PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RNF139 AUP1 23223569 biogrid exp G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G RNF139 UBE2Z 19690564 biogrid,intact exp G GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP G GP GP G GP GP G HLA-C RNF139 19720873 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G VHL RNF139 12032852 hprd,intact,bci exp G G G G G G G G G G GP GP GP G G G G G P G G GP G G G G G GP G ERLIN1 RNF139 21343306 biogrid exp G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G G GP G GP GP G RNF139 INSIG2 22143767 biogrid exp G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP HM13 RNF139 19720873,25239945 biogrid,intact exp G GP G G GP GP G G GP G G G GP G G GP GP GP GP G GP GP G G GP G GP GP G ERLIN2 RNF139 21343306 biogrid exp G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G UBE2U RNF139 19690564 biogrid,intact exp P P P P P P P P P P P P P P P GP SCAP RNF139 19706601 biogrid exp G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G EIF3A RNF139 20068067 biogrid exp G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G INSIG1 RNF139 20068067,22143767 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF139 TMUB1 21343306 biogrid exp G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G SREBF2 RNF139 19706601 biogrid exp G GP G G GP GP G G GP G GP G GP G G GP GP GP G G GP G G GP GP G GP GP G XBP1 RNF139 25239945 intact exp G G G G GP GP G G GP G GP G G G G GP GP G GP G G G G GP GP G GP GP G HMGCR RNF139 22143767 biogrid exp G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G UBE2H RNF139 19549727 biogrid,intact exp G GP G G GP GP G G G G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G SEC24B RNF139 19706601 biogrid exp G GP G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP G GP GP G GP GP G RNF139 COPS5 12032852, 21836163 hprd,bci exp, ortho, pred G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G UBE2G2 RNF139 23223569, 23023127 biogrid exp, pred G GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP G G GP G GP GP G EIF3F RNF139 ortho G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G EIF3H RNF139 ortho G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G KIAA0196 RNF139 25402006 pred G GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP G GP GP G GP GP G CUL1 RNF139 23023127, 21836163 pred G G G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G RING1 RNF139 23023127 pred G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G FHIT RNF139 21836163 pred G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP GP GP G RNF139 CARD9 25402006 pred G GP P G P G P P RNF139 UBE2E2 23023127 pred G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G BMP2 RNF139 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D2 RNF139 23023127 pred G G G G GP GP G G GP G GP GP GP G G G GP GP GP G GP GP G GP G G GP GP G DGKI RNF139 25402006 pred G G G G G GP UBE2L3 RNF139 23023127 pred G G G G G GP G G GP G GP G G G G GP GP G GP G G G G GP GP G GP GP G RNF139 FEM1A 23023127 pred G GP G G G GP G G GP G GP G GP G G GP GP GP G G G G G GP GP G GP GP G BMI1 RNF139 23023127 pred P P P P P P P P P P P P P P P P P UBE2C RNF139 23023127 pred G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G UBE2K RNF139 23023127 pred G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G RNF139 KLHDC2 21836163 pred G GP G G G GP G G GP G GP G GP G G GP GP GP GP G GP GP G GP GP G GP GP G UBE2N RNF139 23023127 pred G GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP G GP GP G GP GP G UBE2D3 RNF139 23023127 pred G G G G GP GP G G GP G GP GP GP G G G GP GP GP G GP GP G GP G G GP GP G POLR2G RNF139 25402006 pred G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G RBX1 RNF139 25402006 pred G G G G G GP G G G G G G GP G G G GP G GP G GP GP G G G G G GP G RNF139 RNF2 23023127 pred P P P GP P P P P P P P P P P P RNF139 UBE2E3 23023127 pred G GP G G G GP G G GP G GP G G G G GP GP GP G G GP G G GP GP G GP GP G RNF139 HIF1AN 25402006 pred G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G RNF139 EGLN3 25402006 pred P G G G G G G G G G G G G G G G G G G G G VBP1 RNF139 25402006 pred G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G CTCF RNF139 23023127 pred G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G JADE1 RNF139 25402006 pred G GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP G G GP G GP GP G COPS6 RNF139 21836163 pred G GP G G GP GP G G GP G GP G GP G G GP GP GP GP G GP GP G G GP G GP GP G UBE2G1 RNF139 23023127 pred G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G ZNF197 RNF139 25402006 pred G GP G G GP GP G G GP G GP G GP G G GP GP G GP G G G G GP GP G GP GP G RNF139 UBE2D4 23023127 pred G G G G GP GP G G GP G GP GP GP G G G GP GP GP G GP GP G GP G G GP GP G RNF139 UBE2F 23023127 pred G GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP G GP GP G GP GP G RNF139 SAP130 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2R2 RNF139 23023127 pred G G G G GP G G G G G G G G G G G G G G G G G G G G G GP G G UBE2D1 RNF139 23023127 pred G G G G GP GP G G GP G GP GP GP G G G GP GP GP G GP GP G GP G G GP GP G RNF139 COPS8 21836163 pred G G G G G GP G G G G G G GP G G G GP G G G G G G G G G G GP G MPL RNF139 21836163 pred P P P P P P P P P P P P P P USP33 RNF139 25402006 pred G GP G G GP GP G G GP G GP GP GP G G GP GP G GP G GP GP G GP GP G GP GP G NEDD8 RNF139 23023127 pred G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G CUL2 RNF139 21836163 pred G GP G G G GP G G GP G GP GP GP G G G GP GP GP G GP GP G G G G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8WU17 Q8TCT9-4 affinity chromatography technology 19720873 physical association X 2 Q8WU17 Q8TCT9-4 affinity chromatography technology 25239945 physical association X 2 Q8WU17 two hybrid 19690564 direct interaction X 2 Q8WU17 O15503-2 affinity chromatography technology 20068067 physical association X 2 Q8WU17 O15503-2 affinity chromatography technology 22143767 physical association X 2 Q8WU17 A0A024RAI2 affinity chromatography technology 22143767 physical association X 2 Q8WU17 A0A024RAP2 affinity chromatography technology 22143767 physical association X 2 D3DR65 Q8WU17 affinity chromatography technology 21343306 physical association X 2 Q9Y679-2 Q8WU17 affinity chromatography technology 23223569 physical association X 2 Q8WU17 P60604-2 affinity chromatography technology 23223569 physical association X 2 Q8WU17 O19617 affinity chromatography technology 19720873 physical association X 2 Q8WU17 Q9H832 two hybrid 19690564 direct interaction X 2 Q8WU17 two hybrid 19549727 direct interaction X 2 Q8WU17 A0A024R1Q0 affinity chromatography technology 19706601 physical association X 2 Q8WU17 A0A024R1Q0 affinity chromatography technology 19706601 physical association X 2 Q8WU17 Q12770 affinity chromatography technology 19706601 physical association X 2 Q8WU17 O95487 affinity chromatography technology 19706601 physical association X 2 Q8WU17 affinity chromatography technology 21343306 physical association X 2 Q8WU17 A0A090N8Q3 affinity chromatography technology 21343306 physical association X 2 P0CG48 Q8WU17 affinity chromatography technology 20068067 physical association X 2 P0CG48 Q8WU17 affinity chromatography technology 19706601 physical association X 2 Q14152 Q8WU17 pull down 20068067 direct interaction X 2 Q8WU17 Q15369-2 in vitro 12032852 - X 2 Q8WU17 Q15369-2 in vitro 12032852 - X 2 A0A024R7W9 Q8WU17 in vitro 12032852 - X 2 A0A024R7W9 Q8WU17 in vitro 12032852 - X 2 Q8WU17 A4D1L5 two hybrid array 19549727 physical association X 2 Q8WU17 Q5VVX9 two hybrid array 19690564 physical association X 2 A0A024R2F2 Q8WU17 anti bait coimmunoprecipitation 12032852 physical association X 2 A0A024R2F2 Q8WU17 anti bait coimmunoprecipitation 12032852 physical association X 2 Q8WU17 Q9H832 two hybrid array 19690564 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SCAP RNF139 MI:0004(affinity chromatography technology) 19706601 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_148302 prey bait ERLIN2 RNF139 MI:0004(affinity chromatography technology) 21343306 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_155084 bait prey SEC24B RNF139 MI:0004(affinity chromatography technology) 19706601 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_148304 bait prey HMGCR RNF139 MI:0004(affinity chromatography technology) 22143767 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_159954 prey bait VHL RNF139 MI:0492(in vitro)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 12032852 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|(intact)|(intact) HPRD_4901|UniProt_70235|UniProt_70236 -|prey|prey -|bait|bait RNF139 AUP1 MI:0004(affinity chromatography technology) 23223569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_248573 bait prey RNF139 INSIG2 MI:0004(affinity chromatography technology) 22143767 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_159952 bait prey ERLIN1 RNF139 MI:0004(affinity chromatography technology) 21343306 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_155082 bait prey INSIG1 RNF139 MI:0004(affinity chromatography technology)|MI:0096(pull down) 20068067,22143767 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_159951|BIOGRID_146300 prey|prey bait|bait RNF139 UBE2Z MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123720|UniProt_102709 prey|prey bait|bait SREBF2 RNF139 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19706601 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_148301|BIOGRID_148300 bait|prey prey|bait UBC RNF139 MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down) 17016439,19706601,20068067 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_148305|BIOGRID_199807|BIOGRID_146299 prey|prey|prey bait|bait|bait NRF1 RNF139 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_296986 bait prey UBE2G2 RNF139 MI:0004(affinity chromatography technology) 23223569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_248574 prey bait RNF139 TMUB1 MI:0004(affinity chromatography technology) 21343306 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_155122 prey bait COPS5 RNF139 MI:0492(in vitro) 12032852 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_11940 - - UBE2H RNF139 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101342|BIOGRID_124488 bait|bait prey|prey UBE2U RNF139 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102662|BIOGRID_123673 bait|bait prey|prey EIF3A RNF139 MI:0096(pull down) 20068067 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_146306 prey bait

PPI - HINT Gene A Gene B PMID Method Quality INSIG1 RNF139 20068067,22143767 0004,0004 LC UBC RNF139 17016439,20068067,19706601 0096,0004,0004 LC HM13 RNF139 19720873,25239945,25239945,25239945 0004,0004,0007,0276 LC INSIG1 RNF139 20068067,22143767 0004,0004 LC UBC RNF139 17016439,20068067,19706601 0096,0004,0004 LC HM13 RNF139 19720873,25239945,25239945,25239945 0004,0004,0007,0276 LC UBE2H RNF139 19549727,19549727 0397,0018 HT UBE2U RNF139 19690564,19690564 0397,0018 HT HM13 RNF139 25239945,25239945,25239945 0004,0007,0276 LC RNF139 UBE2Z 19690564,19690564 0397,0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8WU17 Q8TCT9 RNF139 HM13 0.61 25239945,19720873 Q8WU17 O75477 RNF139 ERLIN1 0.126 21343306 Q8WU17 O94905 RNF139 ERLIN2 0.126 21343306 Q8WU17 O95487 RNF139 SEC24B 0.21 19706601 Q9H832 Q8WU17 UBE2Z RNF139 0.286 19690564 Q8WU17 O15503 RNF139 INSIG1 0.376 20068067,22143767 Q9Y5U4 Q8WU17 INSIG2 RNF139 0.21 22143767 Q8WU17 P40337 RNF139 VHL 0.376 12032852 Q8WU17 P10321 RNF139 HLA-C 0.21 19720873 Q8WU17 P04035 RNF139 HMGCR 0.21 22143767 Q8WU17 Q12770 RNF139 SCAP 0.21 19706601 Q8WU17 P60604 RNF139 UBE2G2 0.21 23223569 Q8WU17 P62256 RNF139 UBE2H 0.376 19549727 Q8WU17 Q5VVX9 RNF139 UBE2U 0.376 19690564 Q8WU17 Q12772 RNF139 SREBF2 0.376 19706601 Q8WU17 Q14152 RNF139 EIF3A 0.309 20068067 Q9Y679 Q8WU17 AUP1 RNF139 0.21 23223569 Q9BVT8 Q8WU17 TMUB1 RNF139 0.126 21343306 Q8WU17 P17861 RNF139 XBP1 0.21 25239945

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 EIF3F RNF139 MI:0362 inference MI:0461 interaction database EIF3H RNF139 MI:0362 inference MI:0461 interaction database INSIG1 RNF139 MI:0045 experimental interaction detection MI:0461 interaction database ERLIN1 RNF139 MI:0045 experimental interaction detection MI:0461 interaction database ERLIN2 RNF139 MI:0045 experimental interaction detection MI:0461 interaction database SEC24B RNF139 MI:0045 experimental interaction detection MI:0461 interaction database HMGCR RNF139 MI:0045 experimental interaction detection MI:0461 interaction database UBB RNF139 MI:0362 inference MI:1106 pathways database UBC RNF139 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database HLA-C RNF139 MI:0045 experimental interaction detection MI:0461 interaction database XBP1 RNF139 MI:0045 experimental interaction detection MI:0461 interaction database VHL RNF139 MI:0045 experimental interaction detection MI:0461 interaction database UBE2G2 RNF139 MI:0045 experimental interaction detection MI:0461 interaction database UBE2H RNF139 MI:0045 experimental interaction detection MI:0461 interaction database RPS27A RNF139 MI:0362 inference MI:1106 pathways database UBA52 RNF139 MI:0362 inference MI:1106 pathways database SCAP RNF139 MI:0045 experimental interaction detection MI:0461 interaction database SREBF2 RNF139 MI:0045 experimental interaction detection MI:0461 interaction database OS9 RNF139 MI:0362 inference MI:1106 pathways database EIF3A RNF139 MI:0045 experimental interaction detection MI:0461 interaction database UBE2U RNF139 MI:0045 experimental interaction detection MI:0461 interaction database HM13 RNF139 MI:0045 experimental interaction detection MI:0461 interaction database RNF139 COPS5 MI:0362 inference MI:0461 interaction database RNF139 TMUB1 MI:0045 experimental interaction detection MI:0461 interaction database RNF139 DERL2 MI:0362 inference MI:1106 pathways database RNF139 UBE2Z MI:0045 experimental interaction detection MI:0461 interaction database RNF139 SEL1L MI:0362 inference MI:1106 pathways database RNF139 INSIG2 MI:0045 experimental interaction detection MI:0461 interaction database RNF139 AUP1 MI:0045 experimental interaction detection MI:0461 interaction database