PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ZBTB5 DCX 25416956 biogrid,intact exp P G GP G G P P P GP G G G P P G ZBTB5 ST3GAL3 16169070 hprd,biogrid,i2d,mint,intact exp GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G G GP GP G GP GP GP GP G ZBTB5 SWAP70 25416956 biogrid,intact exp GP GP G G G GP G G GP G GP GP GP G G GP GP G G G GP GP G GP GP GP GP GP G ZBTB5 PTPN5 21988832 biogrid,intact exp P G GP G G G P G P GP G P P P P ZBTB5 HERC2 25476789 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB5 ZBTB7B 25416956 biogrid,intact exp GP GP G G P G GP G G G G G G GP P G GP GP GP G GP G GP P ZBTB5 PPARG 20211142 biogrid exp GP P P GP P GP G GP P G GP P P P P GP P ZBTB5 SOX2 23667531 biogrid exp P P G GP G P GP G P P GP GP GP P G P GP P GP P GP GP G ZBTB5 CCDC85B 16189514 hprd,biogrid,mint,intact exp GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G ZBTB5 KIFC3 26496610 biogrid,intact exp G G G G G G G G GP G GP GP G G G GP G G GP G GP GP G GP GP GP GP G ZBTB5 JADE2 20211142 biogrid exp G GP G G G GP G G GP G G G G G G GP GP GP G G GP GP G GP GP G G G G ZBTB5 ZSCAN29 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB5 ZNF148 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB5 ZBTB33 23023127 pred GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB5 ZNF559 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP P GP GP GP GP G ZNF197 ZBTB5 23023127 pred G GP G G G GP G GP GP G GP G GP G G GP GP G GP G G G GP GP GP G GP GP G ZBTB5 NACC1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP GP GP GP G ZBTB5 BTBD7 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G ZBTB5 ZNF709 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB5 KLHL28 23023127 pred G G G G G G G G G G GP GP G G G G G G GP G GP G G G G G G G G ZBTB5 ZNF260 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB5 ZFP69 23023127 pred P P P P P P P P P P P ZBTB5 ZKSCAN1 23023127 pred GP GP G G G GP G G GP G G GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G ZBTB5 KLHL23 23023127 pred G G G G G P P G G G GP P GP G G G ZBTB5 TCEB2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB5 IKZF1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G GP G G G ZBTB5 ZCCHC7 21836163 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB5 BACH2 23023127 pred GP P G G G GP G GP GP G GP GP GP G G GP GP GP GP G P GP GP GP GP GP GP P G ZBTB5 ZNF93 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB5 ZNF670 23023127 pred P P P P P P P P P P P P P P P P P P P ZBTB5 ZBTB26 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB5 KLHL13 23023127 pred GP G G G G GP GP G GP GP G G GP G G GP G GP GP GP GP GP GP G ZBTB5 BCL6 23023127 pred G G G G G G G G G G G G G G G G G G G G GP G G G G GP G G G ZBTB5 STOML2 25402006 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB5 ZNF253 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB5 ZNF430 23023127 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G G G G G GP G GP G GP GP G ZBTB5 ZBTB34 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G ZBTB5 ZNF823 23023127 pred G P G P G G GP GP G G G P G P GP G G G G GP G ZBTB5 KLHL25 23023127 pred GP GP G G G GP G P GP G GP GP GP G G GP GP G GP G P GP GP GP GP GP GP GP G ZBTB5 ZNF34 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G G G P GP GP G GP GP G ZBTB5 ZNF140 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G ZBTB5 ZBTB6 23023127 pred P P P P P P P P P P P P P BTBD17 ZBTB5 23023127 pred P P P P P P ZBTB5 ZFP37 23023127 pred G G G G G G P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O15062 O43602-5 two hybrid 25416956 direct interaction X 2 Q9UH65 O15062 two hybrid 25416956 direct interaction X 2 P61956-2 O15062 affinity chromatography technology 21693764 physical association X 2 P48431 O15062 affinity chromatography technology 23667531 physical association X 2 P0CG48 O15062 affinity chromatography technology 23000965 physical association X 2 P0CG48 O15062 affinity chromatography technology 21906983 physical association X 2 P37231-3 O15062 two hybrid 20211142 direct interaction X 2 Q15834 O15062 two hybrid 16189514 direct interaction X 2 Q9NQC1 O15062 two hybrid 20211142 direct interaction X 2 O15062 two hybrid 25416956 direct interaction X 2 O15062 B7Z2F8 two hybrid 21988832 direct interaction X 2 O15062 Q11203-2 two hybrid 16169070 direct interaction X 2 Q8R4T5 O15062 two hybrid 12586822 direct interaction X 2 Q11203-18 O15062 two hybrid 16169070 - X 2 Q11203-18 O15062 two hybrid 16169070 - X 2 Q15834 O15062 two hybrid 16189514 - X 2 Q15834 O15062 two hybrid 16189514 - X 2 Q11203 O15062 two hybrid pooling approach 16169070 physical association X 2 O15062 Q81VP2 two hybrid pooling approach 20711500 physical association X 2 Q9UH65 O15062 two hybrid prey pooling approach 25416956 physical association X 2 Q9UH65 O15062 two hybrid array 25416956 physical association X 2 Q9UH65 O15062 validated two hybrid 25416956 physical association X 2 Q15834 O15062 two hybrid pooling approach 16189514 physical association X 2 P54829 O15062 two hybrid array 21988832 physical association X 2 O15156 O15062 two hybrid prey pooling approach 25416956 physical association X 2 O15156 O15062 two hybrid array 25416956 physical association X 2 O15156 O15062 validated two hybrid 25416956 physical association X 2 Q8R4T5 O15062 two hybrid 12586822 physical association X 2 O43602 O15062 two hybrid prey pooling approach 25416956 physical association X 2 O43602 O15062 two hybrid array 25416956 physical association X 2 O43602 O15062 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ZBTB5 ZFP36 MI:0018(two hybrid) 21952135 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_14529 prey bait ZBTB5 PPARG MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128637 prey bait ZBTB5 SOX2 MI:0004(affinity chromatography technology) 23667531 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_275154 prey bait ZBTB5 ST3GAL3 MI:0018(two hybrid)|MI:0492(in vitro)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0468(hprd)|(intact)|MI:0471(mint)|MI:0471(mint) BIOGRID_93970|HPRD_29500|UniProt_156545|MINT_34271|MINT_63227 prey|-|prey|prey|prey bait|-|bait|bait|bait ZBTB5 PHF15 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128823 bait prey ZBTB5 UBC MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21906983,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_177731|BIOGRID_268411 prey|prey bait|bait ZBTB5 PTPN5 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_286578|UniProt_118183 prey|unspecified role bait|unspecified role ZBTB5 CCDC85B MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0468(hprd)|(biogrid)|MI:0471(mint) MINT_38914|UniProt_153205|HPRD_23209|BIOGRID_80363|MINT_68157 bait|unspecified role|-|bait|bait prey|unspecified role|-|prey|prey ZBTB5 SUMO2 MI:0004(affinity chromatography technology) 21693764 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_165462 prey bait

PPI - HINT Gene A Gene B PMID Method Quality ZBTB5 KIFC3 26496610,26496610 0007,0004 HT ZBTB5 KIFC3 26496610,26496610 0007,0004 HT ZBTB5 ZBTB7B 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT ZBTB5 DCX 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT ZBTB5 PPARG 20211142 0018 HT ZBTB5 PTPN5 21988832,21988832 0397,0018 HT ZBTB5 ST3GAL3 16169070,16169070 0018,0398 HT ZBTB5 CCDC85B 16189514,16189514 0398,0018 HT ZBTB5 JADE2 20211142 0018 HT ZBTB5 SWAP70 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q81VP2 O15062 Q81VP2 ZBTB5 0.126 20711500 Q11203 O15062 ST3GAL3 ZBTB5 0.286 16169070 Q9NQC1 O15062 JADE2 ZBTB5 0.183 20211142 Q6A065 O15062 CEP170 ZBTB5 0.126 26496610 O95714 O15062 HERC2 ZBTB5 0.126 25476789 Q9NRN9 O15062 METTL5 ZBTB5 0.236 unassigned1304 Q8R4T5 O15062 GRASP ZBTB5 0.523 12586822 Q9BVG8 O15062 KIFC3 ZBTB5 0.236 26496610 O95429 O15062 BAG4 ZBTB5 0.236 unassigned1304 O15156 O15062 ZBTB7B ZBTB5 0.583 25416956,unassigned1304 Q4U2R1 O15062 HERC2 {ECO:0000312|EMBL:AAD08658.1, ECO:0000312|MGI:MGI:103234} ZBTB5 0.236 26496610 O15062 A0A140LJL1 ZBTB5 DCX {ECO:0000313|ENSEMBL:ENSP00000337697} 0.236 unassigned1304 O43602 O15062 DCX ZBTB5 0.454 25416956 P37231 O15062 PPARG ZBTB5 0.183 20211142 Q9UH65 O15062 SWAP70 ZBTB5 0.454 25416956 P48431 O15062 SOX2 ZBTB5 0.126 23667531 O15062 D3Z482 ZBTB5 D3Z482 0.126 26496610 O15062 H7BX26 ZBTB5 H7BX26 0.126 26496610 Q15834 O15062 CCDC85B ZBTB5 0.286 16189514 P54829 O15062 PTPN5 ZBTB5 0.286 21988832

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 ZBTB5 ZBTB7B MI:0045 experimental interaction detection MI:0461 interaction database ZBTB5 DCX MI:0045 experimental interaction detection MI:0461 interaction database ZBTB5 ZBTB7A MI:0362 inference MI:0461 interaction database ZBTB5 HERC2 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB5 UBC MI:0045 experimental interaction detection MI:0461 interaction database ZBTB5 PPARG MI:0045 experimental interaction detection MI:0461 interaction database ZBTB5 SOX2 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB5 PTPN5 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB5 SUMO2 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB5 ST3GAL3 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB5 CCDC85B MI:0045 experimental interaction detection MI:0461 interaction database ZBTB5 CEP170 MI:0362 inference MI:0461 interaction database ZBTB5 GRASP MI:0362 inference MI:0461 interaction database ZBTB5 KIFC3 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB5 JADE2 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB5 SWAP70 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB5 ANKRD26 MI:0362 inference MI:0461 interaction database