PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SRPK2 USP39 26167880 biogrid exp G G G G G G G G G G G G G G G G G G G G G G PTEN USP39 24270891 biogrid exp G G G G G G G G G G G G G G G G G G G G G G USP39 DDX23 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G HSPA4 USP39 26344197 biogrid exp G G G G G G G G G G G G G G G G G G G G G G USP39 PRPF31 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G NCAPD3 USP39 26344197 biogrid exp G G G G G G G G G G G G G G G G G G G G G CETN2 USP39 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G USP39 CAND1 21145461 biogrid exp G G G G G G G G G G G G G G G G G G G G G G USP39 TRIM39 23105109 biogrid exp USP39 WWOX 24550385 biogrid exp G G G G G G G G G G G G G G G G G G G G G G HNRNPC USP39 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G LSM8 USP39 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G USP39 CCDC8 24711643 biogrid exp G G G G G G G G G G G G G G G G G G G G G G SRSF5 USP39 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G SRSF3 USP39 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G SART1 USP39 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G CD2BP2 USP39 19615732,17353931 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G USP39 RUVBL2 26344197 biogrid exp G G G G G G G G G G G G G G G G G G G G G G CSNK1A1 USP39 19888210 i2d exp G G G G G G G G G G G G G G G G G G G G G G JUN USP39 25609649 intact exp G G G G G G G G G G G G G G G G G G G G G G USP39 DHX38 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G PRPF3 USP39 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G CBX1 USP39 19615732 intact exp G G G G G G G G G G G G G G G G G G G G G G USP12 USP39 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G USP39 NOC3L 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G SNRNP200 USP39 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G VTN USP39 22939629 biogrid exp SON USP39 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G USP39 DDX41 25920683 intact exp G G G G G G G G G G G G G G G G G G G G G G HNRNPU USP39 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G PRPF4 USP39 26496610,19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G OBSL1 USP39 24711643 biogrid exp G G G G G G G G G G G G G G G G G G G G NSUN2 USP39 26344197 biogrid exp G G G G G G G G G G G G G G G G G G G G G G USP39 PA2G4 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G USP39 SAE1 25027693 biogrid exp G G G G G G G G G G G G G G G G G G G G G G USP39 DDX24 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G ZRANB2 USP39 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G SP1 USP39 20195357 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G NTRK1 USP39 25921289 biogrid exp RBM39 USP39 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G USP39 NKD1 19888210 i2d exp G G G G G SRSF7 USP39 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G USP39 SRPK1 23602568 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G CSNK1E USP39 19888210,26344197 biogrid,i2d exp G G G G G G G G G G G G G G G G G G G G G G USP39 TSR2 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G USP39 ZC3H18 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G USP39 COPRS 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G USP39 RNMTL1 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G APP USP39 21832049 biogrid exp G G G G G G G G G G G G G G G G G G G G G G MCM7 USP39 23764002 intact exp G G G G G G G G G G G G G G G G G G G G G G USP39 PRPF19 26344197 biogrid exp G G G G G G G G G G G G G G G G G G G G G G USP39 RPL22L1 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G ACVR1 USP39 15761153 hprd,i2d exp G G G G G G G G G G G G G G G G G G G G G G USP4 USP39 21415856 mint,intact exp G G G G G G G G G G G G G G G G G G G G G G USP39 NCSTN 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G PRPF4B USP39 23602568,19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G GTF3C1 USP39 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G CUL7 USP39 24711643 biogrid exp G G G G G G G G G G G G G G G G G G G G G G USP39 PRPF8 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G PCNA USP39 26344197 biogrid exp G G G G G G G G G G G G G G G G G G G G G G DHX9 USP39 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G TRIM25 USP39 23105109 biogrid exp G G G G G G G G G G G G G G G G G G G G G G TRIM26 USP39 23105109 biogrid exp G G G G G G G G G G G G G G G G G G G G G G LGALS9 USP39 26344197 biogrid exp G G G G G G G G G G G G G G G G G APEH USP39 26344197 biogrid exp G G G G G G G G G G G G G G G G G G G G G G SF3B1 USP39 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G USP39 MMS19 22678362 biogrid exp G G G G G G G G G G G G G G G G G G G G G G ADARB1 USP39 26344197 biogrid exp G G G G G G G G G G G G G G G G G G G G USP39 HSPH1 26344197 biogrid exp G G G G G G G G G G G G G G G G G G G G G G USP39 TRMT10C 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G USP39 TRIM5 23105109 biogrid exp G G G G G G G G G G G G G G G G G G USP39 GAR1 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G FN1 USP39 19738201 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G SNW1 USP39 20467437 intact exp G G G G G G G G G G G G G G G G G G G G G G USP39 TRIM8 23105109 biogrid exp G G G G G G G G G G G G G G G G G G G G G G SAFB USP39 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G ARF1 USP39 26344197 biogrid exp G G G G G G G G G G G G G G G G G G G G USP39 SF3B6 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G SRSF11 USP39 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G TP53 USP39 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G USP39 TRAF6 23105109 biogrid exp G G G G G G G G G G G G G G G G G G G G G G USP39 CDC5L 20467437 intact exp G G G G G G G G G G G G G G G G G G G G G G USP39 SUPT16H 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G EFTUD2 USP39 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G USP39 TRIM55 22939629 biogrid exp G G G G RRP8 USP39 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G SRSF10 USP39 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G USP39 SNRNP40 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G TPBG USP39 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G USP39 MEPCE 17643375, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G USP39 SNRNP27 19615732, 21836163 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G TXNL4A USP39 19615732, 25402006 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G SART3 USP39 19615732, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G SF3A1 USP39 22939629, 23023127 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G PRPF6 USP39 19615732, 25402006 biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G PDIA3 USP39 ortho G G G G G G G G G G G G G G G G G G G G G G DUT USP39 ortho G G G G G G G G G G G G G G G G G G G G G G YWHAH USP39 ortho G G G G G G G G G G G G G G G G G G G G G G CNN3 USP39 ortho G G G G G G G G G G G G G G G G G G G G G G UBXN1 USP39 ortho G G G G G G G G G G G G G G G G G G G G G G SUMO3 USP39 ortho G G G G G G G G G G G G G G G G G G G G G G ANXA6 USP39 ortho G G G G G G G G G G G G G G G G G G G G G G YWHAE USP39 ortho G G G G G G G G G G G G G G G G G G G G G G SNRPB USP39 25402006 pred G G G G G G G G G G G G G G G G G G G G G G PPIH USP39 25402006 pred G G G G G G G G G G G G G G G G G G G G G G SNRPN USP39 25402006 pred G G SF1 USP39 25402006 pred G G G G G G G G G G G G G G G G G G G G G G USP39 WBP11 25402006 pred G G G G G G G G G G G G G G G G G G G G G G USP39 USP15 25402006 pred G G G G G G G G G G G G G G G G G G G G G G SF3B4 USP39 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G SNRNP70 USP39 21836163 pred G G G G G G G G G G G G G G G G G G G G G G SRSF9 USP39 23023127 pred PPP1R8 USP39 16082366 pred G G G G G G G G G G G G G G G G G G G G G G CAPG USP39 23023127 pred G G G G G G G G G G G G G G G G G G G G G G RPL24 USP39 23023127 pred G G G G G G G G G G G G G G G G G G G G G G USP39 USP22 23023127 pred G G G G G G G G G G G G G G G G G G G G G G SUMO2 USP39 23023127 pred G G G G G G G G G G G G G G G G G G G G G G USP39 PSMF1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G USP39 USP21 23023127 pred G G G G G G G G G G G G G G G G G G G G G G SNRPA USP39 23023127 pred G G G G G G G G G G G G G G G G G G G G G G USP39 AKNA 25402006 pred G G G G G G G G G G G G G G G G G G USP14 USP39 23023127 pred G G G G G G G G G G G G G G G G G G G G G G USP39 MAGED1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G USP39 UHRF2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q86VP6 Q53GS9 affinity chromatography technology 21145461 physical association X 2 Q12789 Q53GS9 biochemical 22939629 colocalization X 2 Q15020 Q53GS9 affinity chromatography technology 19615732 physical association X 2 Q53GS9 P05067-7 pull down 21832049 direct interaction X 2 Q53GS9 Q05519-2 biochemical 22939629 colocalization X 2 Q53GS9 A0A024R1K8 biochemical 22939629 colocalization X 2 Q53GS9 A0A024R6D8 biochemical 22939629 colocalization X 2 Q53GS9 Q7Z497 biochemical 22939629 colocalization X 2 Q53GS9 Q08211 biochemical 22939629 colocalization X 2 Q53GS9 P18583-6 biochemical 22939629 colocalization X 2 Q53GS9 Q15424-2 biochemical 22939629 colocalization X 2 Q53GS9 Q9BYV6-4 biochemical 22939629 colocalization X 2 Q53GS9 Q86VM9 biochemical 22939629 colocalization X 2 Q53GS9 P41208 biochemical 22939629 colocalization X 2 Q53GS9 Q9Y4K3 two hybrid 23105109 direct interaction X 2 Q53GS9 Q14258 two hybrid 23105109 direct interaction X 2 Q53GS9 A0A024RCP3 two hybrid 23105109 direct interaction X 2 Q53GS9 A0A024RCP5 two hybrid 23105109 direct interaction X 2 Q53GS9 Q9C035 two hybrid 23105109 direct interaction X 2 Q53GS9 Q96T76 affinity chromatography technology 22678362 physical association X 2 Q53GS9 P08047 pull down 20195357 direct interaction X 2 Q53GS9 A0A024QZY5 affinity chromatography technology 23602568 physical association X 2 Q53GS9 Q96SB4 enzymatic study 23602568 direct interaction X 2 Q53GS9 A0A024R3Z2 affinity chromatography technology 24654937 physical association X 2 Q53GS9 P55854 affinity chromatography technology 25027693 physical association X 2 Q53GS9 Q9UBE0-3 enzymatic study 25027693 direct interaction X 2 Q53GS9 affinity chromatography technology 24711643 physical association X 2 Q53GS9 A0A024QZC1 affinity chromatography technology 17353931 physical association X 2 Q53GS9 A0A024RB85 affinity chromatography technology 19615732 physical association X 2 Q53GS9 P04637-7 affinity chromatography technology 19615732 physical association X 2 Q53GS9 A0A024QZY5 affinity chromatography technology 19615732 physical association X 2 Q53GS9 Q15029-3 affinity chromatography technology 19615732 physical association X 2 Q53GS9 Q92620 affinity chromatography technology 19615732 physical association X 2 Q53GS9 A0A024QZC1 affinity chromatography technology 19615732 physical association X 2 Q53GS9 Q6P2Q9 affinity chromatography technology 19615732 physical association X 2 Q53GS9 P83876 affinity chromatography technology 19615732 physical association X 2 Q53GS9 A8K513 affinity chromatography technology 19615732 physical association X 2 Q53GS9 Q7L0Y3 affinity chromatography technology 19615732 physical association X 2 Q53GS9 Q9HC36 affinity chromatography technology 19615732 physical association X 2 Q53GS9 Q9NQ92 affinity chromatography technology 19615732 physical association X 2 Q53GS9 Q8WTT2 affinity chromatography technology 19615732 physical association X 2 Q53GS9 Q99PV0 affinity chromatography technology 20360068 physical association X 2 F6KD01 Q53GS9 affinity chromatography technology 24270891 physical association X 2 D9ZGG2 Q53GS9 biochemical 22939629 colocalization X 2 O75643 Q53GS9 affinity chromatography technology 19615732 physical association X 2 Q9Y3B4 Q53GS9 biochemical 22939629 colocalization X 2 Q53GS9 B2R6F3 biochemical 22939629 colocalization X 2 Q53GS9 E1P5S2 biochemical 22939629 colocalization X 2 Q53GS9 Q16629-4 biochemical 22939629 colocalization X 2 Q53GS9 biochemical 22939629 colocalization X 2 Q53GS9 Q96BA7 biochemical 22939629 colocalization X 2 Q53GS9 Q92542 biochemical 22939629 colocalization X 2 Q53GS9 Q13641 biochemical 22939629 colocalization X 2 Q53GS9 O75494 biochemical 22939629 colocalization X 2 Q53GS9 Q9Y5B9 biochemical 22939629 colocalization X 2 Q53GS9 Q9BZR9 two hybrid 23105109 direct interaction X 2 Q53GS9 affinity chromatography technology 19738201 physical association X 2 Q53GS9 pull down 22174317 direct interaction X 2 Q53GS9 Q9NZC7-5 affinity chromatography technology 24550385 physical association X 2 Q53GS9 Q15843 affinity chromatography technology 24654937 physical association X 2 Q53GS9 P61956-2 affinity chromatography technology 25027693 physical association X 2 Q53GS9 affinity chromatography technology 24711643 physical association X 2 Q53GS9 Q9H0W5 affinity chromatography technology 24711643 physical association X 2 Q53GS9 O43290 affinity chromatography technology 19615732 physical association X 2 Q53GS9 O43172-2 affinity chromatography technology 19615732 physical association X 2 Q53GS9 O43395 affinity chromatography technology 19615732 physical association X 2 Q53GS9 O95218-2 affinity chromatography technology 19615732 physical association X 2 Q53GS9 A0MNP2 affinity chromatography technology 19615732 physical association X 2 Q53GS9 A0A024R0Z3 affinity chromatography technology 19615732 physical association X 2 Q53GS9 O75317 affinity chromatography technology 19615732 physical association X 2 Q53GS9 O43172-2 affinity chromatography technology 19615732 physical association X 2 Q53GS9 O43159 affinity chromatography technology 19615732 physical association X 2 Q53GS9 O94906 affinity chromatography technology 19615732 physical association X 2 Q53GS9 F1T0A5 affinity chromatography technology 19615732 physical association X 2 Q53GS9 A4D0W0 affinity chromatography technology 19615732 physical association X 2 Q53GS9 A0A024RDJ3 affinity chromatography technology 19615732 physical association X 2 Q53GS9 Q9GZR7 affinity chromatography technology 19615732 physical association X 2 Q53GS9 A0A024R9U9 affinity chromatography technology 19615732 physical association X 2 Q53GS9 Q6P5R6 affinity chromatography technology 19615732 physical association X 2 Q53GS9 Q7L2J0 affinity chromatography technology 17643375 physical association X 2 Q53GS9 P61956-2 affinity chromatography technology 21693764 physical association X 2 Q53GS9 P0CG48 affinity chromatography technology 21139048 physical association X 2 Q53GS9 P61956-2 affinity chromatography technology 19471022 physical association X 2 Q53GS9 anti tag coimmunoprecipitation 12226669 association C 143 Q53GS9 molecular sieving 12226669 association C 143 Q53GS9 mass spectrometry studies of complexes 12226669 association C 143 Q53GS9 D3DPA4 in vivo 15761153 - X 2 Q53GS9 D3DPA4 in vivo 15761153 - X 2 Q53GS9 cross-linking study 19738201 association C 402 Q53GS9 anti tag coimmunoprecipitation 19615732 physical association C 29 Q53GS9 tandem affinity purification 23602568 association C 17 Q53GS9 A0A024QZC1 anti bait coimmunoprecipitation 17353931 physical association X 2 Q53GS9 P08047 display technology 20195357 physical association X 2 Q53GS9 Q96SB4 protein kinase assay 23602568 phosphorylation reaction X 2 Q53GS9 anti tag coimmunoprecipitation 19615732 physical association C 30 Q53GS9 tandem affinity purification 20360068 physical association C 54 Q53GS9 anti bait coimmunoprecipitation 23764002 association C 80 Q53GS9 anti tag coimmunoprecipitation 19615732 physical association C 15 Q53GS9 A0A024R2T0 surface plasmon resonance 21415856 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B TRIM25 USP39 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248228 prey bait USP39 TRIM5 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248232 bait prey USP39 DDX23 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120053|UniProt_100674 bait|bait prey|prey USP39 TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237843 bait prey DHX9 USP39 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_235037 bait prey USP39 DHX38 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120095|UniProt_100674 bait|bait prey|prey PTEN USP39 MI:0004(affinity chromatography technology) 24270891 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_310057 bait prey USP39 TRIM8 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248231 bait prey UBC USP39 MI:0004(affinity chromatography technology) 21139048 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_168492 bait prey PRPF6 USP39 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120343|UniProt_100674 prey|prey bait|bait USP39 TSR2 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100674|BIOGRID_120763 bait|bait prey|prey ACVR1 USP39 MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17244 - - TPBG USP39 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237528 prey bait WHSC1 USP39 MI:0004(affinity chromatography technology) 22751105 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_261406 bait prey RBM39 USP39 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_235022 bait prey USP39 DDX24 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120589|UniProt_100674 bait|bait prey|prey USP39 RNMTL1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120518|UniProt_100674 bait|bait prey|prey USP39 TRIM39 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248230 bait prey VTN USP39 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240466 prey bait USP12 USP39 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120191|UniProt_100659 bait|bait prey|prey SRSF5 USP39 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_234968 bait prey USP39 ZC3H18 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_238304 bait prey USP39 CAND1 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_206308 prey bait PRPF4 USP39 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(intact) UniProt_100717|BIOGRID_120014|BIOGRID_120192|UniProt_100674 bait|prey|bait|prey prey|bait|prey|bait SRSF11 USP39 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_234595 bait prey p53 USP39 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119829|UniProt_100674 prey|prey bait|bait TXNL4A USP39 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120208|UniProt_100674 prey|prey bait|bait SRSF3 USP39 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_234771 bait prey NAA38 USP39 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120470|UniProt_100674 prey|prey bait|bait SART1 USP39 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120004|UniProt_100674 prey|prey bait|bait USP39 SUPT16H MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_243690 bait prey USP39 TRAF6 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248227 bait prey USP39 SF3B14 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_234594 prey bait NRF1 USP39 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295449 bait prey SNRNP200 USP39 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120265|UniProt_100674 prey|prey bait|bait USP39 PRPF8 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120177|UniProt_100674 bait|bait prey|prey USP39 RPL22L1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120841|UniProt_100674 bait|bait prey|prey SF3B1 USP39 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_235013 bait prey USP39 WWOX MI:0004(affinity chromatography technology) 24550385 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_309198 prey bait SRSF10 USP39 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_239709 bait prey SP1 USP39 MI:0096(pull down)|MI:0034(display technology) 20195357 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_290422|UniProt_104411 bait|bait prey|prey USP39 TRMT10C MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120500|UniProt_100674 bait|bait prey|prey USP39 COPR5 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120531|UniProt_100674 bait|bait prey|prey USP39 MEPCE MI:0415(enzymatic study) 17643375 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_121388 prey bait HNRNPU USP39 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_235254 bait prey USP39 GAR1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120487|UniProt_100674 bait|bait prey|prey JUND USP39 MI:0004(affinity chromatography technology) 11971955 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_211013 prey bait USP39 SNRNP40 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120050|UniProt_100674 bait|bait prey|prey TRIM26 USP39 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248229 prey bait CD2BP2 USP39 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 17353931,19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(intact) UniProt_145887|BIOGRID_82185|BIOGRID_120157|UniProt_100674 bait|bait|prey|prey prey|prey|bait|bait SART3 USP39 MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_121758 bait prey SRSF7 USP39 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_235040 bait prey RRP8 USP39 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120315|UniProt_100674 prey|prey bait|bait SON USP39 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236631 prey bait USP39 MMS19 MI:0004(affinity chromatography technology) 22678362 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_271363 prey bait USP39 SRPK1 MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification) 23602568 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0217(phosphorylation reaction) (biogrid)|(intact) BIOGRID_291565|UniProt_129109 prey|neutral component bait|neutral component USP39 NCSTN MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236464 prey bait USP4 USP39 MI:0107(surface plasmon resonance) 21415856 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (intact) UniProt_112891 bait prey HNRNPC USP39 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_235192 bait prey SAFB USP39 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237104 bait prey PRPF3 USP39 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120018|UniProt_100674 prey|prey bait|bait GTF3C1 USP39 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236632 prey bait CETN2 USP39 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_243752 bait prey SUMO2 USP39 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19471022,21693764 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_165946|BIOGRID_183439 bait|bait prey|prey APP USP39 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_228646 prey bait USP39 PRPF31 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120375|UniProt_100674 bait|bait prey|prey SF3A1 USP39 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_234698 bait prey USP39 SNRNP27 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120231|UniProt_100674 bait|bait prey|prey USP39 NOC3L MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120632|UniProt_100674 bait|bait prey|prey FN1 USP39 MI:0030(cross-linking study)|MI:0004(affinity chromatography technology) 19738201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_103099|BIOGRID_252886 bait|bait prey|prey ZRANB2 USP39 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120049|UniProt_100674 prey|prey bait|bait PRPF4B USP39 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification)|MI:0007(anti tag coimmunoprecipitation) 19615732,23602568 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact)|(intact) BIOGRID_291084|BIOGRID_119987|UniProt_128776|UniProt_100674 bait|prey|bait|prey prey|bait|prey|bait USP39 PA2G4 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119629|UniProt_100674 bait|bait prey|prey EFTUD2 USP39 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120041|UniProt_100674 prey|prey bait|bait

PPI - HINT Gene A Gene B PMID Method Quality WDR57 USP39 19615732 0004 HT LGALS9 USP39 26344197 0401 HT RRP8 USP39 19615732,19615732 0004,0007 HT PRPF4 USP39 26496610,19615732,19615732,26496610 0007,0004,0007,0004 HT SART1 USP39 19615732,19615732 0004,0007 HT PRPF3 USP39 19615732,19615732 0004,0007 HT USP12 USP39 19615732,19615732 0004,0007 HT SRSF10 USP39 22939629 0401 HT SF3B1 USP39 22939629 0401 HT SNRNP200 USP39 19615732,19615732 0004,0007 HT PRPF6 USP39 19615732,19615732 0004,0007 HT ZRANB2 USP39 19615732,19615732 0004,0007 HT CD2BP2 USP39 19615732,17353931,19615732,17353931 0004,0006,0007,0004 HT LSM8 USP39 19615732,19615732 0004,0007 HT VTN USP39 22939629 0401 HT TP53 USP39 19615732,19615732 0004,0007 HT JUN USP39 25609649 0006 HT HNRNPC USP39 22939629 0401 HT PCNA USP39 26344197 0401 HT APEH USP39 26344197 0401 HT HSPA4 USP39 26344197 0401 HT CETN2 USP39 22939629 0401 HT NCAPD3 USP39 26344197 0401 HT CSNK1E USP39 26344197 0401 HT ADARB1 USP39 26344197 0401 HT TXNL4A USP39 19615732,19615732 0004,0007 HT CBX1 USP39 19615732 0007 HT ARF1 USP39 26344197 0401 HT SRSF3 USP39 22939629 0401 HT SRSF11 USP39 22939629 0401 HT DHX9 USP39 22939629 0401 HT NSUN2 USP39 26344197 0401 HT GTF3C1 USP39 22939629 0401 HT SRSF5 USP39 22939629 0401 HT PRPF4B USP39 19615732,23602568,19615732,23602568 0004,0004,0007,0676 HT TPBG USP39 22939629 0401 HT RBM39 USP39 22939629 0401 HT SART3 USP39 19615732 0004 HT EFTUD2 USP39 19615732,19615732 0004,0007 HT SAFB USP39 22939629 0401 HT SF3A1 USP39 22939629 0401 HT SRSF7 USP39 22939629 0401 HT Q53GA5 USP39 19615732 0004 HT USP39 PRPF8 19615732,19615732 0004,0007 HT USP39 RPL22L1 19615732,19615732 0004,0007 HT USP39 Q6ZRV7 22939629 0401 HT USP39 TRMT10C 19615732,19615732 0004,0007 HT USP39 MEPCE 17643375 0004 HT USP39 ZC3H18 22939629 0401 HT USP39 CAND1 21145461 0004 HT USP39 NOC3L 19615732,19615732 0004,0007 HT USP39 SNRNP27 19615732,19615732 0004,0007 HT USP39 PRPF31 19615732,19615732 0004,0007 HT USP39 NCSTN 22939629 0401 HT USP39 HSPH1 26344197 0401 HT USP39 DHX38 19615732,19615732 0004,0007 HT USP39 TSR2 19615732,19615732 0004,0007 HT USP39 Q96BA7 22939629 0401 HT USP39 SNRNP40 19615732,19615732 0004,0007 HT USP39 DDX23 19615732,19615732 0004,0007 HT USP39 TRIM55 22939629 0401 HT USP39 DDX24 19615732,19615732 0004,0007 HT USP39 RNMTL1 19615732,19615732 0004,0007 HT USP39 COPRS 19615732,19615732 0004,0007 HT USP39 GAR1 19615732,19615732 0004,0007 HT USP39 PRPF19 26344197 0401 HT USP39 PA2G4 19615732,19615732 0004,0007 HT USP39 Q9UQS6 19738201 0004 HT USP39 RUVBL2 26344197 0401 HT USP39 SF3B6 22939629 0401 HT USP39 SUPT16H 22939629 0401 HT WDR57 USP39 19615732 0004 HT LGALS9 USP39 26344197 0401 HT RRP8 USP39 19615732,19615732 0004,0007 HT PRPF4 USP39 26496610,19615732,19615732,26496610 0007,0004,0007,0004 HT SART1 USP39 19615732,19615732 0004,0007 HT PRPF3 USP39 19615732,19615732 0004,0007 HT USP12 USP39 19615732,19615732 0004,0007 HT SRSF10 USP39 22939629 0401 HT SF3B1 USP39 22939629 0401 HT SNRNP200 USP39 19615732,19615732 0004,0007 HT PRPF6 USP39 19615732,19615732 0004,0007 HT ZRANB2 USP39 19615732,19615732 0004,0007 HT CD2BP2 USP39 19615732,17353931,19615732,17353931 0004,0006,0007,0004 HT LSM8 USP39 19615732,19615732 0004,0007 HT VTN USP39 22939629 0401 HT TP53 USP39 19615732,19615732 0004,0007 HT JUN USP39 25609649 0006 HT HNRNPC USP39 22939629 0401 HT PCNA USP39 26344197 0401 HT APEH USP39 26344197 0401 HT HSPA4 USP39 26344197 0401 HT CETN2 USP39 22939629 0401 HT NCAPD3 USP39 26344197 0401 HT CSNK1E USP39 26344197 0401 HT ADARB1 USP39 26344197 0401 HT TXNL4A USP39 19615732,19615732 0004,0007 HT CBX1 USP39 19615732 0007 HT ARF1 USP39 26344197 0401 HT SRSF3 USP39 22939629 0401 HT SRSF11 USP39 22939629 0401 HT DHX9 USP39 22939629 0401 HT NSUN2 USP39 26344197 0401 HT GTF3C1 USP39 22939629 0401 HT SRSF5 USP39 22939629 0401 HT PRPF4B USP39 19615732,23602568,19615732,23602568 0004,0004,0007,0676 HT TPBG USP39 22939629 0401 HT RBM39 USP39 22939629 0401 HT SART3 USP39 19615732 0004 HT EFTUD2 USP39 19615732,19615732 0004,0007 HT SAFB USP39 22939629 0401 HT SF3A1 USP39 22939629 0401 HT SRSF7 USP39 22939629 0401 HT Q53GA5 USP39 19615732 0004 HT USP39 PRPF8 19615732,19615732 0004,0007 HT USP39 RPL22L1 19615732,19615732 0004,0007 HT USP39 Q6ZRV7 22939629 0401 HT USP39 TRMT10C 19615732,19615732 0004,0007 HT USP39 MEPCE 17643375 0004 HT USP39 ZC3H18 22939629 0401 HT USP39 CAND1 21145461 0004 HT USP39 NOC3L 19615732,19615732 0004,0007 HT USP39 SNRNP27 19615732,19615732 0004,0007 HT USP39 PRPF31 19615732,19615732 0004,0007 HT USP39 NCSTN 22939629 0401 HT USP39 HSPH1 26344197 0401 HT USP39 DHX38 19615732,19615732 0004,0007 HT USP39 TSR2 19615732,19615732 0004,0007 HT USP39 Q96BA7 22939629 0401 HT USP39 SNRNP40 19615732,19615732 0004,0007 HT USP39 DDX23 19615732,19615732 0004,0007 HT USP39 TRIM55 22939629 0401 HT USP39 DDX24 19615732,19615732 0004,0007 HT USP39 RNMTL1 19615732,19615732 0004,0007 HT USP39 COPRS 19615732,19615732 0004,0007 HT USP39 GAR1 19615732,19615732 0004,0007 HT USP39 PRPF19 26344197 0401 HT USP39 PA2G4 19615732,19615732 0004,0007 HT USP39 Q9UQS6 19738201 0004 HT USP39 RUVBL2 26344197 0401 HT USP39 SF3B6 22939629 0401 HT USP39 SUPT16H 22939629 0401 HT LGALS9 USP39 26344197 0401 LC SRSF10 USP39 22939629 0401 LC SF3B1 USP39 22939629 0401 LC FN1 USP39 19738201 0030 LC VTN USP39 22939629 0401 LC HNRNPC USP39 22939629 0401 LC SP1 USP39 20195357,20195357 0034,0096 LC PCNA USP39 26344197 0401 LC APEH USP39 26344197 0401 LC HSPA4 USP39 26344197 0401 LC CETN2 USP39 22939629 0401 LC NCAPD3 USP39 26344197 0401 LC CSNK1E USP39 26344197 0401 LC SRPK2 USP39 26167880 0415 LC ADARB1 USP39 26344197 0401 LC ARF1 USP39 26344197 0401 LC SRSF3 USP39 22939629 0401 LC ACVR1 USP39 15761153 0019 HT SRSF11 USP39 22939629 0401 LC DHX9 USP39 22939629 0401 LC NSUN2 USP39 26344197 0401 LC GTF3C1 USP39 22939629 0401 LC TRIM26 USP39 23105109 0018 LC USP4 USP39 21415856 0107 LC SRSF5 USP39 22939629 0401 LC TPBG USP39 22939629 0401 LC TRIM25 USP39 23105109 0018 LC RBM39 USP39 22939629 0401 LC SAFB USP39 22939629 0401 LC SF3A1 USP39 22939629 0401 LC SRSF7 USP39 22939629 0401 LC USP39 Q6ZRV7 22939629 0401 LC USP39 ZC3H18 22939629 0401 LC USP39 NCSTN 22939629 0401 LC USP39 HSPH1 26344197 0401 LC USP39 Q96BA7 22939629 0401 LC USP39 SRPK1 23602568,23602568 0415,0424 LC USP39 TRIM55 22939629 0401 LC USP39 TRIM8 23105109 0018 LC USP39 TRIM5 23105109 0018 LC USP39 TRIM39 23105109 0018 LC USP39 SAE1 25027693 0415 LC USP39 PRPF19 26344197 0401 LC USP39 RUVBL2 26344197 0401 LC USP39 SF3B6 22939629 0401 LC USP39 TRAF6 23105109 0018 LC USP39 SUPT16H 22939629 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q53GS9 O00182 USP39 LGALS9 0.081 26344197 Q53GS9 P04004 USP39 VTN 0.081 22939629 Q53GS9 P05067 USP39 APP 0.183 21832049 Q53GS9 P18583 USP39 SON 0.081 22939629 Q53GS9 P78563 USP39 ADARB1 0.081 26344197 Q53GS9 Q08J23 USP39 NSUN2 0.081 26344197 Q53GS9 Q12789 USP39 GTF3C1 0.081 22939629 Q53GS9 Q12899 USP39 TRIM26 0.183 23105109 Q53GS9 Q13107 USP39 USP4 0.309 21415856 Q53GS9 Q13641 USP39 TPBG 0.081 22939629 Q53GS9 Q14258 USP39 TRIM25 0.183 23105109 Q86VM9 Q53GS9 ZC3H18 USP39 0.081 22939629 Q9BYV6 Q53GS9 TRIM55 USP39 0.081 22939629 Q9BZR9 Q53GS9 TRIM8 USP39 0.183 23105109 Q9C035 Q53GS9 TRIM5 USP39 0.183 23105109 Q9HCM9 Q53GS9 TRIM39 USP39 0.183 23105109 Q9Y4K3 Q53GS9 TRAF6 USP39 0.183 23105109 Q9Y5B9 Q53GS9 SUPT16H USP39 0.081 22939629 Q9Y654 Q53GS9 CBX1 USP39 0.126 19615732 Q53GS9 P60484 USP39 PTEN 0.21 24270891 Q9H0W5 Q53GS9 CCDC8 USP39 0.126 24711643 Q9NZC7 Q53GS9 WWOX USP39 0.126 24550385 Q53GS9 P07910 USP39 HNRNPC 0.081 22939629 Q53GS9 O75147 USP39 OBSL1 0.126 24711643 Q9Y230 Q53GS9 RUVBL2 USP39 0.081 26344197 Q53GS9 O75494 USP39 SRSF10 0.081 22939629 Q53GS9 O75533 USP39 SF3B1 0.081 22939629 Q9Y3B4 Q53GS9 SF3B6 USP39 0.081 22939629 Q7L2J0 Q53GS9 MEPCE USP39 0.126 17643375 Q86VP6 Q53GS9 CAND1 USP39 0.126 21145461 Q53GS9 O95400 USP39 CD2BP2 0.416 17353931,19615732 Q53GS9 P13798 USP39 APEH 0.081 26344197 Q53GS9 P04618 USP39 REV 0.183 22174317 Q53GS9 P04629 USP39 NTRK1 0.126 25921289 Q53GS9 P05412 USP39 JUN 0.126 25609649 Q9Z315 Q53GS9 SART1 USP39 0.236 26496610 Q53GS9 P08047 USP39 SP1 0.286 20195357 Q53GS9 P02751 USP39 FN1 0.236 19738201 Q99459 Q53GS9 CDC5L USP39 0.236 20467437 Q99PV0 Q53GS9 PRPF8 USP39 0.236 20360068 Q53GS9 Q13523 USP39 PRPF4B 0.416 23602568,19615732 Q9CQ10 Q53GS9 CHMP3 USP39 0.236 26496610 Q8WVK2 Q53GS9 SNRNP27 USP39 0.236 19615732 Q8WTT2 Q53GS9 NOC3L USP39 0.236 19615732 Q7L0Y3 Q53GS9 TRMT10C USP39 0.236 19615732 Q53GS9 O43159 USP39 RRP8 0.236 19615732 Q6P5R6 Q53GS9 RPL22L1 USP39 0.236 19615732 Q53GS9 O95218 USP39 ZRANB2 0.236 19615732 Q53GS9 O43290 USP39 SART1 0.236 19615732 Q53GS9 O43172 USP39 PRPF4 0.554 26496610,19615732 Q53GS9 O94906 USP39 PRPF6 0.236 19615732 Q53GS9 O43395 USP39 PRPF3 0.236 19615732 Q53GS9 O75643 USP39 SNRNP200 0.236 19615732 Q6P2Q9 Q53GS9 PRPF8 USP39 0.236 19615732 Q53GS9 P04637 USP39 TP53 0.236 19615732 Q53GS9 O95777 USP39 LSM8 0.236 19615732 Q53GS9 Q15029 USP39 EFTUD2 0.236 19615732 Q53GS9 P83876 USP39 TXNL4A 0.236 19615732 Q9HC36 Q53GS9 RNMTL1 USP39 0.236 19615732 Q969E8 Q53GS9 TSR2 USP39 0.236 19615732 Q8WWY3 Q53GS9 PRPF31 USP39 0.236 19615732 Q92620 Q53GS9 DHX38 USP39 0.236 19615732 Q9GZR7 Q53GS9 DDX24 USP39 0.236 19615732 Q96DI7 Q53GS9 SNRNP40 USP39 0.236 19615732 Q9BUQ8 Q53GS9 DDX23 USP39 0.236 19615732 Q9UQ80 Q53GS9 PA2G4 USP39 0.236 19615732 Q9NQ92 Q53GS9 COPRS USP39 0.236 19615732 Q9NY12 Q53GS9 GAR1 USP39 0.236 19615732 Q53GS9 O75317 USP39 USP12 0.236 19615732 Q92598 Q53GS9 HSPH1 USP39 0.081 26344197 Q92542 Q53GS9 NCSTN USP39 0.081 22939629 Q96SB4 Q53GS9 SRPK1 USP39 0.21 23602568 Q96T76 Q53GS9 MMS19 USP39 0.126 22678362 Q9UBE0 Q53GS9 SAE1 USP39 0.309 25027693 Q9UJV9 Q53GS9 DDX41 USP39 0.126 25920683 Q53GS9 P33993 USP39 MCM7 0.126 23764002 Q9UMS4 Q53GS9 PRPF19 USP39 0.081 26344197 Q53GS9 P34932 USP39 HSPA4 0.081 26344197 Q53GS9 P42695 USP39 NCAPD3 0.081 26344197 Q53GS9 P41208 USP39 CETN2 0.081 22939629 Q53GS9 Q13573 USP39 SNW1 0.126 20467437 Q53GS9 P78362 USP39 SRPK2 0.183 26167880 Q53GS9 P84077 USP39 ARF1 0.081 26344197 Q53GS9 Q14498 USP39 RBM39 0.081 22939629 Q53GS9 Q15020 USP39 SART3 0.126 19615732 Q53GS9 Q00839 USP39 HNRNPU 0.081 22939629 Q53GS9 Q15424 USP39 SAFB 0.081 22939629 Q53GS9 Q13243 USP39 SRSF5 0.081 22939629 Q53GS9 Q05519 USP39 SRSF11 0.081 22939629 Q53GS9 Q16629 USP39 SRSF7 0.081 22939629 Q53GS9 Q08211 USP39 DHX9 0.081 22939629

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 U2SURP USP39 MI:0362 inference MI:1106 pathways database POLR2D USP39 MI:0362 inference MI:1106 pathways database DHX15 USP39 MI:0362 inference MI:1106 pathways database RRP8 USP39 MI:0045 experimental interaction detection MI:0461 interaction database PRPF4 USP39 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SART1 USP39 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database HNRNPR USP39 MI:0362 inference MI:1106 pathways database PRPF3 USP39 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PPIH USP39 MI:0362 inference MI:1106 pathways database PLRG1 USP39 MI:0362 inference MI:1106 pathways database NUDT21 USP39 MI:0362 inference MI:1106 pathways database DHX16 USP39 MI:0362 inference MI:1106 pathways database AQR USP39 MI:0362 inference MI:1106 pathways database CDC40 USP39 MI:0362 inference MI:1106 pathways database PQBP1 USP39 MI:0362 inference MI:1106 pathways database OBSL1 USP39 MI:0045 experimental interaction detection MI:0461 interaction database USP12 USP39 MI:0045 experimental interaction detection MI:0461 interaction database PRPF40A USP39 MI:0362 inference MI:1106 pathways database SF3B1 USP39 MI:0362 inference MI:1106 pathways database WBP4 USP39 MI:0362 inference MI:1106 pathways database SNRNP200 USP39 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database BCAS2 USP39 MI:0362 inference MI:1106 pathways database DNAJC8 USP39 MI:0362 inference MI:1106 pathways database SMNDC1 USP39 MI:0362 inference MI:1106 pathways database PRPF6 USP39 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PCF11 USP39 MI:0362 inference MI:1106 pathways database ZRANB2 USP39 MI:0045 experimental interaction detection MI:0461 interaction database CD2BP2 USP39 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CPSF4 USP39 MI:0362 inference MI:1106 pathways database LSM8 USP39 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database WHSC1 USP39 MI:0045 experimental interaction detection MI:0461 interaction database FN1 USP39 MI:0045 experimental interaction detection MI:0461 interaction database NTRK1 USP39 MI:0045 experimental interaction detection MI:0461 interaction database TP53 USP39 MI:0045 experimental interaction detection MI:0461 interaction database APP USP39 MI:0045 experimental interaction detection MI:0461 interaction database JUN USP39 MI:0045 experimental interaction detection MI:0461 interaction database P4HB USP39 MI:0362 inference MI:0461 interaction database HNRNPC USP39 MI:0362 inference MI:1106 pathways database SP1 USP39 MI:0045 experimental interaction detection MI:0461 interaction database ANXA6 USP39 MI:0362 inference MI:0461 interaction database SNRPB2 USP39 MI:0362 inference MI:1106 pathways database SNRNP70 USP39 MI:0362 inference MI:1106 pathways database SNRPA USP39 MI:0362 inference MI:1106 pathways database SNRPC USP39 MI:0362 inference MI:1106 pathways database HNRNPA1 USP39 MI:0362 inference MI:1106 pathways database SNRPA1 USP39 MI:0362 inference MI:1106 pathways database UBC USP39 MI:0045 experimental interaction detection MI:0461 interaction database HSPA1B USP39 MI:0362 inference MI:0461 interaction database HSPA8 USP39 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database GTF2F2 USP39 MI:0362 inference MI:1106 pathways database SNRPB USP39 MI:0362 inference MI:1106 pathways database HNRNPL USP39 MI:0362 inference MI:1106 pathways database HSPA6 USP39 MI:0362 inference MI:0461 interaction database DDX5 USP39 MI:0362 inference MI:1106 pathways database TCP1 USP39 MI:0362 inference MI:0461 interaction database POLR2C USP39 MI:0362 inference MI:1106 pathways database POLR2E USP39 MI:0362 inference MI:1106 pathways database HNRNPA2B1 USP39 MI:0362 inference MI:1106 pathways database POLR2A USP39 MI:0362 inference MI:1106 pathways database U2AF2 USP39 MI:0362 inference MI:1106 pathways database PTBP1 USP39 MI:0362 inference MI:1106 pathways database POLR2B USP39 MI:0362 inference MI:1106 pathways database HNRNPH1 USP39 MI:0362 inference MI:1106 pathways database CSTF2 USP39 MI:0362 inference MI:1106 pathways database MCM7 USP39 MI:0045 experimental interaction detection MI:0461 interaction database HSPA1L USP39 MI:0362 inference MI:0461 interaction database GTF2F1 USP39 MI:0362 inference MI:1106 pathways database FUS USP39 MI:0362 inference MI:1106 pathways database POLR2I USP39 MI:0362 inference MI:1106 pathways database RBMX USP39 MI:0362 inference MI:1106 pathways database EIF4A3 USP39 MI:0362 inference MI:1106 pathways database BUD31 USP39 MI:0362 inference MI:1106 pathways database HNF4A USP39 MI:0045 experimental interaction detection MI:0461 interaction database CEBPA USP39 MI:0362 inference MI:0461 interaction database PAPOLA USP39 MI:0362 inference MI:1106 pathways database HNRNPA3 USP39 MI:0362 inference MI:1106 pathways database HNRNPM USP39 MI:0362 inference MI:1106 pathways database NCBP2 USP39 MI:0362 inference MI:1106 pathways database POLR2H USP39 MI:0362 inference MI:1106 pathways database POLR2J USP39 MI:0362 inference MI:1106 pathways database HNRNPF USP39 MI:0362 inference MI:1106 pathways database RBM5 USP39 MI:0362 inference MI:1106 pathways database HMGA2 USP39 MI:0362 inference MI:0461 interaction database POLR2K USP39 MI:0362 inference MI:1106 pathways database HSPA2 USP39 MI:0362 inference MI:0461 interaction database SNU13 USP39 MI:0362 inference MI:1106 pathways database HNRNPH2 USP39 MI:0362 inference MI:1106 pathways database SUMO3 USP39 MI:0045 experimental interaction detection MI:0461 interaction database PTEN USP39 MI:0045 experimental interaction detection MI:0461 interaction database POLR2F USP39 MI:0362 inference MI:1106 pathways database SUMO2 USP39 MI:0045 experimental interaction detection MI:0461 interaction database HNRNPK USP39 MI:0362 inference MI:1106 pathways database YWHAG USP39 MI:0362 inference MI:0461 interaction database SNRPE USP39 MI:0362 inference MI:1106 pathways database SNRPF USP39 MI:0362 inference MI:1106 pathways database SNRPG USP39 MI:0362 inference MI:1106 pathways database LSM3 USP39 MI:0362 inference MI:1106 pathways database LSM6 USP39 MI:0362 inference MI:1106 pathways database SNRPD1 USP39 MI:0362 inference MI:1106 pathways database SNRPD2 USP39 MI:0362 inference MI:1106 pathways database SNRPD3 USP39 MI:0362 inference MI:1106 pathways database POLR2G USP39 MI:0362 inference MI:1106 pathways database POLR2L USP39 MI:0362 inference MI:1106 pathways database SNRPN USP39 MI:0362 inference MI:1106 pathways database SUMO1 USP39 MI:0045 experimental interaction detection MI:0461 interaction database YBX1 USP39 MI:0362 inference MI:1106 pathways database SRPK2 USP39 MI:0045 experimental interaction detection MI:0461 interaction database TXNL4A USP39 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SRSF3 USP39 MI:0362 inference MI:1106 pathways database HNRNPU USP39 MI:0362 inference MI:1106 pathways database U2AF1 USP39 MI:0362 inference MI:1106 pathways database SRSF2 USP39 MI:0362 inference MI:1106 pathways database UBXN1 USP39 MI:0362 inference MI:0461 interaction database ACVR1 USP39 MI:0045 experimental interaction detection MI:0461 interaction database YWHAH USP39 MI:0362 inference MI:0461 interaction database CSTF1 USP39 MI:0362 inference MI:1106 pathways database SRSF11 USP39 MI:0362 inference MI:1106 pathways database SRSF1 USP39 MI:0362 inference MI:1106 pathways database SRSF4 USP39 MI:0362 inference MI:1106 pathways database DHX9 USP39 MI:0362 inference MI:1106 pathways database NCBP1 USP39 MI:0362 inference MI:1106 pathways database CPSF1 USP39 MI:0362 inference MI:1106 pathways database SF3A3 USP39 MI:0362 inference MI:1106 pathways database TRIM26 USP39 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL2 USP39 MI:0362 inference MI:1106 pathways database CSTF3 USP39 MI:0362 inference MI:1106 pathways database USP4 USP39 MI:0045 experimental interaction detection MI:0461 interaction database HNRNPA0 USP39 MI:0362 inference MI:1106 pathways database SRSF9 USP39 MI:0362 inference MI:1106 pathways database SRSF5 USP39 MI:0362 inference MI:1106 pathways database SRSF6 USP39 MI:0362 inference MI:1106 pathways database SF3B2 USP39 MI:0362 inference MI:1106 pathways database PRPF4B USP39 MI:0045 experimental interaction detection MI:0461 interaction database SNW1 USP39 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database HNRNPD USP39 MI:0362 inference MI:1106 pathways database TRIM25 USP39 MI:0045 experimental interaction detection MI:0461 interaction database CUL7 USP39 MI:0045 experimental interaction detection MI:0461 interaction database SART3 USP39 MI:0045 experimental interaction detection MI:0461 interaction database EFTUD2 USP39 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RNPS1 USP39 MI:0362 inference MI:1106 pathways database PCBP1 USP39 MI:0362 inference MI:1106 pathways database PCBP2 USP39 MI:0362 inference MI:1106 pathways database SF3B3 USP39 MI:0362 inference MI:1106 pathways database SF3B4 USP39 MI:0362 inference MI:1106 pathways database SF3A2 USP39 MI:0362 inference MI:1106 pathways database SF3A1 USP39 MI:0362 inference MI:1106 pathways database ELAVL1 USP39 MI:0362 inference MI:1106 pathways database NEDD8 USP39 MI:0045 experimental interaction detection MI:0461 interaction database SRSF7 USP39 MI:0362 inference MI:1106 pathways database USP39 SUMO4 MI:0362 inference MI:0461 interaction database USP39 PRPF8 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP39 RPL22L1 MI:0045 experimental interaction detection MI:0461 interaction database USP39 FIP1L1 MI:0362 inference MI:1106 pathways database USP39 CWC27 MI:0362 inference MI:1106 pathways database USP39 DDX46 MI:0362 inference MI:1106 pathways database USP39 TRMT10C MI:0045 experimental interaction detection MI:0461 interaction database USP39 MEPCE MI:0045 experimental interaction detection MI:0461 interaction database USP39 PHF5A MI:0362 inference MI:1106 pathways database USP39 PABPN1 MI:0362 inference MI:1106 pathways database USP39 ALYREF MI:0362 inference MI:1106 pathways database USP39 CAND1 MI:0045 experimental interaction detection MI:0461 interaction database USP39 DDX42 MI:0362 inference MI:1106 pathways database USP39 CHERP MI:0362 inference MI:1106 pathways database USP39 SUGP1 MI:0362 inference MI:1106 pathways database USP39 CCAR1 MI:0362 inference MI:1106 pathways database USP39 SRRM1 MI:0362 inference MI:1106 pathways database USP39 CPSF7 MI:0362 inference MI:1106 pathways database USP39 PRPF38A MI:0362 inference MI:1106 pathways database USP39 NOC3L MI:0045 experimental interaction detection MI:0461 interaction database USP39 U2AF1L4 MI:0362 inference MI:1106 pathways database USP39 SNRNP27 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP39 PRPF31 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP39 CTNNBL1 MI:0362 inference MI:1106 pathways database USP39 DHX38 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP39 PRCC MI:0362 inference MI:1106 pathways database USP39 UPF1 MI:0362 inference MI:0461 interaction database USP39 GPKOW MI:0362 inference MI:1106 pathways database USP39 CLP1 MI:0362 inference MI:1106 pathways database USP39 TSR2 MI:0045 experimental interaction detection MI:0461 interaction database USP39 SNRNP40 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP39 RBM17 MI:0362 inference MI:1106 pathways database USP39 SRPK1 MI:0045 experimental interaction detection MI:0461 interaction database USP39 MMS19 MI:0045 experimental interaction detection MI:0461 interaction database USP39 CDC5L MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP39 HNRNPUL1 MI:0362 inference MI:1106 pathways database USP39 DDX23 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database USP39 SF3B5 MI:0362 inference MI:1106 pathways database USP39 SRRT MI:0362 inference MI:1106 pathways database USP39 CRNKL1 MI:0362 inference MI:1106 pathways database USP39 TRIM8 MI:0045 experimental interaction detection MI:0461 interaction database USP39 TRIM5 MI:0045 experimental interaction detection MI:0461 interaction database USP39 DDX24 MI:0045 experimental interaction detection MI:0461 interaction database USP39 CCDC8 MI:0045 experimental interaction detection MI:0461 interaction database USP39 MRM3 MI:0045 experimental interaction detection MI:0461 interaction database USP39 CWC22 MI:0362 inference MI:1106 pathways database USP39 TRIM39 MI:0045 experimental interaction detection MI:0461 interaction database USP39 XAB2 MI:0362 inference MI:1106 pathways database USP39 COPRS MI:0045 experimental interaction detection MI:0461 interaction database USP39 RBM22 MI:0362 inference MI:1106 pathways database USP39 CWC25 MI:0362 inference MI:1106 pathways database USP39 GAR1 MI:0045 experimental interaction detection MI:0461 interaction database USP39 WWOX MI:0045 experimental interaction detection MI:0461 interaction database USP39 CWC15 MI:0362 inference MI:1106 pathways database USP39 CPSF2 MI:0362 inference MI:1106 pathways database USP39 SAE1 MI:0045 experimental interaction detection MI:0461 interaction database USP39 PUF60 MI:0362 inference MI:1106 pathways database USP39 DDX41 MI:0045 experimental interaction detection MI:0461 interaction database USP39 LSM7 MI:0362 inference MI:1106 pathways database USP39 CPSF3 MI:0362 inference MI:1106 pathways database USP39 ISY1 MI:0362 inference MI:1106 pathways database USP39 PRPF19 MI:0362 inference MI:1106 pathways database USP39 PPIE MI:0362 inference MI:1106 pathways database USP39 SRRM2 MI:0362 inference MI:1106 pathways database USP39 PA2G4 MI:0045 experimental interaction detection MI:0461 interaction database USP39 WBP11 MI:0362 inference MI:1106 pathways database USP39 LSM2 MI:0362 inference MI:1106 pathways database USP39 SF3B6 MI:0362 inference MI:1106 pathways database USP39 PPIL1 MI:0362 inference MI:1106 pathways database USP39 CHMP3 MI:0362 inference MI:0461 interaction database USP39 TRAF6 MI:0045 experimental interaction detection MI:0461 interaction database USP39 LSM5 MI:0362 inference MI:1106 pathways database USP39 LSM4 MI:0362 inference MI:1106 pathways database