PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus POLH POLH 16763556 mint,intact exp GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP FRYL POLH 26496610 biogrid,intact exp GP G G G GP GP G GP GP G GP P P G GP GP GP G GP P GP GP GP GP GP GP DYNLL1 POLH 14760703 hprd exp G G G G G G G G G G G G G G G G G G G G G G G MDM2 POLH 22056306 biogrid exp GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP SIRT7 POLH 26496610 biogrid,intact exp GP G G G GP GP G GP GP G GP P G GP GP GP G GP GP GP GP GP GP GP APP POLH 21832049 biogrid exp G G G G GP GP G G GP G G G GP GP GP G GP P G G GP G G GP PLD1 POLH 26496610 biogrid,intact exp GP G G G GP GP G GP GP G GP P P P G GP GP GP G P P GP P GP GP GP GP HSP90AA1 POLH 20129057 biogrid exp GP G G G G GP G G GP G G G G GP G G GP G G G G G GP GTPBP2 POLH 26496610 biogrid,intact exp G G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP G GP GP TUBA1B POLH 16824193 biogrid exp GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP PACSIN3 POLH 26496610 biogrid,intact exp GP G GP G GP P P P P G GP GP GP GP P GP GP GP GP P SPRTN POLH 22902628 biogrid exp G GP P GP G P G G GP LGR4 POLH 24639526 biogrid exp GP G G P GP G GP GP G GP P P G GP GP GP G GP P GP GP GP GP GP GP H2AFX POLH 24485656 intact exp GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP FANCD2 POLH 23388460 biogrid exp G G P P GP P G GP P GP P P GP G GP GP CASC5 POLH 26496610 biogrid,intact exp P G GP P P GP G GP P P GP GP GP DHX16 POLH 26496610 biogrid,intact exp GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP PALB2 POLH 24485656 biogrid,intact exp GP P GP P GP G GP P P P G GP GP P P P GP GP GP GP GP GP TUBB POLH 16824193 biogrid exp GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP BRCA2 POLH 24485656 biogrid,intact exp P G GP P P P P P P P P P P P P P P P P GP UBC POLH 25766642,16357261,17304240,20129057,16763556 biogrid,mint,intact exp GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP CENPF POLH 26496610 biogrid,intact exp GP G G GP P G GP GP P P P P GP P GP GP P GP GP GP GP GP GP TRAIP POLH 24553286 biogrid exp P P P P P P P P P P P P P P P P P P P GP NXF1 POLH 22658674 biogrid exp GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP RCHY1 POLH 20008555,21791603 biogrid exp G G G G G GP G GP GP G GP P G GP GP GP G G GP G GP G GP G RPS27A POLH 17304240 hprd exp GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP USP7 POLH 25435364 biogrid exp GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP MLH1 POLH 19703417 biogrid exp GP G G G GP GP G GP GP G GP P P G GP GP GP G GP GP G GP GP GP GP PCBP1 POLH 25268038 biogrid exp GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP REV3L POLH 22828282 intact exp G G G G G GP G GP GP G GP P P G GP GP GP G GP GP G GP G GP GP PCNA POLH 23388460,23345618,22989887,11585903,20129057,15342632,21791603,25766642,23761444,15149598,20159558,23042605,16763556,21855803, 25402006, 21836163 hprd,biogrid,mint,intact exp, ortho, pred GP G G G GP G G G GP G GP P G GP G GP G GP P GP G GP GP GP GP REV1 POLH 16824193,19170759,21690293,22828282,15189446,15380106,22691049, 25402006, 21836163 hprd,biogrid,i2d,mint,intact exp, ortho, pred GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP UBE2B POLH 16824193, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G POLI POLH 23248005,12426396,12606586,16763556, 25402006, 21836163 hprd,biogrid exp, pred G G G G GP GP G GP GP G GP P G G GP GP G G G P G G GP GP RAD18 POLH 16824193,23345618,21396873,15359278,21098111, 25402006, 21836163 biogrid exp, pred P P P P P P P G P P GP P BRCA1 POLH 23901102, 23023127, 16082366 biogrid exp, pred P G GP P P P P P P P GP P P P P P P P P P GP POLD4 POLH 25402006 pred G G G G G G G G G G G G G G G G G POLK POLH 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G RFC4 POLH 25402006, 21836163 pred GP G G G GP GP G G GP G GP P P G GP GP GP G GP P GP G GP GP GP GP RFC1 POLH 25402006, 21836163 pred GP G G G GP GP G GP GP G GP P P G GP GP GP G GP P GP GP GP GP GP GP SHPRH POLH 21836163 pred GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP UBE2V2 POLH 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G POLD2 POLH 25402006 pred GP G G G GP GP G G GP G GP P P G GP GP GP G GP G G GP GP GP GP DBF4 POLH 21836163 pred G G P G P P G G P G G G GP MUTYH POLH 25402006 pred GP G G G G GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP DTL POLH 23023127 pred P G GP P G P P P G P P P P P G G G GP HUS1 POLH 25402006 pred GP G G G GP P G GP GP P P G GP GP GP G GP P GP GP GP G GP GP KCTD13 POLH 25402006 pred GP G G G G GP G GP GP G GP P P G GP GP GP G GP P GP GP GP G GP GP KIAA0101 POLH 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G FHL2 POLH 25402006 pred GP G G G GP GP G GP GP GP P P G GP GP G G GP P G GP GP G GP GP WRN POLH 25402006 pred GP G G G GP GP G G GP G GP P P G GP GP GP G P GP GP GP G GP GP RFC3 POLH 21836163 pred GP G G G GP GP G GP GP G GP P P G GP GP GP G GP P GP GP GP GP GP GP MAD2L2 POLH 25402006 pred GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP G GP GP GP GP DAZAP2 POLH 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G RFC2 POLH 25402006 pred GP G G G GP GP G P GP G P P P G GP GP GP G GP P GP G GP G GP GP XRCC6 POLH 25402006 pred GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP POLQ POLH 25402006 pred GP G G GP GP G P GP G GP P P P G GP GP P G P P GP GP GP GP GP GP POLH 16082366 pred LIG1 POLH 25402006 pred GP G G GP GP P GP G P P P P G GP GP GP G GP P P GP GP GP GP GP RNF20 POLH 25402006 pred GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP DSCC1 POLH 25402006, 21836163 pred GP G G G GP GP G GP GP G GP P P P G GP GP GP P P GP GP GP P GP GP CHTF18 POLH 21836163 pred G G G G G G G G G G G G G G G G G G G G G G TP53BP1 POLH 25402006 pred GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP FEN1 POLH 25402006, 21836163 pred GP G G G GP GP G G GP G GP P P P G GP GP GP G GP P GP G GP GP GP GP CDK2 POLH 25402006 pred GP G G G GP GP G GP GP G GP P G GP GP G G GP P G G GP G GP GP RPS3 POLH 23023127 pred GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP G GP GP GP GP TOP3A POLH 21836163 pred GP G G G GP GP G G GP G GP P P G G GP GP G GP P GP GP G GP GP GP CDC7 POLH 21836163 pred GP G G G GP GP G GP G GP P P G GP GP GP G GP P G GP G GP GP MUS81 POLH 21836163 pred GP G G G GP GP G GP GP G GP G GP GP GP G GP G GP GP G G GP RAD9A POLH 21836163 pred GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP G GP GP GP GP CCNA2 POLH 25402006 pred G G G G GP G G G GP G G P G GP G G G G G GP GP GP GP ERCC5 POLH 25402006 pred GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP DNTT POLH 25402006 pred GP G G G G G G G G P P P G G G P G P P G G GP RFC5 POLH 25402006 pred GP G G G GP GP G GP GP G GP P P G GP GP GP G GP GP GP GP GP GP GP HLTF POLH 25402006 pred GP G G G GP GP G G GP G G G G GP G G GP G G G G GP GP EME1 POLH 21836163 pred GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP CDKN2A POLH 25402006 pred G G G G GP GP G G G G G P P G G GP GP G GP G G G GP GP G RNF40 POLH 25402006 pred GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP UBE2N POLH 16082366 pred GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP UBE2A POLH 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G POLL POLH 25402006 pred G CDT1 POLH 25402006 pred P G GP P GP GP P P P P GP P GP G P P P P GP P GP P XRCC5 POLH 25402006 pred GP G G G GP GP G GP GP G GP P P G GP GP GP G GP P GP GP GP GP GP GP DDX11 POLH 21836163 pred GP G G G GP GP G GP GP G GP P P G GP GP GP G GP P GP GP GP GP GP GP POLD1 POLH 25402006 pred GP G GP P G GP GP GP P P P G GP GP GP G GP P GP GP GP GP GP GP POLD3 POLH 25402006 pred GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP CCNO POLH 25402006 pred G G G G G P G G G GP G GP G P G G GP GP GP CHAF1A POLH 25402006 pred G G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP G GP GP GP GP CDC25C POLH 25402006 pred P G GP P P GP P P P GP P P P P P P GP P P GP

PPI - HINT Gene A Gene B PMID Method Quality DHX16 POLH 26496610,26496610 0007,0004 HT FRYL POLH 26496610 0007 HT UBC POLH 25766642,16763556,16357261,16763556,16357261,16357261,20129057,16763556,22118674 0004,0096,0004,0018,0018,0096,0096,0004,0004 LC PCNA POLH 23388460,23761444,21791603,11585903,16763556,15342632,20159558,21791603,11585903,25766642,15149598,20159558,23345618,21855803,23042605,20129057,24474685,20159558,16763556,22989887,23388460,20129057 0004,0004,0096,0018,0096,0004,0096,0415,0096,0004,0004,0004,0004,0004,0004,0004,0096,0018,0018,0401,0401,0096 LC CENPF POLH 26496610,26496610 0007,0004 HT PLD1 POLH 26496610 0007 HT Q59EA4 POLH 26496610 0004 HT Q6ZR29 POLH 26496610 0004 HT CASC5 POLH 26496610,26496610 0007,0004 HT RCHY1 POLH 21791603,20008555,21791603 0096,0004,0415 LC GTPBP2 POLH 26496610,26496610 0007,0004 HT SIRT7 POLH 26496610,26496610 0007,0004 HT RAD18 POLH 16824193,15359278,23345618,15359278,21396873,15359278,21098111 0004,0004,0004,0428,0004,0096,0004 LC REV1 POLH 19170759,15380106,16824193,15189446,15189446,19170759,22828282,15380106,22828282,15189446,21690293 0096,0096,0004,0019,0018,0018,0096,0018,0077,0004,0096 LC PACSIN3 POLH 26496610,26496610 0007,0004 HT DHX16 POLH 26496610,26496610 0007,0004 HT FRYL POLH 26496610 0007 HT CENPF POLH 26496610,26496610 0007,0004 HT PLD1 POLH 26496610 0007 HT Q59EA4 POLH 26496610 0004 HT Q6ZR29 POLH 26496610 0004 HT CASC5 POLH 26496610,26496610 0007,0004 HT GTPBP2 POLH 26496610,26496610 0007,0004 HT SIRT7 POLH 26496610,26496610 0007,0004 HT PACSIN3 POLH 26496610,26496610 0007,0004 HT UBC POLH 25766642,16763556,16357261,16763556,16357261,16357261,20129057,16763556,22118674 0004,0096,0004,0018,0018,0096,0096,0004,0004 LC PCNA POLH 23388460,23761444,21791603,11585903,16763556,15342632,20159558,21791603,11585903,25766642,15149598,20159558,23345618,21855803,23042605,20129057,24474685,20159558,16763556,22989887,23388460,20129057 0004,0004,0096,0018,0096,0004,0096,0415,0096,0004,0004,0004,0004,0004,0004,0004,0096,0018,0018,0401,0401,0096 LC RCHY1 POLH 21791603,20008555,21791603 0096,0004,0415 LC RAD18 POLH 16824193,15359278,23345618,15359278,21396873,15359278,21098111 0004,0004,0004,0428,0004,0096,0004 LC REV1 POLH 19170759,15380106,16824193,15189446,15189446,19170759,22828282,15380106,22828282,15189446,21690293 0096,0096,0004,0019,0018,0018,0096,0018,0077,0004,0096 LC REV3L POLH 22828282 0077 LC UBC POLH 17304240,16763556,16357261,21791603,16763556,16357261,16357261,16763556 0077,0096,0004,0415,0018,0018,0096,0004 LC PCNA POLH 23388460,21791603,11585903,16763556,20159558,21791603,11585903,20159558,20159558,16763556,22989887,23388460 0004,0096,0018,0096,0096,0415,0096,0004,0018,0018,0401,0401 LC H2AFX POLH 24485656 0416 LC POLD2 POLH 25662213,25662213 0096,0018 LC BRCA2 POLH 24485656,24485656,24485656,24485656,24485656,24485656 0007,0006,0416,0096,0428,0004 LC Q59EG3 POLH 19703417,19703417,19703417 0096,0004,0018 LC Q86SX1 POLH 20129057,20129057 0401,0004 LC PALB2 POLH 24485656,24485656,24485656,24485656,24485656 0416,0006,0004,0428,0096 LC USP7 POLH 25435364,25435364,25435364 0004,0415,0096 LC RCHY1 POLH 21791603,21791603 0096,0415 LC TRAIP POLH 24553286,24553286,24553286 0018,0428,0004 LC FANCD2 POLH 23388460,23388460 0004,0401 LC REV1 POLH 22691049,19170759,15380106,15189446,15189446,19170759,22828282,22691049,15380106,22828282,15189446 0018,0096,0096,0019,0018,0018,0096,0114,0018,0077,0004 LC POLI POLH 12606586,23248005,23248005,16763556,23248005,12606586,12426396 0018,0047,0004,0018,0018,0047,0018 LC POLH POLH 16763556 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9Y253 Q9H040 POLH SPRTN 0.376 22902628 Q9Y253 Q9Y253 POLH POLH 0.332 16763556 Q9Y253 Q00987 POLH MDM2 0.21 22056306 Q9Y253 Q86YC2 POLH PALB2 0.623 24485656 Q9Y253 Q9BWF2 POLH TRAIP 0.623 24553286 Q9Y253 P49454 POLH CENPF 0.126 26496610 Q9Y253 O60231 POLH DHX16 0.126 26496610 Q9Y253 P07437 POLH TUBB 0.21 16824193 Q9Y253 P38398 POLH BRCA1 0.21 23901102 Q9Y253 P07900 POLH HSP90AA1 0.454 20129057 Q9Y253 P05067 POLH APP 0.183 21832049 Q9Y253 P63146 POLH UBE2B 0.21 16824193 Q9Y253 P51587 POLH BRCA2 0.623 24485656 Q9Y253 P68363 POLH TUBA1B 0.21 16824193 Q9Y253 Q7TPQ3 POLH SHPRH 0.21 21396873 Q9Y253 Q81U22 POLH HEMH1 0.126 20711500 Q9Y253 O94915 POLH FRYL 0.236 26496610 Q9Y253 Q13393 POLH PLD1 0.236 26496610 Q9Y253 Q8NG31 POLH CASC5 0.236 26496610 Q9Y253 Q93009 POLH USP7 0.794 25435364 Q9Y253 Q9BX10 POLH GTPBP2 0.236 26496610 Q9Y253 Q9NRC8 POLH SIRT7 0.236 26496610 Q9Y253 Q9NS91 POLH RAD18 0.814 21396873,21098111,23345618,15359278,16824193 Q9Y253 Q9UKS6 POLH PACSIN3 0.236 26496610 Q9Y253 Q96PM5 POLH RCHY1 0.523 21791603 Q9Y253 Q6FI35 POLH PCNA 0.523 16763556 Q9Y253 P49005 POLH POLD2 0.523 25662213 Q9Y253 P0CG48 POLH UBC 0.968 17304240,25766642,20129057,16763556,16357261 Q9Y253 Q9UBZ9 POLH REV1 0.985 15189446,21690293,15380106,22691049,22828282,16824193,19170759 Q9Y253 Q9UNA4 POLH POLI 0.82 23248005,12606586 Q9Y253 P12004 POLH PCNA 0.998 21791603,20159558,20129057,11585903,15342632,15149598,23761444,24474685,23388460,22989887,23042605,25766642,21855803,16763556,23345618 Q9Y253 Q9BXB1 POLH LGR4 0.126 24639526 Q9Y253 Q9BXW9 POLH FANCD2 0.454 23388460 Q9Y253 Q9UBU9 POLH NXF1 0.126 22658674 Q9Y253 Q9UI95 POLH MAD2L2 0.21 22828282 Q9Y253 P40692 POLH MLH1 0.623 19703417 Q9Y253 Q15365 POLH PCBP1 0.21 25268038