PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus DDI1 CYGB 25416956 biogrid,intact exp P P G GP GP G P GP PHC3 DDI1 26186194 biogrid exp P P P P G GP GP P G P P GP SMC1A DDI1 26496610 biogrid,intact exp P P P P G GP GP P G P P GP ADRM1 DDI1 18497817 hprd exp P P P P G GP GP P G P P GP DDI1 KLHL42 25416956 biogrid,intact exp P P P G GP GP G GP PRRT2 DDI1 26186194 biogrid exp P P G G G G GP DDI1 SFXN1 26186194 biogrid exp P P P G GP GP P G P P GP DDI1 CCL28 25416956,21516116 biogrid,mint,intact exp G G G G G DDI1 RSC1A1 26186194 biogrid exp P P P P P P P P P P DVL2 DDI1 16189514 hprd,biogrid,mint,intact exp P P P P G GP GP P G P P GP DDI1 USP47 26186194 biogrid exp P P P P G GP GP P G P P GP DDI1 NRIP3 26186194 biogrid exp P P P G GP GP P G P P GP UBC DDI1 16007098 biogrid exp, ortho P P P P G GP GP P G P P GP UBE2K DDI1 25416956, 23023127 biogrid,intact exp, pred P P P P G GP GP P G P P GP PARK2 DDI1 23023127 pred P P P P G P P G P GP DDI1 TMUB1 23023127 pred P P P P G GP GP P G P GP UBE2B DDI1 23023127 pred G G G G G DDI1 UBQLN2 23023127 pred P P P P G GP GP P G P P GP UBE2D1 DDI1 23023127 pred P P P P G GP GP P G P P GP DDI1 NSFL1C 23023127 pred P P P P G GP GP P G P P GP DDI1 UHRF2 23023127 pred P P P P G GP GP P G P P GP SH3D21 DDI1 23023127 pred P P P P GP GP P G P P GP DDI1 STAMBPL1 23023127 pred P P P G GP P P G P P GP FCHSD2 DDI1 23023127 pred P P P P G GP GP P G P P G UBE2A DDI1 23023127 pred G G G G G DDI1 NUB1 23023127 pred P P G GP GP P G P P GP UBE2G2 DDI1 23023127 pred P P P P G GP GP P G P P GP DDI1 UBL7 23023127 pred P P P P G GP GP P G P P GP SUMO3 DDI1 23023127 pred P P P P G GP GP P G P P GP SUMO1 DDI1 23023127 pred P P P P G GP GP P G P P GP BAG6 DDI1 23023127 pred P P P P G GP GP P G P P GP DDI2 DDI1 23023127 pred P P P P P P UBQLNL DDI1 23023127 pred P P G P P GP UBE2E1 DDI1 23023127 pred P P P G G GP G P GP UBE2L3 DDI1 23023127 pred P P P G GP G G P GP DDI1 GGA3 23023127 pred P P P P G GP GP G P P GP DDI1 UBA2 23023127 pred P P P P G GP G P G P P GP DDI1 USP21 23023127 pred P P P G GP GP P G P GP DDI1 UBXN10 23023127 pred P P P P G GP GP P G P GP UBE2N DDI1 23023127 pred P P P P G GP GP P G P P GP UBFD1 DDI1 23023127 pred P P P P G GP GP P G P P GP UBE2C DDI1 23023127 pred P P P P G GP GP P G P P GP SUMO4 DDI1 23023127 pred P P P P G GP GP P G P P GP UBE2D3 DDI1 23023127 pred P P P P G GP GP P G P P GP DDI1 PACSIN3 23023127 pred P P P G GP GP P G P P DDI1 CUEDC1 23023127 pred P P P P G P GP P G P P P DDI1 USP44 23023127 pred P P P P GP P P P GP UCHL3 DDI1 23023127 pred P P P P G GP GP P G P P GP DDI1 UBTD2 23023127 pred P P P P G GP GP P G P P GP UBE2V1 DDI1 23023127 pred UBC DDI1 23023127 pred DDI1 AMFR 23023127 pred P P P P G GP GP P G P P GP UBE2D2 DDI1 23023127 pred P P P P G GP GP P G P P GP DDI1 UBE2D4 23023127 pred P P P P G GP GP P G P P GP DDI1 SENP2 23023127 pred P P P P G GP GP P G P P GP RAD23B DDI1 25402006, 23023127 pred P P P P G GP GP P G P P GP DDI1 SENP1 23023127 pred P P P P G GP GP P G P P GP UBXN7 DDI1 23023127 pred P P P P G GP GP P G P P GP UBE2G1 DDI1 23023127 pred P P P P G GP GP P G P P GP UBL4B DDI1 23023127 pred P P P P P P P P P P USP14 DDI1 23023127 pred P P P P G GP GP P G P P GP TCEB1 DDI1 23023127 pred G G G G G UBXN2A DDI1 23023127 pred G G G G G NFATC2IP DDI1 23023127 pred G G G G G DDI1 CD2AP 23023127 pred P P P P G GP GP P G P P GP NCK1 DDI1 23023127 pred P P P P G GP GP P G P P GP USP5 DDI1 23023127 pred P P P P G GP GP P G P P GP DDI1 USP7 23023127 pred P P P P G GP GP P G P P GP MIDN DDI1 23023127 pred P P P P G G GP P G P GP UBE2S DDI1 23023127 pred G G G GP SUMO2 DDI1 23023127 pred P P P P G GP GP P G P P GP DDI1 UBQLN3 23023127 pred G GP DDI1 FAF1 23023127 pred P P P P G GP GP P G P P GP CBLB DDI1 23023127 pred P P P G GP GP P G P P GP UBE2I DDI1 23023127 pred P P P P G GP GP P G P P GP UBE2V2 DDI1 23023127 pred G G G G G UBXN2B DDI1 23023127 pred G G G P G P GP DDI1 UBTD1 23023127 pred P P P G GP P G GP USP2 DDI1 23023127 pred P P P G GP GP P G P P GP RAD23A DDI1 23023127 pred P P P P G GP GP P G P P GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8WTU0 O14641 two hybrid 16189514 direct interaction X 2 Q8WTU0 P61086 two hybrid 25416956 direct interaction X 2 Q8WTU0 A0N0Q3 two hybrid 25416956 direct interaction X 2 Q8WTU0 B2RNT7 two hybrid 25416956 direct interaction X 2 Q8WTU0 Q8WWM9 two hybrid 25416956 direct interaction X 2 Q8WTU0 P0CG48 pull down 16007098 direct interaction X 2 Q8WTU0 Q9JKV1 pull down 18497817 direct interaction X 2 Q8WTU0 O14641 two hybrid 16189514 - X 2 Q8WTU0 O14641 two hybrid 16189514 - X 2 Q8WTU0 Q16186 in vitro 18497817 - X 2 Q8WTU0 Q16186 in vitro 18497817 - X 2 Q8WTU0 O14641 two hybrid pooling approach 16189514 physical association X 2 Q8WTU0 A0N0Q3 two hybrid 21516116 physical association X 2 Q8WTU0 P61086 two hybrid prey pooling approach 25416956 physical association X 2 Q8WTU0 Q8WWM9 two hybrid prey pooling approach 25416956 physical association X 2 Q8WTU0 A0N0Q3 two hybrid prey pooling approach 25416956 physical association X 2 Q8WTU0 B2RNT7 two hybrid prey pooling approach 25416956 physical association X 2 Q8WTU0 P61086 two hybrid array 25416956 physical association X 2 Q8WTU0 Q8WWM9 two hybrid array 25416956 physical association X 2 Q8WTU0 A0N0Q3 two hybrid array 25416956 physical association X 2 Q8WTU0 B2RNT7 two hybrid array 25416956 physical association X 2 Q8WTU0 P61086 validated two hybrid 25416956 physical association X 2 Q8WTU0 Q8WWM9 validated two hybrid 25416956 physical association X 2 Q8WTU0 A0N0Q3 validated two hybrid 25416956 physical association X 2 Q8WTU0 B2RNT7 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B DVL2 DDI1 MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|- (intact)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0468(hprd) UniProt_152753|BIOGRID_79907|MINT_38139|MINT_67322|HPRD_21917 unspecified role|bait|bait|bait|- unspecified role|prey|prey|prey|- DDI1 CCL28 MI:0018(two hybrid) 21516116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_114654 prey bait ADRM1 DDI1 MI:0492(in vitro) 18497817 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_33089 - -

PPI - HINT Gene A Gene B PMID Method Quality SMC1A DDI1 26496610,26496610 0007,0004 HT PRRT2 DDI1 26186194 0004 HT PHC3 DDI1 26186194 0004 HT DDI1 RSC1A1 26186194 0004 HT DDI1 USP47 26186194 0004 HT DDI1 SFXN1 26186194 0004 HT DDI1 NRIP3 26186194 0004 HT SMC1A DDI1 26496610,26496610 0007,0004 HT PRRT2 DDI1 26186194 0004 HT PHC3 DDI1 26186194 0004 HT DDI1 RSC1A1 26186194 0004 HT DDI1 USP47 26186194 0004 HT DDI1 SFXN1 26186194 0004 HT DDI1 NRIP3 26186194 0004 HT DVL2 DDI1 16189514,16189514 0398,0018 HT UBE2K DDI1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT DDI1 DDI1 PDB_3S8I 0114 LC DDI1 CYGB 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT DDI1 CCL28 25416956,25416956,25416956,21516116,25416956 1112,0397,0018,0018,1356 HT DDI1 KLHL42 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9H9B4 Q8WTU0 SFXN1 DDI1 0.126 26186194 Q8WTU0 Q7Z6L0 DDI1 PRRT2 0.126 26186194 Q8WTU0 P10507 DDI1 MAS1 0.332 27107014 Q8WTU0 P20618 DDI1 PSMB1 0.236 unassigned1304 Q8WW81 Q8WTU0 Q8WW81 DDI1 0.236 unassigned1304 Q9P2K6 Q8WTU0 KLHL42 DDI1 0.583 25416956,unassigned1304 Q96MY7 Q8WTU0 FAM161B DDI1 0.236 unassigned1304 Q8WTU0 Q14683 DDI1 SMC1A 0.236 26496610 Q9BUL9 Q8WTU0 RPP25 DDI1 0.236 unassigned1304 Q9BXF9 Q8WTU0 TEKT3 DDI1 0.236 unassigned1304 Q8WTU0 A0A087WYA8 DDI1 RALGAPA2 {ECO:0000313|ENSEMBL:ENSP00000481660} 0.236 unassigned1304 Q8WTU0 Q12933 DDI1 TRAF2 0.236 unassigned1304 Q8WTU0 O75604 DDI1 USP2 0.236 unassigned1304 Q8WTU0 P61086 DDI1 UBE2K 0.454 25416956 Q8WTU0 P0CG48 DDI1 UBC 0.309 16007098 Q8WTU0 O14641 DDI1 DVL2 0.286 16189514 Q9NRJ3 Q8WTU0 CCL28 DDI1 0.722 21516116,25416956,unassigned1304 Q8WTU0 Q8NDX5 DDI1 PHC3 0.126 26186194 Q9NQ35 Q8WTU0 NRIP3 DDI1 0.126 26186194 Q92681 Q8WTU0 RSC1A1 DDI1 0.126 26186194 Q96K76 Q8WTU0 USP47 DDI1 0.126 26186194 Q8WWM9 Q8WTU0 CYGB DDI1 0.454 25416956 Q8WTU0 P40087 DDI1 DDI1 0.332 27107014

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PSMD14 DDI1 MI:0362 inference MI:0461 interaction database DVL2 DDI1 MI:0045 experimental interaction detection MI:0461 interaction database STX16 DDI1 MI:0362 inference MI:0461 interaction database BCL2L11 DDI1 MI:0362 inference MI:0461 interaction database VAMP4 DDI1 MI:0362 inference MI:0461 interaction database CS DDI1 MI:0362 inference MI:0461 interaction database PMPCB DDI1 MI:0362 inference MI:0461 interaction database CAT DDI1 MI:0362 inference MI:0461 interaction database HSP90AB1 DDI1 MI:0362 inference MI:0461 interaction database UBB DDI1 MI:0362 inference MI:0461 interaction database UBC DDI1 MI:0045 experimental interaction detection MI:0461 interaction database HSPD1 DDI1 MI:0362 inference MI:0461 interaction database PSKH1 DDI1 MI:0362 inference MI:0461 interaction database PSMC3 DDI1 MI:0362 inference MI:0461 interaction database PDIA3 DDI1 MI:0362 inference MI:0461 interaction database UQCRC1 DDI1 MI:0362 inference MI:0461 interaction database STX2 DDI1 MI:0362 inference MI:0461 interaction database TALDO1 DDI1 MI:0362 inference MI:0461 interaction database GNAL DDI1 MI:0362 inference MI:0461 interaction database EIF4A3 DDI1 MI:0362 inference MI:0461 interaction database RPS27 DDI1 MI:0362 inference MI:0461 interaction database PSMD8 DDI1 MI:0362 inference MI:0461 interaction database PSMB2 DDI1 MI:0362 inference MI:0461 interaction database SEPHS1 DDI1 MI:0362 inference MI:0461 interaction database DNM2 DDI1 MI:0362 inference MI:0461 interaction database GPC3 DDI1 MI:0362 inference MI:0461 interaction database RAD23A DDI1 MI:0362 inference MI:0461 interaction database RAD23B DDI1 MI:0362 inference MI:0461 interaction database PSMD4 DDI1 MI:0362 inference MI:0461 interaction database UBE2K DDI1 MI:0045 experimental interaction detection MI:0461 interaction database STX1B DDI1 MI:0362 inference MI:0461 interaction database PSMC5 DDI1 MI:0362 inference MI:0461 interaction database PPP2CB DDI1 MI:0362 inference MI:0461 interaction database RPS27A DDI1 MI:0362 inference MI:0461 interaction database UBA52 DDI1 MI:0362 inference MI:0461 interaction database VAMP2 DDI1 MI:0362 inference MI:0461 interaction database PPP2CA DDI1 MI:0362 inference MI:0461 interaction database GPC5 DDI1 MI:0362 inference MI:0461 interaction database ACY1 DDI1 MI:0362 inference MI:0461 interaction database DNM1 DDI1 MI:0362 inference MI:0461 interaction database PSMD2 DDI1 MI:0362 inference MI:0461 interaction database STX3 DDI1 MI:0362 inference MI:0461 interaction database CUL1 DDI1 MI:0362 inference MI:0461 interaction database CUL2 DDI1 MI:0362 inference MI:0461 interaction database CAMK1 DDI1 MI:0362 inference MI:0461 interaction database SMC1A DDI1 MI:0045 experimental interaction detection MI:0461 interaction database VAMP3 DDI1 MI:0362 inference MI:0461 interaction database NEDD8 DDI1 MI:0362 inference MI:0461 interaction database ADRM1 DDI1 MI:0362 inference MI:0461 interaction database CAMK4 DDI1 MI:0362 inference MI:0461 interaction database STX1A DDI1 MI:0362 inference MI:0461 interaction database GNPTAB DDI1 MI:0362 inference MI:0461 interaction database NOL9 DDI1 MI:0362 inference MI:0461 interaction database DDI2 DDI1 MI:0362 inference MI:0461 interaction database PNCK DDI1 MI:0362 inference MI:0461 interaction database PLXDC2 DDI1 MI:0362 inference MI:0461 interaction database SSH2 DDI1 MI:0362 inference MI:0461 interaction database PRRT2 DDI1 MI:0045 experimental interaction detection MI:0461 interaction database CAMK1D DDI1 MI:0362 inference MI:0461 interaction database PLXDC1 DDI1 MI:0362 inference MI:0461 interaction database PHC3 DDI1 MI:0045 experimental interaction detection MI:0461 interaction database DDI1 CYGB MI:0045 experimental interaction detection MI:0461 interaction database DDI1 DNAH7 MI:0362 inference MI:0461 interaction database DDI1 SSH1 MI:0362 inference MI:0461 interaction database DDI1 RSC1A1 MI:0045 experimental interaction detection MI:0461 interaction database DDI1 MED30 MI:0362 inference MI:0461 interaction database DDI1 USP47 MI:0045 experimental interaction detection MI:0461 interaction database DDI1 CAMK1G MI:0362 inference MI:0461 interaction database DDI1 SFXN1 MI:0045 experimental interaction detection MI:0461 interaction database DDI1 SCPEP1 MI:0362 inference MI:0461 interaction database DDI1 NRIP3 MI:0045 experimental interaction detection MI:0461 interaction database DDI1 CCL28 MI:0045 experimental interaction detection MI:0461 interaction database DDI1 ABCF3 MI:0362 inference MI:0461 interaction database DDI1 C4orf27 MI:0362 inference MI:0461 interaction database DDI1 KLHL42 MI:0045 experimental interaction detection MI:0461 interaction database DDI1 ABCD2 MI:0362 inference MI:0461 interaction database DDI1 PUF60 MI:0362 inference MI:0461 interaction database DDI1 PSMD13 MI:0362 inference MI:0461 interaction database DDI1 DNM3 MI:0362 inference MI:0461 interaction database DDI1 WBP11 MI:0362 inference MI:0461 interaction database DDI1 EXOSC1 MI:0362 inference MI:0461 interaction database