Disease associated variation - GWASdb Chr Pos SNP ID(dbSNP 142) Ref Alt Ori SNP ID P-value Drug Name Drug Anno GWAS Trait HPO ID DO ID AA Type Trait or Drug 4 16648246 rs3763969 C T rs3763969 0.000449 METHIONINE CASPASE 1|CASPASE 9|CASP9 PROTEIN, HUMAN|5'-METHYLTHIOADENOSINE|APIP PROTEIN, HUMAN|DEOXYADENOSINES|THIONUCLEOSIDES|APOPTOSIS REGULATORY PROTEINS Salmonella-induced pyroptosis NA NA C intron GWASdb_drug 4 16892585 rs1483009 C A rs1483009 3.13E-04 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 A intron GWASdb_drug 4 16892585 rs1483009 C A rs1483009 5.05E-04 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 A intron GWASdb_drug 4 16514408 rs955943 C T rs955943 5.00E-06 Rhegmatogenous retinal detachment HPOID:0012230 DOID:5327|DOID:5328 G intron GWASdb_trait 4 16524379 rs11732672 C T rs11732672 7.67E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 T intron GWASdb_trait 4 16526736 rs4698491 A G rs4698491 3.71E-05 Serum metabolites HPOID:0011111 NA G intron GWASdb_trait 4 16535471 rs16893604 T C rs16893604 3.33E-04 Type 2 diabetes HPOID:0005978 DOID:9352 T intron GWASdb_trait 4 16554347 rs13134676 G C rs13134676 8.50E-07 Urinary metabolites HPOID:0000079 DOID:557 C intron GWASdb_trait 4 16585917 rs4072813 A C rs4072813 2.38E-06 Blood Pressure HPOID:0011025 DOID:10763 A intron GWASdb_trait 4 16587201 rs7669580 C T rs7669580 3.06E-06 Blood Pressure HPOID:0011025 DOID:10763 T intron GWASdb_trait 4 16610699 rs10939676 A C rs10939676 9.06E-04 Coronary Artery Disease HPOID:0001677 DOID:3393 A intron GWASdb_trait 4 16641790 rs4698501 A T rs4698501 3.20E-05 Sarcoidosis HPOID:0012220 DOID:11335 T intron GWASdb_trait 4 16648246 rs3763969 C T rs3763969 0.000449 Salmonella-induced pyroptosis NA NA C intron GWASdb_trait 4 16656578 rs13110156 C G rs13110156 5.08E-04 Type 2 diabetes HPOID:0005978 DOID:9352 C intron GWASdb_trait 4 16668043 rs6449262 G A rs6449262 8.06E-04 Myocardial Infarction HPOID:0001658 DOID:5844 G,A intron GWASdb_trait 4 16671794 rs16893733 T C rs16893733 8.29E-04 Multiple complex diseases HPOID:0000118 NA T intron GWASdb_trait 4 16677019 rs17492017 G A rs17492017 9.44E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 G intron GWASdb_trait 4 16677019 rs17492017 G A rs17492017 9.88E-05 Body Composition HPOID:0001513|HPOID:0001627 DOID:9970|DOID:114 G intron GWASdb_trait 4 16677019 rs17492017 G A rs17492017 7.93E-06 Body Mass Index HPOID:0001507 DOID:9970 G intron GWASdb_trait 4 16679965 rs6837229 A T rs6837229 9.55E-04 Multiple complex diseases HPOID:0000118 NA A intron GWASdb_trait 4 16681543 rs7692454 T C rs7692454 9.83E-05 Body Mass Index HPOID:0001507 DOID:9970 T intron GWASdb_trait 4 16698184 rs283029 A C rs283029 6.58E-05 Body Composition HPOID:0001513|HPOID:0001627 DOID:9970|DOID:114 C intron GWASdb_trait 4 16698184 rs283029 A C rs283029 9.70E-06 Body Mass Index HPOID:0001507 DOID:9970 C intron GWASdb_trait 4 16724354 rs1399364 C T rs1399364 7.44E-04 Multiple complex diseases HPOID:0000118 NA C intron GWASdb_trait 4 16724803 rs1995614 C G rs1995614 7.87E-04 Insulin resistance HPOID:0000855 DOID:9352 C intron GWASdb_trait 4 16726650 rs16893890 G A rs16893890 8.20E-04 Myocardial Infarction HPOID:0001658 DOID:5844 G intron GWASdb_trait 4 16733397 rs16893898 C T rs16893898 3.14E-04 Insulin resistance HPOID:0000855 DOID:9352 C intron GWASdb_trait 4 16736755 rs283025 C T rs283025 7.93E-05 Body Mass Index HPOID:0001507 DOID:9970 A intron GWASdb_trait 4 16744084 rs883086 T G rs883086 5.34E-04 Multiple complex diseases HPOID:0000118 NA T intron GWASdb_trait 4 16744084 rs883086 T G rs883086 1.34E-05 Amyotrophic lateral sclerosis (sporadic) HPOID:0007354 DOID:332 T intron GWASdb_trait 4 16778287 rs157613 C T rs157613 4.13E-117 Multiple complex diseases HPOID:0000118 NA A intron GWASdb_trait 4 16806252 rs16894028 A G rs16894028 3.26E-04 Multiple complex diseases HPOID:0000118 NA A intron GWASdb_trait 4 16834490 rs207709 A G rs207709 6.00E-05 Prostate cancer HPOID:0012125 DOID:10283 A,G intron GWASdb_trait 4 16842716 rs12503223 G A rs12503223 5.26E-07 Lung adenocarcinoma HPOID:0100526 DOID:3910 A,G intron GWASdb_trait 4 16892585 rs1483009 C A rs1483009 3.13E-04 Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 A intron GWASdb_trait 4 16892585 rs1483009 C A rs1483009 5.05E-04 Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 A intron GWASdb_trait 4 16893893 rs1483012 G A rs1483012 7.00E-06 QT interval HPOID:0012232|HPOID:0001657 DOID:10273|DOID:2843 A intron GWASdb_trait 4 16899946 rs7690911 A G rs7690911 9.91E-04 Stroke HPOID:0001297 DOID:6713 A intron GWASdb_trait

Disease associated variation - OMIM Ensembl_gene_ID Approved Gene Symbol MIM Number ENSG00000169744.12 LDB2 603450