_gene_variant MELA-AU 10 22608695 22608695 single base substitution C T upstream_gene_variant MELA-AU 10 22610331 22610331 single base substitution G A 5_prime_UTR_variant MELA-AU 10 22610331 22610331 single base substitution G A upstream_gene_variant MELA-AU 10 22611215 22611215 single base substitution C T intron_variant MELA-AU 10 22611215 22611215 single base substitution C T upstream_gene_variant MELA-AU 10 22611263 22611263 single base substitution G A intron_variant MELA-AU 10 22611263 22611263 single base substitution G A upstream_gene_variant MELA-AU 10 22612201 22612201 single base substitution G A intron_variant MELA-AU 10 22612201 22612201 single base substitution G A upstream_gene_variant MELA-AU 10 22612609 22612609 single base substitution T C intron_variant MELA-AU 10 22612609 22612609 single base substitution T C upstream_gene_variant MELA-AU 10 22612972 22612972 single base substitution G A intron_variant MELA-AU 10 22612972 22612972 single base substitution G A upstream_gene_variant MELA-AU 10 22613864 22613864 single base substitution C T intron_variant MELA-AU 10 22613864 22613864 single base substitution C T upstream_gene_variant MELA-AU 10 22614488 22614488 single base substitution C T intron_variant MELA-AU 10 22614488 22614488 single base substitution C T upstream_gene_variant MELA-AU 10 22615839 22615839 single base substitution C T downstream_gene_variant MELA-AU 10 22615839 22615839 single base substitution C T exon_variant MELA-AU 10 22615839 22615839 single base substitution C T missense_variant R22C 64C>T MELA-AU 10 22615839 22615839 single base substitution C T missense_variant R45C 133C>T MELA-AU 10 22615839 22615839 single base substitution C T upstream_gene_variant MELA-AU 10 22616871 22616871 single base substitution C T downstream_gene_variant MELA-AU 10 22616871 22616871 single base substitution C T exon_variant MELA-AU 10 22616871 22616871 single base substitution C T intron_variant MELA-AU 10 22616871 22616871 single base substitution C T splice_region_variant MELA-AU 10 22616871 22616871 single base substitution C T upstream_gene_variant MELA-AU 10 22617087 22617087 single base substitution C T downstream_gene_variant MELA-AU 10 22617087 22617087 single base substitution C T exon_variant MELA-AU 10 22617087 22617087 single base substitution C T synonymous_variant D150D 450C>T MELA-AU 10 22617087 22617087 single base substitution C T synonymous_variant D55D 165C>T MELA-AU 10 22617228 22617228 single base substitution A G downstream_gene_variant MELA-AU 10 22617228 22617228 single base substitution A G intron_variant MELA-AU 10 22617557 22617557 single base substitution C T downstream_gene_variant MELA-AU 10 22617557 22617557 single base substitution C T exon_variant MELA-AU 10 22617557 22617557 single base substitution C T missense_variant P167L 500C>T MELA-AU 10 22617557 22617557 single base substitution C T missense_variant P72L 215C>T MELA-AU 10 22618126 22618126 single base substitution C T downstream_gene_variant MELA-AU 10 22618126 22618126 single base substitution C T intron_variant MELA-AU 10 22618172 22618172 single base substitution C T downstream_gene_variant MELA-AU 10 22618172 22618172 single base substitution C T exon_variant MELA-AU 10 22618172 22618172 single base substitution C T stop_gained R133* 397C>T MELA-AU 10 22618172 22618172 single base substitution C T stop_gained R228* 682C>T MELA-AU 10 22618840 22618840 single base substitution C T 3_prime_UTR_variant MELA-AU 10 22618840 22618840 single base substitution C T downstream_gene_variant MELA-AU 10 22619032 22619032 single base substitution G A 3_prime_UTR_variant MELA-AU 10 22619032 22619032 single base substitution G A downstream_gene_variant MELA-AU 10 22619386 22619386 single base substitution A G 3_prime_UTR_variant MELA-AU 10 22619386 22619386 single base substitution A G downstream_gene_variant MELA-AU 10 22619430 22619430 single base substitution T C 3_prime_UTR_variant MELA-AU 10 22619430 22619430 single base substitution T C downstream_gene_variant MELA-AU 10 22619496 22619496 single base substitution C T 3_prime_UTR_variant MELA-AU 10 22619496 22619496 single base substitution C T downstream_gene_variant MELA-AU 10 22619738 22619738 single base substitution T A 3_prime_UTR_variant MELA-AU 10 22619738 22619738 single base substitution T A downstream_gene_variant MELA-AU 10 22620284 22620284 single base substitution G A 3_prime_UTR_variant MELA-AU 10 22620284 22620284 single base substitution G A downstream_gene_variant MELA-AU 10 22621343 22621343 single base substitution G A downstream_gene_variant MELA-AU 10 22621350 22621350 single base substitution C T downstream_gene_variant MELA-AU 10 22621719 22621719 single base substitution C T downstream_gene_variant MELA-AU 10 22622741 22622741 single base substitution C T downstream_gene_variant MELA-AU 10 22623392 22623392 single base substitution C T downstream_gene_variant MELA-AU 10 22623812 22623812 single base substitution C T downstream_gene_variant MELA-AU 10 22623988 22623989 multiple base substitution (>=2bp and <=200bp) CC TT downstream_gene_variant MELA-AU 10 22624265 22624265 single base substitution A G downstream_gene_variant MELA-AU 10 22625003 22625003 single base substitution C T downstream_gene_variant MELA-AU 10 22625152 22625152 single base substitution G A downstream_gene_variant MELA-AU 10 22625257 22625257 single base substitution C T downstream_gene_variant ORCA-IN 10 22622793 22622793 single base substitution C T downstream_gene_variant ORCA-IN 10 22623053 22623053 single base substitution G A downstream_gene_variant OV-AU 10 22610282 22610282 single base substitution C G 5_prime_UTR_variant OV-AU 10 22610282 22610282 single base substitution C G upstream_gene_variant OV-AU 10 22610342 22610342 single base substitution C G 5_prime_UTR_variant OV-AU 10 22610342 22610342 single base substitution C G upstream_gene_variant OV-AU 10 22622922 22622922 single base substitution G A downstream_gene_variant OV-AU 10 22622944 22622944 single base substitution C T downstream_gene_variant PACA-AU 10 22611610 22611610 single base substitution C T intron_variant PACA-AU 10 22611610 22611610 single base substitution C T upstream_gene_variant PACA-AU 10 22612655 22612655 single base substitution A C intron_variant PACA-AU 10 22612655 22612655 single base substitution A C upstream_gene_variant PACA-AU 10 22615502 22615502 single base substitution G A exon_variant PACA-AU 10 22615502 22615502 single base substitution G A intron_variant PACA-AU 10 22615502 22615502 single base substitution G A upstream_gene_variant PACA-AU 10 22616923 22616923 single base substitution G A downstream_gene_variant PACA-AU 10 22616923 22616923 single base substitution G A exon_variant PACA-AU 10 22616923 22616923 single base substitution G A intron_variant PACA-AU 10 22616923 22616923 single base substitution G A missense_variant D121N 361G>A PACA-AU 10 22618348 22618348 single base substitution T C downstream_gene_variant PACA-AU 10 22618348 22618348 single base substitution T C exon_variant PACA-AU 10 22618348 22618348 single base substitution T C synonymous_variant F286F 858T>C PACA-AU 10 22622088 22622088 single base substitution G T downstream_gene_variant PACA-AU 10 22623686 22623686 single base substitution C A downstream_gene_variant PACA-AU 10 22624086 22624086 single base substitution G A downstream_gene_variant PACA-CA 10 22606520 22606520 single base substitution T C upstream_gene_variant PACA-CA 10 22606834 22606834 single base substitution T C upstream_gene_variant PACA-CA 10 22607451 22607451 single base substitution A C upstream_gene_variant PACA-CA 10 22609209 22609209 single base substitution A G upstream_gene_variant PACA-CA 10 22611240 22611240 insertion of <=200bp - G intron_variant PACA-CA 10 22611240 22611240 insertion of <=200bp - G upstream_gene_variant PACA-CA 10 22611856 22611856 single base substitution T G intron_variant PACA-CA 10 22611856 22611856 single base substitution T G upstream_gene_variant PACA-CA 10 22613160 22613160 single base substitution C T intron_variant PACA-CA 10 22613160 22613160 single base substitution C T upstream_gene_variant PACA-CA 10 22615524 22615524 single base substitution T C exon_variant PACA-CA 10 22615524 22615524 single base substitution T C intron_variant PACA-CA 10 22615524 22615524 single base substitution T C upstream_gene_variant PACA-CA 10 22616843 22616843 single base substitution G T downstream_gene_variant PACA-CA 10 22616843 22616843 single base substitution G T exon_variant PACA-CA 10 22616843 22616843 single base substitution G T intron_variant PACA-CA 10 22616843 22616843 single base substitution G T upstream_gene_variant PACA-CA 10 22617289 22617289 insertion of <=200bp - A downstream_gene_variant PACA-CA 10 22617289 22617289 insertion of <=200bp - A intron_variant PACA-CA 10 22618506 22618506 single base substitution C G 3_prime_UTR_variant PACA-CA 10 22618506 22618506 single base substitution C G downstream_gene_variant PACA-CA 10 22619610 22619610 single base substitution A G 3_prime_UTR_variant PACA-CA 10 22619610 22619610 single base substitution A G downstream_gene_variant PACA-CA 10 22620635 22620635 single base substitution A G downstream_gene_variant PACA-CA 10 22622533 22622533 single base substitution A G downstream_gene_variant PAEN-AU 10 22605197 22605197 single base substitution G A upstream_gene_variant PAEN-IT 10 22608813 22608813 single base substitution A C upstream_gene_variant PBCA-DE 10 22605826 22605826 single base substitution G A upstream_gene_variant PBCA-DE 10 22606622 22606624 deletion of <=200bp TTG - upstream_gene_variant PBCA-DE 10 22624585 22624585 single base substitution G A downstream_gene_variant PRAD-CA 10 22612476 22612476 single base substitution C T intron_variant PRAD-CA 10 22612476 22612476 single base substitution C T upstream_gene_variant PRAD-UK 10 22610382 22610399 deletion of <=200bp GGAGGAGGCCGAGGCGCC - 5_prime_UTR_variant PRAD-UK 10 22610382 22610399 deletion of <=200bp GGAGGAGGCCGAGGCGCC - upstream_gene_variant PRAD-UK 10 22623316 22623316 single base substitution G T downstream_gene_variant READ-US 10 22617070 22617070 single base substitution C T downstream_gene_variant READ-US 10 22617070 22617070 single base substitution C T exon_variant READ-US 10 22617070 22617070 single base substitution C T missense_variant R145W 433C>T READ-US 10 22617070 22617070 single base substitution C T missense_variant R50W 148C>T RECA-EU 10 22607552 22607552 single base substitution T C upstream_gene_variant RECA-EU 10 22619271 22619271 single base substitution A T 3_prime_UTR_variant RECA-EU 10 22619271 22619271 single base substitution A T downstream_gene_variant RECA-EU 10 22622486 22622486 single base substitution C A downstream_gene_variant SKCA-BR 10 22605228 22605228 single base substitution A G upstream_gene_variant SKCA-BR 10 22605266 22605266 single base substitution C A upstream_gene_variant SKCA-BR 10 22605398 22605398 single base substitution C G upstream_gene_variant SKCA-BR 10 22609466 22609466 single base substitution A C upstream_gene_variant SKCA-BR 10 22614558 22614558 single base substitution G C intron_variant SKCA-BR 10 22614558 22614558 single base substitution G C upstream_gene_variant SKCA-BR 10 22623520 22623520 single base substitution A G downstream_gene_variant SKCM-US 10 22607905 22607905 single base substitution C T upstream_gene_variant SKCM-US 10 22615839 22615839 single base substitution C T downstream_gene_variant SKCM-US 10 22615839 22615839 single base substitution C T exon_variant SKCM-US 10 22615839 22615839 single base substitution C T missense_variant R22C 64C>T SKCM-US 10 22615839 22615839 single base substitution C T missense_variant R45C 133C>T SKCM-US 10 22615839 22615839 single base substitution C T upstream_gene_variant SKCM-US 10 22616968 22616968 single base substitution G A downstream_gene_variant SKCM-US 10 22616968 22616968 single base substitution G A exon_variant SKCM-US 10 22616968 22616968 single base substitution G A intron_variant SKCM-US 10 22616968 22616968 single base substitution G A missense_variant E136K 406G>A SKCM-US 10 22617070 22617070 single base substitution C T downstream_gene_variant SKCM-US 10 22617070 22617070 single base substitution C T exon_variant SKCM-US 10 22617070 22617070 single base substitution C T missense_variant R145W 433C>T SKCM-US 10 22617070 22617070 single base substitution C T missense_variant R50W 148C>T SKCM-US 10 22618176 22618176 single base substitution C T downstream_gene_variant SKCM-US 10 22618176 22618176 single base substitution C T exon_variant SKCM-US 10 22618176 22618176 single base substitution C T missense_variant P134L 401C>T SKCM-US 10 22618176 22618176 single base substitution C T missense_variant P229L 686C>T SKCM-US 10 22618322 22618322 single base substitution C T downstream_gene_variant SKCM-US 10 22618322 22618322 single base substitution C T exon_variant SKCM-US 10 22618322 22618322 single base substitution C T missense_variant P183S 547C>T SKCM-US 10 22618322 22618322 single base substitution C T missense_variant P278S 832C>T STAD-US 10 22616977 22616977 single base substitution G A downstream_gene_variant STAD-US 10 22616977 22616977 single base substitution G A exon_variant STAD-US 10 22616977 22616977 single base substitution G A intron_variant STAD-US 10 22616977 22616977 single base substitution G A missense_variant D139N 415G>A STAD-US 10 22617625 22617625 single base substitution C G downstream_gene_variant STAD-US 10 22617625 22617625 single base substitution C G missense_variant Q190E 568C>G STAD-US 10 22617625 22617625 single base substitution C G missense_variant Q95E 283C>G STAD-US 10 22617625 22617625 single base substitution C G splice_region_variant STAD-US 10 22618055 22618055 single base substitution A T downstream_gene_variant STAD-US 10 22618055 22618055 single base substitution A T missense_variant R122W 364A>T STAD-US 10 22618055 22618055 single base substitution A T missense_variant R217W 649A>T STAD-US 10 22618055 22618055 single base substitution A T splice_region_variant STAD-US 10 22618263 22618263 single base substitution C T downstream_gene_variant STAD-US 10 22618263 22618263 single base substitution C T exon_variant STAD-US 10 22618263 22618263 single base substitution C T missense_variant A163V 488C>T STAD-US 10 22618263 22618263 single base substitution C T missense_variant A258V 773C>T THCA-SA 10 22605398 22605398 single base substitution C G upstream_gene_variant THCA-SA 10 22618667 22618667 single base substitution G T 3_prime_UTR_variant THCA-SA 10 22618667 22618667 single base substitution G T downstream_gene_variant UCEC-US 10 22606835 22606835 single base substitution C T upstream_gene_variant UCEC-US 10 22607917 22607917 single base substitution T G upstream_gene_variant UCEC-US 10 22615489 22615489 single base substitution C A exon_variant UCEC-US 10 22615489 22615489 single base substitution C A splice_region_variant UCEC-US 10 22615489 22615489 single base substitution C A upstream_gene_variant UCEC-US 10 22618256 22618256 single base substitution G A downstream_gene_variant UCEC-US 10 22618256 22618256 single base substitution G A exon_variant UCEC-US 10 22618256 22618256 single base substitution G A missense_variant D161N 481G>A UCEC-US 10 22618256 22618256 single base substitution G A missense_variant D256N 766G>A UCEC-US 10 22618327 22618327 single base substitution G A downstream_gene_variant UCEC-US 10 22618327 22618327 single base substitution G A exon_variant UCEC-US 10 22618327 22618327 single base substitution G A synonymous_variant V184V 552G>A UCEC-US 10 22618327 22618327 single base substitution G A synonymous_variant V279V 837G>A UCEC-US 10 22618428 22618428 single base substitution G A downstream_gene_variant UCEC-US 10 22618428 22618428 single base substitution G A missense_variant R313Q 938G>A

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand BN24 COSM1603318 c.249T>A p.V83V Substitution - coding silent 10:22327634-22327634 + CHC2127T COSM4952833 c.589G>C p.E197Q Substitution - Missense 10:22329066-22329066 + pfg166T COSM4751165 c.781C>T p.P261S Substitution - Missense 10:22329342-22329342 + TCGA-EE-A2A0-06 COSM3436549 c.832C>T p.P278S Substitution - Missense 10:22329393-22329393 + TCGA-DR-A0ZM-01 COSM458855 c.742G>A p.E248K Substitution - Missense 10:22329303-22329303 + HT115 COSM2133118 c.683G>A p.R228Q Substitution - Missense 10:22329244-22329244 + T578 COSM4674144 c.411C>A p.F137L Substitution - Missense 10:22328044-22328044 + PD23554a COSM5798393 c.268G>A p.E90K Substitution - Missense 10:22327744-22327744 + T3417 COSM4674145 c.927C>A p.A309A Substitution - coding silent 10:22329488-22329488 + TCGA-AA-3715-01 COSM268754 c.98A>T p.E33V Substitution - Missense 10:22326547-22326547 + 587278 COSM1184753 c.821G>A p.S274N Substitution - Missense 10:22329382-22329382 + 8665_CLM COSM5753450 c.930T>G p.N310K Substitution - Missense 10:22329491-22329491 + TCGA-EE-A29C-06 COSM3436547 c.133C>T p.R45C Substitution - Missense 10:22326910-22326910 + TCGA-BR-8361-01 COSM4013336 c.649A>T p.R217W Substitution - Missense 10:22329126-22329126 + 587284 COSM1184754 c.418C>A p.Q140K Substitution - Missense 10:22328051-22328051 + H322T COSM1195035 c.766G>T p.D256Y Substitution - Missense 10:22329327-22329327 + TCGA-IR-A3LI-01 COSM4846250 c.847C>T p.H283Y Substitution - Missense 10:22329408-22329408 + TCGA-BR-4201-01 COSM4013337 c.773C>T p.A258V Substitution - Missense 10:22329334-22329334 + ESCC_55 COSM5631683 c.862C>T p.H288Y Substitution - Missense 10:22329423-22329423 + LC_S15 COSM1187905 c.43C>T p.H15Y Substitution - Missense 10:22326492-22326492 + Pat_40_A COSM5836671 c.682C>T p.R228* Substitution - Nonsense 10:22329243-22329243 + BRC31 COSM4013334 c.415G>A p.D139N Substitution - Missense 10:22328048-22328048 + 8050939 COSM3769092 c.858T>C p.F286F Substitution - coding silent 10:22329419-22329419 + PT34 COSM5910677 c.304C>T p.P102S Substitution - Missense 10:22327780-22327780 + TCGA-BR-4191-01 COSM4013335 c.568C>G p.Q190E Substitution - Missense 10:22328696-22328696 + TCGA-06-2565-01 COSM2152987 c.552C>T p.D184D Substitution - coding silent 10:22328680-22328680 + GHE0988 COSM5713512 c.451_452delAA p.K151fs*4 Deletion - Frameshift 10:22328159-22328160 + BN24T COSM1603318 c.249T>A p.V83V Substitution - coding silent 10:22327634-22327634 + TCGA-A2-A0YK-01 COSM427389 c.229G>C p.D77H Substitution - Missense 10:22327614-22327614 + ESCC_136 COSM5642975 c.586G>T p.E196* Substitution - Nonsense 10:22329063-22329063 + 96T COSM108646 c.944C>T p.S315L Substitution - Missense 10:22329505-22329505 + HCC2998 COSM458855 c.742G>A p.E248K Substitution - Missense 10:22329303-22329303 + 254 COSM3731605 c.574G>C p.D192H Substitution - Missense 10:22329051-22329051 + P146 COSM1737163 c.571-1G>A p.? Unknown 10:22329047-22329047 + Pat_40_B COSM5836671 c.682C>T p.R228* Substitution - Nonsense 10:22329243-22329243 + HCC2998 COSM458855 c.742G>A p.E248K Substitution - Missense 10:22329303-22329303 + TCGA-B5-A11E-01 COSM917040 c.837G>A p.V279V Substitution - coding silent 10:22329398-22329398 + 587376 COSM1184755 c.187A>G p.T63A Substitution - Missense 10:22326964-22326964 + TCGA-AA-3866-01 COSM296072 c.221C>G p.T74S Substitution - Missense 10:22327606-22327606 + TCGA-FU-A3HY-01 COSM4838639 c.337G>C p.D113H Substitution - Missense 10:22327970-22327970 + TCGA-85-6561-01 COSM683635 c.15G>T p.T5T Substitution - coding silent 10:22326464-22326464 + 5853_PT COSM5753450 c.930T>G p.N310K Substitution - Missense 10:22329491-22329491 + RK117_C01 COSM3699883 c.317-3T>C p.? Unknown 10:22327947-22327947 + TCGA-B5-A11E-01 COSM917038 c.111C>A p.S37S Substitution - coding silent 10:22326560-22326560 + TCGA-DD-A3A0-01 COSM4934766 c.722A>G p.D241G Substitution - Missense 10:22329283-22329283 + 12-P412 COSM4573546 c.186G>T p.K62N Substitution - Missense 10:22326963-22326963 + NCI-H322M COSM1195035 c.766G>T p.D256Y Substitution - Missense 10:22329327-22329327 + TCGA-E2-A1LA-01 COSM1474555 c.846T>G p.P282P Substitution - coding silent 10:22329407-22329407 + TCGA-AN-A046-01 COSM3436547 c.133C>T p.R45C Substitution - Missense 10:22326910-22326910 + RK006_C1 COSM1627436 c.844C>T p.P282S Substitution - Missense 10:22329405-22329405 + ZZUFHECRKL-G012T COSM5435273 c.382G>A p.D128N Substitution - Missense 10:22328015-22328015 + ESCC_160 COSM5647241 c.167G>C p.C56S Substitution - Missense 10:22326944-22326944 + TCGA-EB-A44O-01 COSM3436548 c.686C>T p.P229L Substitution - Missense 10:22329247-22329247 + RK006_C01 COSM1627436 c.844C>T p.P282S Substitution - Missense 10:22329405-22329405 + CHC892T COSM4959727 c.761G>A p.G254E Substitution - Missense 10:22329322-22329322 + Case1 COSM1579153 c.971C>A p.S324Y Substitution - Missense 10:22329532-22329532 + TCGA-BC-A10U-01 COSM4942436 c.618A>G p.L206L Substitution - coding silent 10:22329095-22329095 + 5853_CLM COSM5753450 c.930T>G p.N310K Substitution - Missense 10:22329491-22329491 + RKO COSM2133116 c.596C>A p.P199H Substitution - Missense 10:22329073-22329073 + TCGA-GF-A6C9-06 COSM3414907 c.433C>T p.R145W Substitution - Missense 10:22328141-22328141 + CHC892T COSM4959727 c.761G>A p.G254E Substitution - Missense 10:22329322-22329322 + TCGA-28-5211-01 COSM3397044 c.102T>G p.C34W Substitution - Missense 10:22326551-22326551 + TCGA-BR-7717-01 COSM4013334 c.415G>A p.D139N Substitution - Missense 10:22328048-22328048 + TCGA-06-0166-01 COSM3397045 c.156T>G p.Y52* Substitution - Nonsense 10:22326933-22326933 + DN14066 COSM5962906 c.839A>C p.Q280P Substitution - Missense 10:22329400-22329400 + CHC2127T COSM4952833 c.589G>C p.E197Q Substitution - Missense 10:22329066-22329066 + TCGA-D1-A101-01 COSM917039 c.766G>A p.D256N Substitution - Missense 10:22329327-22329327 + TCGA-FW-A3R5-06 COSM3866992 c.406G>A p.E136K Substitution - Missense 10:22328039-22328039 + TCGA-06-2565 COSM2152987 c.552C>T p.D184D Substitution - coding silent 10:22328680-22328680 + ESO-0013 COSM1246137 c.674A>G p.Y225C Substitution - Missense 10:22329235-22329235 + TCGA-IA-A40Y-01 COSM3985556 c.756C>G p.D252E Substitution - Missense 10:22329317-22329317 + TCGA-24-1567-01 COSM77340 c.86C>A p.T29K Substitution - Missense 10:22326535-22326535 + TCGA-BT-A20R-01 COSM1297171 c.212C>G p.S71* Substitution - Nonsense 10:22327597-22327597 + HT115 COSM2133114 c.429G>T p.L143F Substitution - Missense 10:22328137-22328137 + LUAD-B02216 COSM335302 c.554T>C p.I185T Substitution - Missense 10:22328682-22328682 + cSCCP6 COSM136774 c.782C>T p.P261L Substitution - Missense 10:22329343-22329343 + 326_CLM COSM5753450 c.930T>G p.N310K Substitution - Missense 10:22329491-22329491 + T3080 COSM4674146 c.935C>A p.P312H Substitution - Missense 10:22329496-22329496 + TCGA-B5-A0JY-01 COSM917041 c.938G>A p.R313Q Substitution - Missense 10:22329499-22329499 + TCGA-FG-A4MY-01 COSM3966997 c.744A>G p.E248E Substitution - coding silent 10:22329305-22329305 + I2L-P10-Tumor-Organoid COSM4674144 c.411C>A p.F137L Substitution - Missense 10:22328044-22328044 + TCGA-F5-6814-01 COSM3414907 c.433C>T p.R145W Substitution - Missense 10:22328141-22328141 + Pat_53_B COSM5836670 c.7C>T p.R3* Substitution - Nonsense 10:22326456-22326456 + TCGA-BT-A20Q-01 COSM415071 c.329C>G p.S110C Substitution - Missense 10:22327962-22327962 + 8058339 COSM3382811 c.361G>A p.D121N Substitution - Missense 10:22327994-22327994 +

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.380390;Hs.380403 10p11.23 164831 1509020|dbSNP|BC011652|A/G|non-coding||1652|Validated; 1509044|dbSNP|BC011652|C/T|non-coding||2222|Validated

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer A G IntronicSNV . c.651+40A>G 10 22618097 NSCLC A G Missense p.Y225C c.674A>G 10 22618164 ESCA C A Missense p.P282T c.844C>A 10 22618334 HNSC C A Missense p.T29K c.86C>A 10 22615464 OV C A Nonsense p.Y211* c.633C>A 10 22618039 CM C G Missense p.Q190E c.568C>G 10 22617625 STAD C G Missense p.S110C c.329C>G 10 22616891 BLCA C G Missense p.T74S c.221C>G 10 22616535 COREAD C G Nonsense p.S71* c.212C>G 10 22616526 BLCA C T 3-UTRSNV . c.978+100C>T 10 22618568 CM C T Missense p.A258V c.773C>T 10 22618263 STAD C T Missense p.P278S c.832C>T 10 22618322 CM C T Missense p.P282S c.844C>T 10 22618334 HC C T Missense p.R45C c.133C>T 10 22615839 CM C T Missense p.S315L c.944C>T 10 22618434 CM C T Missense p.S321L c.962C>T 10 22618452 HNSC C T Synonymous p.D184D c.552C>T 10 22617609 GBM G A Missense p.D139N c.415G>A 10 22616977 BRCA G A Missense p.D256N c.766G>A 10 22618256 UCEC G A Missense p.G115R c.343G>A 10 22616905 CM G C Missense p.D77H c.229G>C 10 22616543 BRCA G T Synonymous p.T5T c.15G>T 10 22615393 LUSC T A IntronicSNV . c.425+23T>A 10 22617010 CM T G Missense p.C34W c.102T>G 10 22615480 GBM T G Nonsense p.Y52* c.156T>G 10 22615862 GBM T G Synonymous p.P282P c.846T>G 10 22618336 BRCA