Disease associated variation - GWASdb Chr Pos SNP ID(dbSNP 142) Ref Alt Ori SNP ID P-value Drug Name Drug Anno GWAS Trait HPO ID DO ID AA Type Trait or Drug 1 20209469 rs12124726 A C rs12124726 2.55E-08 Sickle cell anemia (severity) HPOID:0008346 DOID:10923 A intron GWASdb_trait 1 20213087 rs4654910 C A rs4654910 4.70E-05 Longevity HPOID:0000118 NA C intron GWASdb_trait 1 20222500 rs1339717 G A rs1339717 8.52E-04 Alzheimer's disease HPOID:0002511 DOID:10652 C intron GWASdb_trait 1 20227723 rs4654925 G C,T rs4654925 9.00E-22 Ulcerative colitis HPOID:0100279 DOID:8577 G intron GWASdb_trait 1 20227723 rs4654925 G C,T rs4654925 9.00E-22 Multiple sclerosis HPOID:0000096|HPOID:0001967|HPOID:0009741|HPOID:0008664|HPOID:0001150|HPOID:0005450|HPOID:0005652|HPOID:0005686|HPOID:0005789|HPOID:0100923|HPOID:0100925|HPOID:0006623|HPOID:0100861|HPOID:0002694|HPOID:0004979|HPOID:0003881|HPOID:0003991|HPOID:0003854|HPOID:0003933|HPOID:0004030|HPOID:0100899|HPOID:0002634 DOID:2377 G intron GWASdb_trait 1 20233086 rs10916668 G A rs10916668 7.82E-05 Pulmonary function HPOID:0002795 DOID:2841|DOID:3083 G missense GWASdb_trait 1 20237760 rs10492999 A G rs10492999 7.83E-05 Pulmonary function HPOID:0002795 DOID:2841|DOID:3083 A UTR-3 GWASdb_trait 1 20238343 rs1046548 A G rs1046548 9.66E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 G UTR-3 GWASdb_trait 1 20238466 rs17401847 A G rs17401847 1.35E-05 Longevity HPOID:0000118 NA A UTR-3 GWASdb_trait

Disease associated variation - GWAS Central Study Name Source Marker Accession Chromosome Marker Start Marker Stop Alleles Gene Section P-value -log(p-value) GWAS of prostate cancer rs12124726 1 20209469 20209469 intronic 0.523844 0.280798026043169 GWAS of prostate cancer rs1339717 1 20222500 20222500 intronic 0.404229 0.393372532759882 GWAS of prostate cancer rs1046548 1 20238343 20238343 UTR3 0.321524 0.492786603832936 GWAS of prostate cancer rs10492999 1 20237760 20237760 UTR3 0.089064 1.05029780393961 GWAS of prostate cancer rs10916668 1 20233086 20233086 exonic 0.08812 1.0549255115212701

Disease associated variation - OMIM Ensembl_gene_ID Approved Gene Symbol MIM Number ENSG00000169914.5 OTUD3 611758