PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ZBTB49 GOPC 25416956 biogrid,intact exp G GP G G GP GP GP G GP G GP G G GP GP G P G GP G GP GP G G GP G ZBTB49 KAT5 25245946 biogrid exp G GP G G GP GP GP G GP G GP G G GP GP G P G GP G GP GP G G GP G HSP90AA1 ZBTB49 22939624 biogrid exp G GP G G GP G GP G G G G G G G GP G G G G G G G G GP G TRAF2 ZBTB49 25416956 biogrid,intact exp P P P P P P P P P P P P G G P EP300 ZBTB49 25245946 biogrid exp G GP G G GP GP GP G GP G GP G G GP GP G P G GP G GP GP G G GP G ZBTB49 HINFP 25245946 biogrid exp G GP G G GP P G G GP G GP G G G GP G P G G G GP G G G GP HSP90AB1 ZBTB49 22939624 intact exp G GP G G GP GP GP G GP G GP G G GP GP G P G GP G GP GP G G GP G ZBTB49 POT1 21988832 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G ZBTB49 ZBTB8A 25416956 biogrid,intact exp G GP G G GP GP GP G GP G GP G G GP GP G P G GP G GP GP G G GP G ZBTB17 ZBTB49 25245946 biogrid exp G GP G G GP GP GP G GP G GP G G GP GP G P G GP G GP GP G G GP G ZBTB49 CEP70 25416956 biogrid,intact exp G GP G G GP GP GP G GP G GP G G GP GP G P G GP G GP GP G G GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A0A024R8H5 Q6ZSB9 two hybrid 25416956 direct interaction X 2 Q6ZSB9 P07900-2 affinity chromatography technology 22939624 physical association X 2 Q6ZSB9 Q9NUX5-2 two hybrid 21988832 direct interaction X 2 Q6ZSB9 two hybrid 25416956 direct interaction X 2 Q6ZSB9 Q9HD26-3 two hybrid 25416956 direct interaction X 2 Q6ZSB9 Q8NHQ1 two hybrid 25416956 direct interaction X 2 Q6ZSB9 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B NRF1 ZBTB49 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_294808 bait prey ZBTB49 POT1 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_288809|UniProt_120197 prey|unspecified role bait|unspecified role HSP90AA1 ZBTB49 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255456 bait prey HSP90AB1 ZBTB49 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125127 prey bait

PPI - HINT Gene A Gene B PMID Method Quality HSP90AB1 ZBTB49 22939624 0729 HT TRAF2 ZBTB49 25416956 0018 HT Q53EM1 ZBTB49 25245946,25245946,25245946 0004,0055,0428 LC ZBTB49 CEP70 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT ZBTB49 ZBTB8A 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT ZBTB49 GOPC 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT ZBTB49 POT1 21988832 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q6ZSB9 Q09472 ZBTB49 EP300 0.623 25245946 Q9NUX5 Q6ZSB9 POT1 ZBTB49 0.332 21988832 Q6ZSB9 P07900 ZBTB49 HSP90AA1 0.126 22939624 Q6ZSB9 P08238 ZBTB49 HSP90AB1 0.126 22939624 Q6ZSB9 P68587 ZBTB49 YSCP 0.126 20711500 Q92993 Q6ZSB9 KAT5 ZBTB49 0.21 25245946 Q8NHQ1 Q6ZSB9 CEP70 ZBTB49 0.454 25416956 Q6ZSB9 Q08AM6 ZBTB49 VAC14 0.236 unassigned1304 Q6ZSB9 Q13114 ZBTB49 TRAF3 0.236 unassigned1304 Q9NRD5 Q6ZSB9 PICK1 ZBTB49 0.236 unassigned1304 Q99828 Q6ZSB9 CIB1 ZBTB49 0.236 unassigned1304 Q96BR9 Q6ZSB9 ZBTB8A ZBTB49 0.583 25416956,unassigned1304 Q8N680 Q6ZSB9 ZBTB2 ZBTB49 0.236 unassigned1304 Q9HD26 Q6ZSB9 GOPC ZBTB49 0.583 25416956,unassigned1304 Q6ZSB9 Q12933 ZBTB49 TRAF2 0.376 unassigned1304,25416956 Q9BQA5 Q6ZSB9 HINFP ZBTB49 0.454 25245946 Q6ZSB9 Q13105 ZBTB49 ZBTB17 0.623 25245946

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 HSP90AA1 ZBTB49 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 ZBTB49 MI:0045 experimental interaction detection MI:0461 interaction database EP300 ZBTB49 MI:0045 experimental interaction detection MI:0461 interaction database TRAF2 ZBTB49 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB17 ZBTB49 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB49 CEP70 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB49 KAT5 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB49 ZBTB8A MI:0045 experimental interaction detection MI:0461 interaction database ZBTB49 HINFP MI:0045 experimental interaction detection MI:0461 interaction database ZBTB49 GOPC MI:0045 experimental interaction detection MI:0461 interaction database ZBTB49 POT1 MI:0045 experimental interaction detection MI:0461 interaction database