PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus USP47 URM1 21209336 dip exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NTRK1 USP47 25921289 biogrid exp P P P G P P P P P P P P P P P P P P P MYZAP USP47 26186194 biogrid exp P P P P P P P P P P P P P P P RBPJ USP47 25609649 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HOGA1 USP47 26186194 biogrid exp GP GP G P GP GP P G GP GP P G G P GP P P G P P P P P P P G USP47 OBFC1 26186194 biogrid exp GP G G G G GP G GP GP G GP G G G G GP GP G G G GP GP GP G GP G G GP G USP47 FBXW11 19966869,25515538,25332235,19615732,25900982,25609649,22017875 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AP4M1 USP47 25416956 biogrid,intact exp G G G G G G G G USP47 KIFC3 25253721 biogrid exp G G G G G G G G GP G GP GP G GP G GP G G GP G GP GP G GP GP GP GP G USP47 GMPPB 22863883 biogrid exp P P P P P P P P P P P P P P P P P P P P P UBXN1 USP47 26186194 biogrid exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G WDR44 USP47 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G KATNA1 USP47 23904609 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP G GP GP GP G GP GP G PSMD5 USP47 26344197 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP47 MED29 14576168 hprd exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G USP47 HDAC6 23752268 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G USP47 MED9 14638676 hprd exp G GP G G G GP G G GP G GP G G G G GP GP G GP G GP G G G GP G GP GP G FOXK2 USP47 25609649 intact exp GP GP G G GP GP G GP GP G GP GP G G G GP GP G GP G GP GP G GP GP G GP GP G PDXDC1 USP47 22863883 biogrid exp GP GP G G GP G G G GP G GP G GP G G GP G GP GP G GP GP GP G GP G GP GP G DDI1 USP47 26186194 biogrid exp P P P P G GP GP P G P P GP USP47 WRAP73 26186194 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G P GP GP GP GP G GP GP G GRK5 USP47 22952844 biogrid exp, ortho GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP47 SIRT7 22586326 biogrid exp, ortho GP GP G G GP GP G GP GP G GP G G GP G GP GP G GP G GP G GP GP GP GP GP GP G AURKA USP47 26186194 biogrid exp, ortho G GP P G G G G GP G P G P G G G G GP XPO1 USP47 26673895 biogrid exp, ortho GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP47 ATP6V1H 22863883 biogrid exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G FOXK1 USP47 25609649 intact exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SNCA USP47 17893145 biogrid exp, ortho G G G G GP GP G GP GP G GP G G G G GP GP G G G G G G G GP G GP G USP47 BTRC 19966869,25332235,19615732,25900982 biogrid,intact exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G MAPK14 USP47 26186194 biogrid exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G PLA2G2A USP47 22118674 biogrid exp, ortho GP GP G GP P G GP GP P G G G G GP GP GP GP GP GP G GP GP G GP GP G USP47 KATNAL1 ortho GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G GP GP G GP G GP GP G CLK2 USP47 ortho GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP GP G FAM58A USP47 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SEP15 USP47 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G YWHAE USP47 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TP53 USP47 25402006 pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G MDM4 USP47 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP34 USP47 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP G G GP GP GP GP GP GP GP GP G MDM2 USP47 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SUMO2 USP47 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP47 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP47 USP40 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP G G GP GP GP GP GP G SQSTM1 USP47 23023127 pred GP GP G G GP G G G GP G GP GP GP GP G GP G GP GP G GP GP GP GP GP GP GP GP G DYNLT3 USP47 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP G GP G GP GP G G GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96K76 anti tag coimmunoprecipitation 21209336 - C 15 Q96K76 anti tag coimmunoprecipitation 21209336 - C 12 Q96K76 A0A024R8C7 anti tag coimmunoprecipitation 21209336 physical association X 2 Q96K76 A0A024R8C7 anti tag coimmunoprecipitation 21209336 physical association X 2 Q96K76 anti tag coimmunoprecipitation 23752268 association C 27 Q96K76 anti tag coimmunoprecipitation 19615732 physical association C 21 Q96K76 anti tag coimmunoprecipitation 19615732 physical association C 24 Q96K76 O00189 two hybrid prey pooling approach 25416956 physical association X 2 Q96K76 O00189 two hybrid array 25416956 physical association X 2 Q96K76 O00189 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B PLA2G2A USP47 MI:0415(enzymatic study) 22118674 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_160304 prey bait USP47 MED29 MI:0492(in vitro) 14576168 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_16763 - - USP47 MED9 MI:0492(in vitro) 14638676 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_15758 - - USP47 BTRC MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19615732,19966869 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_100704|BIOGRID_120506|BIOGRID_194002 prey|prey|prey bait|bait|bait USP47 GMPPB MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_299973 bait prey SNCA USP47 MI:0686(unspecified method) 17893145 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_227094 bait prey GRK5 USP47 MI:0004(affinity chromatography technology) 22952844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_218500 bait prey USP47 HDAC6 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 23752268 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_280691|UniProt_131417 prey|prey bait|bait USP47 ATP6V1H MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_298694 bait prey UBC USP47 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983,22118674,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_173992|BIOGRID_172680|BIOGRID_181758|BIOGRID_160370|BIOGRID_269439 bait|bait|bait|bait|bait prey|prey|prey|prey|prey KATNA1 USP47 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23904609 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_293759|BIOGRID_293760 bait|prey prey|bait USP47 FBXW11 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19615732,19966869,22017875 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(biogrid) UniProt_100705|BIOGRID_194003|BIOGRID_221040|BIOGRID_120507 prey|prey|prey|prey bait|bait|bait|bait PDXDC1 USP47 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301883 prey bait USP47 SIRT7 MI:0004(affinity chromatography technology) 22586326 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_189525 prey bait WDR44 USP47 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304993 prey bait

PPI - HINT Gene A Gene B PMID Method Quality AURKA USP47 26186194 0004 HT POLR2M USP47 26186194 0004 HT FOXK1 USP47 25609649,25609649 0676,0004 HT FOXK2 USP47 25609649,25609649 0676,0004 HT UBXN1 USP47 26186194 0004 HT RBPJ USP47 25609649,25609649 0676,0004 HT PSMD5 USP47 26344197 0401 HT MAPK14 USP47 26186194 0004 HT WDR44 USP47 22863883 0401 HT PDXDC1 USP47 22863883 0401 HT HOGA1 USP47 26186194 0004 HT DDI1 USP47 26186194 0004 HT USP47 OBFC1 26186194 0004 HT USP47 WRAP73 26186194 0004 HT USP47 ATP6V1H 22863883 0401 HT USP47 FBXW11 25515538,25900982,25609649,19615732,19615732,19966869,25900982,25332235,22017875 0004,0004,0676,0004,0007,0004,1313,0004,0004 LC,HT USP47 BTRC 25900982,19615732,19615732,19966869,25900982,25332235 0004,0004,0007,0004,1313,0004 LC,HT USP47 GMPPB 22863883 0401 HT AURKA USP47 26186194 0004 HT POLR2M USP47 26186194 0004 HT FOXK1 USP47 25609649,25609649 0676,0004 HT FOXK2 USP47 25609649,25609649 0676,0004 HT UBXN1 USP47 26186194 0004 HT RBPJ USP47 25609649,25609649 0676,0004 HT PSMD5 USP47 26344197 0401 HT MAPK14 USP47 26186194 0004 HT WDR44 USP47 22863883 0401 HT PDXDC1 USP47 22863883 0401 HT HOGA1 USP47 26186194 0004 HT DDI1 USP47 26186194 0004 HT USP47 OBFC1 26186194 0004 HT USP47 WRAP73 26186194 0004 HT USP47 ATP6V1H 22863883 0401 HT USP47 FBXW11 25609649,19615732,19615732 0676,0004,0007 HT USP47 BTRC 19615732,19615732 0004,0007 HT USP47 GMPPB 22863883 0401 HT USP47 FBXW11 25515538,25900982,19966869,25900982,25332235,22017875 0004,0004,0004,1313,0004,0004 LC USP47 BTRC 25900982,19966869,25900982,25332235 0004,0004,1313,0004 LC AP4M1 USP47 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT PLA2G2A USP47 22118674 0415 LC PSMD5 USP47 26344197 0401 LC WDR44 USP47 22863883 0401 LC PDXDC1 USP47 22863883 0401 LC USP47 ATP6V1H 22863883 0401 LC USP47 GMPPB 22863883 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96K76 O14965 USP47 AURKA 0.126 26186194 Q9H668 Q96K76 OBFC1 USP47 0.126 26186194 Q9NRC8 Q96K76 SIRT7 USP47 0.126 22586326 Q96K76 P0CAP1 USP47 MYZAP 0.126 26186194 Q96K76 P0CAP2 USP47 POLR2M 0.126 26186194 Q96K76 P0CK56 USP47 P0CK56 0.126 22810586 Q96K76 Q6EEV4 USP47 POLR2M 0.126 26186194 Q96K76 Q6P5F9 USP47 XPO1 0.126 26673895 Q96K76 Q86XE5 USP47 HOGA1 0.126 26186194 Q96K76 P04629 USP47 NTRK1 0.126 25921289 Q9UBN7 Q96K76 HDAC6 USP47 0.236 23752268 Q96K76 Q06330 USP47 RBPJ 0.236 25609649 Q96K76 P85037 USP47 FOXK1 0.236 25609649 Q96K76 Q01167 USP47 FOXK2 0.236 25609649 Q96K76 O00189 USP47 AP4M1 0.583 25416956,unassigned1304 Q9Z2V5 Q96K76 HDAC6 USP47 0.332 26496610,20360068 Q9Y297 Q96K76 BTRC USP47 0.597 25900982,19966869,19615732,25332235 Q9UKB1 Q96K76 FBXW11 USP47 0.757 25609649,19966869,25332235,22017875,25900982,25515538,19615732 Q96K76 Q8WTU0 USP47 DDI1 0.126 26186194 Q96K76 P37840 USP47 SNCA 0.309 17893145 Q96K76 O75449 USP47 KATNA1 0.376 23904609 Q96K76 P14555 USP47 PLA2G2A 0.309 22118674 Q96K76 Q5JSH3 USP47 WDR44 0.081 22863883 Q96K76 Q6P996 USP47 PDXDC1 0.081 22863883 Q9UI12 Q96K76 ATP6V1H USP47 0.081 22863883 Q9Y5P6 Q96K76 GMPPB USP47 0.081 22863883 Q9BVG8 Q96K76 KIFC3 USP47 0.21 25253721 Q9P2S5 Q96K76 WRAP73 USP47 0.126 26186194 Q96K76 P34947 USP47 GRK5 0.126 22952844 Q96K76 Q16401 USP47 PSMD5 0.081 26344197 Q96K76 Q16539 USP47 MAPK14 0.126 26186194 Q96K76 Q04323 USP47 UBXN1 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 AP4M1 USP47 MI:0045 experimental interaction detection MI:0461 interaction database AURKA USP47 MI:0045 experimental interaction detection MI:0461 interaction database XPO1 USP47 MI:0045 experimental interaction detection MI:0461 interaction database OGT USP47 MI:0362 inference MI:0461 interaction database KATNA1 USP47 MI:0045 experimental interaction detection MI:0461 interaction database IKBKAP USP47 MI:0362 inference MI:0461 interaction database MOCS3 USP47 MI:0362 inference MI:0461 interaction database TF USP47 MI:0362 inference MI:0461 interaction database HPX USP47 MI:0362 inference MI:0461 interaction database NTRK1 USP47 MI:0045 experimental interaction detection MI:0461 interaction database POLB USP47 MI:0362 inference MI:1106 pathways database MYZAP USP47 MI:0045 experimental interaction detection MI:0461 interaction database POLR2M USP47 MI:0045 experimental interaction detection MI:0461 interaction database UBC USP47 MI:0045 experimental interaction detection MI:0461 interaction database PLA2G2A USP47 MI:0045 experimental interaction detection MI:0461 interaction database CBR1 USP47 MI:0362 inference MI:0461 interaction database TAF1 USP47 MI:0045 experimental interaction detection MI:0461 interaction database DDX6 USP47 MI:0362 inference MI:0461 interaction database GRK5 USP47 MI:0045 experimental interaction detection MI:0461 interaction database SNCA USP47 MI:0362 inference MI:0461 interaction database RANGAP1 USP47 MI:0362 inference MI:0461 interaction database CSE1L USP47 MI:0362 inference MI:0461 interaction database LCN2 USP47 MI:0362 inference MI:0461 interaction database FOXK1 USP47 MI:0045 experimental interaction detection MI:0461 interaction database FOXK2 USP47 MI:0045 experimental interaction detection MI:0461 interaction database UBXN1 USP47 MI:0045 experimental interaction detection MI:0461 interaction database RBPJ USP47 MI:0045 experimental interaction detection MI:0461 interaction database NSUN2 USP47 MI:0362 inference MI:0461 interaction database NUP160 USP47 MI:0362 inference MI:0461 interaction database ELAVL1 USP47 MI:0362 inference MI:0461 interaction database MAPK14 USP47 MI:0045 experimental interaction detection MI:0461 interaction database RNF20 USP47 MI:0362 inference MI:0461 interaction database POLR2M USP47 MI:0045 experimental interaction detection MI:0461 interaction database PRPF8 USP47 MI:0362 inference MI:0461 interaction database CTU1 USP47 MI:0362 inference MI:0461 interaction database HOGA1 USP47 MI:0045 experimental interaction detection MI:0461 interaction database SERBP1 USP47 MI:0362 inference MI:0461 interaction database DDI1 USP47 MI:0045 experimental interaction detection MI:0461 interaction database UPF1 USP47 MI:0362 inference MI:0461 interaction database USP47 URM1 MI:0362 inference MI:0461 interaction database USP47 KIFC3 MI:0045 experimental interaction detection MI:0461 interaction database USP47 OBFC1 MI:0045 experimental interaction detection MI:0461 interaction database USP47 SIRT7 MI:0045 experimental interaction detection MI:0461 interaction database USP47 WRAP73 MI:0045 experimental interaction detection MI:0461 interaction database USP47 HDAC6 MI:0045 experimental interaction detection MI:0461 interaction database USP47 NXF1 MI:0362 inference MI:0461 interaction database USP47 FBXW11 MI:0045 experimental interaction detection MI:0461 interaction database USP47 BTRC MI:0045 experimental interaction detection MI:0461 interaction database USP47 USP15 MI:0362 inference MI:0461 interaction database