PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HIC1 HIC2 11554746 biogrid,intact exp G GP P G G GP GP GP G G GP P G P G P G P GP GP G GP G HIC2 BARD1 22990118 biogrid exp P G GP P P GP P P G G GP P G P P GP P GP P G GP GP G HIC2 CDC5L 20467437 intact exp GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G APP HIC2 21832049 biogrid exp G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP G JUN HIC2 25609649 intact exp GP GP G G G GP G G GP G GP G GP G G GP GP G G G GP G GP G GP G GP G G HIC2 HIC2 11554746 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G HIC2 FOXJ2 25609649 intact exp GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP G GP GP GP G GP GP G PDK2 HIC2 16169070 hprd,i2d,mint,intact exp GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G FOXA3 HIC2 25609649 intact exp P P G GP P P GP P G P GP P GP P P P P GP GP P HIC2 FOXQ1 25609649 intact exp GP G G G GP G GP GP G GP G GP G G GP GP G G G GP GP GP G GP G GP GP G HIC2 FOXB1 25609649 intact exp CCNT1 HIC2 12944466 hprd,bci exp GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G CTBP1 HIC2 26186194 biogrid exp GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G LIG4 HIC2 22990118 biogrid exp GP GP G G GP GP G GP GP G GP G GP G G GP GP P G P GP P GP GP G GP GP YWHAE HIC2 ortho GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G HIC2 ZBTB32 23023127 pred P P P P P P P P P GP BCL6B HIC2 23023127 pred GP GP G G G G G GP GP G GP G G G G GP G G G G G G G G GP G GP GP G HIC2 HDAC9 21836163 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP GP G P GP GP GP GP G GP GP G ZBTB38 HIC2 23023127 pred GP GP G G G GP G GP G G G G G G G G GP G G G G GP G G G G GP GP G HIC2 BTBD6 23023127 pred G G G G GP G G G GP G G G G G G GP G G G G G G G GP GP G G G G ZBTB14 HIC2 23023127, 16082366 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP G P G GP GP GP G GP G GP P BACH1 HIC2 23023127 pred GP GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G ZBTB7A HIC2 23023127 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G ZBTB17 HIC2 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G CUX1 HIC2 23023127 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G VHL HIC2 23023127 pred G G G G G G G G G G GP G GP G G G G G P G G GP GP G G G G GP G HIC2 IKZF4 23023127 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G HIC2 NACC1 23023127 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G HIVEP1 HIC2 23023127 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP G P G GP GP GP GP GP G GP GP G ZBTB16 HIC2 23023127 pred G GP G G G GP G G GP G G G GP G G GP GP G GP G G GP GP G GP G G GP G HIC2 KLHL11 23023127 pred P P P P P P P P P P P P P P GP HIC2 ZBTB18 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BCL6 HIC2 23023127, 16082366 pred G G G G GP G G G G G G G G G G G G G G G GP G G G G G G G G CTNNB1 HIC2 25402006 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q99728 Q96JB3 affinity chromatography technology 22990118 physical association X 2 A0A024RE06 Q96JB3 affinity chromatography technology 22990118 physical association X 2 Q96JB3 A0PJI1 two hybrid 11554746 direct interaction X 2 Q96JB3 A0PJI1 imaging technique 11554746 colocalization X 2 Q96JB3 P05067-7 pull down 21832049 direct interaction X 2 Q96JB3 Q96JB3 two hybrid 11554746 direct interaction X 2 Q96JB3 O60563 two hybrid 12944466 - X 2 Q96JB3 O60563 in vivo 12944466 - X 2 Q96JB3 O60563 in vivo 12944466 - X 2 Q96JB3 O60563 two hybrid 12944466 - X 2 Q96JB3 Q15119 two hybrid 16169070 - X 2 Q96JB3 Q15119 two hybrid 16169070 - X 2 Q2I360 Q96JB3 two hybrid 16534844 physical association X 2 Q14526 Q96JB3 two hybrid 11554746 physical association X 2 Q14526 Q96JB3 imaging technique 11554746 colocalization X 2 Q96JB3 Q96JB3 two hybrid 11554746 physical association X 2 Q96JB3 Q15119 two hybrid pooling approach 16169070 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B APP HIC2 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_228471 prey bait HIC1 HIC2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 11554746 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid)|(intact)|(intact)|(intact) BIOGRID_257766|BIOGRID_257765|UniProt_67760|UniProt_67758|UniProt_67759 bait|bait|neutral component|bait|neutral component prey|prey|null|prey|null PDK2 HIC2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0492(in vitro) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- MI:0471(mint)|MI:0471(mint)|(intact)|MI:0468(hprd) MINT_34415|MINT_63371|UniProt_157055|HPRD_29089 bait|bait|bait|- prey|prey|prey|- HIC2 BARD1 MI:0004(affinity chromatography technology) 22990118 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_245556 prey bait LIG4 HIC2 MI:0004(affinity chromatography technology) 22990118 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_246060 bait prey CCNT1 HIC2 MI:0493(in vivo) 12944466 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_10951 - -

PPI - HINT Gene A Gene B PMID Method Quality JUN HIC2 25609649 0006 HT FOXA3 HIC2 25609649,25609649 0676,0004 HT CTBP1 HIC2 26186194 0004 HT HIC2 FOXB1 25609649,25609649 0676,0004 HT HIC2 FOXQ1 25609649,25609649 0676,0004 HT HIC2 FOXJ2 25609649,25609649 0676,0004 HT JUN HIC2 25609649 0006 HT FOXA3 HIC2 25609649,25609649 0676,0004 HT CTBP1 HIC2 26186194 0004 HT HIC2 FOXB1 25609649,25609649 0676,0004 HT HIC2 FOXQ1 25609649,25609649 0676,0004 HT HIC2 FOXJ2 25609649,25609649 0676,0004 HT CCNT1 HIC2 12944466 0018 LC HIC1 HIC2 11554746,11554746 0428,0018 LC PDK2 HIC2 16169070,16169070 0018,0398 HT HIC2 HIC2 11554746 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96JB3 P05412 HIC2 JUN 0.126 25609649 Q9P0K8 Q96JB3 FOXJ2 HIC2 0.236 25609649 Q96JB3 Q8NHQ1 HIC2 CEP70 0.236 unassigned1304 Q96JB3 Q96BR9 HIC2 ZBTB8A 0.236 unassigned1304 Q96KQ7 Q96JB3 EHMT2 HIC2 0.236 unassigned1304 Q96JB3 Q14526 HIC2 HIC1 0.396 11554746 Q99853 Q96JB3 FOXB1 HIC2 0.236 25609649 Q9C009 Q96JB3 FOXQ1 HIC2 0.236 25609649 Q96JB3 A0A0G2JQ02 HIC2 A0A0G2JQ02 0.236 unassigned1304 Q96JB3 P55318 HIC2 FOXA3 0.236 25609649 Q96JB3 P05067 HIC2 APP 0.183 21832049 Q96JB3 Q15119 HIC2 PDK2 0.126 16169070 Q96JB3 Q2I360 HIC2 Q2I360 0.309 16534844 Q96JB3 Q96JB3 HIC2 HIC2 0.332 11554746 Q99728 Q96JB3 BARD1 HIC2 0.126 22990118 Q99459 Q96JB3 CDC5L HIC2 0.126 20467437 Q96JB3 P49917 HIC2 LIG4 0.126 22990118 Q96JB3 Q13363 HIC2 CTBP1 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 APP HIC2 MI:0045 experimental interaction detection MI:0461 interaction database JUN HIC2 MI:0045 experimental interaction detection MI:0461 interaction database LIG4 HIC2 MI:0045 experimental interaction detection MI:0461 interaction database FOXA3 HIC2 MI:0045 experimental interaction detection MI:0461 interaction database CTBP1 HIC2 MI:0045 experimental interaction detection MI:0461 interaction database HIC1 HIC2 MI:0045 experimental interaction detection MI:0461 interaction database PDK2 HIC2 MI:0045 experimental interaction detection MI:0461 interaction database NEDD8 HIC2 MI:0045 experimental interaction detection MI:0461 interaction database HIC2 CDC5L MI:0045 experimental interaction detection MI:0461 interaction database HIC2 BARD1 MI:0045 experimental interaction detection MI:0461 interaction database HIC2 FOXB1 MI:0045 experimental interaction detection MI:0461 interaction database HIC2 FOXQ1 MI:0045 experimental interaction detection MI:0461 interaction database HIC2 FOXJ2 MI:0045 experimental interaction detection MI:0461 interaction database HIC2 ELF5 MI:0362 inference MI:0461 interaction database