PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CNBP TRIM56 17353931 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G TMEM173 TRIM56 25505063,21074459 innatedb,biogrid exp GP G G G GP GP G GP GP G G G GP GP G G GP G GP G GP GP G G GP GP GP G TRIM56 MOV10 22658674 biogrid exp G G G G G G G G G G G G G G G G G G G G G G TRIM56 ING4 26496610 biogrid,intact exp GP GP G G GP GP G GP G G GP G GP GP G GP GP GP P G GP GP G P GP GP GP GP G RNF2 TRIM56 24457600 biogrid exp P P P P GP P P P P P P P P P P HSP90AB1 TRIM56 25036637,22939624 intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G P GP GP GP GP G MYH9 TRIM56 26496610 biogrid,intact exp GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP G P GP G GP GP G USP43 TRIM56 26496610 biogrid,intact exp GP P G G GP GP P P G P G GP P G GP GP GP GP GP GP G P GP P GP GP TICAM1 TRIM56 22948160 innatedb,biogrid exp GP GP G P G GP GP GP G GP GP G GP P GP GP GP GP G P GP GP GP P G APC TRIM56 20936779 i2d exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G P GP G P GP GP GP GP ILF2 TRIM56 22939629 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G P GP GP GP GP G UBE2H TRIM56 19690564 biogrid,intact exp GP GP G G GP GP G GP G G GP G GP GP G GP GP GP GP G GP GP G P GP GP GP GP G ILF3 TRIM56 22939629 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G P GP GP GP GP G SPC24 TRIM56 26496610 biogrid,intact exp P P G GP P P P GP P P P P P PTGES3 TRIM56 25036637 intact exp GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP G GP GP GP GP G TRIM56 SUGT1 25036637 intact exp G G G G G G G GP GP G GP G G G G GP G G GP G G G G P GP G GP GP G CEP128 TRIM56 26638075 biogrid,intact exp P P G GP P P P P P P P P P P P P P P P GP FKBP5 TRIM56 25036637 intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G P GP GP GP GP G TRIM56 LSM2 22939629 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G P GP GP GP GP G IFI16 TRIM56 25693804 biogrid exp G G G G GP GP G G GP G GP G G GP G G GP GP G G G G G G GP G G G HSP90AA1 TRIM56 25036637,22939624 biogrid,intact exp GP GP G G G GP G G GP G G G G G G G GP G G G GP G G G G G GP G TRIM56 FOXP3 ortho G G G P P G G P P YWHAE TRIM56 ortho GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G P GP GP GP GP G YWHAH TRIM56 ortho GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP GP G P GP GP GP GP G TRIM21 TRIM56 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G P GP GP GP GP G TRIM73 TRIM56 23023127 pred GP G G G G GP G GP GP G GP G G G G GP GP G P G P GP G P GP G GP G G UBE2L6 TRIM56 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP G GP GP GP GP G TRIM56 RNF114 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G P GP GP GP GP G TRIM56 TRAF6 23023127 pred GP GP G G GP G G GP GP G GP G GP G G GP G GP G G GP GP G GP GP GP GP G UBE2F TRIM56 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP G P GP GP GP GP G UBE2B TRIM56 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D1 TRIM56 23023127 pred GP G G G GP GP G G GP G GP G GP GP G G GP GP GP G GP GP G P G GP GP GP G BARD1 TRIM56 23023127 pred P G GP P P GP P P GP G GP P G P P GP P P GP GP GP G CUL4A TRIM56 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL5 TRIM56 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G P GP GP GP GP G TRIM56 MRC2 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G G GP G P GP GP GP GP G CETN3 TRIM56 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP G P GP GP GP GP G UBE2A TRIM56 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2C TRIM56 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G P GP GP GP GP G UBE2N TRIM56 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP G P GP GP GP GP G TRIM56 TRIM6 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G RNF135 TRIM56 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP G P GP G GP GP G TRIM56 UBE2T 23023127 pred G G G GP G GP P P P GP GP P GP P GP P GP G TRIM56 UBE2D4 23023127 pred GP G G G GP GP G G GP G GP G GP GP G G GP GP GP G GP GP G P G GP GP GP G PDLIM4 TRIM56 23023127 pred GP GP G P GP G GP GP G GP GP G G GP GP G GP G G G G GP GP GP G G TRIM56 AUP1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G P GP GP GP GP G TRIM22 TRIM56 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G P GP GP GP GP G CUL1 TRIM56 23023127 pred GP G G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP G P GP GP GP GP G UBE2G1 TRIM56 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G P GP GP GP GP G C1S TRIM56 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G CAPNS1 TRIM56 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G GP GP GP GP G TGFB1I1 TRIM56 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G G P GP GP GP GP G CHFR TRIM56 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2S TRIM56 23023127 pred G G G G G G G G GP G G G GP G G G G G G G G G G GP G RNF149 TRIM56 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP GP GP G G GP G P GP G GP GP G DTX3L TRIM56 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP G G GP G G P GP GP GP GP G UBE2NL TRIM56 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G C1R TRIM56 23023127 pred G G G G GP GP G G G G GP G GP GP G GP GP GP GP G G GP G GP GP G GP G UBE2D3 TRIM56 23023127 pred GP G G G GP GP G G GP G GP G GP GP G G GP GP GP G GP GP G P G GP GP GP G UBE2I TRIM56 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G GP GP GP GP G CETN2 TRIM56 23023127 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP GP G GP G GP GP G PXN TRIM56 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP G GP GP G GP G ZNF217 TRIM56 23023127 pred GP GP G G G P G GP GP GP G GP GP G GP P GP GP G GP GP G P GP G GP GP G TNFRSF1A TRIM56 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G P GP GP GP GP G HEATR2 TRIM56 23023127 pred G GP G G GP GP G G GP G GP G GP G G G GP G G G G G G G G G GP G TRIM47 TRIM56 23023127 pred GP P G P GP G GP GP G GP G GP GP G GP GP G GP P GP G GP GP GP G LIMS1 TRIM56 23023127 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G P GP GP GP GP G CUL4B TRIM56 23023127 pred GP GP G G GP GP G GP GP G GP G G GP G GP GP G GP G GP GP G P GP GP GP GP G IRF3 TRIM56 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G GP GP GP GP G LPP TRIM56 23023127 pred GP G G G G GP G GP GP G GP G G G G GP GP GP G G GP G G P GP G GP G G UBE2D2 TRIM56 23023127 pred GP G G G GP GP G G GP G GP G GP GP G G GP GP GP G GP GP G P G GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8IUC6 Q9BRZ2 affinity chromatography technology 22948160 physical association X 2 Q8IUC6 Q9BRZ2 affinity chromatography technology 22948160 physical association X 2 Q9BRZ2 O15205 affinity chromatography technology 22797925 physical association X 2 Q9BRZ2 Q9Y333 biochemical 22939629 colocalization X 2 Q9BRZ2 P07900-2 affinity chromatography technology 22939624 physical association X 2 Q9BRZ2 Q99496 affinity chromatography technology 24457600 physical association X 2 F4ZW62 Q9BRZ2 biochemical 22939629 colocalization X 2 Q9BRZ2 biochemical 22939629 colocalization X 2 Q9BRZ2 two hybrid 19690564 direct interaction X 2 Q9BRZ2 Q86WV6 affinity chromatography technology 21074459 physical association X 2 P0CG48 Q9BRZ2 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q9BRZ2 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q9BRZ2 affinity chromatography technology 24816145 physical association X 2 P0CG48 Q9BRZ2 affinity chromatography technology 25147182 physical association X 2 P0CG48 Q9BRZ2 affinity chromatography technology 21139048 physical association X 2 Q9BRZ2 tandem affinity purification 22810585 association C 7 Q9BRZ2 tandem affinity purification 22810585 association C 8 Q9BRZ2 tandem affinity purification 22810585 association C 4 Q9F286 Q9BRZ2 two hybrid pooling approach 20711500 physical association X 2 Q9BRZ2 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2 Q9BRZ2 Q6PK50 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q9BRZ2 P62633 anti bait coimmunoprecipitation 17353931 physical association X 2 Q9BRZ2 A4D1L5 two hybrid array 19690564 physical association X 2 Q9BRZ2 Q13451 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q9BRZ2 K9JA46 luminescence based mammalian interactome mapping 25036637 physical association X 2 A0A024RB32 Q9BRZ2 luminescence based mammalian interactome mapping 25036637 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ILF2 TRIM56 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237235 bait prey ILF3 TRIM56 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_242319 bait prey HSP90AB1 TRIM56 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125114 prey bait UBC TRIM56 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_170289|BIOGRID_268940|BIOGRID_225224 bait|bait|bait prey|prey|prey TRIM56 LSM2 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236767 prey bait TMEM173 TRIM56 MI:0004(affinity chromatography technology) 21074459 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_142201 prey bait CNBP TRIM56 MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_145074 bait prey TICAM1 TRIM56 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22948160 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_208539|BIOGRID_208540 prey|bait bait|prey UBD TRIM56 MI:0004(affinity chromatography technology) 22797925 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226468 bait prey RNF2 TRIM56 MI:0004(affinity chromatography technology) 24457600 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_306879 bait prey HSP90AA1 TRIM56 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255376 bait prey UBE2H TRIM56 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102577|BIOGRID_123588 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality MYH9 TRIM56 26496610,26496610 0007,0004 HT CNBP TRIM56 17353931 0006 HT ILF3 TRIM56 22939629 0401 HT Q53FG3 TRIM56 22939629 0401 HT CEP128 TRIM56 26638075,26638075 1314,1313 HT USP43 TRIM56 26496610,26496610 0007,0004 HT SPC24 TRIM56 26496610,26496610 0007,0004 HT TRIM56 ING4 26496610,26496610 0007,0004 HT TRIM56 LSM2 22939629 0401 HT MYH9 TRIM56 26496610,26496610 0007,0004 HT CNBP TRIM56 17353931 0006 HT ILF3 TRIM56 22939629 0401 HT Q53FG3 TRIM56 22939629 0401 HT CEP128 TRIM56 26638075,26638075 1314,1313 HT USP43 TRIM56 26496610,26496610 0007,0004 HT SPC24 TRIM56 26496610,26496610 0007,0004 HT TRIM56 ING4 26496610,26496610 0007,0004 HT TRIM56 LSM2 22939629 0401 HT B4DYC6 TRIM56 25036637 0729 HT HSP90AA1 TRIM56 25036637 0729 HT HSP90AB1 TRIM56 25036637,22939624 0729,0729 HT UBE2H TRIM56 19690564,19690564 0397,0018 HT ILF3 TRIM56 22939629 0401 LC FKBP5 TRIM56 25036637 0729 HT PTGES3 TRIM56 25036637 0729 HT Q53FG3 TRIM56 22939629 0401 LC TRIM56 LSM2 22939629 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9BRZ2 B4DYC6 TRIM56 B4DYC6 0.126 25036637 Q9BRZ2 Q5U8Y3 TRIM56 Q5U8Y3 0.126 22810585 Q9HCE1 Q9BRZ2 MOV10 TRIM56 0.126 22658674 Q9BRZ2 Q8VC31 TRIM56 CCDC9 0.126 26496610 Q9Y333 Q9BRZ2 LSM2 TRIM56 0.081 22939629 Q9BRZ2 P08238 TRIM56 HSP90AB1 0.126 22939624 Q9UNL4 Q9BRZ2 ING4 TRIM56 0.236 26496610 Q9BRZ2 Q8NBT2 TRIM56 SPC24 0.236 26496610 Q9D3R3 Q9BRZ2 CEP72 TRIM56 0.236 26496610 Q9BRZ2 P35579 TRIM56 MYH9 0.236 26496610 Q9BRZ2 Q6ZU80 TRIM56 CEP128 0.236 26638075 Q9BRZ2 Q70EL4 TRIM56 USP43 0.236 26496610 Q9BRZ2 Q8C8M1 TRIM56 FAM60A 0.236 26496610 Q9BRZ2 P60330 TRIM56 ESPL1 0.236 26496610 Q9BRZ2 P62256 TRIM56 UBE2H 0.286 19690564 Q9BRZ2 P07900 TRIM56 HSP90AA1 0.236 22939624,25036637 Q9BRZ2 P62633 TRIM56 CNBP 0.126 17353931 Q9BRZ2 Q13451 TRIM56 FKBP5 0.126 25036637 Q9BRZ2 Q15185 TRIM56 PTGES3 0.126 25036637 Q9BRZ2 Q4G0A6 TRIM56 FAM188B 0.126 unassigned1312 Q9BRZ2 Q6PK50 TRIM56 HSP90AB1 0.126 25036637 Q9BRZ2 Q86WV6 TRIM56 TMEM173 0.21 21074459 Q9BRZ2 Q8IUC6 TRIM56 TICAM1 0.376 22948160 Q9BSE5 Q9BRZ2 AGMAT TRIM56 0.126 unassigned1312 Q9BRZ2 Q99496 TRIM56 RNF2 0.126 24457600 Q9F286 Q9BRZ2 YAPG TRIM56 0.126 20711500 Q9BRZ2 D2CFJ1 TRIM56 D2CFJ1 0.126 22810585 Q9BRZ2 D6RFU6 TRIM56 D6RFU6 0.126 26496610 Q9BRZ2 Q12905 TRIM56 ILF2 0.081 22939629 Q9BRZ2 Q12906 TRIM56 ILF3 0.081 22939629 Q9BRZ2 Q16666 TRIM56 IFI16 0.126 25693804 Q9BRZ2 A9YDK9 TRIM56 NPRO 0.126 22810585

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBD TRIM56 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 TRIM56 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 TRIM56 MI:0045 experimental interaction detection MI:0461 interaction database UBB TRIM56 MI:0362 inference MI:1106 pathways database UBC TRIM56 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database MYH9 TRIM56 MI:0045 experimental interaction detection MI:0461 interaction database YWHAG TRIM56 MI:0362 inference MI:0461 interaction database UBE2H TRIM56 MI:0045 experimental interaction detection MI:0461 interaction database CNBP TRIM56 MI:0045 experimental interaction detection MI:0461 interaction database RPS27A TRIM56 MI:0362 inference MI:1106 pathways database UBA52 TRIM56 MI:0362 inference MI:1106 pathways database YWHAH TRIM56 MI:0362 inference MI:0461 interaction database TRIM32 TRIM56 MI:0362 inference MI:1106 pathways database FKBP5 TRIM56 MI:0045 experimental interaction detection MI:0461 interaction database ESPL1 TRIM56 MI:0362 inference MI:0461 interaction database PTGES3 TRIM56 MI:0045 experimental interaction detection MI:0461 interaction database IFI16 TRIM56 MI:0045 experimental interaction detection MI:0461 interaction database CEP128 TRIM56 MI:0045 experimental interaction detection MI:0461 interaction database USP43 TRIM56 MI:0045 experimental interaction detection MI:0461 interaction database TMEM173 TRIM56 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TICAM1 TRIM56 MI:0045 experimental interaction detection MI:0461 interaction database SPC24 TRIM56 MI:0045 experimental interaction detection MI:0461 interaction database RNF2 TRIM56 MI:0045 experimental interaction detection MI:0461 interaction database TRIM56 FOXP3 MI:0362 inference MI:0461 interaction database TRIM56 MOV10 MI:0045 experimental interaction detection MI:0461 interaction database TRIM56 FAM60A MI:0362 inference MI:0461 interaction database TRIM56 CEP72 MI:0362 inference MI:0461 interaction database TRIM56 ING4 MI:0045 experimental interaction detection MI:0461 interaction database TRIM56 CCDC9 MI:0362 inference MI:0461 interaction database